AutismKB 2.0

Annotation Detail for SLC13A1


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Basic Information Top
Gene Symbol:SLC13A1 ( NAS1,NaSi-1 )
Gene Full Name: solute carrier family 13 (sodium/sulfate symporters), member 1
Band: 7q31.32
Quick LinksEntrez ID:6561; OMIM: 606193; Uniprot ID:S13A1_HUMAN; ENSEMBL ID: ENSG00000081800; HGNC ID: 10916
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transmembrane transport of small molecules
Bile salt and organic anion SLC transporters
No data
No data
Pathway IDPathway Name
500002Sodium-coupled sulphate, di- and tri-carboxylate transporters
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of SLC13A1 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the reaction [SLC13A1 protein affects the abundance of Sulfates]affects abundance|affects reaction 16729303
D000082 Acetaminophen SLC13A1 gene mutant form results in increased susceptibility to Acetaminophenincreases response to substance 16729303
D000082 Acetaminophen SLC13A1 protein affects the reaction [Acetaminophen affects the expression of SLC26A1 mRNA]affects expression|affects reaction 16729303
D000082 Acetaminophen SLC13A1 protein affects the reaction [Acetaminophen results in increased expression of CYP1A2 mRNA]affects reaction|increases expression 16729303
D000082 Acetaminophen SLC13A1 protein affects the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]affects reaction|increases expression 16729303
D000082 Acetaminophen SLC13A1 protein affects the reaction [Acetaminophen results in increased expression of CYP3A11 mRNA]affects reaction|increases expression 16729303
D000082 Acetaminophen SLC13A1 protein affects the reaction [Acetaminophen results in increased expression of GSTP1 mRNA]affects reaction|increases expression 16729303
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC13A1 mRNAaffects expression 16483693
D015118 Eicosapentaenoic Acid PPARA protein promotes the reaction [Eicosapentaenoic Acid results in decreased expression of SLC13A1 mRNA]decreases expression|increases reaction 18489776
D019301 Oleic Acid PPARA protein promotes the reaction [Oleic Acid results in decreased expression of SLC13A1 mRNA]decreases expression|increases reaction 18489776
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC13A1 mRNAaffects binding|decreases expression|increases activity 18489776
D013431 Sulfates SLC13A1 protein results in increased uptake of Sulfatesincreases uptake 16729303
D013431 Sulfates Acetaminophen affects the reaction [SLC13A1 protein affects the abundance of Sulfates]affects abundance|affects reaction 16729303
D014415 Tunicamycin Tunicamycin results in increased expression of SLC13A1 mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D000860 Anoxia Oleic Acid 6.2315090967
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.401440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.917296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.913084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.917505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.4319486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.4319176532
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1014531868 18759878 11906362 2524372 11298694 8156756 8970840 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.752952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.9118648102 1440618 6679447 9328219 9653073 7440962 9022650 18289764 11289319 16192314 6482804 18692083 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9116485898 19085960 11287661 16081117 11743745 17522070 18713872 15619225 10915739 11834606 11739529 12958197 12594235 19420014 14725611 16109766 19370779 16227642 16781746 17906064 17562736 10774834 10663392 14986274 12705907 11421492 18071297 16177239 19923254 15968718 11461765 2444490 12392966 12540782 16393943 19164858 19416960 12153990 11529661 19739265 14550746
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005234 Fatty Liver pirinixic acid 3.0119236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006529 Hepatomegaly pirinixic acid 3.3016221962 19772884 18467677 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.408074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.3215629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.176582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.339327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6716611625 19784758 19014921 12969438 19460945 12587719 11587558 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.8916377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.67598648 6587162 1399818 3712494
MESH:D055370 Lung Injury Oleic Acid 5.6515090967
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.654026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D011654 Pulmonary Edema Oleic Acid 6.1815090967
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012128 Respiratory Distress Syndrome, Adult Oleic Acid 5.6118549715
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.066587162 1399818 7505956 3712494 6582329
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.358074119
MESH:D014581 Urticaria Acetaminophen 3.2410982225
Pathway ID Pathway Name
REACT:20633 Bile salt and organic anion SLC transporters
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA322
    • Releated gene ID Related gene Name
    PA322SLC13A1
    Releated disease ID Related disease Name
    PA443937Drug Toxicity
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA164925725Toxic liver disease
    Releated drug ID Related drug Name
    PA452621antineoplastic agents
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00139 - Ubicoenzyme Anti-Ulcer Agents;Dietary supplement;Micronutrient;Radiation-Protective Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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