AutismKB 2.0

Annotation Detail for SLC11A1


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Basic Information Top
Gene Symbol:SLC11A1 ( LSH,NRAMP,NRAMP1 )
Gene Full Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Band: 2q35
Quick LinksEntrez ID:6556; OMIM: 600266; Uniprot ID:NRAM1_HUMAN; ENSEMBL ID: ENSG00000018280; HGNC ID: 10907
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04142Lysosome
Pathway IDPathway Name
Transmembrane transport of small molecules
Pathway IDPathway Name
200171Validated targets of C-MYC transcriptional repression
No data
Pathway IDPathway Name
500353Metal ion SLC transporters
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1723Brucellosis
1756Esophageal tumor
1804Chronic obstructive airway disease
1807Autoimmune disease
1818Systemic scleroderma
1848Embryoma
1869Behcet syndrome
1998Enteritis
2029Tuberculosis
2074Asthma
2076Spondylarthropathies
2110Leprosy
2219Mucocutaneous lymph node syndrome
2231Arthritis
2240Anemia
1805Mycobacterium infection, Atypical
Desease Name
rheumatoid arthritis
tuberculosis
diabetes, type 1
Behcet Syndrome
CANCER
ulcerative colitis
esophageal cancer
susceptibility to tuberculosis
microscopy-positive tuberculosis
inflammatory bowel disease
IMMUNE
Crohn's disease
INFECTION
No data
Desease Name
Mycobacterium tuberculosis, susceptibility to infection by
Buruli ulcer, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SLC11A1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC11A1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of SLC11A1 mRNAincreases expression 20458559
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SLC11A1 mRNAaffects expression 17484886
D004041 Dietary Fats Dietary Fats results in decreased expression of SLC11A1 mRNAdecreases expression 18042831
D004958 Estradiol Estradiol affects the expression of SLC11A1 mRNAaffects expression 16684588
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SLC11A1 mRNAincreases expression 12072388
C013531 ferric ammonium citrate ferric ammonium citrate results in increased expression of SLC11A1 mRNAincreases expression 11054110
D007501 Iron [CP gene mutant form results in increased abundance of Iron] which results in increased expression of SLC11A1 mRNAincreases abundance|increases expression 16988052
C041786 palm oil palm oil results in decreased expression of SLC11A1 mRNAdecreases expression 18042831
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma arsenic trioxide 7.2711798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 7.2711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.2714692618
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.8916640825
MESH:D000544 Alzheimer Disease Iron 3.0316640825 16563566
MESH:D000740 Anemia Iron 4.5316434484 16566752
MESH:D018798 Anemia, Iron-Deficiency Iron 4.8117375513 17147795 17163184 17162259 16569441
MESH:D000756 Anemia, Sideroblastic Iron 4.9816910769
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001145 Arrhythmias, Cardiac Iron 4.5316604332
MESH:D001161 Arteriosclerosis Dietary Fats 10.6415238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001171 Arthritis, Juvenile Rheumatoid marker/mechanism 16597321
MESH:D001172 Arthritis, Rheumatoid marker/mechanism 16597321
MESH:D001260 Ataxia Telangiectasia Iron 5.6915336622
MESH:D050197 Atherosclerosis Iron 3.8016640825 16632123
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Iron 2.1417352947
MESH:D001424 Bacterial Infections Iron 5.4316640825
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.8416206674
MESH:D001943 Breast Neoplasms Dietary Fats 2.1320435547
MESH:D001943 Breast Neoplasms Estradiol 2.1317018787 16675129 17289903 14630087 19861407 12948864 18497071 17261762
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D054312 Buruli Ulcer marker/mechanism
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9916124888 15700767 3786805 15721981 16227642 18705752 10355542 16097048 16050911 15673190 16192424 16011737
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.753084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.7515553829 16217749 11135700 15073043 14691202
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7518788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7516924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D009202 Cardiomyopathies Iron 4.1516640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.5116604332
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8818566989
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0011677210 17333356 17681005 16919318 17110522 15861022 16105132
