AutismKB 2.0

Annotation Detail for SLC9A1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SLC9A1 ( APNH,FLJ42224,NHE1 )
Gene Full Name: solute carrier family 9 (sodium/hydrogen exchanger), member 1
Band: 1p36.11
Quick LinksEntrez ID:6548; OMIM: 107310; Uniprot ID:SL9A1_HUMAN; ENSEMBL ID: ENSG00000090020; HGNC ID: 11071
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04970Salivary secretion
hsa04972Pancreatic secretion
hsa04971Gastric acid secretion
hsa04810Regulation of actin cytoskeleton
hsa04260Cardiac muscle contraction
Pathway IDPathway Name
Transmembrane transport of small molecules
Pathway IDPathway Name
200004Endothelins
200007RhoA signaling pathway
200154Signaling mediated by p38-alpha and p38-beta
200113ErbB1 downstream signaling
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
1779Cervical cancer
1878Ischemia
1944Breast cancer
1841Stomach cancer
2120Rabies
Desease Name
diabetes, type 1
IMMUNE
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C061282 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]decreases reaction|increases expression 15452191
C074107 3-methylsulfonyl-4-piperidinobenzoyl guanidine 3-methylsulfonyl-4-piperidinobenzoyl guanidine inhibits the reaction [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium]decreases reaction|increases activity|increases transport 16236312
C074107 3-methylsulfonyl-4-piperidinobenzoyl guanidine 3-methylsulfonyl-4-piperidinobenzoyl guanidine results in decreased activity of SLC9A1 proteindecreases activity 11159350
11704563
C039465 5-dimethylamiloride 5-dimethylamiloride results in decreased activity of SLC9A1 proteindecreases activity 11930639
D000450 Aldosterone Aldosterone results in increased expression of SLC9A1 mRNAincreases expression 16373419
D000450 Aldosterone eplerenone inhibits the reaction [Aldosterone results in increased expression of SLC9A1 mRNA]decreases reaction|increases expression 16373419
D000584 Amiloride Amiloride results in decreased activity of SLC9A1 proteindecreases activity 16884771
12765964
14602837
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC9A1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of SLC9A1 mRNAdecreases expression 20458559
C110772 benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [resveratrol results in decreased expression of SLC9A1 protein]decreases expression|decreases reaction 18951995
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of SLC9A1 mRNAdecreases expression 12760830
D002118 Calcium 3-methylsulfonyl-4-piperidinobenzoyl guanidine inhibits the reaction [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium]decreases reaction|increases activity|increases transport 16236312
D002118 Calcium [Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calciumincreases activity|increases transport 16236312
D002118 Calcium [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] which results in increased expression of ATP2A2 proteinincreases activity|increases expression|increases transport 16236312
D002217 Carbachol Carbachol results in increased activity of SLC9A1 proteinincreases activity 12842825
D002245 Carbon Dioxide SLC9A1 protein affects the susceptibility to Carbon Dioxideaffects response to substance 16831598
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SLC9A1 mRNAaffects expression 17805973
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of SLC9A1 mRNAdecreases expression 16644059
C093373 cariporide cariporide results in decreased activity of SLC9A1 proteindecreases activity 14749038
C093373 cariporide cariporide results in decreased activity of SLC9A1 proteindecreases activity 15681704
14602837
D016572 Cyclosporine Cyclosporine results in increased expression of SLC9A1 mRNAincreases expression 20106945
D004317 Doxorubicin [ethylisopropylamiloride results in decreased activity of SLC9A1 protein] which results in increased abundance of Doxorubicindecreases activity|increases abundance 15729714
D004317 Doxorubicin SLC9A1 protein results in decreased susceptibility to Doxorubicindecreases response to substance 15729714
C414690 eplerenone eplerenone inhibits the reaction [Aldosterone results in increased expression of SLC9A1 mRNA]decreases reaction|increases expression 16373419
C039614 ethylisopropylamiloride ethylisopropylamiloride results in decreased activity of SLC9A1 proteindecreases activity 12562776
C039614 ethylisopropylamiloride [ethylisopropylamiloride results in decreased activity of SLC9A1 protein] which results in increased abundance of Doxorubicindecreases activity|increases abundance 15729714
