AutismKB 2.0

Annotation Detail for SLC10A2


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Basic Information Top
Gene Symbol:SLC10A2 ( ASBT,IBAT,ISBT,NTCP2,PBAM )
Gene Full Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 2
Band: 13q33.1
Quick LinksEntrez ID:6555; OMIM: 601295; Uniprot ID:NTCP2_HUMAN; ENSEMBL ID: ENSG00000125255; HGNC ID: 10906
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500831Recycling of bile acids and salts
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2053Colon cancer
2097Hyperlipidemia
Desease Name
colorectal cancer
CHEMDEPENDENCY
CANCER
colorectal adenomas
alcohol dependence
No data
Desease Name
Bile acid malabsorption, primary
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C466800 1-(4-(4-(3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl)phenoxy)butyl)-4-aza-1-azoniabicyclo(2.2.2)octane 1-(4-(4-(3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl)phenoxy)butyl)-4-aza-1-azoniabicyclo(2.2.2)octane results in increased expression of SLC10A2 mRNAincreases expression 15254889
D000082 Acetaminophen Acetaminophen affects the expression of SLC10A2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC10A2 mRNAaffects expression 16483693
C065179 atorvastatin atorvastatin results in increased expression of SLC10A2 mRNAincreases expression 15986414
C065179 atorvastatin atorvastatin results in increased expression of SLC10A2 proteinincreases expression 15986414
D001647 Bile Acids and Salts SLC10A2 protein affects the transport of Bile Acids and Saltsaffects transport 12663868
D003907 Dexamethasone Dexamethasone affects the expression of SLC10A2 mRNAaffects expression 15102944
D002117 Calcitriol Calcitriol results in increased expression of SLC10A2 mRNAincreases expression 16002434
D000431 Ethanol Ethanol results in decreased expression of SLC10A2 mRNAdecreases expression 15353170
C099406 L 742694 L 742694 affects the expression of SLC10A2 mRNAaffects expression 15102944
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLC10A2 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of SLC10A2 mRNAincreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC10A2 mRNAaffects binding|decreases expression|increases activity 19710929
D013655 Taurochenodeoxycholic Acid Taurochenodeoxycholic Acid results in increased expression of SLC10A2 proteinincreases expression 11672435
D013656 Taurocholic Acid SLC10A2 protein results in increased uptake of Taurocholic Acidincreases uptake 15209631
C037351 tauromuricholic acid tauromuricholic acid results in increased expression of SLC10A2 proteinincreases expression 11672435
C031655 tauroursodeoxycholic acid tauroursodeoxycholic acid results in increased expression of SLC10A2 proteinincreases expression 11672435
D014050 Toluene Toluene affects the expression of SLC10A2 mRNAaffects expression 18653662
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 8.7617676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.766195326
MESH:D000138 Acidosis Ammonium Chloride 10.5418287403
MESH:D000138 Acidosis Ethanol 10.5411192467
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.1917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.1916434500
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.3515451039 15451040
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D000853 Anophthalmos Ethanol 4.8315513904
MESH:D001008 Anxiety Disorders Ethanol 4.0111141031
MESH:D001169 Arthritis, Experimental Dexamethasone 3.5417659584
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
OMIM:613291 BILE ACID MALABSORPTION, PRIMARY marker/mechanism
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.1519483382
MESH:D001943 Breast Neoplasms Calcitriol 2.6111237771
MESH:D002056 Burns Ethanol 4.6616374292
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.623084413
MESH:D006528 Carcinoma, Hepatocellular Ethanol 4.6215289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.626705139 1701930 17173139 20007298 20935162
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6211237771
MESH:D006332 Cardiomegaly atorvastatin 7.6118360054
MESH:D006332 Cardiomegaly Ethanol 7.6119332462
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.264080065
MESH:D002547 Cerebral Palsy Toluene 5.879294310
MESH:D002779 Cholestasis pirinixic acid 2.8319176532
MESH:D002971 Cleft Lip Ethanol 3.5815513904
MESH:D002972 Cleft Palate Ethanol 3.1715513904
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4915824018
MESH:D003324 Coronary Artery Disease atorvastatin 4.1416368305
MESH:D019465 Craniofacial Abnormalities Dexamethasone 4.1017728286
MESH:D019465 Craniofacial Abnormalities Ethanol 4.1010194807 11198716 15451040 19302082 11873399 15451039 15513904
MESH:D019465 Craniofacial Abnormalities Toluene 4.109294310
MESH:D003643 Death Toluene 5.706431079
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.4212438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003967 Diarrhea Dexamethasone 3.717237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9512705907 16485898 18071297 11529661 14725611 19164858 16081117 10774834 16177239 12153990 10915739 14986274 19739265 11421492 18713872 11743745 11461765 16227642 16781746 12540782 16109766 11834606 19416960 12594235 10663392 2444490 11287661 11739529 17906064 12392966 15619225 17522070 16393943 19085960 19420014 15968718 19923254 19370779 14550746 17562736 12958197
MESH:D056486 Drug-Induced Liver Injury Ethanol 3.9511566570
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004421 Dystonia Phenobarbital 4.011851702
MESH:D004485 Eczema Dexamethasone 4.4712438553
MESH:D004487 Edema Dexamethasone 6.9319703484
MESH:D004487 Edema pirinixic acid 6.9312083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.9415138306
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.123659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.903922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8920417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.546401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.267750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.043659116