MESH:D003093 Colitis, Ulcerative marker/mechanism 16059695
MESH:D003110 Colonic Neoplasms Iron 2.9116640825
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003424 Crohn Disease marker/mechanism 16059695
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D003876 Dermatitis, Atopic marker/mechanism 16597321
MESH:D003920 Diabetes Mellitus Iron 4.6016640825 16604332
MESH:D003922 Diabetes Mellitus, Type 1 marker/mechanism 16597321
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.4016506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 3.1216506275
MESH:D003928 Diabetic Nephropathies Estradiol 3.5619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8916781746 19370779 18713872 16109766 14725611 15619225 14550746 16393943 12540782 2444490 11739529 16485898 11743745 12594235 10663392 16081117 10774834 11421492 12153990 11287661 19416960 19923254 11529661 11834606 11461765 19739265 12392966 16227642 19164858 19420014 10915739 12705907 17562736 16177239 17906064 18071297 19085960 15968718 17522070 14986274 12958197
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.8911566570 16177239 17522070 2869522 6623471 9327722 15998439 19085960 7120509 15027814 4309450 7440962 3732212 16227642 3786805 6884620 19336974 7179309 15968718 21278145 10092053 10915739
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D016889 Endometrial Neoplasms Estradiol 3.0911473722 18566989 19148513
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3412903497
MESH:D005234 Fatty Liver arsenic trioxide 26.6415073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 26.6412631006 15959796 16045604 16239168 19224547 17595544 12795759 61145
MESH:D005234 Fatty Liver Dietary Fats 26.6418296743 19551842 17967931 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 26.6415345470
MESH:D005234 Fatty Liver Iron 26.6416640825
MESH:D005355 Fibrosis Carbon Tetrachloride 9.5418705752
MESH:D005355 Fibrosis Dietary Fats 9.5418296743
MESH:D005512 Food Hypersensitivity marker/mechanism 16597321
MESH:D005621 Friedreich Ataxia Iron 5.6416604332 16640825
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D006432 Hemochromatosis Iron 4.6116574947 17236123 17053826 16604332 16640825 17255318
MESH:D006486 Hemosiderosis Iron 5.4816604332
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919110552 19900420
MESH:D006525 Hepatitis, Viral, Human Iron 5.7316640825
MESH:D006527 Hepatolenticular Degeneration Iron 5.1517182432
MESH:D006529 Hepatomegaly Iron 4.5316890145
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D015658 HIV Infections marker/mechanism 16597321
MESH:D015658 HIV Infections Iron 3.7516597321
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007006 Hypogonadism Iron 4.5216640825
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007037 Hypothyroidism Iron 5.3016640825
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Dietary Fats 2.5120412841
MESH:D015212 Inflammatory Bowel Diseases marker/mechanism 16597321
MESH:D007333 Insulin Resistance Dietary Fats 7.7318457598 11836018
MESH:D007333 Insulin Resistance Estradiol 7.7316627594 16393666
MESH:D019189 Iron Metabolism Disorders Iron 5.2217163184
MESH:D007674 Kidney Diseases Acetaminophen 6.1915629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.1915618244
MESH:D007680 Kidney Neoplasms Estradiol 3.1215610895
MESH:D007898 Leishmaniasis, Visceral marker/mechanism 16597321
MESH:D007918 Leprosy marker/mechanism 16597321
MESH:D007938 Leukemia arsenic trioxide 2.9115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9712560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616968895 17050201 19850784 20471514 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3215748426 11468182 16966277 16330433 11161223 15336539 17869043 17217047 15622746 12712474 19075265 17649720 12679006 19642359 16331271 16112521 19225113 15213294 16891316 9834237 16823087 17107899 12018890 19035177 17712046
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D020961 Lewy Body Disease Iron 5.6416563566
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 11.6516221502 11903743 17157831 11408273 21278145 16943688 17174718 16239168 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 11.6518296743
MESH:D008103 Liver Cirrhosis Iron 11.6516640825
