AutismKB 2.0

Annotation Detail for SLC16A2


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Basic Information Top
Gene Symbol:SLC16A2 ( AHDS,DXS128,DXS128E,MCT 7,MCT 8,MCT7,MCT8,MRX22,XPCT )
Gene Full Name: solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
Band: Xq13.2
Quick LinksEntrez ID:6567; OMIM: 300095; Uniprot ID:MOT8_HUMAN; ENSEMBL ID: ENSG00000147100; HGNC ID: 10923
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Allan-Herndon-Dudley syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SLC16A2 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLC16A2 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC16A2 mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of SLC16A2 mRNAdecreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in decreased expression of SLC16A2 mRNA]affects reaction|decreases expression 18929588
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of SLC16A2 mRNAincreases expression 15336504
D002220 Carbamazepine Carbamazepine results in increased expression of SLC16A2 mRNAincreases expression 17112801
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SLC16A2 mRNAaffects expression 17484886
D002330 Carmustine Carmustine results in increased expression of SLC16A2 mRNAincreases expression 15980968
D016572 Cyclosporine Cyclosporine results in decreased expression of SLC16A2 mRNAdecreases expression 20106945
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of SLC16A2 mRNAaffects cotreatment|increases expression 17183730
C064116 S-(1,1,2,2-tetrafluoroethyl)cysteine S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of SLC16A2 mRNAdecreases expression 16678137
C517826 tetrabrominated diphenyl ether 47 tetrabrominated diphenyl ether 47 results in decreased expression of SLC16A2 mRNAdecreases expression 17964624
D014212 Tretinoin Tretinoin results in increased expression of SLC16A2 mRNAincreases expression 16249480
D014212 Tretinoin Tretinoin results in increased expression of SLC16A2 mRNAincreases expression 16604517
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of SLC16A2 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 9.218986270
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.218875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9819490988
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:C537047 Allan-Herndon-Dudley syndrome marker/mechanism
MESH:D000505 Alopecia Tretinoin 3.6615955085
MESH:D000550 Amblyopia Valproic Acid 5.3317688650
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6217497229
MESH:D001169 Arthritis, Experimental Tretinoin 3.1116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D001321 Autistic Disorder Acetaminophen 2.3018445737
MESH:D001321 Autistic Disorder tetrabrominated diphenyl ether 47 2.3019211157
MESH:D001321 Autistic Disorder Valproic Acid 2.3018396377 18775368 20603192 16609825 15238991 19232924 18985861 19460635 18558336 18940202 18316065 17507914 17157402 17688650 18177632
MESH:D001471 Barrett Esophagus Tretinoin 4.4716935849
MESH:D001714 Bipolar Disorder Carbamazepine 7.6320046352 17594078
MESH:D001714 Bipolar Disorder Valproic Acid 7.6317594078 20046352
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.6616206674 16197459
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.438888407
MESH:D001932 Brain Neoplasms Carmustine 4.4416187019
MESH:D001943 Breast Neoplasms Tretinoin 2.2716443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6716813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8510355542 16097048 15673190 3786805 15721981 16192424 16227642 16050911 15700767 18705752 16124888 16011737
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2616168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.633084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.6321507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.6318788625
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.631917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3016051514 16096774
MESH:D002386 Cataract Acetaminophen 7.3310977129
MESH:D002386 Cataract Tretinoin 7.3317460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5612371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6716129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D002779 Cholestasis Cyclosporine 2.9519486331
MESH:D002822 Choriocarcinoma Tretinoin 5.2616461808
MESH:D002972 Cleft Palate Tretinoin 2.699407595
MESH:D003092 Colitis Tretinoin 3.7817035595
MESH:D003110 Colonic Neoplasms arsenite 2.5915037631
MESH:D019465 Craniofacial Abnormalities Carbamazepine 4.029014606
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.029664655 10589399 14991402 16925845 9125849 9211117 8800419 17551590 9142499 9224671
MESH:D019465 Craniofacial Abnormalities Valproic Acid 4.0216575769 8888407 17688650
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.5211748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.4416538176 16538175 20216337 15057820
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.1714550746 19923254 11529661 11743745 12540782 2444490 11461765 10774834 16781746 18713872 19739265 19420014 11421492 19370779 11287661 16393943 14725611 15968718 17522070 12392966 12705907 16177239 10915739 10663392 17906064 15619225 19416960 19085960 12958197 16227642 18071297 16109766 17562736 12594235 19164858 14986274 11739529 11834606 16081117 16485898 12153990
