AutismKB 2.0

Annotation Detail for SLC34A1


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Basic Information Top
Gene Symbol:SLC34A1 ( FRTS2,NAPI-3,NPHLOP1,NPT2,NPTIIa,SLC11,SLC17A2 )
Gene Full Name: solute carrier family 34 (sodium phosphate), member 1
Band: 5q35.3
Quick LinksEntrez ID:6569; OMIM: 182309; Uniprot ID:NPT2A_HUMAN; ENSEMBL ID: ENSG00000131183; HGNC ID: 11019
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Transmembrane transport of small molecules
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Related Diseases/Disorders Top
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Desease Name
Chronic kidney disease
Desease Name
Nephrolithiasis/osteoporosis, hypophosphatemic, 1
Fanconi renotubular syndrome 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC34A1 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SLC34A1 mRNAaffects expression 17805973
C004656 chloroacetaldehyde chloroacetaldehyde inhibits the reaction [SLC34A1 protein results in increased transport of Phosphates]decreases reaction|increases transport 17003823
C004656 chloroacetaldehyde chloroacetaldehyde results in decreased expression of and results in decreased activity of SLC34A1 proteindecreases activity|decreases expression 17003823
C004656 chloroacetaldehyde chloroacetaldehyde results in decreased expression of SLC34A1 mRNAdecreases expression 17003823
C004656 chloroacetaldehyde Mesna inhibits the reaction [chloroacetaldehyde results in decreased activity of SLC34A1 protein]decreases activity|decreases reaction 17003823
D003520 Cyclophosphamide Cyclophosphamide analog inhibits the reaction [SLC34A1 protein results in increased transport of Phosphates]decreases reaction|increases transport 17003823
D003520 Cyclophosphamide Cyclophosphamide analog results in decreased expression of SLC34A1 proteindecreases expression 17003823
C012353 hydroperoxyisophosphamide hydroperoxyisophosphamide inhibits the reaction [SLC34A1 protein results in increased transport of Phosphates]decreases reaction|increases transport 17003823
C012353 hydroperoxyisophosphamide hydroperoxyisophosphamide results in decreased expression of and results in decreased activity of SLC34A1 proteindecreases activity|decreases expression 17003823
C012353 hydroperoxyisophosphamide hydroperoxyisophosphamide results in decreased expression of SLC34A1 mRNAdecreases expression 17003823
D007069 Ifosfamide Ifosfamide analog inhibits the reaction [SLC34A1 protein results in increased transport of Phosphates]decreases reaction|increases transport 17003823
D007069 Ifosfamide Ifosfamide analog results in decreased expression of SLC34A1 mRNAdecreases expression 17003823
D007069 Ifosfamide Ifosfamide analog results in decreased expression of SLC34A1 proteindecreases expression 17003823
D015080 Mesna Mesna inhibits the reaction [chloroacetaldehyde results in decreased activity of SLC34A1 protein]decreases activity|decreases reaction 17003823
C025589 ochratoxin A ochratoxin A results in decreased expression of SLC34A1 mRNAdecreases expression 16251485
D010658 Phenylglyoxal Phenylglyoxal results in decreased activity of SLC34A1 proteindecreases activity 12029367
D010710 Phosphates SLC34A1 protein affects the abundance of Phosphatesaffects abundance 16011465
D010710 Phosphates chloroacetaldehyde inhibits the reaction [SLC34A1 protein results in increased transport of Phosphates]decreases reaction|increases transport 17003823
D010710 Phosphates Cyclophosphamide analog inhibits the reaction [SLC34A1 protein results in increased transport of Phosphates]decreases reaction|increases transport 17003823
D010710 Phosphates hydroperoxyisophosphamide inhibits the reaction [SLC34A1 protein results in increased transport of Phosphates]decreases reaction|increases transport 17003823
D010710 Phosphates Ifosfamide analog inhibits the reaction [SLC34A1 protein results in increased transport of Phosphates]decreases reaction|increases transport 17003823
D010710 Phosphates SLC34A1 protein results in increased uptake of [Uranium binds to Phosphates]affects binding|increases uptake 16476458
D016226 Phosphorus, Dietary SLC34A1 protein affects the reaction [Phosphorus, Dietary results in increased expression of FGF23 protein]affects reaction|increases expression 16123154
D016226 Phosphorus, Dietary Phosphorus, Dietary affects the expression of SLC34A1 mRNAaffects expression 12851780
15166007
D016226 Phosphorus, Dietary Phosphorus, Dietary results in decreased expression of SLC34A1 mRNAdecreases expression 15618618
D011188 Potassium Potassium affects the expression of SLC34A1 proteinaffects expression 11473652
C080938 tris(2-carboxyethyl)phosphine tris(2-carboxyethyl)phosphine results in decreased activity of SLC34A1 proteindecreases activity 10926679
D014501 Uranium SLC34A1 protein results in increased uptake of [Uranium binds to Phosphates]affects binding|increases uptake 16476458
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.6715014928
MESH:D001848 Bone Diseases, Developmental marker/mechanism 9560283
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.9616978400 18234424 15136595 12006526 17020986 17388661 15093573 11325840 18323546
MESH:D001943 Breast Neoplasms ochratoxin A 2.9611921183
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8516124888 16192424 18705752 15721981 16011737 16050911 16097048 16227642 15700767 3786805 10355542 15673190
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.3218788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 3.3219701751
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.9716152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.5616201981
