AutismKB 2.0

Annotation Detail for SLC20A2


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Basic Information Top
Gene Symbol:SLC20A2 ( GLVR2,Glvr-2,MLVAR,PIT-2 )
Gene Full Name: solute carrier family 20 (phosphate transporter), member 2
Band: 8p11.21
Quick LinksEntrez ID:6575; OMIM: 158378; Uniprot ID:S20A2_HUMAN; ENSEMBL ID: ENSG00000168575; HGNC ID: 10947
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Transmembrane transport of small molecules
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SLC20A2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SLC20A2 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SLC20A2 mRNAdecreases expression 20064835
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SLC20A2 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of SLC20A2 mRNAdecreases expression 20106945
D000431 Ethanol Ethanol results in increased expression of SLC20A2 mRNAincreases expression 15353170
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC20A2 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of SLC20A2 mRNAdecreases expression 18035473
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in increased expression of SLC20A2 mRNAincreases expression 17616710
C006253 pirinixic acid pirinixic acid results in increased expression of SLC20A2 mRNAincreases expression 17426115
C017947 sodium arsenite sodium arsenite results in increased expression of SLC20A2 mRNAincreases expression 16966095
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SLC20A2 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC20A2 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 8.9918926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.9915322242 14514962 11752688
MESH:D000138 Acidosis Ethanol 4.6511192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2620127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2614692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0817306315 16712894
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.4915451039 15451040
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D000853 Anophthalmos Ethanol 4.9615513904
MESH:D001008 Anxiety Disorders Ethanol 4.0911141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8817474063 20146248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002056 Burns Ethanol 4.7916374292
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9210355542 15673190 16097048 16011737 16227642 18705752 15700767 16124888 16050911 3786805 15721981 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.0516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.053084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.0518788625
MESH:D006528 Carcinoma, Hepatocellular Ethanol 9.0515289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 9.0515276417 17306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7020419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.7018572023
MESH:D006332 Cardiomegaly Ethanol 7.0419332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.0418850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9012371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.9019524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 13.8219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.8216105132 11677210 15861022 17681005 17110522 17333356 16919318
MESH:D002779 Cholestasis pirinixic acid 13.8219176532
MESH:D002971 Cleft Lip Ethanol 3.6415513904
MESH:D002972 Cleft Palate Ethanol 6.0915513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0912621046 16354765 15668235 8697196 15340226
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.6820423518
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 2.6615513904 11198716 15451040 19302082 10194807 11873399 15451039
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6615322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1518551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.3421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.3419739265 11834606 10663392 17906064 14725611 18071297 12392966 15619225 12540782 19085960 14550746 10774834 16781746 11421492 11743745 15968718 19416960 10915739 11529661 16227642 12153990 2444490 17562736 19923254 16393943 16177239 16485898 16081117 11739529 14986274 18713872 11287661 11461765 19420014 19370779 16109766 17522070 12958197 12705907 12594235 19164858
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.3415998439 10092053 19336974 16177239 3732212 17522070 15968718 21278145 9327722 16227642 6623471 10915739 4309450 19085960 11566570 6884620 7120509 2869522 3786805 15027814 7440962 7179309
MESH:D056486 Drug-Induced Liver Injury Ethanol 12.3411566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.3420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6816530937
MESH:D004938 Esophageal Neoplasms Ethanol 4.6816704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 25.9016045604 12631006 16239168 19224547 15959796 61145 17595544 12795759
MESH:D005234 Fatty Liver Cyclosporine 25.9019224547
MESH:D005234 Fatty Liver Ethanol 25.9019236843 18620774 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.9015345470
MESH:D005234 Fatty Liver pirinixic acid 25.9020131406 19236843
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.8417920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.4510194807 15513904 15451040 16946407
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Carbon Tetrachloride 15.5518705752
MESH:D005355 Fibrosis Cyclosporine 15.5512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.5520067830
MESH:D005756 Gastritis Acetaminophen 11.7216983495
MESH:D005756 Gastritis Ethanol 11.7215046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8316452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 8.7319772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7315340226 12621046 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.2512676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.228697196 18606429 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 8.1116870215
MESH:D006930 Hyperalgesia Ethanol 8.1118783367
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.8817937319
MESH:D007248 Infertility, Male sodium arsenite 6.8815346721 12646999
MESH:D007249 Inflammation Flavonoids 5.1717296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1712200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007569 Jaw Abnormalities Ethanol 10.4915513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.4916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 10.3612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.368314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 10.3620008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.5816705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5812371664
MESH:D007859 Learning Disorders Ethanol 4.3515451040
MESH:D017880 Limb Deformities, Congenital Ethanol 3.8917676605
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.0017334410 17157831 17174718 16943688 16221502 11903743 21278145 11408273 16239168
MESH:D008103 Liver Cirrhosis Ethanol 7.0015289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.2518295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.0414512876 16015684 17766677 12649538 16192424 18277467 15818738 12958196 17805973 17976157 18210741 11481614 18412020 18279442 18376398 18054572 13678700 17721639 14620537 17869086 12546737 15893842 12666154 20821823 17714472 12741479 18395914 15931870 17708605 18263696 18418968 18472094 18156304 18395095 14716496 12445418 15730626 17922224 15338365 14716833 18251166 10355542 15370692 18472332 18187930 17900296 17698563 18205269 17525996 14724832 17823541 16011737 12898905 16097048 12667390 16033810 12632512 12609069 15925388 17944888 17640975 18317297 15876570 15123356 16248980 16027843 17557913 15996030 12445421 16116963 17761835 18705752 12389079 15057751 12632514 16638106 15673190 15052691 18006644 15959796 17631135 15650968 18339082 17565644 18166357 15362042 16136751 12586293 18481824 18429990 17481882 14748882 18420326
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 5.0418166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0412878042
MESH:D008107 Liver Diseases Acetaminophen 3.9819014921 19784758 11587558 12969438 19460945 16611625 16610002 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9817285989 15830285 16964402 16246199 15720792
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.7917207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.7616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.7614706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.6520195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.6519294768
MESH:D008113 Liver Neoplasms pirinixic acid 14.6516377806 15890375 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 14.6516712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.6516984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.9812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9812151625
MESH:D008171 Lung Diseases sodium arsenite 3.2419095001
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4220064080 17053015 6695378 20464547 20869020 18520028 20135361 18569708 18816296
MESH:D008175 Lung Neoplasms sodium arsenite 3.4216712894 17077188 17306315 15276417 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4211884234 19555203
MESH:D008545 Melanoma sodium arsenite 2.0416487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008569 Memory Disorders Ethanol 4.3115451040 18411066
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0118551238
MESH:D009369 Neoplasms Benzo(a)pyrene 8.5011141357
MESH:D009369 Neoplasms pirinixic acid 8.5017405874
MESH:D009369 Neoplasms sodium arsenite 8.5011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8020056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.2112854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5316049721 12819281
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4617306315 15276417
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms Ethanol 3.0012384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411896295 11222880 11399792 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1617292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.1616039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3418551238
MESH:D012640 Seizures Ethanol 6.349754883
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.6819755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 9.6818572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.6816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8812854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.562093021 20155912
MESH:D013274 Stomach Neoplasms Ethanol 2.5618456281
MESH:D013276 Stomach Ulcer Ethanol 3.649211565 11906479 17189318 9562338 17918041 16755016
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.369754883
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 5.1015864552
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.5316049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5317053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.5316712894 11723127 17306315 16452187
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4710091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.8711813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014652 Vascular Diseases sodium arsenite 4.5817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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