AutismKB 2.0

Annotation Detail for SLCO2A1


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Basic Information Top
Gene Symbol:SLCO2A1 ( OATP2A1,PGT,SLC21A2 )
Gene Full Name: solute carrier organic anion transporter family, member 2A1
Band: 3q22.1-q22.2
Quick LinksEntrez ID:6578; OMIM: 601460; Uniprot ID:SO2A1_HUMAN; ENSEMBL ID: ENSG00000174640; HGNC ID: 10955
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Transmembrane transport of small molecules
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SLCO2A1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SLCO2A1 mRNAaffects expression 17562736
D001151 Arsenic Arsenic results in decreased expression of SLCO2A1 mRNAdecreases expression 19654921
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SLCO2A1 mRNAincreases expression 20106945
C006780 bisphenol A bisphenol A results in increased expression of SLCO2A1 mRNAincreases expression 19371625
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SLCO2A1 mRNAaffects expression 17484886
C019304 ciprofibrate ciprofibrate results in decreased expression of SLCO2A1 mRNAdecreases expression 15919853
D002994 Clofibrate Clofibrate results in decreased expression of SLCO2A1 mRNAdecreases expression 15919853
D003907 Dexamethasone Dexamethasone results in decreased expression of SLCO2A1 mRNAdecreases expression 15919853
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of SLCO2A1 mRNAdecreases expression 15919853
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of SLCO2A1 mRNAincreases expression 20360939
D005472 Fluorouracil Fluorouracil affects the expression of SLCO2A1 mRNAaffects expression 16584549
D019833 Genistein Genistein results in increased expression of SLCO2A1 mRNAincreases expression 19371625
C016340 o,p'-DDT o,p'-DDT results in increased expression of SLCO2A1 mRNAincreases expression 19371625
D010126 Ozone Ozone results in decreased expression of SLCO2A1 mRNAdecreases expression 16716893
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of SLCO2A1 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of SLCO2A1 mRNAdecreases expression 19482888
C006253 pirinixic acid pirinixic acid results in decreased expression of SLCO2A1 mRNAdecreases expression 17426115
D011285 Pregnenolone Carbonitrile Pregnenolone Carbonitrile results in decreased expression of SLCO2A1 mRNAdecreases expression 15919853
C059514 resveratrol resveratrol results in increased expression of SLCO2A1 mRNAincreases expression 19371625
D013148 Spironolactone Spironolactone results in decreased expression of SLCO2A1 mRNAdecreases expression 15919853
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SLCO2A1 mRNAincreases expression 20106945
C024746 tobacco tar tobacco tar results in decreased expression of SLCO2A1 mRNAdecreases expression 19559774
C025643 vinclozolin vinclozolin affects the expression of SLCO2A1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 13.466734493
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.466195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.4615322242 14514962 11752688
MESH:D058186 Acute Kidney Injury resveratrol 3.7116538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.9718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.9120464547 20127859
MESH:D000230 Adenocarcinoma Fluorouracil 6.9117638652
MESH:D000230 Adenocarcinoma Genistein 6.9111473722
MESH:D000236 Adenoma Benzo(a)pyrene 10.706695378
MESH:D000236 Adenoma Diethylnitrosamine 10.706695378 10737359
MESH:D000236 Adenoma resveratrol 10.7015688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 23.6117162532 17620307 18056438 19061943 19052882 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 23.6117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 23.6116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 23.6116835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.0617306315
MESH:D000544 Alzheimer Disease Ozone 4.2715513908
MESH:D000544 Alzheimer Disease resveratrol 4.2716162502 16183991
MESH:D000740 Anemia Fluorouracil 8.2415504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.2411748828
MESH:D000799 Angioedema Acetaminophen 3.6910982225
MESH:D001008 Anxiety Disorders vinclozolin 3.5219015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9219183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8316835338 12569548 18414634 16251483
MESH:D001169 Arthritis, Experimental Dexamethasone 7.3817659584
MESH:D001169 Arthritis, Experimental resveratrol 7.3817115116
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5215570426
MESH:D001249 Asthma Ozone 2.5917854713 16373670
MESH:D050197 Atherosclerosis Arsenic 6.5912928151 19371607
MESH:D050197 Atherosclerosis resveratrol 6.5917967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001778 Blood Coagulation Disorders Clofibrate 14.5519483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.5519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.5512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D001862 Bone Resorption bisphenol A 3.7211985600
MESH:D002545 Brain Ischemia resveratrol 4.1317600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.6717474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 3.6717123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.6717474063
MESH:D001943 Breast Neoplasms Fluorouracil 3.6718357371 15136595 16110121 18608205 19217205 16557594 16595493
MESH:D001943 Breast Neoplasms Genistein 3.6716541309 16873071 17200150
MESH:D001943 Breast Neoplasms resveratrol 3.6716393696 17534123 17651959
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6720435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5615516495 18315731 19059883 18417511 17626835 14754758 16777450