C039614 ethylisopropylamiloride ethylisopropylamiloride results in decreased activity of SLC9A1 proteindecreases activity 17552965
C039614 ethylisopropylamiloride ethylisopropylamiloride results in decreased activity of SLC9A1 proteindecreases activity 16884771
D006861 Hydrogen Peroxide [resveratrol results in increased abundance of Hydrogen Peroxide] which results in decreased expression of SLC9A1 proteindecreases expression|increases abundance 18951995
D019344 Lactic Acid SLC9A1 protein results in decreased susceptibility to Lactic Aciddecreases response to substance 15801799
D008094 Lithium Phloretin inhibits the reaction [SLC9A1 protein alternative form affects the transport of [Sodium co-treated with Lithium]]affects cotreatment|affects transport|decreases reaction 12765964
D008094 Lithium SLC9A1 protein alternative form affects the transport of [Sodium co-treated with Lithium]affects cotreatment|affects transport 12765964
D008094 Lithium Lithium results in decreased expression of SLC9A1 mRNAdecreases expression 18506424
D008094 Lithium Lithium results in increased activity of SLC9A1 proteinincreases activity 18506424
D008623 Mercaptoethanol Mercaptoethanol affects the reaction [resveratrol results in decreased expression of SLC9A1 mRNA]affects reaction|decreases expression 18951995
D008623 Mercaptoethanol Mercaptoethanol affects the reaction [resveratrol results in decreased expression of SLC9A1 protein]affects reaction|decreases expression 18951995
D018721 Muscarinic Agonists Muscarinic Agonists results in increased activity of SLC9A1 proteinincreases activity 12842825
C084956 N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]decreases reaction|increases expression 15452191
C048599 N(6)-cyclopentyladenosine N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]decreases reaction|increases expression 15452191
D010618 Phenanthrolines Phenanthrolines affects the reaction [resveratrol results in decreased expression of SLC9A1 mRNA]affects reaction|decreases expression 18951995
D010618 Phenanthrolines Phenanthrolines affects the reaction [resveratrol results in decreased expression of SLC9A1 protein]affects reaction|decreases expression 18951995
D010656 Phenylephrine SLC9A1 protein affects the reaction [Phenylephrine results in increased activity of MMP9 protein]affects reaction|increases activity 18539131
D010656 Phenylephrine 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]decreases reaction|increases expression 15452191
D010656 Phenylephrine 3-methylsulfonyl-4-piperidinobenzoyl guanidine inhibits the reaction [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium]decreases reaction|increases activity|increases transport 16236312
D010656 Phenylephrine N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]decreases reaction|increases expression 15452191
D010656 Phenylephrine N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]decreases reaction|increases expression 15452191
D010656 Phenylephrine Phenylephrine results in increased activity of SLC9A1 proteinincreases activity 16236312
D010656 Phenylephrine [Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calciumincreases activity|increases transport 16236312
D010656 Phenylephrine [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] which results in increased expression of ATP2A2 proteinincreases activity|increases expression|increases transport 16236312
D010656 Phenylephrine Phenylephrine results in increased expression of SLC9A1 mRNAincreases expression 16517124
D010656 Phenylephrine Phenylephrine results in increased expression of SLC9A1 proteinincreases expression 15452191
D010656 Phenylephrine RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 mRNA]decreases reaction|increases expression 16517124
D010656 Phenylephrine SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]increases activity|increases phosphorylation|increases reaction 16513848
D010656 Phenylephrine SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]increases activity|increases phosphorylation|increases reaction 16513848
D010693 Phloretin Phloretin inhibits the reaction [SLC9A1 protein alternative form affects the transport of [Sodium co-treated with Lithium]]affects cotreatment|affects transport|decreases reaction 12765964
D010693 Phloretin Phloretin results in decreased activity of SLC9A1 proteindecreases activity 12765964
D010693 Phloretin Phloretin results in decreased activity of SLC9A1 protein alternative formdecreases activity 12765964
