AutismKB 2.0

Annotation Detail for SLC19A1


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Basic Information Top
Gene Symbol:SLC19A1 ( CHMD,FOLT,IFC1,REFC,RFC1 )
Gene Full Name: solute carrier family 19 (folate transporter), member 1
Band: 21q22.3
Quick LinksEntrez ID:6573; OMIM: 600424; Uniprot ID:S19A1_HUMAN; ENSEMBL ID: ENSG00000173638; HGNC ID: 10937
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of vitamins and cofactors
No data
No data
Pathway IDPathway Name
501009Metabolism of folate and pterines
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1902Kidney failure
1983Down syndrome
1996Abruption placentae
2051Leukemia
2064Spinal dysraphism
2066Lung cancer
2117Folic acid deficiency
2239Lymphoma
2251Osteosarcoma
Desease Name
HEMATOLOGICAL
rheumatoid arthritis
esophageal cancer stomach cancer
heart anomalies, congenital
CARDIOVASCULAR
CANCER
PHARMACOGENOMIC
methotrexate toxicity
neural tube defects
IMMUNE
METABOLIC
red cell folate concentrations
DEVELOPMENTAL
folate homocysteine
oxidative stress
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]decreases reaction|increases uptake 17482559
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased activity of SLC19A1 proteindecreases activity 17482559
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene bisindolylmaleimide inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]]decreases reaction|increases uptake 17482559
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SLC19A1 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of SLC19A1 mRNAaffects expression 21346803
C030371 5,6,7,8-tetrahydrofolic acid 5,6,7,8-tetrahydrofolic acid inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]affects transport|decreases reaction 14612385
C030371 5,6,7,8-tetrahydrofolic acid 5,6,7,8-tetrahydrofolic acid results in decreased activity of SLC19A1 proteindecreases activity 14612385
C005984 5-methyltetrahydrofolate [5-methyltetrahydrofolate results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Aciddecreases activity|decreases uptake 17034785
C005984 5-methyltetrahydrofolate 5-methyltetrahydrofolate inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]affects transport|decreases reaction 14612385
C005984 5-methyltetrahydrofolate 5-methyltetrahydrofolate results in decreased activity of SLC19A1 proteindecreases activity 14612385
D012856 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid [4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Aciddecreases activity|decreases uptake 17034785
D000082 Acetaminophen Acetaminophen affects the expression of SLC19A1 mRNAaffects expression 17562736
D012435 S-Adenosylhomocysteine SLC19A1 protein affects the abundance of S-Adenosylhomocysteineaffects abundance 15705887
D012436 S-Adenosylmethionine SLC19A1 protein affects the abundance of S-Adenosylmethionineaffects abundance 15705887
D019386 Alendronate Alendronate affects the expression of SLC19A1 mRNAaffects expression 16079270
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC19A1 mRNAaffects expression 16483693
D001262 Atenolol Atenolol results in decreased expression of SLC19A1 mRNAdecreases expression 19616087
D001397 Azoxymethane SLC19A1 gene mutant form results in increased susceptibility to Azoxymethaneincreases response to substance 15705887
C504663 BGC638 BGC638 binds to and results in decreased activity of SLC19A1 proteinaffects binding|decreases activity 16357184
C504663 BGC638 BGC638 binds to and results in decreased activity of SLC19A1 proteinaffects binding|decreases activity 16357184
C504662 BGC945 BGC945 binds to and results in decreased activity of SLC19A1 proteinaffects binding|decreases activity 16357184
C504662 BGC945 BGC945 binds to and results in decreased activity of SLC19A1 proteinaffects binding|decreases activity 16357184
C088060 bisindolylmaleimide bisindolylmaleimide inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]]decreases reaction|increases uptake 17482559
C088060 bisindolylmaleimide bisindolylmaleimide inhibits the reaction [Phenobarbital inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]]decreases reaction|increases uptake 17482559
C088060 bisindolylmaleimide bisindolylmaleimide inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]]decreases reaction|increases uptake 17482559
D002034 Bumetanide Bumetanide inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]affects transport|decreases reaction 14612385
D002034 Bumetanide Bumetanide results in decreased activity of SLC19A1 proteindecreases activity 14612385
D002220 Carbamazepine Carbamazepine inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]decreases reaction|increases uptake 17482559
D002220 Carbamazepine Carbamazepine results in decreased activity of SLC19A1 proteindecreases activity 17482559
D002746 Chlorpromazine Chlorpromazine inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]decreases reaction|increases uptake 17482559
D002746 Chlorpromazine Chlorpromazine results in decreased activity of SLC19A1 proteindecreases activity 17482559
D020355 Cholates Cholates inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]affects transport|decreases reaction 14612385
D020355 Cholates Cholates results in decreased activity of SLC19A1 proteindecreases activity 14612385
D003022 Clotrimazole Clotrimazole inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]decreases reaction|increases uptake 17482559
D003022 Clotrimazole Clotrimazole results in decreased activity of SLC19A1 proteindecreases activity 17482559