MESH:D004938 Esophageal Neoplasms Ethanol 2.7516704527
MESH:D004942 Esophagitis, Peptic Bile Acids and Salts 6.5811346197
MESH:D005234 Fatty Liver Ethanol 7.9019236843 18620774 16409862
MESH:D005234 Fatty Liver pirinixic acid 7.9020131406 19236843
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.7017920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.3216946407 15513904 10194807 15451040
MESH:D005756 Gastritis Acetaminophen 11.2316983495
MESH:D005756 Gastritis Ethanol 11.2315046732
MESH:D006333 Heart Failure atorvastatin 7.4816360360
MESH:D006333 Heart Failure pirinixic acid 7.4820558911
MESH:D006529 Hepatomegaly Phenobarbital 8.5216109766
MESH:D006529 Hepatomegaly pirinixic acid 8.5219772884 16221962 18467677 19176532
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.077520565
MESH:D006930 Hyperalgesia Acetaminophen 7.8216870215
MESH:D006930 Hyperalgesia Ethanol 7.8218783367
MESH:D006937 Hypercholesterolemia atorvastatin 5.0811583720
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006938 Hyperlipoproteinemia Type II atorvastatin 5.1416238680
MESH:D006973 Hypertension atorvastatin 6.0117042910
MESH:D006973 Hypertension Dexamethasone 6.0117042910
MESH:D007249 Inflammation atorvastatin 5.8416908763
MESH:D007249 Inflammation Dexamethasone 5.8411099482 8960868
MESH:D007333 Insulin Resistance pirinixic acid 2.6316306350
MESH:D007569 Jaw Abnormalities Ethanol 4.4115513904
MESH:D007674 Kidney Diseases Acetaminophen 2.2012587719 15629191
MESH:D007859 Learning Disorders Ethanol 4.2215451040
MESH:D017880 Limb Deformities, Congenital Ethanol 3.8117676605
MESH:D008103 Liver Cirrhosis Ethanol 6.8515289165
MESH:D008103 Liver Cirrhosis Phenobarbital 6.8521047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.1218295389
MESH:D008106 Liver Cirrhosis, Experimental atorvastatin 5.0817347453
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 5.0816718785
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 5.0818166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0815474484
MESH:D008107 Liver Diseases Acetaminophen 3.9316610002 12969438 11587558 16611625 12587719 19784758 19460945 19014921
MESH:D008107 Liver Diseases Phenobarbital 3.9319363144
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.6617347304 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2416871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 4.4719073162 15975961 19812893 8742319 19482888 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 4.4716377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.701399818 2563599 18308698 17172636 6150874
MESH:D008175 Lung Neoplasms Dexamethasone 2.2611195469 15824018
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008569 Memory Disorders Ethanol 4.2018411066 15451040
MESH:D008607 Mental Retardation Toluene 3.659294310
MESH:D019957 Motor Skills Disorders Toluene 5.249294310
MESH:D009101 Multiple Myeloma Dexamethasone 3.5115867202 16118317 15744524
MESH:D009135 Muscular Diseases atorvastatin 10.7916239165
MESH:D009135 Muscular Diseases pirinixic acid 10.7916239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.549809623
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5017484760
MESH:D009369 Neoplasms pirinixic acid 1.9517405874
MESH:D009404 Nephrotic Syndrome atorvastatin 5.1519348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D010018 Osteomalacia Phenobarbital 4.3817016548
MESH:D010146 Pain Acetaminophen 2.3916870215
MESH:D010190 Pancreatic Neoplasms Ethanol 5.4712384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4716965848
MESH:D010195 Pancreatitis Taurocholic Acid 5.2220035747
MESH:D011230 Precancerous Conditions Phenobarbital 3.622563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.5421297632
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.8015572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.5512479363 18247401 16644109 15754350 16289102
MESH:D019310 Pseudolymphoma Phenobarbital 4.5312752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.0218379247 11700416
MESH:D012640 Seizures Ethanol 10.079754883
MESH:D012640 Seizures Phenobarbital 10.0716876388 4039156 3137016 11442880
MESH:D012640 Seizures Toluene 10.079294310 6431079
MESH:D003294 Seizures, Febrile Phenobarbital 4.846407741
MESH:D013272 Stomach Diseases Dexamethasone 4.3415472012
MESH:D013274 Stomach Neoplasms Ethanol 2.3018456281
MESH:D013276 Stomach Ulcer Dexamethasone 7.5615138204
MESH:D013276 Stomach Ulcer Ethanol 7.569562338 17918041 17189318 16755016 9211565 11906479
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.269754883
MESH:D013733 Testicular Diseases Toluene 4.9810514026 10048760
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.051399818
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D014605 Uveitis Dexamethasone 4.851336536
Pathway ID Pathway Name
KEGG:04976 Bile secretion
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA318
    • No data
    Releated disease ID Related disease Name
    PA445425Prostatic Neoplasms
    Releated drug ID Related drug Name
    PA449383docetaxel
    PA451644thalidomide
    PA449789glycine
    Drug Bank Top
    No data
    No data
    Drugbank ID Action Drug Name Description
    DB00091 inhibitor Cyclosporine Antirheumatic Agents;Immunomodulatory Agents;Enzyme Inhibitors;Dermatologic Agents;Immunosuppressive Agents;Antifungal Agents
    DB01586 inhibitor Ursodeoxycholic acid Cholagogues and Choleretics
    DB02123 substrate Glycochenodeoxycholic Acid Detergents
    DB02659 inducer Cholic Acid
    DB03619 inhibitor Deoxycholic Acid Cholagogues and Choleretics
    DB04348 inducer Taurocholic Acid Cholagogues and Choleretics;Detergents
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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