D016226 Phosphorus, Dietary Phosphorus, Dietary affects the expression of SLC9A1 mRNAaffects expression 17651324
C006253 pirinixic acid pirinixic acid results in decreased expression of SLC9A1 mRNAdecreases expression 17426115
D011522 Protons SLC9A1 protein affects the transport of Protonsaffects transport 12562776
17943310
C059514 resveratrol CASP3 protein affects the reaction [resveratrol results in decreased expression of SLC9A1 mRNA]affects reaction|decreases expression 18951995
C059514 resveratrol CASP3 protein affects the reaction [resveratrol results in decreased expression of SLC9A1 protein]affects reaction|decreases expression 18951995
C059514 resveratrol CASP6 protein affects the reaction [resveratrol results in decreased expression of SLC9A1 mRNA]affects reaction|decreases expression 18951995
C059514 resveratrol CASP6 protein affects the reaction [resveratrol results in decreased expression of SLC9A1 protein]affects reaction|decreases expression 18951995
C059514 resveratrol CAT protein affects the reaction [resveratrol results in decreased expression of SLC9A1 mRNA]affects reaction|decreases expression 18951995
C059514 resveratrol CAT protein affects the reaction [resveratrol results in decreased expression of SLC9A1 protein]affects reaction|decreases expression 18951995
C059514 resveratrol Mercaptoethanol affects the reaction [resveratrol results in decreased expression of SLC9A1 mRNA]affects reaction|decreases expression 18951995
C059514 resveratrol Mercaptoethanol affects the reaction [resveratrol results in decreased expression of SLC9A1 protein]affects reaction|decreases expression 18951995
C059514 resveratrol Phenanthrolines affects the reaction [resveratrol results in decreased expression of SLC9A1 mRNA]affects reaction|decreases expression 18951995
C059514 resveratrol Phenanthrolines affects the reaction [resveratrol results in decreased expression of SLC9A1 protein]affects reaction|decreases expression 18951995
C059514 resveratrol resveratrol results in decreased expression of SLC9A1 mRNAdecreases expression 18951995
C059514 resveratrol resveratrol results in decreased expression of SLC9A1 proteindecreases expression 18951995
C059514 resveratrol benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [resveratrol results in decreased expression of SLC9A1 protein]decreases expression|decreases reaction 18951995
C059514 resveratrol CASP3 protein affects the reaction [resveratrol results in decreased expression of SLC9A1 protein]affects reaction|decreases expression 18951995
C059514 resveratrol CASP6 protein affects the reaction [resveratrol results in decreased expression of SLC9A1 protein]affects reaction|decreases expression 18951995
C059514 resveratrol CAT protein inhibits the reaction [resveratrol results in decreased expression of SLC9A1 protein]decreases expression|decreases reaction 18951995
C059514 resveratrol resveratrol results in decreased expression of SLC9A1 mRNAdecreases expression 18951995
C059514 resveratrol resveratrol results in decreased expression of SLC9A1 proteindecreases expression 18951995
C059514 resveratrol [resveratrol results in increased abundance of Hydrogen Peroxide] which results in decreased expression of SLC9A1 proteindecreases expression|increases abundance 18951995
D012964 Sodium Phloretin inhibits the reaction [SLC9A1 protein alternative form affects the transport of [Sodium co-treated with Lithium]]affects cotreatment|affects transport|decreases reaction 12765964
D012964 Sodium SLC9A1 protein affects the transport of Sodiumaffects transport 12562776
D012964 Sodium SLC9A1 protein alternative form affects the transport of [Sodium co-treated with Lithium]affects cotreatment|affects transport 12765964
D012964 Sodium SLC9A1 protein affects the transport of Sodiumaffects transport 15681704
C017947 sodium arsenite sodium arsenite results in increased expression of SLC9A1 mRNAincreases expression 12760830
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 10.0918287403
MESH:D000138 Acidosis Lactic Acid 10.0918406487 20872349
MESH:D058186 Acute Kidney Injury resveratrol 3.5516538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.8118653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.2619825857 11798837
MESH:D000230 Adenocarcinoma Doxorubicin 4.2617418594
MESH:D000236 Adenoma resveratrol 3.1215688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.1416434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5616712894 17306315
