AutismKB 2.0

Annotation Detail for SLIT3


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Basic Information Top
Gene Symbol:SLIT3 ( FLJ10764,MEGF5,SLIL2,SLIT1,Slit-3,slit2 )
Gene Full Name: slit homolog 3 (Drosophila)
Band: 5q34-q35.1
Quick LinksEntrez ID:6586; OMIM: 603745; Uniprot ID:SLIT3_HUMAN; ENSEMBL ID: ENSG00000184347; HGNC ID: 11087
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
Pathway IDPathway Name
Axon guidance
No data
Pathway IDPathway Name
P00008Axon guidance mediated by Slit/Robo
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2069Schizophrenia
Desease Name
pravastatin kinetics
PHARMACOGENOMIC
Desease Name
Height
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SLIT3 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLIT3 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SLIT3 mRNAdecreases expression 20064835
D004041 Dietary Fats Dietary Fats results in decreased expression of SLIT3 mRNAdecreases expression 18042831
D004317 Doxorubicin Doxorubicin results in increased expression of SLIT3 mRNAincreases expression 16404146
D008628 Mercury Mercury results in decreased expression of SLIT3 mRNAdecreases expression 16823088
D015735 Mifepristone Mifepristone results in decreased expression of SLIT3 mRNAdecreases expression 17584828
C041786 palm oil palm oil results in decreased expression of SLIT3 mRNAdecreases expression 18042831
C025643 vinclozolin vinclozolin affects the expression of SLIT3 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.6020127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 4.6017418594
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D000419 Albuminuria Doxorubicin 4.7821441931
MESH:D001008 Anxiety Disorders vinclozolin 3.8019015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.1515238619
MESH:D001321 Autistic Disorder Mercury 2.7717497416
MESH:D001327 Autoimmune Diseases Mercury 5.1316634805
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.0214601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.0017150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9320146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 1.9320435547
MESH:D001943 Breast Neoplasms Doxorubicin 1.9315136595 15994142 19526202 16595493 16096432 16935488 18628466 16322301 15668708 11325840 15939500 15692762 18695136 15567936 17983394 15993339 15634643 18234424 16826403 16115903 18382427 17426702 17369602 16264153
MESH:D002276 Carcinoid Tumor Doxorubicin 5.1316051944
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.2116705839
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 3.2116023760 16234567 18059187 17876044
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.241485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8620419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.866189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.6616109756 18627295 15505089 16651473 17131338 17382496 16364871 15792986 16731534 16278810 16455267 16612575 17007740 17928571 16242529 17974986 17519947 16952015 15476868 17924179 17308081 17351982 16269455 15811867 17329180
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 6.3816243910 17334414
MESH:D002311 Cardiomyopathy, Dilated Mercury 6.3810334427
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D003456 Cryptorchidism vinclozolin 4.5814966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2718551238
MESH:D017449 Dermatitis, Allergic Contact Mercury 4.0516823706
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.2018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 4.2017416283
MESH:D004362 Drug Toxicity Doxorubicin 3.8218602426
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.5817359293
MESH:D004715 Endometriosis Mifepristone 4.5616134523
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.4718037988
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0516530937
MESH:D005234 Fatty Liver Dietary Fats 3.4419551842 19004024 17967931 18296743
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.8719069698
MESH:D005355 Fibrosis Dietary Fats 3.7818296743
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6216417039
MESH:D005909 Glioblastoma Doxorubicin 3.4717150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.6615692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006331 Heart Diseases Doxorubicin 3.6216879835 18674790 12587719 16707910 16144979 16244372 16330681 16495754 17875725 17888722 18006777 16244371 14766674
MESH:D006333 Heart Failure Doxorubicin 3.4617481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1115692506
MESH:D006548 Hernia, Diaphragmatic marker/mechanism 17436238
MESH:D006689 Hodgkin Disease Doxorubicin 3.5918501091 15147373 17606976
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8021332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D007248 Infertility, Male vinclozolin 3.1716467254
MESH:D007249 Inflammation Dietary Fats 2.5220412841
MESH:D007333 Insulin Resistance Dietary Fats 3.2318457598 11836018
MESH:D007674 Kidney Diseases Doxorubicin 6.9215699352 15369732 16775033
MESH:D007674 Kidney Diseases Mercury 6.9217934191
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.3616707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.1416705839
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.4716085563
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0216417039
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9818296743
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.1516595196 16439617
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1021137059 20195826
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.1317085340 16842330
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5720464547 17053015 18569708 20064080 18816296 20869020 18520028 20135361 6695378
MESH:D008175 Lung Neoplasms Doxorubicin 2.5717418594 6189445
MESH:D008223 Lymphoma Doxorubicin 3.6016098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.9617654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.8315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.1515458769
MESH:D008545 Melanoma Doxorubicin 2.3116827129
MESH:D008654 Mesothelioma Doxorubicin 3.1317638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7015792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D052016 Mucositis Doxorubicin 5.0817415656
MESH:D009203 Myocardial Infarction Doxorubicin 3.0219429709 15857846
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.1418551238
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0218259882
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2511141357
MESH:D009401 Nephrosis Doxorubicin 5.0316899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.1815640375 16889571
MESH:D009447 Neuroblastoma Doxorubicin 3.3615555623
MESH:D009765 Obesity Dietary Fats 2.3311836018 20132043 19632207 17217161 21332399 20518802 16723640 18674790 18457598
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6212819281 16049721
MESH:D012516 Osteosarcoma Doxorubicin 4.2815930896
MESH:D010051 Ovarian Neoplasms Mifepristone 3.1816525653
MESH:D003557 Phyllodes Tumor Doxorubicin 5.4717983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.4717638057
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.1819015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.2218220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2317292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.2316868541 15897917 15749863 18437689 16888761 16729912
MESH:D011472 Prostatitis vinclozolin 5.2218629315
MESH:D051437 Renal Insufficiency Doxorubicin 4.4817922066
MESH:D012509 Sarcoma Doxorubicin 4.1815625365 17203757 15675481 17710206 18313854 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.4816326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.0817846226
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6618551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.0910029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 6.0915692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.8317203757 16767912 15625365
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.5217909728 16010429
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7417053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.7417653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.4816364871 17334414 17638931 17678736
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04360 Axon guidance
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35940
    • No data
    Releated disease ID Related disease Name
    PA152241952Congenital diaphragmatic hernia
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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