AutismKB 2.0

Annotation Detail for SLC22A3


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Basic Information Top
Gene Symbol:SLC22A3 ( EMT,EMTH,OCT3 )
Gene Full Name: solute carrier family 22 (extraneuronal monoamine transporter), member 3
Band: 6q25.3
Quick LinksEntrez ID:6581; OMIM: 604842; Uniprot ID:S22A3_HUMAN; ENSEMBL ID: ENSG00000146477; HGNC ID: 10967
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
Transmembrane transport of small molecules
Related Diseases/Disorders Top
Desease IDDesease Name
1870Drug abuse
2044Pre-Eclampsia
2185Obsessive-compulsive disorder
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C085755 4-(1H-imidazol-4-ylmethyl)piperidine 4-(1H-imidazol-4-ylmethyl)piperidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
C085755 4-(1H-imidazol-4-ylmethyl)piperidine 4-(1H-imidazol-4-ylmethyl)piperidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D000082 Acetaminophen Acetaminophen affects the expression of SLC22A3 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLC22A3 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC22A3 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SLC22A3 mRNAdecreases expression 20106945
C006780 bisphenol A bisphenol A results in increased expression of SLC22A3 mRNAincreases expression 18180321
C105826 BU 224 BU 224 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
C105826 BU 224 BU 224 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
C086108 clobenpropit clobenpropit inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
C086108 clobenpropit clobenpropit inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D003345 Corticosterone Corticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D016572 Cyclosporine Cyclosporine results in decreased expression of SLC22A3 mRNAdecreases expression 20106945
D019259 Lamivudine SLC22A3 protein results in increased uptake of Lamivudineincreases uptake 19141712
D004041 Dietary Fats Dietary Fats results in decreased expression of SLC22A3 mRNAdecreases expression 18042831
C103851 disprocynium 24 disprocynium 24 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
C103851 disprocynium 24 disprocynium 24 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D004958 Estradiol Estradiol results in decreased expression of SLC22A3 mRNAdecreases expression 20106945
D006632 Histamine Histamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D006632 Histamine Histamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium 4-(1H-imidazol-4-ylmethyl)piperidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium BU 224 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium clobenpropit inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium Corticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium disprocynium 24 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium Histamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium Phentolamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridiniumincreases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium thioperamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium trimazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium 4-(1H-imidazol-4-ylmethyl)piperidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium BU 224 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium clobenpropit inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium disprocynium 24 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium Histamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium Phentolamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridiniumincreases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium thioperamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015655 1-Methyl-4-phenylpyridinium trimazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D015735 Mifepristone Mifepristone results in decreased expression of SLC22A3 mRNAdecreases expression 17584828
D017239 Paclitaxel SLC22A3 protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
D017239 Paclitaxel Paclitaxel results in increased expression of SLC22A3 mRNAincreases expression 15585946
C041786 palm oil palm oil results in decreased expression of SLC22A3 mRNAdecreases expression 18042831
D010208 Papaverine Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D010208 Papaverine Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLC22A3 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of SLC22A3 mRNAincreases expression 19482888
D010646 Phentolamine Phentolamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D010646 Phentolamine Phentolamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SLC22A3 mRNAaffects binding|increases activity|increases expression 18489776
C006253 pirinixic acid pirinixic acid results in increased expression of SLC22A3 mRNAincreases expression 17426115
D011794 Quercetin Quercetin results in increased expression of SLC22A3 mRNAincreases expression 18095365
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLC22A3 mRNAdecreases expression 20106945
C052075 thioperamide thioperamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
C052075 thioperamide thioperamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
C005185 trimazosin trimazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
C005185 trimazosin trimazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]decreases reaction|increases uptake 12411423
D014415 Tunicamycin Tunicamycin results in increased expression of SLC22A3 mRNAincreases expression 17127020
D014747 Vinblastine SLC22A3 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA330
  • Releated gene ID Related gene Name
    PA330SLC22A3
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00122 inhibitor Choline Dietary supplement;Micronutrient;Nootropic Agents;Lipotropic Agents
    DB00182 inhibitor Adderall XR 5mg Adrenergic Agents;Dopamine Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Amphetamines;Sympathomimetics
    DB00184 inhibitor Nicotine Anti-craving Agents;Central Nervous System Agents;Autonomic drugs;Nicotinic Agonists;Ganglionic Stimulants
    DB00368 inhibitor Norepinephrine Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists
    DB00396 inhibitor Synovex S Contraceptives;Progestins
    DB00457 inhibitor Minizide Antihypertensive Agents;Adrenergic alpha-Antagonists;Alpha-adrenergic Blocking Agents
    DB00458 inhibitor Imipramine Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00501 inhibitor Cimetidine Anti-Ulcer Agents;Analgesics;Enzyme Inhibitors;Adjuvants;Histamine Antagonists;Histamine H2 Antagonists
    DB00526 substrate Oxaliplatin Antineoplastic Agents
    DB00536 inhibitor Guanidine Parasympathomimetics
    DB00541 inhibitor Vincristine Antineoplastic Agents;Antineoplastic Agents, Phytogenic;Tubulin Modulators
    DB00575 inhibitor Combipres 0.1/15 Tab Antihypertensive Agents;Analgesics;Sympatholytics;Adrenergic alpha-Agonists;Central Alpha-Agonists
    DB00624 substrate Uni-Bol Androgens
    DB00667 inhibitor Histamine Phosphate Diagnostic aid;Histamine Agents
    DB00718 substrate Adefovir Dipivoxil Antiviral Agents;Reverse Transcriptase Inhibitors
    DB00762 inhibitor Irinotecan Antineoplastic Agents;Radiation-Sensitizing Agents;Parasympathomimetics;Enzyme Inhibitors;Prodrugs;Antineoplastic Agents, Phytogenic
    DB00783 inhibitor Triquilar 21 Anticholesteremic Agents;Estrogens;Anti-menopausal Agents
    DB00925 inhibitor Phenoxybenzamine Antihypertensive Agents;Vasodilator Agents;Adrenergic alpha-Antagonists
    DB00988 inhibitor Dopamine Dopamine Agents;Sympathomimetics;Cardiotonic Agents;Sympathomimetic
    DB01035 inhibitor Procainamide Antiarrhythmic Agents;Anti-Arrhythmia Agents
    DB01042 inhibitor Melphalan Antineoplastic Agents, Alkylating;Myeloablative Agonists
    DB01151 inhibitor Desipramine Antidepressants;Adrenergic Uptake Inhibitors;Enzyme Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB01394 inhibitor Sucurnix HP Gout Suppressants;Tubulin Modulators
    DB01577 inhibitor Methamphetamine Adrenergic Agents;Dopamine Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Sympathomimetics
    DB06714 inhibitor Propylhexedrine Adrenergic alpha-Agonists;Nasal Decongestants

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018