MESH:D000419 Albuminuria Doxorubicin 4.2221441931
MESH:D000544 Alzheimer Disease Lithium 4.4819621015
MESH:D000544 Alzheimer Disease resveratrol 4.4816183991 16162502
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.8217460149
MESH:D001169 Arthritis, Experimental resveratrol 3.2917115116
MESH:D050197 Atherosclerosis resveratrol 3.0716873680 17967414
MESH:D001714 Bipolar Disorder Lithium 4.1520338123 19153942 17594078 20046352
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 7.9916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.9919483382
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.3514601052
MESH:D001919 Bradycardia Carbachol 10.0912411408
MESH:D001919 Bradycardia Phenylephrine 10.0915306635
MESH:D002545 Brain Ischemia resveratrol 3.9417600658
MESH:D001932 Brain Neoplasms Doxorubicin 3.5217150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.5416264153 15634643 15939500 17983394 17426702 16935488 18695136 17369602 18382427 19526202 15136595 15994142 15567936 18234424 16096432 15993339 16595493 16322301 16826403 18628466 15692762 16115903 15668708 11325840
MESH:D001943 Breast Neoplasms resveratrol 2.5417651959 16393696 17534123
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0211589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4516011737 15700767 18705752 16192424 16097048 3786805 16124888 16050911 10355542 16227642 15721981 15673190
MESH:D002276 Carcinoid Tumor Doxorubicin 4.4616051944
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.2314691202 15073043 16217749 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.2318788625
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.2316023760 18059187 17876044 16234567
MESH:D006528 Carcinoma, Hepatocellular resveratrol 8.2319321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.2317306315 15276417 16507464
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.2516675471
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5319014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.0016201981 1485588
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8212490120
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.026189445
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.0216227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.0218572023
MESH:D002295 Carcinoma, Transitional Cell Amiloride 4.7914644129
MESH:D006332 Cardiomegaly Phenylephrine 3.3411754973 16170337 15728586 17124262 11179087 17287366
MESH:D009202 Cardiomyopathies Doxorubicin 3.3116455267 15505089 15811867 15476868 17131338 16269455 16278810 17329180 16364871 16651473 15792986 17924179 16242529 18627295 16612575 16109756 16952015 17519947 17007740 17382496 17351982 17974986 17308081 17928571 16731534
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8317334414 16243910
MESH:D002318 Cardiovascular Diseases Aldosterone 11.1011230374
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 11.1016936243
MESH:D002318 Cardiovascular Diseases resveratrol 11.1015458977
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 5.8812371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 5.8820056578 19524636
MESH:D002779 Cholestasis Cyclosporine 6.9319486331
MESH:D002779 Cholestasis pirinixic acid 6.9319176532
MESH:D003092 Colitis Amiloride 9.0412065299
MESH:D003092 Colitis resveratrol 9.0416474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4016338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.3120501625
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.3118259882 18802399
MESH:D015179 Colorectal Neoplasms resveratrol 3.3116550006
MESH:D003327 Coronary Disease resveratrol 3.5316507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8612609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8710525206
MESH:D007644 Darier Disease Lithium 5.5720338123
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7815213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.4119244398
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.5016873680
MESH:D003928 Diabetic Nephropathies resveratrol 3.6816286809
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.7115027814 2869522 15998439 19085960 7179309 15968718 6884620 9327722 3786805 16227642 10915739 7440962 10092053 3732212 6623471 21278145 7120509 11566570 16177239 19336974 17522070 4309450
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 3.7117416283
MESH:D004362 Drug Toxicity Doxorubicin 3.4218602426
MESH:D004487 Edema marker/mechanism 20553904
MESH:D004487 Edema pirinixic acid 5.9112083418