D013759 Tetrahydrocannabinol Tetrahydrocannabinol results in decreased expression of SLC19A1 mRNAdecreases expression 19616087
C010920 dihydrofolate dihydrofolate inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]affects transport|decreases reaction 14612385
C010920 dihydrofolate dihydrofolate results in decreased activity of SLC19A1 proteindecreases activity 14612385
D017878 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid [4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Aciddecreases activity|decreases uptake 17034785
D000431 Ethanol Ethanol results in decreased expression of SLC19A1 mRNAdecreases expression 19616087
D000431 Ethanol Ethanol results in increased expression of SLC19A1 proteinincreases expression 17449590
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SLC19A1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC19A1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SLC19A1 mRNAaffects expression 16079270
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SLC19A1 mRNAdecreases expression 17108234
D005419 Flavonoids Flavonoids results in increased expression of SLC19A1 mRNAincreases expression 18035473
D005492 Folic Acid [4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Aciddecreases activity|decreases uptake 17034785
D005492 Folic Acid [4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Aciddecreases activity|decreases uptake 17034785
D005492 Folic Acid [5-methyltetrahydrofolate results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Aciddecreases activity|decreases uptake 17034785
D005492 Folic Acid Folic Acid affects the expression of SLC19A1 mRNAaffects expression 17311948
D005492 Folic Acid Folic Acid results in decreased expression of SLC19A1 mRNAdecreases expression 17616776
D005492 Folic Acid Folic Acid results in decreased expression of SLC19A1 proteindecreases expression 17616776
D005492 Folic Acid [Indomethacin results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Aciddecreases activity|decreases uptake 17034785
D005492 Folic Acid [Methotrexate results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Aciddecreases activity|decreases uptake 17034785
D005492 Folic Acid SLC19A1 gene SNP affects the uptake of and affects the localization of Folic Acidaffects localization|affects uptake 16750224
D005492 Folic Acid SLC19A1 protein results in increased uptake of Folic Acidincreases uptake 16900951
D005492 Folic Acid SLC19A1 protein affects the uptake of Folic Acidaffects uptake 16495369
D005492 Folic Acid SLC19A1 protein results in increased transport of Folic Acidincreases transport 17616776
D007213 Indomethacin [Indomethacin results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Aciddecreases activity|decreases uptake 17034785
C051890 irinotecan irinotecan analog results in decreased expression of SLC19A1 mRNAdecreases expression 18927307
D008727 Methotrexate [Methotrexate results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Aciddecreases activity|decreases uptake 17034785
D008727 Methotrexate SLC19A1 exon mutant form results in decreased susceptibility to Methotrexatedecreases response to substance 16505119
D008727 Methotrexate SLC19A1 gene SNP affects the susceptibility to Methotrexateaffects response to substance 17410198
D008727 Methotrexate SLC19A1 protein affects the susceptibility to Methotrexateaffects response to substance 14679136
D008727 Methotrexate 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]decreases reaction|increases uptake 17482559
D008727 Methotrexate 5,6,7,8-tetrahydrofolic acid inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]affects transport|decreases reaction 14612385
D008727 Methotrexate 5-methyltetrahydrofolate inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]affects transport|decreases reaction 14612385
D008727 Methotrexate bisindolylmaleimide inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]]decreases reaction|increases uptake 17482559
D008727 Methotrexate bisindolylmaleimide inhibits the reaction [Phenobarbital inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]]decreases reaction|increases uptake 17482559
D008727 Methotrexate bisindolylmaleimide inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]]decreases reaction|increases uptake 17482559
D008727 Methotrexate Bumetanide inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]affects transport|decreases reaction 14612385
D008727 Methotrexate Carbamazepine inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]decreases reaction|increases uptake 17482559
D008727 Methotrexate Chlorpromazine inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]decreases reaction|increases uptake 17482559
D008727 Methotrexate Cholates inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]affects transport|decreases reaction 14612385
D008727 Methotrexate Clotrimazole inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]decreases reaction|increases uptake 17482559
D008727 Methotrexate dihydrofolate inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]affects transport|decreases reaction 14612385
D008727 Methotrexate Methotrexate inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]affects transport|decreases reaction 14612385
D008727 Methotrexate Methotrexate results in decreased activity of SLC19A1 proteindecreases activity 14612385
D008727 Methotrexate Okadaic Acid inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]decreases reaction|increases uptake 17482559
D008727 Methotrexate Phenobarbital inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]decreases reaction|increases uptake 17482559
