AutismKB 2.0

Annotation Detail for SLN


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Basic Information Top
Gene Symbol:SLN ( MGC12301,MGC125854,MGC125855 )
Gene Full Name: sarcolipin
Band: 11q22.3
Quick LinksEntrez ID:6588; OMIM: 602203; Uniprot ID:SARCO_HUMAN; ENSEMBL ID: ENSG00000170290; HGNC ID: 11089
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SLN mRNAaffects expression 17562736
D004041 Dietary Fats Dietary Fats results in increased expression of SLN mRNAincreases expression 18042831
C029424 hydrazine hydrazine results in decreased expression of SLN mRNAdecreases expression 15282401
C041786 palm oil palm oil results in increased expression of SLN mRNAincreases expression 18042831
D010634 Phenobarbital Phenobarbital affects the expression of SLN mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid affects the expression of SLN mRNAaffects expression 19136022
D020849 Raloxifene [Raloxifene co-treated with ESR1 protein] results in decreased expression of SLN mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR1 protein] results in decreased expression of SLN mRNAaffects cotreatment|decreases expression 19059307
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9214745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.786195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.2717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2716434500
MESH:D000419 Albuminuria Raloxifene 4.8817451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5815800139
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001930 Brain Injuries Raloxifene 4.7816580743
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Raloxifene 1.9617049068 17595753 15775269 16837676 15758505 16912660 17440819 17952589 15572757 17261762 17893378 17242785
MESH:D001943 Breast Neoplasms Tamoxifen 1.9620390343 18351453 17893378 18984771 19289846 17242785 18425577 18855134 19288272 20065188 18815881 18821012 19487384 19189210 15668708 16202921 20859285 20135344 17440819 18629630 19244106 20005174 19221464 19155303 16873071 19066611 19103187 19084267 19410462 18997820 20544844 11161223 19059307 19189212 19115204 16818667 16273361 19142967 19200415 21152245 17261762 17049068 15565566 21138602 19011961
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8119066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.723084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.726705139 1701930 20935162 17173139 20007298
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7216924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.2717572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.2717572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6015775269
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D003072 Cognition Disorders Raloxifene 4.9215800139
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6719031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3817474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003928 Diabetic Nephropathies Raloxifene 9.7617451421 15920148 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.7619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6416227642 18071297 16109766 16781746 19085960 12540782 11834606 12153990 14986274 11739529 12392966 14725611 15968718 17906064 12958197 2444490 16081117 17562736 17522070 12594235 15619225 19370779 11287661 16485898 11421492 11461765 19739265 10774834 10915739 14550746 19420014 16393943 16177239 19416960 11743745 10663392 19164858 19923254 12705907 18713872 11529661
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004487 Edema pirinixic acid 7.7012083418
MESH:D004487 Edema Raloxifene 7.7015860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.2015845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.2019031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1917893378 20544844 19155303 16202921
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.253922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D005234 Fatty Liver Dietary Fats 20.9119004024 18296743 19551842 17967931
MESH:D005234 Fatty Liver pirinixic acid 20.9119236843 20131406
MESH:D005234 Fatty Liver Raloxifene 20.9117473493
MESH:D005234 Fatty Liver Tamoxifen 20.9114986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3716709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5219069698
MESH:D005355 Fibrosis Dietary Fats 3.8318296743
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006331 Heart Diseases Raloxifene 3.6911110106
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006529 Hepatomegaly Phenobarbital 9.5216109766
MESH:D006529 Hepatomegaly pirinixic acid 9.5218467677 16221962 19176532 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006973 Hypertension Raloxifene 2.9417577099 15787275
MESH:D007249 Inflammation Dietary Fats 5.4820412841
MESH:D007249 Inflammation Tamoxifen 5.4819457130
MESH:D007333 Insulin Resistance Dietary Fats 7.7411836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.7416306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3215629191 12587719
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2418625569
MESH:D007889 Leiomyoma Raloxifene 4.7616973256
MESH:D008064 Lipidoses Tamoxifen 3.3215342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 7.0618296743
MESH:D008103 Liver Cirrhosis Phenobarbital 7.0621047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3815474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3818564211
MESH:D008107 Liver Diseases Acetaminophen 4.1019460945 12969438 12587719 19784758 16610002 19014921 11587558 16611625
MESH:D008107 Liver Diseases Phenobarbital 4.1019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 7.878742319 21047994 19812893 15975961 19482888 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 7.8720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 7.8716684651
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.846150874 17172636 18308698 2563599 1399818
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7619196723 19196722 16827153 14580682 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 4.9219453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.9315863610
MESH:D009101 Multiple Myeloma Raloxifene 3.6016497877
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009232 Myxoma Raloxifene 5.9316343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5819410462
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3819200415 19196722 19189210
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity Dietary Fats 4.6019632207 17217161 20518802 20132043 18674790 16723640 21332399 18457598 11836018
MESH:D009765 Obesity pirinixic acid 4.6020558911
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D010024 Osteoporosis Raloxifene 3.5319059307 15775268 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4915758505 15579764 17893378 17823083
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5616965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.842563599
MESH:D011471 Prostatic Neoplasms Raloxifene 3.3116536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3115067354
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D011693 Purpura Raloxifene 5.9315770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012640 Seizures Phenobarbital 2.8416876388 3137016 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D013088 Spermatocele Tamoxifen 4.6716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3819457130
MESH:D020521 Stroke Raloxifene 4.0116837676
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.231399818
MESH:D013978 Tibial Fractures Raloxifene 5.5819048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.5017572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.5016712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D054556 Venous Thromboembolism Raloxifene 5.5816837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.9316343187
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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