MESH:D004487 Edema resveratrol 5.918985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.7117872969
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.2317359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8118037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.5217923197
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.2212903497
MESH:D005234 Fatty Liver arsenic trioxide 16.2715073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 16.2716045604 15959796 61145 12795759 17595544 16239168 19224547 12631006
MESH:D005234 Fatty Liver Cyclosporine 16.2719224547
MESH:D005234 Fatty Liver pirinixic acid 16.2719236843 20131406
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.2519069698
MESH:D005355 Fibrosis Carbon Tetrachloride 7.5718705752
MESH:D005355 Fibrosis Cyclosporine 7.5712639820 12168785
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9416904648
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3416452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.888708960
MESH:D005909 Glioblastoma Doxorubicin 3.1317150277
MESH:D006130 Growth Disorders Amiloride 4.5419703807
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.3015692506
MESH:D006330 Heart Defects, Congenital Lithium 4.0419638421
MESH:D006331 Heart Diseases Doxorubicin 3.2517888722 18006777 16144979 16495754 16330681 17875725 16244371 16879835 12587719 16244372 18674790 16707910 14766674
MESH:D006333 Heart Failure Doxorubicin 6.3517481944
MESH:D006333 Heart Failure pirinixic acid 6.3520558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6015692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0815720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2719110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 2.6719176532 19772884 18467677 16221962
MESH:D006561 Herpes Simplex resveratrol 3.8416876885
MESH:D006689 Hodgkin Disease Doxorubicin 6.5417606976 18501091 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 6.5412676792
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1916899240
MESH:D006937 Hypercholesterolemia resveratrol 3.7017188708
MESH:D006943 Hyperglycemia pirinixic acid 2.8920558911
MESH:D006949 Hyperlipidemias resveratrol 3.7216873680
MESH:D006973 Hypertension Amiloride 8.0819344079 18524855 15174897
MESH:D006973 Hypertension Cyclosporine 8.0810903974
MESH:D006973 Hypertension Phenylephrine 8.0812717712 8949925
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7515338365
MESH:D006984 Hypertrophy Phenylephrine 4.2512791704 18502941
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.0117488730
MESH:D020514 Hypokalemic Periodic Paralysis Amiloride 5.5119822448
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.3117600658
MESH:D007248 Infertility, Male sodium arsenite 2.7715346721 12646999
MESH:D007249 Inflammation Amiloride 7.8317237260
MESH:D007249 Inflammation ethylisopropylamiloride 7.8317237260
MESH:D007249 Inflammation resveratrol 7.8316366677
MESH:D007251 Influenza, Human resveratrol 4.2016624496
MESH:D007333 Insulin Resistance pirinixic acid 2.4116306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0915604871
MESH:D007674 Kidney Diseases Cadmium Chloride 12.8716962696
MESH:D007674 Kidney Diseases Cyclosporine 12.878314463 18776723 10903974
MESH:D007674 Kidney Diseases Doxorubicin 12.8715369732 16775033 15699352
MESH:D007674 Kidney Diseases sodium arsenite 12.8720008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.1216707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 9.1216518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.4712371664
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.7016316344
MESH:D007938 Leukemia arsenic trioxide 2.6615070760
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8116085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4912560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.4619077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.0820471514 19850784 16467208 16968895 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.0516112521 12712474 11468182 17869043 19035177 17649720 15336539 11161223 16330433 17712046 16331271 12679006 15748426 16891316 12018890 9834237 17217047 19642359 16966277 17107899 19225113 19075265 16823087 15622746 15213294
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.0516087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0316882451
MESH:D056929 Liddle Syndrome Amiloride 5.6419344079