MESH:D019465 Craniofacial Abnormalities ochratoxin A 3.2120036863
MESH:D003556 Cystitis Cyclophosphamide 5.0815643279 16989017 18372110 16614059 10700343 10498854 18295254 16651033 18093676 18710439 12913760 15276878 12161096 11948286 16413132 12388444 18433785 17010015 17979934 18483878
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.1111751995 10990075 15331540
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2318772604
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.0516177239 9327722 2869522 19336974 10092053 7120509 16227642 11566570 6884620 15998439 7440962 3786805 21278145 15027814 19085960 17522070 15968718 3732212 10915739 7179309 4309450 6623471
MESH:D004802 Eosinophilia Cyclophosphamide 4.2911006010
MESH:D005198 Fanconi Syndrome marker/mechanism
MESH:D005198 Fanconi Syndrome Ifosfamide 6.6417481685
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.2219224547 16239168 15959796 17595544 12631006 61145 16045604 12795759
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5318705752
MESH:D018316 Gliosarcoma Cyclophosphamide 5.6011389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.1115172196 11014644 16376943
MESH:D006394 Hemangiosarcoma chloroacetaldehyde 5.9710626228
MESH:D006467 Hemophilia A Cyclophosphamide 5.3611918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.6314986274
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6619900420 19110552
MESH:D006689 Hodgkin Disease Cyclophosphamide 8.4817606976 16135485
MESH:D006689 Hodgkin Disease Ifosfamide 8.4816135485
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6116899240
MESH:D006934 Hypercalcemia marker/mechanism 9560283
MESH:D053565 Hypercalciuria marker/mechanism 9560283
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1615338365
MESH:D020514 Hypokalemic Periodic Paralysis Potassium 5.9419822448
MESH:D017674 Hypophosphatemia marker/mechanism 9560283
MESH:D007154 Immune System Diseases Cyclophosphamide 5.4316076520
MESH:D007248 Infertility, Male Cyclophosphamide 3.657193160 16517039
MESH:D007674 Kidney Diseases chloroacetaldehyde 11.0716221203
MESH:D007674 Kidney Diseases Ifosfamide 11.0716221203 17035713
MESH:D007674 Kidney Diseases ochratoxin A 11.0711409539
MESH:D007680 Kidney Neoplasms ochratoxin A 4.5416251485
MESH:D007938 Leukemia Cyclophosphamide 3.5110602166
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5217008537 18587576 17658394 17296974 18172266 17802794
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.1310373061
MESH:D007970 Leukopenia Cyclophosphamide 5.0510052129 11830472
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8316239168 16943688 11903743 17157831 17174718 11408273 21278145 16221502 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7415362042 12632512 16011737 18277467 16015684 18412020 17976157 18187930 17823541 18156304 16033810 18210741 18279442 14748882 14512876 17869086 18006644 17761835 18205269 12898905 18705752 12958196 13678700 12546737 12445418 18251166 12586293 16136751 17900296 18376398 18317297 17708605 16097048 15338365 16638106 17525996 15925388 12445421 12666154 15673190 15123356 16248980 11481614 15730626 15370692 17557913 17721639 17640975 18481824 18395914 10355542 16192424 17944888 17805973 18166357 17481882 20821823 15876570 16027843 12632514 18429990 18472094 12389079 17631135 14724832 17766677 15959796 17714472 14716833 12649538 17698563 15818738 18263696 12667390 15052691 18418968 15893842 18472332 17922224 18054572 15057751 15650968 15931870 15996030 12609069 18395095 16116963 12741479 18420326 14620537 18339082 14716496 17565644
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0916246199 15720792 17285989 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7416899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.2419294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.9415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental chloroacetaldehyde 6.9410626228
MESH:D008223 Lymphoma Cyclophosphamide 3.8712854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.6516675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.2111911406
MESH:D008325 Mammary Neoplasms, Experimental ochratoxin A 4.1111921183
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.8716388313
MESH:D001523 Mental Disorders Phosphates 5.0912686366
MESH:D008850 Microphthalmos ochratoxin A 5.8620036863
MESH:D009369 Neoplasms Cyclophosphamide 3.1518854779
OMIM:612286 NEPHROLITHIASIS/OSTEOPOROSIS, HYPOPHOSPHATEMIC, 1 marker/mechanism
MESH:D009436 Neural Tube Defects ochratoxin A 4.4820036863
MESH:D009447 Neuroblastoma Cyclophosphamide 3.6616115947 8761367 15176712
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.978761367 12837982
MESH:D009503 Neutropenia Cyclophosphamide 4.388291058
MESH:D009845 Oligospermia Cyclophosphamide 4.7916517039
MESH:D010146 Pain Cyclophosphamide 3.6718093676 12161096
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 3.2011332152
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.8321297632
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 3.9317136230
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.3016636934
MESH:D012509 Sarcoma Ifosfamide 5.7018313854 17710206 15625365
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.8816636934
MESH:D012983 Soft Tissue Neoplasms Ifosfamide 6.3015625365
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.6016517039
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.1412837982
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 3.1614692829
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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