D008727 Methotrexate SLC19A1 protein affects the transport of Methotrexateaffects transport 14612385
D008727 Methotrexate SLC19A1 protein results in increased susceptibility to Methotrexateincreases response to substance 14612385
D008727 Methotrexate SLC19A1 protein results in increased uptake of Methotrexateincreases uptake 17482559
20451541
D008727 Methotrexate Sulfobromophthalein inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]affects transport|decreases reaction 14612385
D008727 Methotrexate Taurocholic Acid inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]affects transport|decreases reaction 14612385
D008727 Methotrexate Tetrachlorodibenzodioxin inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]decreases reaction|increases uptake 20451541
D008727 Methotrexate Tetradecanoylphorbol Acetate inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]decreases reaction|increases uptake 17482559
C008493 methylselenic acid methylselenic acid results in decreased expression of SLC19A1 mRNAdecreases expression 18548127
C085590 N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine SLC19A1 exon mutant form results in decreased susceptibility to N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine analogdecreases response to substance 16505119
D009538 Nicotine Nicotine results in decreased expression of SLC19A1 mRNAdecreases expression 19616087
D019319 Okadaic Acid Okadaic Acid inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]decreases reaction|increases uptake 17482559
D019319 Okadaic Acid Okadaic Acid results in decreased activity of SLC19A1 proteindecreases activity 17482559
C085586 pemetrexed SLC19A1 exon mutant form results in increased susceptibility to pemetrexedincreases response to substance 16505119
D010634 Phenobarbital bisindolylmaleimide inhibits the reaction [Phenobarbital inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]]decreases reaction|increases uptake 17482559
D010634 Phenobarbital Phenobarbital inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]decreases reaction|increases uptake 17482559
D010634 Phenobarbital Phenobarbital results in decreased activity of SLC19A1 proteindecreases activity 17482559
D020849 Raloxifene Raloxifene affects the expression of SLC19A1 mRNAaffects expression 16079270
C068874 raltitrexed SLC19A1 exon mutant form results in decreased susceptibility to raltitrexeddecreases response to substance 16505119
D012643 Selenium Selenium results in decreased expression of SLC19A1 mRNAdecreases expression 19244175
D013448 Sulfobromophthalein Sulfobromophthalein inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]affects transport|decreases reaction 14612385
D013448 Sulfobromophthalein Sulfobromophthalein results in decreased activity of SLC19A1 proteindecreases activity 14612385
D013656 Taurocholic Acid Taurocholic Acid inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]affects transport|decreases reaction 14612385
D013656 Taurocholic Acid Taurocholic Acid results in decreased activity of SLC19A1 proteindecreases activity 14612385
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC19A1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]decreases reaction|increases uptake 20451541
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased activity of SLC19A1 proteindecreases activity 20451541
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLC19A1 mRNAdecreases expression 20451541
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLC19A1 proteindecreases expression 20451541
D013755 Tetradecanoylphorbol Acetate bisindolylmaleimide inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]]decreases reaction|increases uptake 17482559
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]decreases reaction|increases uptake 17482559
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in decreased activity of SLC19A1 proteindecreases activity 17482559
D014810 Vitamin E Vitamin E results in decreased expression of SLC19A1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 27.027525203
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 27.028986270
MESH:D000014 Abnormalities, Drug-Induced Ethanol 27.0218926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 27.0212039119
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 27.026195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 27.0214514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 8.8918287403
MESH:D000138 Acidosis Ethanol 8.8911192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4617505938
MESH:D058186 Acute Kidney Injury Folic Acid 3.9117003819 16595132 16316344
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.0014692618
MESH:D000230 Adenocarcinoma Indomethacin 4.0016537180
MESH:D000236 Adenoma marker/mechanism 16963246
MESH:D000236 Adenoma Folic Acid 6.3116963246
MESH:D000236 Adenoma Indomethacin 6.3111497255
MESH:D018248 Adenoma, Liver Cell Phenobarbital 8.5017620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.5016835633
MESH:D000419 Albuminuria Raloxifene 4.1417451421 17308373
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.8315451040 15451039
MESH:D016301 Alveolar Bone Loss Indomethacin 4.8817225004
MESH:D000544 Alzheimer Disease Folic Acid 8.4517116317
MESH:D000544 Alzheimer Disease Indomethacin 8.4515579461 17627676
MESH:D000544 Alzheimer Disease Nicotine 8.4516627626
MESH:D000544 Alzheimer Disease Raloxifene 8.4515800139
MESH:D000690 Amyotrophic Lateral Sclerosis Tetrahydrocannabinol 4.5315204022
