AutismKB 2.0

Annotation Detail for SLC25A1


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Basic Information Top
Gene Symbol:SLC25A1 ( CTP,SLC20A3 )
Gene Full Name: solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
Band: 22q11.21
Quick LinksEntrez ID:6576; OMIM: 190315; Uniprot ID:TXTP_HUMAN; ENSEMBL ID: ENSG00000100075; HGNC ID: 10979
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of carbohydrates
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500678Gluconeogenesis
500801Fatty Acyl-CoA Biosynthesis
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLC25A1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC25A1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SLC25A1 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of SLC25A1 mRNAdecreases expression 20106945
C014347 decitabine [[decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to SLC25A1 promoter]] which results in increased expression of SLC25A1 mRNAaffects binding|affects cotreatment|increases expression|increases reaction 18706393
C014347 decitabine [decitabine co-treated with trichostatin A] results in increased expression of SLC25A1 mRNAaffects cotreatment|increases expression 18706393
C014347 decitabine [decitabine co-treated with trichostatin A] results in increased expression of SLC25A1 proteinaffects cotreatment|increases expression 18706393
C014347 decitabine decitabine promotes the reaction [SP1 protein binds to SLC25A1 promoter]affects binding|increases reaction 18706393
C014347 decitabine decitabine results in increased expression of SLC25A1 mRNAincreases expression 18706393
C014347 decitabine decitabine results in increased expression of SLC25A1 proteinincreases expression 18706393
D004041 Dietary Fats Dietary Fats results in decreased expression of SLC25A1 mRNAdecreases expression 18042831
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of SLC25A1 mRNAincreases expression 16849584
C041786 palm oil palm oil results in decreased expression of SLC25A1 mRNAdecreases expression 18042831
D010795 Phthalic Acids Phthalic Acids results in decreased expression of SLC25A1 mRNAdecreases expression 15728792
D012643 Selenium Selenium results in increased expression of SLC25A1 mRNAincreases expression 19244175
D012645 Selenomethionine Selenomethionine affects the expression of SLC25A1 mRNAaffects expression 17222674
C025462 sulindac sulfide sulindac sulfide results in decreased expression of SLC25A1 mRNAdecreases expression 16184548
C066340 tolcapone tolcapone binds to SLC25A1 proteinaffects binding 19783845
D014212 Tretinoin Tretinoin results in increased expression of SLC25A1 mRNAincreases expression 16054129
C012589 trichostatin A [[decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to SLC25A1 promoter]] which results in increased expression of SLC25A1 mRNAaffects binding|affects cotreatment|increases expression|increases reaction 18706393
C012589 trichostatin A [decitabine co-treated with trichostatin A] results in increased expression of SLC25A1 mRNAaffects cotreatment|increases expression 18706393
C012589 trichostatin A [decitabine co-treated with trichostatin A] results in increased expression of SLC25A1 proteinaffects cotreatment|increases expression 18706393
C012589 trichostatin A trichostatin A promotes the reaction [SP1 protein binds to SLC25A1 promoter]affects binding|increases reaction 18706393
C012589 trichostatin A trichostatin A results in increased expression of SLC25A1 mRNAincreases expression 18706393
C012589 trichostatin A trichostatin A results in increased expression of SLC25A1 proteinincreases expression 18706393
D014810 Vitamin E Vitamin E results in increased expression of SLC25A1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9820464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.656695378
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.3211080934
MESH:D000505 Alopecia Tretinoin 3.6215955085
MESH:D000544 Alzheimer Disease sulindac sulfide 4.8918759972
MESH:D000544 Alzheimer Disease tolcapone 4.8920150427
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.9015238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.0816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2616292516
MESH:D001249 Asthma Tretinoin 2.3416456186
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.3620106747
MESH:D001471 Barrett Esophagus Tretinoin 4.4116935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.6116197459 16206674
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9720146248 17474063
MESH:D001943 Breast Neoplasms decitabine 1.9719208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 1.9720435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9716443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6116813970
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.9416050911
