AutismKB 2.0

Annotation Detail for HLTF


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Basic Information Top
Gene Symbol:HLTF ( HIP116,HIP116A,HLTF1,RNF80,SMARCA3,SNF2L3,ZBU1 )
Gene Full Name: helicase-like transcription factor
Band: 3q24
Quick LinksEntrez ID:6596; OMIM: 603257; Uniprot ID:HLTF_HUMAN; ENSEMBL ID: ENSG00000071794; HGNC ID: 11099
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00057Wnt signaling pathway
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Related Diseases/Disorders Top
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Desease IDDesease Name
1766Renal Cell cancer
1993Esophagus cancer
1841Stomach cancer
2053Colon cancer
2187Nevus
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015081 2-Naphthylamine 2-Naphthylamine results in decreased expression of HLTF mRNAdecreases expression 18247414
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of HLTF mRNAdecreases expression 18247414
D016572 Cyclosporine Cyclosporine results in decreased expression of HLTF mRNAdecreases expression 20106945
C014347 decitabine decitabine affects the methylation of HLTF promoteraffects methylation 17571247
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of HLTF proteinincreases expression 16762066
D009538 Nicotine Nicotine results in decreased expression of HLTF mRNAdecreases expression 18247414
D014212 Tretinoin Tretinoin results in decreased expression of HLTF mRNAdecreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D000544 Alzheimer Disease Nicotine 3.3316627626
MESH:D000686 Amyloidosis Diethylstilbestrol 4.8115469931
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.2316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8916206674 16197459
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0217474063 20146248
MESH:D001943 Breast Neoplasms decitabine 2.0218320071 19208741
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0215324884 17129689
MESH:D001943 Breast Neoplasms Tretinoin 2.0216443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 3.2915948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.291917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.9420419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.9419215824
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.9416096774 16051514
MESH:D002386 Cataract Tretinoin 3.2417460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7112371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D002779 Cholestasis Cyclosporine 3.1219486331
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D002972 Cleft Palate Tretinoin 2.769407595
MESH:D003092 Colitis Tretinoin 4.0617035595
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.839142499 9125849 10589399 8800419 9211117 9664655 17551590 14991402 16925845 9224671
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.8912952375 16002989
MESH:D020821 Dystonic Disorders Nicotine 6.3217881519
MESH:D004489 Edema, Cardiac Tretinoin 4.9118230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.5619294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 5.0916402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 8.1615700306 16804899
MESH:D016889 Endometrial Neoplasms Tretinoin 8.1616569247
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005124 Eye Abnormalities Tretinoin 3.7816938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 3.1419224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.8116534752 16611131 15751030 16513791 16002989
MESH:D005355 Fibrosis Cyclosporine 9.9112639820 12168785
MESH:D005355 Fibrosis Tretinoin 9.9117994277
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.3416452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D006258 Head and Neck Neoplasms decitabine 8.4219215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.4216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.0920471113
MESH:D006330 Heart Defects, Congenital Tretinoin 7.099664655 14991402
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006930 Hyperalgesia Tretinoin 3.4316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D006965 Hyperplasia Diethylstilbestrol 4.7912960047 14722030
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D007021 Hypospadias Diethylstilbestrol 4.9416002989
MESH:D007246 Infertility Diethylstilbestrol 4.6815036965
MESH:D007248 Infertility, Male decitabine 3.3817581917
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1817551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Cyclosporine 2.488314463 10903974 18776723
MESH:D007680 Kidney Neoplasms marker/mechanism 16762066
MESH:D007680 Kidney Neoplasms Cyclosporine 8.2412371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 8.2415003126 16762066 14681315
MESH:D007859 Learning Disorders Diethylstilbestrol 4.4217184923
MESH:D007938 Leukemia decitabine 6.8319235587 18980019
MESH:D007938 Leukemia Tretinoin 6.8317143497
MESH:D007951 Leukemia, Myeloid decitabine 10.5217236224 19117987 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 10.5219285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.1117679729 19387464 19010910 18704418 18460780 18206229
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.1117596541 16294345 19850784
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.9118055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3217361223 17217047 9834237 17506722 17339181 19225113 16823087 16331271 17294898 12679006 19642359 17301526 17649720 19029980 19035177 16766008 17107899 16935935 16788101 16140955 17712046 15748426 16891316 17368321 19075265
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8116248980 18397230
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.9620195826 21137059
MESH:D008113 Liver Neoplasms Diethylstilbestrol 4.9616712894 15890375
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5718816296 6695378 18569708 17053015 20464547 20064080 20869020 18520028 20135361
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.5515166399
MESH:D008223 Lymphoma decitabine 8.3819470736
MESH:D008223 Lymphoma Diethylstilbestrol 8.3815700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.9616002989
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma decitabine 3.5416505122 17785578
MESH:D008545 Melanoma Tretinoin 3.5416752155
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009101 Multiple Myeloma decitabine 3.5418172295
MESH:D009190 Myelodysplastic Syndromes decitabine 7.9619157545 18608210 19010910 16882708
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.9617596541
MESH:D009369 Neoplasms Benzo(a)pyrene 17.1011141357
MESH:D009369 Neoplasms decitabine 17.1019470736 19116145 17925555
MESH:D009369 Neoplasms Diethylstilbestrol 17.1015313581
MESH:D009369 Neoplasms Nicotine 17.1016365874
MESH:D009369 Neoplasms Tretinoin 17.1016594593 16946489
MESH:D009389 Neovascularization, Pathologic Nicotine 5.3916365874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5318481113 19348381
MESH:D009421 Nervous System Malformations Diethylstilbestrol 10.9711399458
MESH:D009421 Nervous System Malformations Tretinoin 10.979125849
MESH:D009436 Neural Tube Defects Tretinoin 3.229142499
MESH:D010051 Ovarian Neoplasms decitabine 5.2019259094 19331143
MESH:D010051 Ovarian Neoplasms Tretinoin 5.2016936753
MESH:D010146 Pain Tretinoin 3.1316870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.6519294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.6515976015
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.6114722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 5.0315687265 16977796
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.5117184923
MESH:D055728 Primary Myelofibrosis decitabine 5.0917616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2217292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.2217136230 15046698 15846301
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D012208 Rhabdomyosarcoma decitabine 11.9819155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.9816283617 16116481
MESH:D012640 Seizures Nicotine 3.9717873105
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.0610029692 19755658
MESH:D012878 Skin Neoplasms Tretinoin 6.0616467112
MESH:D013088 Spermatocele Diethylstilbestrol 5.1616709447 16002989
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.4920155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 3.4919037991
MESH:D013274 Stomach Neoplasms Tretinoin 3.4917261132
MESH:D013964 Thyroid Neoplasms decitabine 8.0017967635
MESH:D013964 Thyroid Neoplasms Tretinoin 8.0017045167 16026305
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.9216785264 16720336 11259349
MESH:D014029 Tobacco Use Disorder Nicotine 5.8115735609 18305452 17979512 18041664
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 12.8011144890
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.8017053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 12.8019087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 12.8016712894 16452187 17306315
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 10.4016175088
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 10.4016129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.6114652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.4015809267 16690809
MESH:D014604 Uveal Neoplasms decitabine 14.3517785578
MESH:D014604 Uveal Neoplasms Tretinoin 14.3516752155
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.7916513791 16002989
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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