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5411748828
MESH:D000799 Angioedema Acetaminophen 3.3610982225
MESH:D000853 Anophthalmos Ethanol 4.3515513904
MESH:D001008 Anxiety Disorders Ethanol 3.6311141031
MESH:D001014 Aortic Aneurysm Indomethacin 4.4010231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.4110388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0011256880
MESH:D018771 Arthralgia Indomethacin 4.682160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.3615885639
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.6211248219
MESH:D001172 Arthritis, Rheumatoid Methotrexate 4.6217286800
MESH:D050197 Atherosclerosis Tetrahydrocannabinol 4.1815815632
MESH:D001321 Autistic Disorder marker/mechanism 16917939 20468076
MESH:D001321 Autistic Disorder 5-methyltetrahydrofolate 3.3318461502
MESH:D001321 Autistic Disorder Acetaminophen 3.3318445737
MESH:D001321 Autistic Disorder Folic Acid 3.3321388746
MESH:D001321 Autistic Disorder S-Adenosylhomocysteine 3.3320468076 16917939
MESH:D001321 Autistic Disorder S-Adenosylmethionine 3.3316917939 19056591
MESH:D001477 Bartter Syndrome Indomethacin 4.5210684365
MESH:D001714 Bipolar Disorder Carbamazepine 3.8820046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.6212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4515746008
MESH:D001929 Brain Edema Indomethacin 4.5411481608
MESH:D001930 Brain Injuries Raloxifene 4.0116580743
MESH:D002545 Brain Ischemia Indomethacin 3.9412524144
MESH:D001943 Breast Neoplasms Folic Acid 2.7016777985
MESH:D001943 Breast Neoplasms Indomethacin 2.7017401462
MESH:D001943 Breast Neoplasms Methotrexate 2.7016978400
MESH:D001943 Breast Neoplasms pemetrexed 2.7017465208 17575230
MESH:D001943 Breast Neoplasms Raloxifene 2.7017261762 17893378 17595753 16912660 17440819 15758505 15775269 15572757 17049068 17242785 16837676 17952589
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.7020435547
MESH:D002056 Burns Ethanol 9.8316374292
MESH:D002056 Burns Indomethacin 9.8310459503
MESH:D002100 Cachexia Indomethacin 4.5315141370 15625704 11239499 16537180
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.4716050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4216835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 7.8616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 7.863084413
MESH:D006528 Carcinoma, Hepatocellular Ethanol 7.8615763234 18788625 15289165
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 7.8616391822
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 7.866705139 20935162 1701930 20007298 17173139
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.2511053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.8711352223 14736730 18791128
MESH:D002289 Carcinoma, Non-Small-Cell Lung pemetrexed 4.4912023789
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.1417341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 4.5715482327 12636206
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 4.5718922899
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.6617572228
MESH:D006332 Cardiomegaly Atenolol 10.0415969258
MESH:D006332 Cardiomegaly Ethanol 10.0419332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.0416120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Folic Acid 6.6216755160
MESH:D002318 Cardiovascular Diseases Raloxifene 6.6215775269
MESH:D002375 Catalepsy Tetrahydrocannabinol 5.2510318961
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 6.4514694615
MESH:D002386 Cataract Acetaminophen 6.4510977129
MESH:D002471 Cell Transformation, Neoplastic Azoxymethane 4.5515705887 18075178
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.794080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D002764 Cholecystitis Indomethacin 4.6811181007
MESH:D002779 Cholestasis Ethinyl Estradiol 2.5217681005 17110522 16105132 15861022 16919318 11677210 17333356
MESH:D002971 Cleft Lip marker/mechanism 21254359
MESH:D002971 Cleft Lip Ethanol 7.0015513904
MESH:D002971 Cleft Lip Folic Acid 7.0021254359
MESH:D002972 Cleft Palate marker/mechanism 21254359
MESH:D002972 Cleft Palate Ethanol 8.6915513904
MESH:D002972 Cleft Palate Folic Acid 8.698946559 21254359
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.6912621046 15340226 15668235 16354765 8697196
MESH:D003072 Cognition Disorders Raloxifene 4.1515800139
MESH:D003092 Colitis Selenium 3.3217936198
MESH:D003110 Colonic Neoplasms marker/mechanism 15705887
MESH:D003110 Colonic Neoplasms Azoxymethane 5.5515824018 12189186 14668109 16818512 15705887 19056647 16293270
MESH:D003110 Colonic Neoplasms Indomethacin 5.5515637740 15625704 15936596 11260862 15963497 15786552
MESH:D003110 Colonic Neoplasms irinotecan 5.5517287894 17725105
MESH:D015179 Colorectal Neoplasms marker/mechanism 16963246
MESH:D015179 Colorectal Neoplasms Azoxymethane 4.4911076880 10416599
MESH:D015179 Colorectal Neoplasms Folic Acid 4.4916963246 16985020 17116713 17245555 17087956
MESH:D015179 Colorectal Neoplasms Indomethacin 4.4917054584 12606626 11197048 18059344
MESH:D015179 Colorectal Neoplasms irinotecan 4.4915273666 17454858 16391804 18259882 17159606 16303861 18509181
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 7.8515095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.8514669216 17141729
MESH:D018352 Coronavirus Infections Indomethacin 5.2317302372
MESH:D019465 Craniofacial Abnormalities Carbamazepine 6.649014606
MESH:D019465 Craniofacial Abnormalities Ethanol 6.6410194807 19302082 15513904 11198716 15451040 15451039 11873399
