AutismKB 2.0

Annotation Detail for SLC18A1


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Basic Information Top
Gene Symbol:SLC18A1 ( CGAT,VAT1,VMAT1 )
Gene Full Name: solute carrier family 18 (vesicular monoamine), member 1
Band: 8p21.3
Quick LinksEntrez ID:6570; OMIM: 193002; Uniprot ID:VMAT1_HUMAN; ENSEMBL ID: ENSG00000036565; HGNC ID: 10934
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05012Parkinson's disease
Pathway IDPathway Name
Amine compound SLC transporters
Transmembrane transport of small molecules
No data
Pathway IDPathway Name
P00001Adrenaline and noradrenaline biosynthesis
P043745HT2 type receptor mediated signaling pathway
P043765HT4 type receptor mediated signaling pathway
P043755HT3 type receptor mediated signaling pathway
P043735HT1 type receptor mediated signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1757Multiple endocrine neoplasia
2045Bipolar disorder
2069Schizophrenia
Desease Name
bipolar disorder
PSYCH
METABOLIC
major depressive disorder (broad)
triglycerides
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of SLC18A1 mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC18A1 mRNAaffects expression 16483693
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of SLC18A1 mRNAaffects cotreatment|increases expression 18636392
D004390 Chlorpyrifos Chlorpyrifos affects the expression of SLC18A1 mRNAaffects expression 18812211
18835401
D003976 Diazinon Diazinon results in decreased expression of SLC18A1 mRNAdecreases expression 18812211
18835401
D004026 Dieldrin Dieldrin results in decreased expression of SLC18A1 mRNAdecreases expression 18812211
18835401
D009532 Nickel Nickel results in increased expression of SLC18A1 mRNAincreases expression 18835401
18812211
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of SLC18A1 mRNAaffects cotreatment|increases expression 18636392
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D055371 Acute Lung Injury Chlorine 10.5720601635
MESH:D055371 Acute Lung Injury Nickel 10.5716166738
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 10.3217119214 11874814 16611668
MESH:D000382 Agricultural Workers' Diseases Diazinon 10.3216487989
MESH:D000544 Alzheimer Disease Ozone 2.4815513908
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6015570426
MESH:D001249 Asthma Ozone 2.7017854713 16373670
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4011289319 1440618
MESH:D001943 Breast Neoplasms Dieldrin 2.9311859874 15770527
MESH:D001943 Breast Neoplasms Nickel 2.9315986119
MESH:D016535 Bronchial Hyperreactivity Ozone 3.8714754758 18417511 17626835 18315731 15516495 16777450 19059883
MESH:D002100 Cachexia Ozone 5.0816183385
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.777296757 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.917505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.329022650 19486331
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 8.2711298694 2524372 8970840 11906362 14531868 18759878 12868966 8156756
MESH:D017449 Dermatitis, Allergic Contact Nickel 8.2719470301 17244072 17100760
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 10.423621924 2952479
MESH:D003877 Dermatitis, Contact Nickel 10.422952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.019653073 7440962 1440618 16192314 6482804 6679447 8291058 18289764 18648102 18692083 9328219 11289319 9022650
MESH:D004417 Dyspnea Chlorine 11.9620016425
MESH:D004417 Dyspnea Diazinon 11.9616487989
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005739 Gas Poisoning Chlorine 5.3920016425
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.546705139
MESH:D006505 Hepatitis Diazinon 10.5416487989
MESH:D015658 HIV Infections Nickel 3.9317263646
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D007247 Infertility, Female Dieldrin 5.2010630421
MESH:D007248 Infertility, Male Diazinon 3.9712948887 16466525
MESH:D007249 Inflammation Nickel 3.5316166738
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.409022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.176582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008107 Liver Diseases Chlorpyrifos 3.1215991261
MESH:D008113 Liver Neoplasms Dieldrin 3.419539021 8742319
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.671399818 6587162 598648 3712494
MESH:D008171 Lung Diseases Ozone 3.5319066396 8266340
MESH:D055370 Lung Injury Ozone 4.1520417186
MESH:D008175 Lung Neoplasms Ozone 2.108597069 7614698
MESH:D008679 Metaplasia Ozone 5.4810496685
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009369 Neoplasms Dieldrin 3.578820588
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.3215081274
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.654026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010300 Parkinson Disease Dieldrin 3.6017291500 16809432 16112328 11445065 11181820
MESH:D010538 Peritonitis Ozone 4.4416369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D011014 Pneumonia Ozone 4.7318007984 18929643 18381685
MESH:D011041 Poisoning Diazinon 4.6117603234
MESH:D012120 Respiration Disorders Chlorine 5.5918579056
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.9417119214 16611668 11874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.2716611668 17119214
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.476418539
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.061399818 3712494 6582329 7505956 6587162
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.358074119
MESH:D014570 Urologic Diseases Diazinon 5.6516487989
Pathway ID Pathway Name
REACT:20679 Amine compound SLC transporters
KEGG:05012 Parkinson's disease
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA324
    • Releated gene ID Related gene Name
    PA324SLC18A1
    Releated disease ID Related disease Name
    PA444552Hypertension
    Releated drug ID Related drug Name
    PA451236reserpine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01363 antagonist Tartephedreel
    DB01442 antagonist MMDA Psychotropic Drugs
    DB01577 antagonist Methamphetamine Adrenergic Agents;Dopamine Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Sympathomimetics
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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