MESH:D002100 Cachexia Ozone 4.5916183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6315700767 16011737 16124888 16227642 15721981 16050911 16097048 10355542 18705752 16192424 15673190 3786805
MESH:D002276 Carcinoid Tumor Fluorouracil 4.5216051944
MESH:D002277 Carcinoma Fluorouracil 7.7817121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.7816835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5117687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 19.4516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 19.453084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 19.4517306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 19.4518788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 19.4519822196 19052882 11831363 18788625 20524982 19539802 18785209 17055752 17978847 16569478 17761372 18210153 19519916 16698587 16807293 20512989 17138121 20727157 20935162 19107877 20007298 20514400 19394651 19701751 17428255 16830150 16288022 20214788 16779866 18978308 17173139 19919837 21159647 10737359 20084675 3084413 18506893 18665156 19171122 16681979 19335982 19418558 3581430 16540662 10672840 18494052 19383236 16878318 20101231 18056438 19208518 18393292 18691550 17162532 16328049 20432363 18971187 16502159 16935385
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 19.4517088986 18930000 16332177 17045692 16799960 17971768
MESH:D006528 Carcinoma, Hepatocellular Genistein 19.4516924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 19.4520007298 1701930 17173139 6705139 20935162
MESH:D006528 Carcinoma, Hepatocellular resveratrol 19.4519321006 16227395
MESH:D002278 Carcinoma in Situ bisphenol A 4.8417123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.4416675471
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9518695887
MESH:D002294 Carcinoma, Squamous Cell Arsenic 10.4617687452 18922899 15504454
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.4620419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.4616280240 17066447 16757204 18986760
MESH:D002294 Carcinoma, Squamous Cell resveratrol 10.4616227395
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.9418640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2816120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Arsenic 16.5719152805 17938729 15738583
MESH:D002318 Cardiovascular Diseases Genistein 16.5716332659
MESH:D002318 Cardiovascular Diseases resveratrol 16.5715458977
MESH:D002318 Cardiovascular Diseases Spironolactone 16.5711230374
MESH:D002340 Carotid Artery Diseases Arsenic 4.1818022660 16973168
MESH:D002386 Cataract Acetaminophen 2.4910977129
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 10.851399818
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.852727394 17174075 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 10.8519559774
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.104080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.8919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.8916835633
MESH:D002779 Cholestasis pirinixic acid 2.7119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0416354765 15668235 12621046 15340226 8697196
MESH:D003092 Colitis resveratrol 3.9816474422
MESH:D003110 Colonic Neoplasms Dexamethasone 8.1115824018
MESH:D003110 Colonic Neoplasms Fluorouracil 8.1117287894 15001691 17016597 18772588 17169374 16510598 16340194 17725105 17018589 17172411
MESH:D003110 Colonic Neoplasms Genistein 8.1117182828
MESH:D003110 Colonic Neoplasms resveratrol 8.1116338953
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6417594712 18802399 17016601 17695437 18383874 16282729 18509181 20501625 17094418 18448328 17401013 16524972 15148649 16331619 18288408 18949393 16303861 16391804 17255274 14970324 15289873 17454858
MESH:D015179 Colorectal Neoplasms resveratrol 2.6416550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9317141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.6616507316
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.5717728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5715322242 10048152 20055451
MESH:D003456 Cryptorchidism vinclozolin 4.1914966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8618551238
MESH:D007644 Darier Disease Fluorouracil 4.6416733453
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.2612438553
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 6.7416882537
MESH:D003876 Dermatitis, Atopic pirinixic acid 6.7418249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.6416873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.8820387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.8816647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8817107852
MESH:D003928 Diabetic Nephropathies resveratrol 3.8316286809
MESH:D003967 Diarrhea Dexamethasone 3.557237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.5221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.5216081117 12705907 19085960 11743745 11421492 16781746 11834606 19164858 10915739 10774834 16227642 14550746 19420014 2444490 16109766 14725611 16177239 12153990 12958197 11739529 17522070 16393943 14986274 17562736 15968718 11529661 15619225 17906064 19739265 18713872 12392966 18071297 11287661 19370779 19923254 16485898 19416960 12540782 10663392 11461765 12594235
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.5210092053 4309450 21278145 7120509 16227642 6884620 2869522 19336974 9327722 6623471 15027814 15998439 10915739 3786805 15968718 19085960 7440962 17522070 7179309 11566570 16177239 3732212
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.5219107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.5220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D004362 Drug Toxicity marker/mechanism 15805072
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6511462148
MESH:D050171 Dyslipidemias Clofibrate 3.9616707586
MESH:D004421 Dystonia Phenobarbital 3.861851702
MESH:D004485 Eczema Dexamethasone 4.3112438553
MESH:D004487 Edema Dexamethasone 15.3219703484
MESH:D004487 Edema pirinixic acid 15.3212083418
MESH:D004487 Edema resveratrol 15.328985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 15.3212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7516714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.8817872969
MESH:D004714 Endometrial Hyperplasia Genistein 4.4416402032
MESH:D016889 Endometrial Neoplasms Genistein 3.2611473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8910568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.7017923197
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.963659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.7211558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.8120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.416401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.107750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.873659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9716302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3616530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.3615173087 16481741 17638652 16785472 16337965
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 17.6615959796 19224547 17595544 61145 16239168 12631006 16045604 12795759
MESH:D005234 Fatty Liver Clofibrate 17.6619224547
MESH:D005234 Fatty Liver Diethylnitrosamine 17.6620387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 17.6619236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005355 Fibrosis Carbon Tetrachloride 8.1018705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.1020067830
MESH:D005534 Foot Diseases Arsenic 5.416392382
MESH:D005756 Gastritis Acetaminophen 3.5216983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7816973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1516417039
MESH:D005909 Glioblastoma Genistein 3.1616598420
MESH:D005910 Glioma Fluorouracil 2.8116145905
MESH:D015432 Glomerulonephritis, Membranoproliferative Spironolactone 5.8616928621
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.2815102660 18337622 15162350
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1811294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.4420558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4519900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 13.5116109766
MESH:D006529 Hepatomegaly pirinixic acid 13.5118467677 19176532 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.5115340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.027520565
MESH:D006561 Herpes Simplex resveratrol 4.0316876885
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.898697196 16959395 18606429 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5816870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3816899240
MESH:D006937 Hypercholesterolemia resveratrol 3.8717188708
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3217050553
MESH:D006949 Hyperlipidemias resveratrol 3.8916873680
MESH:D006973 Hypertension Arsenic 8.3616076760 11953799 9931084
MESH:D006973 Hypertension Dexamethasone 8.3617042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.3618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9415338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1717488730
MESH:D006987 Hypesthesia Arsenic 5.4116093927
MESH:D020514 Hypokalemic Periodic Paralysis Spironolactone 6.0119822448
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.5017600658
MESH:D007248 Infertility, Male vinclozolin 2.9416467254
MESH:D007249 Inflammation Dexamethasone 11.348960868 11099482
MESH:D007249 Inflammation Diethylnitrosamine 11.3418785209
MESH:D007249 Inflammation resveratrol 11.3416366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.3412878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.3916624496
MESH:D007333 Insulin Resistance bisphenol A 6.9916393666
MESH:D007333 Insulin Resistance pirinixic acid 6.9916306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007642 Keratosis Arsenic 4.8412749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 2.1115629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.0716705839
MESH:D007680 Kidney Neoplasms Fluorouracil 7.0716985049
MESH:D007938 Leukemia Genistein 2.9517468513 18980019
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.5917339181
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.5916087638
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5816417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.5411408273 11903743 16943688 17334410 17157831 21278145 16239168 16221502 17174718
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.5420032147 18665156 18522880 18407596 19638242
MESH:D008103 Liver Cirrhosis Phenobarbital 10.5421047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.5314748882 18187930 17714472 14716833 12586293 12649538 18395914 17944888 12632514 16638106 15673190 17976157 17640975 15057751 12741479 15893842 18376398 12632512 18412020 17481882 18472332 17766677 12546737 18395095 10355542 16011737 18156304 17631135 18418968 18420326 18251166 12609069 18205269 15650968 12667390 17869086 12958196 18317297 16248980 18006644 17823541 16033810 12445418 15123356 12445421 18166357 18279442 17922224 15338365 16192424 16015684 15052691 14716496 14724832 17805973 15959796 17708605 16097048 17721639 15370692 15730626 14512876 16027843 12389079 17557913 17565644 18429990 20821823 18277467 11481614 17525996 14620537 18210741 17900296 15996030 15931870 12666154 18263696 15876570 18472094 13678700 18481824 12898905 18705752 18054572 16136751 17761835 17698563 15818738 15362042 18339082 15925388 16116963
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 6.5316718785
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.5317823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5312878042
MESH:D008107 Liver Diseases Acetaminophen 12.1011587558 12969438 19784758 16611625 12587719 19460945 16610002 19014921
MESH:D008107 Liver Diseases Arsenic 12.1011134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 12.1017285989 16964402 15830285 15720792 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 12.1017034775
MESH:D008107 Liver Diseases Phenobarbital 12.1019363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.9616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.9614706259 16899240
MESH:D008113 Liver Neoplasms Arsenic 37.6616368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 37.6621137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 37.6619294768
MESH:D008113 Liver Neoplasms ciprofibrate 37.6612771043
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 37.6611940454
MESH:D008113 Liver Neoplasms Diethylnitrosamine 37.6618978307 21047994 18648771 12771043 19996281 20137499 19426721 16942905 18977376 19499222 2422723 21278145 20583210 20452335 19294768 20405173 19690152 19427195 2862719 19642983 20501860 19073162 19090486 19833225 18644402 21071580 20434301 19638242 19551842 19812893 15175105 19256749 15885732 12112319 19254457 21167192 19255062 10737359 20118626 20492335 19850985 9163691 20101389 18754104
MESH:D008113 Liver Neoplasms Fluorouracil 37.6615113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms Phenobarbital 37.6621047994 8742319 19073162 19482888 19812893 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 37.6620007298 16377806 15890375
MESH:D008113 Liver Neoplasms resveratrol 37.6619321006 19073162 20405173 19812893
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 37.6616984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.3312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.3318164116 18775883 3124819 18282651 16842330 19519916 18253720 16267830 18308698 17174075 18079962 19539802 18093689 2563599 19126423 19004024 18544905 21159647 17942915 19009564 9362446 17854601
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 13.3317172636 18308698 2563599 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.3312151625
MESH:D008171 Lung Diseases Ozone 3.278266340 19066396
MESH:D055370 Lung Injury Ozone 3.7020417186
MESH:D008175 Lung Neoplasms Arsenic 10.4217306315 17976673 19168569
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.4220464547 20135361 20064080 18520028 6695378 17053015 18816296 20869020 18569708
MESH:D008175 Lung Neoplasms Dexamethasone 10.4215824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.426695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms Fluorouracil 10.4215246190
MESH:D008175 Lung Neoplasms Ozone 10.427614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.4211884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6415086387
MESH:D016393 Lymphoma, B-Cell resveratrol 4.1617088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.7514749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.0915688416
MESH:D008325 Mammary Neoplasms, Experimental Genistein 5.9714578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 5.978985016 11606380
MESH:D008545 Melanoma resveratrol 2.3517992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4219513568
MESH:D008659 Metabolic Diseases resveratrol 4.2417112576
MESH:D008679 Metaplasia Ozone 4.9610496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.1416381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.1416757204 18986760
MESH:D009101 Multiple Myeloma Dexamethasone 7.2115744524 15867202 16118317
MESH:D009101 Multiple Myeloma resveratrol 7.2117164350 17049120 17935668 14749477 16490592 16267019
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.7217962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.469809623
MESH:D009203 Myocardial Infarction Genistein 9.1317141266
MESH:D009203 Myocardial Infarction pirinixic acid 9.1319151258
MESH:D009203 Myocardial Infarction resveratrol 9.1317188708 17125593 16317513 17015251 16525036 16456233
MESH:D017202 Myocardial Ischemia Arsenic 14.6015371236
MESH:D017202 Myocardial Ischemia resveratrol 14.6017015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 14.6012213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.0017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.0016411023
MESH:D009205 Myocarditis resveratrol 4.6117322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3217484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.7118551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.513581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 7.7811141357
MESH:D009369 Neoplasms Fluorouracil 7.7816928823 18239605 18600527
MESH:D009369 Neoplasms pirinixic acid 7.7817405874
MESH:D009374 Neoplasms, Experimental resveratrol 3.858985016
MESH:D009421 Nervous System Malformations bisphenol A 15.5516427766 11399458
MESH:D009421 Nervous System Malformations Genistein 15.5516427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.5514600291
MESH:D009436 Neural Tube Defects Arsenic 3.3616620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 13.3318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 13.3320387270
MESH:D019636 Neurodegenerative Diseases resveratrol 13.3317652729
MESH:D020078 Neurogenic Inflammation Arsenic 10.2217056641