MESH:D019465 Craniofacial Abnormalities Methotrexate 6.649562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.6415322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 6.6419769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.5518551238
MESH:D003550 Cystic Fibrosis Methotrexate 3.8319747007
MESH:D003865 Depressive Disorder, Major Raloxifene 3.7617474826
MESH:D003882 Dermatomyositis Methotrexate 4.6720191521
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 4.1016886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1017107852
MESH:D003928 Diabetic Nephropathies Raloxifene 3.5417308373 15920148 17451421
MESH:D003967 Diarrhea Indomethacin 3.357907874 7237001
MESH:D004314 Down Syndrome marker/mechanism 16845273 17431899
OMIM:607208 DRAVET SYNDROME Carbamazepine 4.9811748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.1116538176 20216337 16538175 15057820
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 19.3021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 19.3021346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 19.3011743745 10915739 12153990 16109766 11739529 16781746 12540782 10663392 12594235 18071297 2444490 11461765 15619225 19416960 19164858 14725611 19923254 18713872 12958197 11287661 15968718 16081117 19370779 19739265 17562736 17906064 11421492 12705907 14986274 11529661 16177239 11834606 17522070 19420014 16227642 16485898 10774834 14550746 12392966 19085960 16393943
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 19.3017465707
MESH:D056486 Drug-Induced Liver Injury Chlorpromazine 19.3011461765
MESH:D056486 Drug-Induced Liver Injury Ethanol 19.3011566570
MESH:D056486 Drug-Induced Liver Injury Selenium 19.3015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 19.3020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6119426721
MESH:D004362 Drug Toxicity Carbamazepine 7.2120216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.2111462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.6716326151 17190690 18446180 12774134 18043480 16133044
MESH:D004381 Duodenal Ulcer Indomethacin 3.6911991626 10671773 16699067 11535926 17351913 17202747 11595415 17045617 11595431 17329845 17151854
MESH:D004421 Dystonia Phenobarbital 3.561851702
MESH:D020821 Dystonic Disorders Nicotine 5.4517881519
MESH:C538011 Eales disease Vitamin E 4.229068938
MESH:D004487 Edema Indomethacin 13.058985016 7907874 10653021 8273558 16100529 7990266 19703484
MESH:D004487 Edema Raloxifene 13.0515860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.0512711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 13.058273558 15177302 8113982 9599246 16716910 7812673 11698051
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4216714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 12.9017654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 12.9012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 12.9015845917
MESH:D016889 Endometrial Neoplasms Folic Acid 3.6917301261
MESH:D004715 Endometriosis Indomethacin 7.7015652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.7010568697 9294722
MESH:D019446 Endotoxemia Indomethacin 4.0318509659
MESH:D004751 Enteritis Indomethacin 4.2610567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.5217980183
MESH:D004802 Eosinophilia Indomethacin 3.5911298111
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 4.8019915237 16415921 16538176 18855540 20485159
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 9.6417275665
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 9.643659116
MESH:D004828 Epilepsies, Partial Carbamazepine 8.7517116037 16628512 15008574
MESH:D004828 Epilepsies, Partial Phenobarbital 8.753922381 11558140
MESH:D004827 Epilepsy Carbamazepine 9.8619700373 18234410 19439326 17178248 821787 7988514 19620853 20417680 9014606 17465707
MESH:D004827 Epilepsy Phenobarbital 9.8620417680
MESH:D004827 Epilepsy Tetrahydrocannabinol 9.86821787
MESH:D004832 Epilepsy, Absence Phenobarbital 3.146401628
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 10.147750514
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.147750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 9.293659116 15276670
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 9.293659116
MESH:D004916 Erythromelalgia Carbamazepine 5.2419549232
MESH:D004938 Esophageal Neoplasms Ethanol 4.4116704527
MESH:D004938 Esophageal Neoplasms Indomethacin 4.4111005569
MESH:D005076 Exanthema Carbamazepine 4.9920485159
MESH:D017889 Exfoliation Syndrome Folic Acid 5.0116504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6511564622
MESH:D005234 Fatty Liver Ethanol 10.7819236843 18620774 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 10.7815345470
MESH:D005234 Fatty Liver Raloxifene 10.7817473493
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.1817920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.8216946407 15451040 15513904 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9911858732
MESH:D005334 Fever Indomethacin 3.7117627676 10431976 11852909
MESH:D005354 Fibrosarcoma Indomethacin 4.4210962813
MESH:D005355 Fibrosis Indomethacin 7.2917994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.2920067830
MESH:D005499 Folliculitis Indomethacin 4.6811298111
MESH:D005756 Gastritis Acetaminophen 23.3416983495
MESH:D005756 Gastritis Ethanol 23.3415046732
MESH:D005756 Gastritis Folic Acid 23.3417171786
MESH:D005756 Gastritis Indomethacin 23.3415046732
MESH:D005901 Glaucoma Folic Acid 4.6416504073
MESH:D005909 Glioblastoma Indomethacin 6.8612870263
MESH:D005909 Glioblastoma Okadaic Acid 6.8617312396
MESH:D005910 Glioma Indomethacin 3.0216487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.9011849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1110696789
MESH:D006073 Gout Indomethacin 4.8711248219
MESH:D006086 Graft vs Host Disease Methotrexate 4.6816518429
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.4215482327
MESH:D006330 Heart Defects, Congenital Folic Acid 9.7117286298 16524890
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.7111294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 9.7116080930
MESH:D006331 Heart Diseases Raloxifene 3.2011110106
MESH:D006333 Heart Failure Atenolol 6.7820082655
MESH:D006333 Heart Failure Selenium 6.7817162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9111000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.1415633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.2315135802
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 11.9416109766
MESH:D006529 Hepatomegaly Phenobarbital 11.9416109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.9416120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5216863852 16490937
MESH:D006561 Herpes Simplex Chlorpromazine 4.821682908
MESH:D006679 HIV Seropositivity Folic Acid 5.0117209195
MESH:D006712 Homocystinuria 5-methyltetrahydrofolate 6.3417413090
MESH:D019584 Hot Flashes Vitamin E 3.4914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5616959395 15340226 16354765 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 15.6616870215
MESH:D006930 Hyperalgesia Alendronate 15.6616769263
MESH:D006930 Hyperalgesia Ethanol 15.6618783367
MESH:D006930 Hyperalgesia Indomethacin 15.6612727271
MESH:D034321 Hyperamylasemia Indomethacin 5.2317883296
MESH:D006940 Hyperemia Indomethacin 4.5312524144
MESH:D020138 Hyperhomocysteinemia Carbamazepine 8.5110459572
MESH:D020138 Hyperhomocysteinemia Folic Acid 8.5116755160 16397167 16395265 16865747 16433478
MESH:D006949 Hyperlipidemias Indomethacin 3.7317546600
MESH:D006965 Hyperplasia Carbamazepine 4.7518773962
MESH:D006973 Hypertension Atenolol 7.7011593098 15237695 11910301 15188945 15969258 14597852 19249413 12022239 15614026 15453913 14700505 12717102
MESH:D006973 Hypertension Raloxifene 7.7015787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.7018850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular Atenolol 5.2915237695
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3416569931 16945680
MESH:D007035 Hypothermia Tetrahydrocannabinol 5.4610318961
MESH:D007077 Ileal Diseases Indomethacin 4.5418306037 10574470
MESH:D007079 Ileitis Indomethacin 4.8710651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.8816133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.1717937319
MESH:D007249 Inflammation Flavonoids 9.8417296493
MESH:D007249 Inflammation Indomethacin 9.847812673 3291741 12568917
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.8412878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 9.847562506 8273558 11698051 15177302 7812673
MESH:D007251 Influenza, Human Selenium 9.3416624496
MESH:D007251 Influenza, Human Vitamin E 9.3416624496
MESH:D007410 Intestinal Diseases Indomethacin 3.8618236018 10210152 17994277 11713966 11855677 17329856 11686837 15610444 15831440
MESH:D019586 Intracranial Hypertension Indomethacin 4.8815241188
MESH:D007569 Jaw Abnormalities Ethanol 8.7015513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.7016580747
MESH:D007579 Jejunal Diseases Indomethacin 4.5416133968 10574470 18306037
MESH:D007674 Kidney Diseases Acetaminophen 8.4612587719 15629191
MESH:D007674 Kidney Diseases Indomethacin 8.4617190690
MESH:D007674 Kidney Diseases Vitamin E 8.4612488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.4616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 2.6016705839
MESH:D007805 Language Development Disorders Methotrexate 4.669562676
MESH:D007859 Learning Disorders Ethanol 3.7515451040
MESH:D007889 Leiomyoma Raloxifene 4.0616973256
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.5210320625 12228301 11703811
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.5716572323 15631656 10785260
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.5518360721
MESH:D007964 Leukocytosis Indomethacin 4.8816537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.2317980183
MESH:D017880 Limb Deformities, Congenital Ethanol 3.4717676605
MESH:D008064 Lipidoses Chlorpromazine 4.4115342952 17567588
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.2311479899
MESH:D008103 Liver Cirrhosis Ethanol 9.6015289165
MESH:D008103 Liver Cirrhosis Methotrexate 9.6014986274
MESH:D008103 Liver Cirrhosis Phenobarbital 9.6021047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.6218295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 5.9918166357
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 5.9918194892
MESH:D008106 Liver Cirrhosis, Experimental S-Adenosylmethionine 5.9915983038
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.9912878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.9916169303
MESH:D008107 Liver Diseases Acetaminophen 8.2716610002 16611625 11587558 12969438 12587719 19014921 19460945 19784758
MESH:D008107 Liver Diseases Chlorpromazine 8.2714986274
MESH:D008107 Liver Diseases Folic Acid 8.2716877991
MESH:D008107 Liver Diseases Phenobarbital 8.2719363144
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.1917207112 17347304
MESH:D017114 Liver Failure, Acute Acetaminophen 2.8216871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 3.7721047994 8742319 19073162 15975961 19812893 19482888
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 3.7716984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 4.786150874 1399818 18308698 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 4.7812151625
MESH:D008171 Lung Diseases Vitamin E 2.8516863852
MESH:D017563 Lung Diseases, Interstitial Methotrexate 4.5418516814
MESH:D008175 Lung Neoplasms Azoxymethane 5.8715824018
MESH:D008175 Lung Neoplasms Indomethacin 5.8711497255 16537180 11053908
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.8711884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 5.8711807781
MESH:D008175 Lung Neoplasms Vitamin E 5.8711062179
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 5.4016628512
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 5.4017718048
MESH:D008223 Lymphoma Methotrexate 3.6117352296
MESH:D008325 Mammary Neoplasms, Experimental Selenium 5.2815318939
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 5.288985016
MESH:D008382 Marfan Syndrome Atenolol 5.7819430350
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.2216832597
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1019513568
MESH:D008569 Memory Disorders Ethanol 3.7418411066 15451040
MESH:D001523 Mental Disorders Chlorpromazine 4.2716856516
MESH:D008607 Mental Retardation Carbamazepine 3.559014606
MESH:D008654 Mesothelioma Selenium 2.5915107826
MESH:D008881 Migraine Disorders Indomethacin 3.3311903285
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.0715863610
MESH:D009062 Mouth Neoplasms Indomethacin 3.6212636206
MESH:D052016 Mucositis irinotecan 11.0117159606
MESH:D052016 Mucositis Methotrexate 11.0117488658
MESH:D009101 Multiple Myeloma Raloxifene 3.1016497877
MESH:D009175 Mycoplasma Infections Chlorpromazine 5.5110773494
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6412213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0017484760
MESH:D009224 Myotonia Congenita Carbamazepine 4.9920399394
MESH:D009232 Myxoma Raloxifene 5.0716343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.3818551238
MESH:D009362 Neoplasm Metastasis Indomethacin 5.4811239499 16537180 11053908
MESH:D009362 Neoplasm Metastasis irinotecan 5.4818259882
MESH:D009369 Neoplasms Nicotine 3.3116365874
MESH:D009374 Neoplasms, Experimental Indomethacin 3.6810663608 15625704
MESH:D009389 Neovascularization, Pathologic Nicotine 4.5216365874
MESH:D009421 Nervous System Malformations Carbamazepine 8.4316990009
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.4314600291
MESH:D009436 Neural Tube Defects 5-methyltetrahydrofolate 10.9217413090
MESH:D009436 Neural Tube Defects Folic Acid 10.9217438019
MESH:D009436 Neural Tube Defects Tetrahydrocannabinol 10.9219040278
MESH:D009447 Neuroblastoma irinotecan 3.228761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.1118514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 7.1112349958
MESH:D017599 Neuroectodermal Tumors irinotecan 4.258761367
MESH:D009503 Neutropenia Folic Acid 8.8016322990
MESH:D009503 Neutropenia pemetrexed 8.8016322990
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.686374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.7612819281 16049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 7.7614694615
MESH:D010003 Osteoarthritis Indomethacin 3.377009135
MESH:D010018 Osteomalacia Carbamazepine 10.5117016548
MESH:D010018 Osteomalacia Phenobarbital 10.5117016548
MESH:D010024 Osteoporosis Alendronate 6.7817882678
MESH:D010024 Osteoporosis Raloxifene 6.7817882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.7915758505 15579764 17823083 17893378
MESH:D010146 Pain Acetaminophen 9.2016870215
MESH:D010146 Pain Carbamazepine 9.2015215642
MESH:D010146 Pain Indomethacin 9.203291741 13679232 17440234 17627676
MESH:D010149 Pain, Postoperative Indomethacin 4.1918702446 12538197
MESH:D010190 Pancreatic Neoplasms Ethanol 7.6512384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 7.6516965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 7.6515976015
MESH:D010195 Pancreatitis Indomethacin 7.7617883296 15028970
MESH:D010195 Pancreatitis Taurocholic Acid 7.7620035747
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2511578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.8318922899 18404319 8330346 12065085
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.2316537180
MESH:D010267 Parapsoriasis Carbamazepine 5.2316538176
MESH:D020734 Parkinsonian Disorders Indomethacin 3.7112349958
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.4517145499 17679678
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.2311903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7612520081
MESH:D010437 Peptic Ulcer Indomethacin 4.6711148446
MESH:D010518 Periodontitis Indomethacin 4.4317225004
MESH:D010954 Plasmacytoma Selenium 4.4015087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1118163543
MESH:D011230 Precancerous Conditions Azoxymethane 8.5014668109 19056647 12458338
MESH:D011230 Precancerous Conditions Phenobarbital 8.502563599
MESH:D011248 Pregnancy Complications Carbamazepine 4.699014606
MESH:D047928 Premature Birth Indomethacin 4.6617000239
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 8.279014606
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.2711222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.9016205645
MESH:D011471 Prostatic Neoplasms Raloxifene 2.9016220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms Vitamin E 2.9015084515
MESH:D011507 Proteinuria Indomethacin 3.7311849393