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1916168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.0812907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.081917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.4512391285
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.5520419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.5519215824
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.5516051514 16096774
MESH:D002386 Cataract Tretinoin 3.0917460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5312371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6116129372
MESH:D002779 Cholestasis Cyclosporine 2.9219486331
MESH:D002822 Choriocarcinoma Tretinoin 5.1916461808
MESH:D002972 Cleft Palate Tretinoin 2.679407595
MESH:D003092 Colitis Selenium 9.5417936198
MESH:D003092 Colitis Tretinoin 9.5417035595
MESH:D003110 Colonic Neoplasms decitabine 2.3417616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.699211117 14991402 16925845 9664655 9142499 10589399 9224671 8800419 9125849 17551590
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.6919769572
MESH:D003866 Depressive Disorder tolcapone 4.3111224284 7768276
MESH:D003865 Depressive Disorder, Major tolcapone 4.9010440460
MESH:D056486 Drug-Induced Liver Injury Selenium 4.4015131321
MESH:D056486 Drug-Induced Liver Injury tolcapone 4.4016604736 19783845
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.4311455177
MESH:D050171 Dyslipidemias Dietary Fats 3.4518367378
MESH:C538011 Eales disease Vitamin E 4.739068938
MESH:D004489 Edema, Cardiac Tretinoin 4.5018230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 14.1319294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 14.1319294695
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1116569247
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0116530937
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 5.9819578428
MESH:D005124 Eye Abnormalities Tretinoin 3.589664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 7.7519224547
MESH:D005234 Fatty Liver Dietary Fats 7.7519551842 19004024 18296743 17967931
MESH:D005355 Fibrosis Cyclosporine 14.8812168785 12639820
MESH:D005355 Fibrosis Dietary Fats 14.8818296743
MESH:D005355 Fibrosis Tretinoin 14.8817994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D005909 Glioblastoma Tretinoin 7.4217312396
MESH:D005909 Glioblastoma trichostatin A 7.4218801729
MESH:D006258 Head and Neck Neoplasms decitabine 7.8419215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.8416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.1920471113
MESH:D006330 Heart Defects, Congenital Tretinoin 11.199664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 11.1916080930
MESH:D006333 Heart Failure Selenium 3.0717162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7016863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.0014716179
MESH:D006930 Hyperalgesia Tretinoin 3.2116870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6021332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5816778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.6221332399
MESH:D006973 Hypertension Cyclosporine 2.1010903974
MESH:D007248 Infertility, Male decitabine 3.2017581917
MESH:D007249 Inflammation Dietary Fats 2.4320412841
MESH:D007251 Influenza, Human Selenium 11.0616624496
MESH:D007251 Influenza, Human Vitamin E 11.0616624496
MESH:D007333 Insulin Resistance Dietary Fats 3.1111836018 18457598
MESH:D007410 Intestinal Diseases Tretinoin 3.7817994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.9015992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Cyclosporine 6.0218776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 6.0212488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.8916518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7412371664
MESH:D007938 Leukemia decitabine 6.4319235587 18980019
MESH:D007938 Leukemia Tretinoin 6.4317143497
MESH:D007951 Leukemia, Myeloid decitabine 9.5818454857 17236224 19117987
MESH:D007951 Leukemia, Myeloid Tretinoin 9.5816932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.2619010910 18704418 18206229 17679729 18460780 19387464
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.2616294345 17596541 19850784
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 6.2618206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4918055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.159834237 17107899 17361223 17506722 19075265 15748426 16891316 17339181 17649720 16331271 16823087 19029980 16788101 16766008 17294898 17301526 17712046 19642359 16140955 19035177 19225113 17217047 17368321 12679006 16935935
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.319224671
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8818296743