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.6211903743 11408273 16943688 16221502 17157831 17174718 17334410 16239168 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.2611481614 18166357 17823541 17761835 12609069 18481824 16638106 12546737 14724832 17766677 17698563 18210741 18006644 13678700 12389079 15123356 18054572 18279442 17714472 18205269 15370692 12667390 17922224 17944888 16033810 15959796 15925388 18429990 14716496 18187930 17869086 18339082 17900296 17721639 16136751 15362042 17481882 15650968 12666154 18156304 14512876 15893842 16015684 12445421 18472094 17631135 18420326 18412020 14716833 16192424 18472332 12632512 18251166 18263696 16097048 18418968 12649538 16248980 18376398 18317297 12445418 15876570 20821823 17557913 14748882 10355542 14620537 18705752 18395095 17565644 18277467 15052691 15931870 16116963 15338365 17976157 12632514 16027843 15673190 15996030 16011737 12958196 17708605 15730626 15818738 18395914 12898905 17805973 12586293 17640975 15057751 17525996 12741479
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.2616439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.2615474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0017285989 16246199 16964402 15830285 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4014706259 16899240
MESH:D008113 Liver Neoplasms arsenic trioxide 12.8014682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 12.8019294768
MESH:D008113 Liver Neoplasms pirinixic acid 12.8015890375 16377806 20007298
MESH:D008113 Liver Neoplasms resveratrol 12.8019321006 20405173 19073162 19812893
MESH:D008113 Liver Neoplasms sodium arsenite 12.8016712894 15276417
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 8.6920377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 8.6915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 8.6916842330 17085340
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0915213294
MESH:D008171 Lung Diseases sodium arsenite 2.9519095001
MESH:D008175 Lung Neoplasms arsenic trioxide 3.2911798837 19825857
MESH:D008175 Lung Neoplasms Doxorubicin 3.296189445 17418594
MESH:D008175 Lung Neoplasms sodium arsenite 3.2919931552 17306315 16712894 15276417 17077188
MESH:D008223 Lymphoma Doxorubicin 3.2216098063
MESH:D016393 Lymphoma, B-Cell resveratrol 3.9917088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 7.9717654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 7.9714749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.2315621674
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.9115688416
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 5.6015458769
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 5.608985016 11606380
MESH:D008545 Melanoma Doxorubicin 4.8216827129
MESH:D008545 Melanoma resveratrol 4.8217992120
MESH:D008545 Melanoma sodium arsenite 4.8216487513 19082730
MESH:D008654 Mesothelioma Doxorubicin 2.9217638057
MESH:D008659 Metabolic Diseases resveratrol 4.0717112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4416801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.1915792986
MESH:D052016 Mucositis Doxorubicin 4.4517415656
MESH:D009101 Multiple Myeloma arsenic trioxide 6.6211468182 19417148 19549372 14977855 15949261
MESH:D009101 Multiple Myeloma resveratrol 6.6217935668 16490592 17164350 17049120 16267019 14749477
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.5317962980
MESH:D009135 Muscular Diseases pirinixic acid 3.1716239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3318349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 2.9516882451 16105982
MESH:D009203 Myocardial Infarction Doxorubicin 12.4115857846 19429709
MESH:D009203 Myocardial Infarction Lithium 12.4116288908
MESH:D009203 Myocardial Infarction pirinixic acid 12.4119151258
MESH:D009203 Myocardial Infarction resveratrol 12.4117188708 17125593 16525036 16456233 17015251 16317513
MESH:D017202 Myocardial Ischemia resveratrol 3.7417015251 17125593
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6916411023
MESH:D009205 Myocarditis resveratrol 4.4217322642
MESH:D009361 Neoplasm Invasiveness Amiloride 9.5914644129
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 9.5916624393
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.8118259882
MESH:D009369 Neoplasms pirinixic acid 4.3817405874
MESH:D009369 Neoplasms sodium arsenite 4.3811559025
MESH:D009374 Neoplasms, Experimental resveratrol 8.138985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.1320056578
MESH:D009401 Nephrosis Doxorubicin 4.4416899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.3518481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.3515640375 16889571