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.4918210741 17766677 18156304 20821823 18395914 18317297 12898905 14620537 15673190 18166357 17805973 18472094 13678700 18205269 15370692 18395095 18376398 18481824 18054572 17631135 12958196 15925388 12666154 14716833 17557913 18472332 15730626 15057751 18418968 18339082 12445421 18187930 15338365 12389079 18412020 12649538 12632514 15362042 18251166 15996030 17823541 17944888 12445418 16192424 15818738 18263696 17761835 16033810 12546737 16011737 14512876 17922224 16248980 12632512 15876570 17481882 17640975 16638106 17714472 18429990 17525996 12586293 16015684 17869086 17708605 12609069 12667390 15893842 15052691 17900296 15650968 14716496 16136751 17565644 14724832 14748882 18420326 17698563 18279442 17721639 18705752 17976157 12741479 10355542 15123356 18277467 16116963 16097048 18006644 15959796 11481614 16027843 15931870
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.4914716833 14659978
MESH:D008107 Liver Diseases Acetaminophen 4.0316610002 16611625 19014921 12969438 11587558 19784758 19460945 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0316964402 16246199 15830285 15720792 17285989
MESH:D008108 Liver Diseases, Alcoholic Iron 5.2216737972 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.9516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.9516899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 7.9414682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.9419294768
MESH:D008113 Liver Neoplasms Iron 7.9416640825 20302851
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.3320377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3312014681 15583823
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.8611798837 19825857
MESH:D008175 Lung Neoplasms Iron 2.8616640825
MESH:D008268 Macular Degeneration Iron 4.0616640825
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6611408345 17203775 11807958 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008585 Meningitis, Meningococcal marker/mechanism 16597321
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2214977855 11468182 15949261 19549372 19417148
MESH:D009103 Multiple Sclerosis marker/mechanism 16597321
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.9417086897
MESH:D009181 Mycoses Iron 5.7316640825
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2316882451 16105982
MESH:D017202 Myocardial Ischemia Iron 4.5816604332
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.1816810080
MESH:D015428 Myocardial Reperfusion Injury Iron 9.1816604332
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009404 Nephrotic Syndrome Iron 4.6717178036
MESH:D009421 Nervous System Malformations Estradiol 3.8511399458 16427766
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2210525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.0018514411
MESH:D019636 Neurodegenerative Diseases Iron 9.0017296847 16604332
MESH:D009765 Obesity Dietary Fats 2.3217217161 20132043 18457598 11836018 16723640 21332399 20518802 19632207 18674790
MESH:D010003 Osteoarthritis Iron 4.0616640825
MESH:D010024 Osteoporosis Iron 3.9616648989 16640825
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.9816624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 4.9819401270
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010212 Papilloma Iron 4.7012065085
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D020447 Parasomnias Iron 6.2817352947
MESH:D010300 Parkinson Disease Iron 3.3716640825 16563566
MESH:D010900 Pituitary Diseases Iron 5.9416604332
MESH:D011041 Poisoning Iron 4.4716604332
MESH:D017119 Porphyria Cutanea Tarda Iron 5.1816640825
MESH:D011225 Pre-Eclampsia Iron 4.5516640825
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1819131511
MESH:D011471 Prostatic Neoplasms Estradiol 3.1816740699
MESH:D011528 Protozoan Infections Iron 6.2816640825
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D012148 Restless Legs Syndrome Iron 4.6716930377
MESH:D012507 Sarcoidosis marker/mechanism 16597321
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012878 Skin Neoplasms Iron 3.5412065085
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013398 Sudden Infant Death Iron 5.6916640825
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2219014326
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D014376 Tuberculosis marker/mechanism 16597321
MESH:D014376 Tuberculosis Iron 4.1916597321
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5320435036 12845720 11780464 12973940
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
Pathway ID Pathway Name
KEGG:04142 Lysosome
KEGG:04978 Mineral absorption
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA319
    • No data
    Releated disease ID Related disease Name
    PA444101Esophageal Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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