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 9.1717465707
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.177120509 15998439 3732212 19336974 17522070 15027814 16227642 7179309 15968718 2869522 19085960 11566570 9327722 10915739 3786805 21278145 16177239 6623471 7440962 10092053 4309450 6884620
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.171733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Carbamazepine 4.5020216337
MESH:D004421 Dystonia Valproic Acid 4.111851702
MESH:D004489 Edema, Cardiac Tretinoin 4.5618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 4.8017654737
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1416569247
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.3216538176 20485159 18855540 16415921 19915237
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 11.4417275665
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 11.443659116 17275665
MESH:D004828 Epilepsies, Partial Carbamazepine 10.7116628512 17116037 15008574
MESH:D004828 Epilepsies, Partial Valproic Acid 10.7116628512 3922381
MESH:D004827 Epilepsy Carbamazepine 7.167988514 17178248 17465707 20417680 821787 19439326 18234410 9014606 19700373 19620853
MESH:D004827 Epilepsy Valproic Acid 7.1618234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.636254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 11.957750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 11.957750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 11.1615276670 3659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 11.163659116
MESH:D004916 Erythromelalgia Carbamazepine 5.8019549232
MESH:D005076 Exanthema Carbamazepine 5.5520485159
MESH:D005124 Eye Abnormalities Tretinoin 3.629664655 16938888
MESH:D005234 Fatty Liver arsenite 19.2818296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.2816239168 61145 15959796 12795759 17595544 16045604 19224547 12631006
MESH:D005234 Fatty Liver Cyclosporine 19.2819224547
MESH:D005234 Fatty Liver Valproic Acid 19.2819224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 4.9816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.198888407 18558336
MESH:D005355 Fibrosis arsenite 21.8318296743
MESH:D005355 Fibrosis Carbon Tetrachloride 21.8318705752
MESH:D005355 Fibrosis Cyclosporine 21.8312168785 12639820
MESH:D005355 Fibrosis Tretinoin 21.8317994277
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D005909 Glioblastoma Carmustine 7.5716187019
MESH:D005909 Glioblastoma Tretinoin 7.5717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2616084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.929664655 14991402
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6619900420 19110552
MESH:D006849 Hydrocephalus Valproic Acid 4.9517688650
MESH:D006930 Hyperalgesia Acetaminophen 7.7716870215
MESH:D006930 Hyperalgesia Tretinoin 7.7716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6116899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6416778211
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.7710459572
MESH:D006965 Hyperplasia Carbamazepine 5.2818773962
MESH:D006973 Hypertension Cyclosporine 2.1210903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1615338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7016612254
MESH:D007410 Intestinal Diseases Tretinoin 3.8417994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.9517551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Acetaminophen 5.8912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.898314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7812371664
MESH:D007938 Leukemia Tretinoin 2.7917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7516482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9219850784 16294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9216294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1917368321 17506722 17301526 16788101 19029980 9834237 16766008 17294898 16935935 17712046 15748426 17649720 16331271 16891316 17217047 17361223 19225113 12679006 17107899 19075265 17339181 16823087 16140955 19642359 19035177
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.349224671
MESH:D008103 Liver Cirrhosis arsenite 6.9218296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.9217157831 11408273 11903743 17174718 16239168 16221502 17334410 16943688 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.5118418968 12898905 12586293 15650968 12445421 18263696 18429990 12609069 16192424 15893842 12632512 17944888 17631135 16011737 16027843 12649538 12958196 15730626 18205269 17761835 10355542 15057751 18156304 12389079 13678700 18277467 18251166 12632514 18376398 12445418 12741479 18472094 15876570 17869086 17640975 12546737 17976157 14748882 15052691 17698563 15362042 16015684 17766677 18317297 17714472 11481614 18395914 14512876 18339082 16136751 18187930 17805973 16097048 17557913 12667390 18166357 15818738 15959796 18279442 15370692 16033810 17922224 17525996 18472332 17900296 15338365 15996030 18006644 17721639 16638106 18412020 14724832 15123356 17565644 14716496 17823541 18420326 16248980 18481824 12666154 18054572 18210741 16116963 14716833 17481882 18705752 14620537 15925388 15673190 17708605 15931870 20821823 18395095
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5116248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 3.9419784758 16610002 19460945 11587558 19014921 12587719 12969438 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9416246199 17285989 15830285 16964402 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.5816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.5814706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.699163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.6919294768
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.108603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1015583823 12014681
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3617228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.7214755239
MESH:D008175 Lung Neoplasms arsenite 2.7216809336
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.5816628512
MESH:D008527 Medulloblastoma Tretinoin 2.8017453147
MESH:D008545 Melanoma Carmustine 3.6712393984
MESH:D008545 Melanoma Tretinoin 3.6716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008591 Meningomyelocele Tretinoin 4.5016940565
MESH:D008607 Mental Retardation Carbamazepine 3.749014606
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D008881 Migraine Disorders Valproic Acid 3.2318803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.088888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.4917596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.4917596541
MESH:D009224 Myotonia Congenita Carbamazepine 5.5520399394
MESH:D009369 Neoplasms Tretinoin 2.4316946489 16594593
MESH:D009389 Neovascularization, Pathologic arsenite 4.4915738583
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3319348381 18481113
MESH:D009421 Nervous System Malformations Carbamazepine 10.3516990009
MESH:D009421 Nervous System Malformations Tretinoin 10.359125849
MESH:D009436 Neural Tube Defects Tretinoin 7.429142499
MESH:D009436 Neural Tube Defects Valproic Acid 7.428888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D010018 Osteomalacia Carbamazepine 5.5517016548
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3616936753
MESH:D010146 Pain Acetaminophen 11.6216870215
MESH:D010146 Pain Carbamazepine 11.6215215642
MESH:D010146 Pain Tretinoin 11.6216870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4815976015
MESH:D010267 Parapsoriasis Carbamazepine 5.7716538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 6.0117679678 17145499
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011248 Pregnancy Complications Carbamazepine 5.229014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 10.379014606
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.3720603192
MESH:D011507 Proteinuria Tretinoin 3.6616636307
MESH:D019310 Pseudolymphoma Carbamazepine 12.929591791 12752131
MESH:D019310 Pseudolymphoma Valproic Acid 12.9212752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011625 Pterygium Tretinoin 4.8816723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.0616283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.0619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0719110320 15737665
MESH:D012640 Seizures Carbamazepine 6.539844417 9046859 16180713 16876388 16938433 15946322 19414003
MESH:D012640 Seizures Valproic Acid 6.5316876388 17978042 1511512 11738929 3137016 15475178 14763951 11044598
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.888532709
MESH:D012878 Skin Neoplasms Tretinoin 5.8816467112
MESH:D012893 Sleep Disorders Carbamazepine 5.2019414003
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8219490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6412833885
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.2818855540 16415921 16538176 19694795 15057820 19915237 20485159
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0616026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.8416051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.3317262798
MESH:D014376 Tuberculosis Tretinoin 3.2616040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.603119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.718888407
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7316129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.7116752155
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D014820 Vitiligo Tretinoin 4.1216761959
MESH:D009396 Wilms Tumor Tretinoin 4.0216287080
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35814
    • No data
    No data
    Releated drug ID Related drug Name
    PA10500thyroid hormones
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00119 - Pyruvic acid Dietary supplement;Micronutrient
    No data
    Drugbank ID Action Drug Name Description
    DB00135 inhibitor L-Tyrosine Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00149 substrate Hi-Test Muscle Octane BCAA's (Anabol Naturals) Dietary supplement;Micronutrient;Essential Amino Acids
    DB00150 inhibitor L-Tryptophan Dietary supplement;Micronutrient;Essential Amino Acids;Antidepressive Agents, Second-Generation
    DB00451 inhibitor Thyrolar Antithyroid Agents
    DB01583 inhibitor Liotrix Hormone Replacement Agents
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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