MESH:D009436 Neural Tube Defects arsenic trioxide 6.6010525206
MESH:D009436 Neural Tube Defects sodium arsenite 6.6012854658
MESH:D009447 Neuroblastoma Doxorubicin 3.0915555623
MESH:D019636 Neurodegenerative Diseases resveratrol 3.5317652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.0917929310
MESH:D009765 Obesity pirinixic acid 1.7320558911
MESH:D010024 Osteoporosis Calcium 3.5717882678
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.9417513867
MESH:D012516 Osteosarcoma Doxorubicin 3.8515930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.5319769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.5315276417 17306315
MESH:D010146 Pain marker/mechanism 19248819
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.4015580305
MESH:D010212 Papilloma Hydrogen Peroxide 3.7612065085
MESH:D010235 Paraganglioma arsenic trioxide 3.8519927285
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8117983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8117638057
MESH:D011041 Poisoning N(6)-cyclopentyladenosine 5.6016105447
MESH:D011230 Precancerous Conditions Cyclosporine 2.9412371664
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 3.8416679765
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1819131511
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.1815749863 16729912 15897917 16888761 16868541 18437689
MESH:D011471 Prostatic Neoplasms resveratrol 2.1817636462 17675339 17804756 16731767 15767336 17718901
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1816039940
MESH:D011565 Psoriasis Cyclosporine 2.1116882103
MESH:D051437 Renal Insufficiency Doxorubicin 3.8917922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.2416325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.0019058328
MESH:D015427 Reperfusion Injury resveratrol 6.0017520802 15827377 16314181 17058453 16317513
MESH:D012509 Sarcoma Doxorubicin 3.7015625365 15675481 18313854 16767912 17203757 17710206
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.2016646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.2014601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4517846226
MESH:D012640 Seizures Lithium 3.7619660546
MESH:D012852 Sinusitis Phenylephrine 4.367327846
MESH:D012878 Skin Neoplasms Doxorubicin 12.2915692506
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 12.2912065085
MESH:D012878 Skin Neoplasms resveratrol 12.298985016 15837718
MESH:D012878 Skin Neoplasms sodium arsenite 12.2919524636 18572023
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2317203757 15625365 16767912
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5412854658
MESH:D013226 Status Epilepticus Lithium 5.4419570321 19430551 19951488
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8517007042
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.1916321402
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.4919014326
MESH:D013964 Thyroid Neoplasms Doxorubicin 6.4917909728 16010429
MESH:D014062 Tongue Neoplasms resveratrol 3.9216227395
MESH:D016171 Torsades de Pointes arsenic trioxide 3.6215213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.5812973940 12845720 11780464 20435036
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 7.5817653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.5817306315 11723127 16452187 16712894
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.5917473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.5911813266
MESH:D014594 Uterine Neoplasms resveratrol 3.8117044934
MESH:D014605 Uveitis Cyclosporine 3.641336536
MESH:D014652 Vascular Diseases sodium arsenite 4.0817056641
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 9.2316364871 17334414 17638931 17678736
MESH:D018487 Ventricular Dysfunction, Left resveratrol 9.2317488730
MESH:D014985 Xerophthalmia Cyclosporine 4.0917120751
Pathway ID Pathway Name
KEGG:04976 Bile secretion
KEGG:04260 Cardiac muscle contraction
KEGG:04971 Gastric acid secretion
KEGG:04972 Pancreatic secretion
KEGG:04810 Regulation of actin cytoskeleton
KEGG:04970 Salivary secretion
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35928
    • No data
    Releated disease ID Related disease Name
    PA443796Coronary Artery Disease
    PA445019Myocardial Infarction
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00594 antagonist Riva-Amilzide 5/50 mg Sodium channel blockers;Diuretics
    DB02624 - Homoserine Lactone
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved