AutismKB 2.0

Annotation Detail for SLC22A3


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Basic Information Top
Gene Symbol:SLC22A3 ( EMT,EMTH,OCT3 )
Gene Full Name: solute carrier family 22 (extraneuronal monoamine transporter), member 3
Band: 6q25.3
Quick LinksEntrez ID:6581; OMIM: 604842; Uniprot ID:S22A3_HUMAN; ENSEMBL ID: ENSG00000146477; HGNC ID: 10967
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transmembrane transport of small molecules
No data
No data
Pathway IDPathway Name
500360Organic cation transport
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1870Drug abuse
2044Pre-Eclampsia
2185Obsessive-compulsive disorder
Desease Name
CARDIOVASCULAR
Coronary Artery Disease
CHEMDEPENDENCY
prostate cancer
CANCER
methamphetamine dependence substance abuse
Desease Name
Prostate cancer
Coronary heart disease
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C085755 4-(1H-imidazol-4-ylmethyl)piperidine 4-(1H-imidazol-4-ylmethyl)piperidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
C085755 4-(1H-imidazol-4-ylmethyl)piperidine 4-(1H-imidazol-4-ylmethyl)piperidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D000082 Acetaminophen Acetaminophen affects the expression of SLC22A3 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLC22A3 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC22A3 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SLC22A3 mRNAdecreases expression 20106945
C006780 bisphenol A bisphenol A results in increased expression of SLC22A3 mRNAincreases expression 18180321
C105826 BU 224 BU 224 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
C105826 BU 224 BU 224 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
C086108 clobenpropit clobenpropit inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
C086108 clobenpropit clobenpropit inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D003345 Corticosterone Corticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D016572 Cyclosporine Cyclosporine results in decreased expression of SLC22A3 mRNAdecreases expression 20106945
D019259 Lamivudine SLC22A3 protein results in increased uptake of Lamivudineincreases uptake 19141712
D004041 Dietary Fats Dietary Fats results in decreased expression of SLC22A3 mRNAdecreases expression 18042831
C103851 disprocynium 24 disprocynium 24 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
C103851 disprocynium 24 disprocynium 24 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D004958 Estradiol Estradiol results in decreased expression of SLC22A3 mRNAdecreases expression 20106945
D006632 Histamine Histamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D006632 Histamine Histamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium 4-(1H-imidazol-4-ylmethyl)piperidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium BU 224 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium clobenpropit inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium Corticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium disprocynium 24 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium Histamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium Phentolamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridiniumincreases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium thioperamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium trimazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium 4-(1H-imidazol-4-ylmethyl)piperidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium BU 224 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium clobenpropit inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium disprocynium 24 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium Histamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium Phentolamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridiniumincreases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium thioperamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium trimazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015735 Mifepristone Mifepristone results in decreased expression of SLC22A3 mRNAdecreases expression 17584828
D017239 Paclitaxel SLC22A3 protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
D017239 Paclitaxel Paclitaxel results in increased expression of SLC22A3 mRNAincreases expression 15585946
C041786 palm oil palm oil results in decreased expression of SLC22A3 mRNAdecreases expression 18042831
D010208 Papaverine Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D010208 Papaverine Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLC22A3 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of SLC22A3 mRNAincreases expression 19482888
D010646 Phentolamine Phentolamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D010646 Phentolamine Phentolamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SLC22A3 mRNAaffects binding|increases activity|increases expression 18489776
C006253 pirinixic acid pirinixic acid results in increased expression of SLC22A3 mRNAincreases expression 17426115
D011794 Quercetin Quercetin results in increased expression of SLC22A3 mRNAincreases expression 18095365
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLC22A3 mRNAdecreases expression 20106945
C052075 thioperamide thioperamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
C052075 thioperamide thioperamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
C005185 trimazosin trimazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
C005185 trimazosin trimazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D014415 Tunicamycin Tunicamycin results in increased expression of SLC22A3 mRNAincreases expression 17127020
D014747 Vinblastine SLC22A3 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.426195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4215322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3018287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.8818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.0520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.0511473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.506695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 15.7617620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.7616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.7616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7211748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.0017084956
MESH:D000799 Angioedema Acetaminophen 3.5810982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8219183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.6315238619
MESH:D001249 Asthma Histamine 3.8216387687
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7115336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases Quercetin 4.1519761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.9919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.9912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6015746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.3215867366
MESH:D001862 Bone Resorption bisphenol A 3.6311985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.5917474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 3.5917123778
MESH:D001943 Breast Neoplasms Dietary Fats 3.5920435547
MESH:D001943 Breast Neoplasms Estradiol 3.5916675129 18497071 12948864 17018787 19861407 17289903 14630087 17261762
MESH:D001943 Breast Neoplasms Paclitaxel 3.5916244791 16115903 15136595 11325840 16273361 18223236 18234424 18323546
MESH:D001943 Breast Neoplasms Quercetin 3.5918628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.5920435547
MESH:D001986 Bronchial Spasm Histamine 5.5518298128
MESH:D002105 Cadmium Poisoning Quercetin 5.2816962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.803084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 10.8021507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.8016924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 10.8016313753
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 10.806705139 17173139 20935162 20007298 1701930
MESH:D006528 Carcinoma, Hepatocellular Quercetin 10.8019519916 12508355
MESH:D002278 Carcinoma in Situ bisphenol A 4.7217123778
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7017234771
MESH:D002292 Carcinoma, Renal Cell Vinblastine 3.661485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 1.9820419170
MESH:D006332 Cardiomegaly Quercetin 6.3219794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.3216120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.4310977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 5.9812371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.9818566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.994080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9416835633
MESH:D002779 Cholestasis Cyclosporine 7.1219486331
MESH:D002779 Cholestasis pirinixic acid 7.1219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9912621046 15340226 16354765 15668235 8697196
MESH:D003110 Colonic Neoplasms Quercetin 2.3817191121 11134977 15741050 19056647 19440933 17148506 16640504
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.5218802399
MESH:D015179 Colorectal Neoplasms Quercetin 3.5218852136 18095365
MESH:D015179 Colorectal Neoplasms Vinblastine 3.5218802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2420055451 15322242 10048152
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5219496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1919279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.3010663392 14986274 10915739 19085960 10774834 19416960 19739265 19370779 14550746 11421492 12540782 18071297 11287661 11461765 11529661 12958197 2444490 16081117 19923254 15968718 19420014 16109766 17906064 12705907 12392966 17522070 11743745 16227642 11739529 16177239 14725611 16485898 12153990 12594235 18713872 16393943 15619225 17562736 16781746 19164858 11834606
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.3020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8319426721
MESH:D004362 Drug Toxicity Lamivudine 7.6915040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.6911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2718367378
MESH:D004421 Dystonia Phenobarbital 3.761851702
MESH:D004487 Edema pirinixic acid 10.3812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.3811000095 12711302
MESH:D004487 Edema thioperamide 10.3819703484
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6416714409 15322242 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 2.8111473722 19148513 18566989
MESH:D004715 Endometriosis Mifepristone 8.4016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.409294722 10568697
MESH:D004802 Eosinophilia Histamine 4.7912689652
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.853659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.6111558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.7620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.326401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.997750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.763659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4116530937
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.4116481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8211564622
MESH:D005234 Fatty Liver Cyclosporine 11.7019224547
MESH:D005234 Fatty Liver Dietary Fats 11.7017967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver pirinixic acid 11.7020131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2011858732
MESH:D005355 Fibrosis Cyclosporine 19.0312639820 12168785
MESH:D005355 Fibrosis Dietary Fats 19.0318296743
MESH:D005355 Fibrosis Quercetin 19.0319474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.0320067830
MESH:D005756 Gastritis Acetaminophen 3.4116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.958708960
MESH:D005909 Glioblastoma Quercetin 3.2219804834
MESH:D005910 Glioma Quercetin 2.9517643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3310696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.9920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9910048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.3820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1011000095
MESH:D006509 Hepatitis B Lamivudine 4.8617703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.8616476009 15631357 12044531 15274664 15309715
MESH:D006529 Hepatomegaly Phenobarbital 12.8916109766
MESH:D006529 Hepatomegaly pirinixic acid 12.8916221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.8912621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.7615709030
MESH:D015658 HIV Infections Lamivudine 3.629296927 11141242 17530837 20032539
MESH:D006689 Hodgkin Disease Vinblastine 3.8218180244 18501091
MESH:D019584 Hot Flashes Estradiol 3.4917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7816959395 18606429 8697196 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5016870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3621332399
MESH:D006943 Hyperglycemia pirinixic acid 8.4920558911
MESH:D006943 Hyperglycemia Quercetin 8.4911834736 18262572
MESH:D006949 Hyperlipidemias Dietary Fats 3.3721332399
MESH:D006973 Hypertension Cyclosporine 7.9810903974
MESH:D006973 Hypertension Quercetin 7.9818356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.9818670907 18850075
MESH:D007249 Inflammation Dietary Fats 4.4720412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.4712878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.2416624496
MESH:D007333 Insulin Resistance bisphenol A 16.2416393666
MESH:D007333 Insulin Resistance Dietary Fats 16.2411836018 18457598
MESH:D007333 Insulin Resistance Estradiol 16.2416393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 16.2416306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1016580747
MESH:D007627 Keloid Quercetin 4.7017086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1715604871
MESH:D007674 Kidney Diseases Acetaminophen 13.1912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 13.1918776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 13.1915618244
MESH:D007674 Kidney Diseases Quercetin 13.1916962696
MESH:D007680 Kidney Neoplasms Cyclosporine 6.5712371664
MESH:D007680 Kidney Neoplasms Estradiol 6.5715610895
MESH:D007938 Leukemia Quercetin 3.0317468513
MESH:D008080 Liposarcoma Paclitaxel 4.5817353645
MESH:D008103 Liver Cirrhosis Dietary Fats 6.1818296743
MESH:D008103 Liver Cirrhosis Phenobarbital 6.1821047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.6614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.6615474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 4.6612741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.6612878042
MESH:D008107 Liver Diseases Acetaminophen 3.7012969438 16611625 19014921 11587558 19784758 19460945 16610002 12587719
MESH:D008107 Liver Diseases Phenobarbital 3.7019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0117185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 16.6515890375 9163691 18177683 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 16.6521137059 20195826
MESH:D008113 Liver Neoplasms Phenobarbital 16.6521047994 19812893 8742319 19073162 19482888 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 16.6520007298 16377806 15890375
MESH:D008113 Liver Neoplasms Quercetin 16.6518980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.6516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 12.798603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 12.791399818 6150874 18308698 2563599 17172636
MESH:D008114 Liver Neoplasms, Experimental Quercetin 12.7919519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.7912151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.5714755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.5720464547 20064080 18520028 20135361 18569708 20869020 18816296 17053015 6695378
MESH:D008175 Lung Neoplasms Quercetin 4.5716280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.5719555203 11884234
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.8814749477
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 5.7912807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.7917203775 11408345 16891317 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.2219453300
MESH:D008545 Melanoma Histamine 5.2317709802
MESH:D008545 Melanoma Paclitaxel 5.2312025231 12040289 16342250
MESH:D008545 Melanoma Vinblastine 5.2316432458 16248763 15577323 17761969 18176117 16809738 18332650 15577320 12374674 18505091
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5216801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9916381670
MESH:D009101 Multiple Myeloma Paclitaxel 3.5014749477
MESH:D009135 Muscular Diseases pirinixic acid 3.2516239165
MESH:D009203 Myocardial Infarction pirinixic acid 5.3619151258
MESH:D009203 Myocardial Infarction Quercetin 5.3619595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.0416810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.0416411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 13.0419207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2117484760
MESH:D009362 Neoplasm Metastasis Paclitaxel 3.1515867366
MESH:D009369 Neoplasms Benzo(a)pyrene 7.4811141357
MESH:D009369 Neoplasms pirinixic acid 7.4817405874
MESH:D009369 Neoplasms Quercetin 7.4815185748
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0618481113 19348381
MESH:D009410 Nerve Degeneration 1-Methyl-4-phenylpyridinium 4.8417433543
MESH:D009421 Nervous System Malformations bisphenol A 14.9016427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 14.9016427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.9014600291
MESH:D019636 Neurodegenerative Diseases 1-Methyl-4-phenylpyridinium 8.1116353238
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.1118514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.1217929310
MESH:D009503 Neutropenia Vinblastine 4.3317378895
MESH:D009765 Obesity Dietary Fats 4.2018457598 17217161 11836018 20518802 19632207 20132043 16723640 21332399 18674790
MESH:D009765 Obesity pirinixic acid 4.2020558911
MESH:D010014 Osteolysis Paclitaxel 4.7215867366
MESH:D010018 Osteomalacia Phenobarbital 4.1017016548
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 3.9819495926
MESH:D010049 Ovarian Diseases bisphenol A 4.7211985600
MESH:D010051 Ovarian Neoplasms Estradiol 10.6619401270
MESH:D010051 Ovarian Neoplasms Mifepristone 10.6616525653