MESH:D020078 Neurogenic Inflammation resveratrol 10.2217929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9720387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3416436463
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.799802331
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.2916049721 12819281
MESH:D010018 Osteomalacia Phenobarbital 4.2117016548
MESH:D010024 Osteoporosis Genistein 3.1619401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.6816169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 9.6817513867
MESH:D010049 Ovarian Diseases bisphenol A 4.8411985600
MESH:D010051 Ovarian Neoplasms Arsenic 4.9317306315
MESH:D010051 Ovarian Neoplasms Genistein 4.9319005980
MESH:D010146 Pain Acetaminophen 2.2716870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.3216540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.3219003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.3216965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.0316093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.846392382 15371236 16905509
MESH:D010538 Peritonitis Ozone 3.9816369182
MESH:D011014 Pneumonia Ozone 4.2418381685 18929643 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.662563599
MESH:D011230 Precancerous Conditions Phenobarbital 8.662563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.4621297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 22.0110548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 22.0116679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 22.0111896295 11222880 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 22.0118042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.7818220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.0720887781
MESH:D011471 Prostatic Neoplasms Arsenic 1.8816140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8819082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 1.8816925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms resveratrol 1.8817636462 15767336 16731767 17675339 17718901 17804756
MESH:D011472 Prostatitis vinclozolin 4.7818629315
MESH:D011507 Proteinuria Arsenic 3.8621343184
MESH:D019310 Pseudolymphoma Phenobarbital 4.3412752131
MESH:D011629 Puberty, Precocious bisphenol A 4.6310548101
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8818722050 15538739 18286688 16160472
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.4316325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.3319058328
MESH:D015427 Reperfusion Injury resveratrol 6.3317058453 16314181 15827377 17520802 16317513
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.8711700416 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012640 Seizures 2,4-dinitrotoluene 5.5818551238
MESH:D012640 Seizures Phenobarbital 5.5811442880 3137016 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.676407741
MESH:D012871 Skin Diseases Arsenic 2.7116702368 17938729 16759981 17050553 19834688 17548696 18709164 16353154 6392382 17453740 15952646
MESH:D012878 Skin Neoplasms Arsenic 13.0016251483 19538983 17050553 15504454 17029826 17976673
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.0010029692 19755658
MESH:D012878 Skin Neoplasms resveratrol 13.0015837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.0016192470
MESH:D013272 Stomach Diseases Dexamethasone 4.1715472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.272093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2718456281
MESH:D013274 Stomach Neoplasms Fluorouracil 3.2716424979 18396642 17172411 16951190 19084572 18567086 17498489 15786421 19015929 17522103
MESH:D013276 Stomach Ulcer Dexamethasone 3.3515138204
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.3516321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.8316684133 16045194
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.807505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.801399818
MESH:D014062 Tongue Neoplasms Fluorouracil 9.5416280240
MESH:D014062 Tongue Neoplasms resveratrol 9.5416227395
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.9916049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 7.9915987713 19322015 19429237 11144890 17976673 17306315 18640142
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.9917053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1610091137
MESH:D014581 Urticaria Acetaminophen 2.8310982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.1616803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.1617473185
MESH:D014591 Uterine Diseases bisphenol A 4.8614652134
MESH:D014594 Uterine Neoplasms resveratrol 3.9917044934
MESH:D014605 Uveitis Dexamethasone 4.671336536
MESH:D014652 Vascular Diseases Arsenic 4.5817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.1517488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
Drug Bank Top
No data
No data
Drugbank ID Action Drug Name Description
DB00119 inhibitor Pyruvic acid Dietary supplement;Micronutrient
DB00695 inhibitor Furosemide Diuretics;Sodium Potassium Chloride Symporter Inhibitors
DB00770 substrate Caverject Sterile Powder - Kit 23.2mcg/Vial Vasodilator Agents;Platelet Aggregation Inhibitors;Fibrinolytic Agents
DB00917 substrate Dinoprostone Oxytocics;Prostaglandins
DB01088 substrate Iloprost Antihypertensive Agents
DB01819 inhibitor Phosphoenolpyruvate
DB02263 inhibitor Glyceraldehyde-3-Phosphate
DB03581 inhibitor Glucose-6-Phosphate
DB04398 inhibitor Lactic Acid
DB04551 inhibitor Fructose-1,6-Diphosphate Neuroprotective Agents;Anti-Arrhythmia Agents;Cardiovascular Agents;Immunologic Factors
DB04557 substrate Arachidonic Acid
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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