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5516248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.5516169303
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.562125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.5620195826 21137059
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.748603461
MESH:D008171 Lung Diseases Vitamin E 3.1816863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4514755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4518816296 18520028 18569708 20464547 20064080 20135361 20869020 6695378 17053015
MESH:D008175 Lung Neoplasms Vitamin E 3.4511062179
MESH:D008223 Lymphoma decitabine 3.4219470736
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.7615318939
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma decitabine 5.2516505122 17785578
MESH:D008545 Melanoma Tretinoin 5.2516752155
MESH:D008545 Melanoma trichostatin A 5.2516505122
MESH:D008591 Meningomyelocele Tretinoin 4.4416940565
MESH:D008654 Mesothelioma Selenium 2.7915107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1916381670
MESH:D009101 Multiple Myeloma decitabine 7.6618172295
MESH:D009101 Multiple Myeloma trichostatin A 7.6618172295
MESH:D009190 Myelodysplastic Syndromes decitabine 7.4819157545 16882708 19010910 18608210
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.4817596541
MESH:D009369 Neoplasms Benzo(a)pyrene 8.3011141357
MESH:D009369 Neoplasms decitabine 8.3017925555 19470736 19116145
MESH:D009369 Neoplasms Tretinoin 8.3016594593 16946489
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2919348381 18481113
MESH:D009421 Nervous System Malformations Tretinoin 3.799125849
MESH:D009436 Neural Tube Defects Tretinoin 3.059142499
MESH:D009765 Obesity Dietary Fats 2.2919632207 17217161 18674790 18457598 21332399 16723640 11836018 20518802 20132043
MESH:D010051 Ovarian Neoplasms decitabine 8.0419331143 19259094
MESH:D010051 Ovarian Neoplasms Tretinoin 8.0416936753
MESH:D010051 Ovarian Neoplasms trichostatin A 8.0419331143
MESH:D010146 Pain Tretinoin 2.9016870215
MESH:D010190 Pancreatic Neoplasms decitabine 8.7719294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.7715976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 8.7719294695
MESH:D010300 Parkinson Disease tolcapone 3.6010651109 1977408 11432539 8635184 20216409 9305320 9333106 16758261 20334432 9591521 11586115 19578428 9754991 11793426 11746615 9708959 7566641 18328768 17089403 8739811 19783845
MESH:D010954 Plasmacytoma Selenium 4.9215087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.2212371664
MESH:D055728 Primary Myelofibrosis decitabine 12.4717616702
MESH:D055728 Primary Myelofibrosis trichostatin A 12.4717616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6617292933
MESH:D011471 Prostatic Neoplasms trichostatin A 2.6618798265 19789329
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6615084515
MESH:D011507 Proteinuria Tretinoin 3.6116636307
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D011625 Pterygium Tretinoin 4.8116723453
MESH:D012208 Rhabdomyosarcoma decitabine 10.9719155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.9716116481 16283617
MESH:D012871 Skin Diseases Vitamin E 2.4418709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6810029692 19755658
MESH:D012878 Skin Neoplasms Tretinoin 5.6816467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.3720155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 3.3719037991
MESH:D013274 Stomach Neoplasms Tretinoin 3.3717261132
MESH:D020521 Stroke Vitamin E 3.5216517955
MESH:D013964 Thyroid Neoplasms decitabine 7.3017967635
MESH:D013964 Thyroid Neoplasms Tretinoin 7.3017045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.7916051514
MESH:D014376 Tuberculosis Tretinoin 3.2316040207
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 5.9819578428
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1317053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.1317616700 19087683
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6816129372
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.6618645019
MESH:D014604 Uveal Neoplasms decitabine 12.9317785578
MESH:D014604 Uveal Neoplasms Tretinoin 12.9316752155
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D014820 Vitiligo tolcapone 11.1310573327
MESH:D014820 Vitiligo Tretinoin 11.1316761959
MESH:D015430 Weight Gain Dietary Fats 3.7416723640
MESH:D009396 Wilms Tumor Tretinoin 3.9716287080
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
Pathway ID Pathway Name
REACT:474 Metabolism of carbohydrates
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35855
    • No data
    No data
    Releated drug ID Related drug Name
    PA448625biotin
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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