MESH:D010051 Ovarian Neoplasms Paclitaxel 10.6611161223
MESH:D010051 Ovarian Neoplasms Quercetin 10.6619005980
MESH:D010146 Pain Acetaminophen 2.1916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.1016965848
MESH:D010190 Pancreatic Neoplasms Quercetin 5.1016965848
MESH:D010300 Parkinson Disease 1-Methyl-4-phenylpyridinium 4.0417433543
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3118163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.0612371664
MESH:D011230 Precancerous Conditions Phenobarbital 14.062563599
MESH:D011230 Precancerous Conditions Quercetin 14.0619056647
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.6310548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.6311118676 11399792 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.7720887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.7720887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17173048
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8916740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.8917136230 16356831 16729912 17172428
MESH:D011471 Prostatic Neoplasms Quercetin 1.8914715546 17292933
MESH:D019310 Pseudolymphoma Phenobarbital 4.2312752131
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011629 Puberty, Precocious bisphenol A 4.5210548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.2619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5918990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.279296927
MESH:D012220 Rhinitis Histamine 4.7512689652
MESH:D012554 Schistosomiasis japonica Quercetin 5.2816862918
MESH:D012640 Seizures Phenobarbital 2.523137016 4039156 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.566407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.0619755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.0616192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.5220155912 2093021
MESH:D013274 Stomach Neoplasms Paclitaxel 2.5218396642 18506536
MESH:D019966 Substance-Related Disorders bisphenol A 3.7216045194 16684133
MESH:D024801 Tauopathies Paclitaxel 4.5516930453
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6412697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 2.861399818
MESH:D013978 Tibial Fractures Estradiol 4.4219048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.8117053015
MESH:D001749 Urinary Bladder Neoplasms Quercetin 4.8116720314
MESH:D014581 Urticaria Acetaminophen 8.3210982225
MESH:D014581 Urticaria Histamine 8.3218298128
MESH:D014591 Uterine Diseases bisphenol A 4.7414652134
MESH:D014605 Uveitis Cyclosporine 3.721336536
MESH:D014625 Vaginal Neoplasms Vinblastine 4.7915577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3312125929
MESH:D020301 Vasospasm, Intracranial Papaverine 6.3219057314
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9815886252
MESH:D015430 Weight Gain Dietary Fats 3.5216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.1717120751
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA330
    • Releated gene ID Related gene Name
    PA330SLC22A3
    Releated disease ID Related disease Name
    PA443890Diabetes Mellitus, Type 2
    PA443937Drug Toxicity
    PA444818Lung Neoplasms
    PA445425Prostatic Neoplasms
    PA443635Cardiovascular Diseases
    Releated drug ID Related drug Name
    PA450395metformin
    PA164713176Platinum compounds
    PA450649norepinephrine
    PA10069emtricitabine
    PA450163lamivudine
    PA451954zidovudine
    Drug Bank Top
    No data
    No data
    Drugbank ID Action Drug Name Description
    DB00122 inhibitor Choline Dietary supplement;Micronutrient;Nootropic Agents;Lipotropic Agents
    DB00182 inhibitor Adderall XR 5mg Adrenergic Agents;Dopamine Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Amphetamines;Sympathomimetics
    DB00184 inhibitor Nicotine Anti-craving Agents;Central Nervous System Agents;Autonomic drugs;Nicotinic Agonists;Ganglionic Stimulants
    DB00368 inhibitor Norepinephrine Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists
    DB00396 inhibitor Synovex S Contraceptives;Progestins
    DB00457 inhibitor Minizide Antihypertensive Agents;Adrenergic alpha-Antagonists;Alpha-adrenergic Blocking Agents
    DB00458 inhibitor Imipramine Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00501 inhibitor Cimetidine Anti-Ulcer Agents;Analgesics;Enzyme Inhibitors;Adjuvants;Histamine Antagonists;Histamine H2 Antagonists
    DB00526 substrate Oxaliplatin Antineoplastic Agents
    DB00536 inhibitor Guanidine Parasympathomimetics
    DB00541 inhibitor Vincristine Antineoplastic Agents;Antineoplastic Agents, Phytogenic;Tubulin Modulators
    DB00575 inhibitor Combipres 0.1/15 Tab Antihypertensive Agents;Analgesics;Sympatholytics;Adrenergic alpha-Agonists;Central Alpha-Agonists
    DB00624 substrate Uni-Bol Androgens
    DB00667 inhibitor Histamine Phosphate Diagnostic aid;Histamine Agents
    DB00718 substrate Adefovir Dipivoxil Antiviral Agents;Reverse Transcriptase Inhibitors
    DB00762 inhibitor Irinotecan Antineoplastic Agents;Radiation-Sensitizing Agents;Parasympathomimetics;Enzyme Inhibitors;Prodrugs;Antineoplastic Agents, Phytogenic
    DB00783 inhibitor Triquilar 21 Anticholesteremic Agents;Estrogens;Anti-menopausal Agents
    DB00925 inhibitor Phenoxybenzamine Antihypertensive Agents;Vasodilator Agents;Adrenergic alpha-Antagonists
    DB00988 inhibitor Dopamine Dopamine Agents;Sympathomimetics;Cardiotonic Agents;Sympathomimetic
    DB01035 inhibitor Procainamide Antiarrhythmic Agents;Anti-Arrhythmia Agents
    DB01042 inhibitor Melphalan Antineoplastic Agents, Alkylating;Myeloablative Agonists
    DB01151 inhibitor Desipramine Antidepressants;Adrenergic Uptake Inhibitors;Enzyme Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB01394 inhibitor Sucurnix HP Gout Suppressants;Tubulin Modulators
    DB01577 inhibitor Methamphetamine Adrenergic Agents;Dopamine Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Sympathomimetics
    DB06714 inhibitor Propylhexedrine Adrenergic alpha-Agonists;Nasal Decongestants
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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