MESH:D011537 Pruritus Ethinyl Estradiol 2.8416919318 15861022
MESH:D019310 Pseudolymphoma Carbamazepine 10.9612752131 9591791
MESH:D019310 Pseudolymphoma Phenobarbital 10.9612752131
MESH:D011565 Psoriasis Methotrexate 3.2517410198
MESH:D011693 Purpura Raloxifene 5.0715770314
MESH:D051437 Renal Insufficiency Folic Acid 9.1515728788
MESH:D051437 Renal Insufficiency Methotrexate 9.1517352296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3818990726
MESH:D012559 Schizophrenia Folic Acid 2.8316641680
MESH:D012640 Seizures 2,4-dinitrotoluene 15.1218551238
MESH:D012640 Seizures Carbamazepine 15.1216876388 15946322 9844417 16938433 19414003 9046859 16180713
MESH:D012640 Seizures Ethanol 15.129754883
MESH:D012640 Seizures Nicotine 15.1217873105
MESH:D012640 Seizures Phenobarbital 15.124039156 11442880 3137016 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.346407741
MESH:D012871 Skin Diseases Folic Acid 4.7418709164
MESH:D012871 Skin Diseases Vitamin E 4.7418709164
MESH:D012878 Skin Neoplasms Okadaic Acid 8.3212628509
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.3216192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 8.3218404319 12065085 8985016 11807781 8330346
MESH:D012893 Sleep Disorders Carbamazepine 4.6519414003
MESH:D013088 Spermatocele Ethinyl Estradiol 3.4616709447
MESH:D013118 Spinal Cord Diseases Folic Acid 5.0116361298
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 4.7518855540 15057820 19915237 19694795 16415921 16538176 20485159
MESH:D013272 Stomach Diseases Indomethacin 3.9418209964 16113693 17160473 16184426 10486359 18545984 10215738 15038085 10192188 17638125 16280098 15472012 17207306
MESH:D013274 Stomach Neoplasms Ethanol 5.8218456281
MESH:D013274 Stomach Neoplasms Folic Acid 5.8217171786
MESH:D013274 Stomach Neoplasms Indomethacin 5.8215609394
MESH:D013274 Stomach Neoplasms irinotecan 5.8215723263
MESH:D013274 Stomach Neoplasms pemetrexed 5.8215958060
MESH:D013276 Stomach Ulcer Ethanol 6.1917918041 17189318 16755016 9211565 11906479 9562338
MESH:D013276 Stomach Ulcer Indomethacin 6.1911595431 17918041 11906479 12498302 18181030 16397915 17657623 12500499 18237397 10878458 16934674 17135157 18209962 12467913 18193104 15138204 18726076 16252198 16169175 10423059 1323529 12077510 15255614 18087811 12787963 11595415 17654042 18299717 11523592 17895592 14567935 16631530 10750652 17977527 17627676 18431645 11145282 11729361 16755016 18543354 15104355 16150113
MESH:D020521 Stroke Folic Acid 12.3316517955
MESH:D020521 Stroke Raloxifene 12.3316837676
MESH:D020521 Stroke Vitamin E 12.3316517955
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.849754883
MESH:D013576 Syndactyly Methotrexate 4.589562676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4212697716
MESH:D018382 Thyroid Hormone Resistance Syndrome Atenolol 5.929349583
MESH:D013964 Thyroid Neoplasms Indomethacin 6.2011352223 14736730 18791128
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.201399818
MESH:D013978 Tibial Fractures Raloxifene 4.7219048282
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.3816785264 11259349 16720336
MESH:D014029 Tobacco Use Disorder Nicotine 4.9817979512 15735609 18041664 18305452
MESH:D014456 Ulcer Indomethacin 4.4210574470 17380554
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 4.5216049721
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 4.5217572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.8410091137
MESH:D014581 Urticaria Acetaminophen 2.5410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8514692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1112125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.7216837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1114671159 15869587
MESH:D014839 Vomiting Indomethacin 4.2611897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.0716343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7615886252
Pathway ID Pathway Name
REACT:11193 Metabolism of vitamins and cofactors
KEGG:04977 Vitamin digestion and absorption
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA327
    • Releated gene ID Related gene Name
    PA327SLC19A1
    Releated disease ID Related disease Name
    PA164925725Toxic liver disease
    PA445601Osteosarcoma
    PA445850Thrombosis
    PA444367Heart Defects, Congenital
    PA446286Spina Bifida Cystica
    PA443937Drug Toxicity
    PA165817398Myelosuppression
    PA446166Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
    PA444750Leukemia
    PA445451Psoriasis
    PA443434Arthritis, Rheumatoid
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA444552Hypertension
    PA444101Esophageal Neoplasms
    PA445742Stomach Neoplasms
    PA445062Neoplasms
    PA443622Carcinoma, Non-Small-Cell Lung
    Releated drug ID Related drug Name
    PA449247dexamethasone
    PA449014cisplatin
    PA449165cyclophosphamide
    PA151917012dactinomycin
    PA449412doxorubicin
    PA452621antineoplastic agents
    PA164777036hydroxychloroquine
    PA451547sulfasalazine
    PA449789glycine
    PA451330l-serine
    PA131625240raltitrexed
    PA449692folic acid
    PA448492asparaginase
    PA449177cytarabine
    PA449212daunorubicin
    PA449552etoposide
    PA450198leucovorin
    PA450379mercaptopurine
    PA450428methotrexate
    PA451100prednisone
    PA451879vincristine
    PA128406956fluorouracil
    PA450085irinotecan
    PA448803carboplatin
    PA10810pemetrexed
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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