Annotation Detail for PLEKHA3
Basic Information
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| Gene Symbol: | PLEKHA3 ( FAPP1,FLJ20067 ) |
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| Gene Full Name: | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 |
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| Band: | 2q31.2 |
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| Quick Links | Entrez ID:65977; OMIM: 607774; Uniprot ID:PKHA3_HUMAN; ENSEMBL ID: ENSG00000116095; HGNC ID: 14338 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D004997 |
Ethinyl Estradiol |
Ethinyl Estradiol results in increased expression of PLEKHA3 mRNA | increases expression | 17942748
|
| D004997 |
Ethinyl Estradiol |
[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLEKHA3 mRNA | affects cotreatment|increases expression | 17942748
|
| D012402 |
Rotenone |
Rotenone results in increased expression of PLEKHA3 mRNA | increases expression | 19013527
|
| D013749 |
Tetrachlorodibenzodioxin |
[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLEKHA3 mRNA | affects cotreatment|increases expression | 17942748
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000014 |
Abnormalities, Drug-Induced |
|
Tetrachlorodibenzodioxin |
3.59 | 15322242 14514962 11752688 |
| MESH:D000152 |
Acne Vulgaris |
|
Ethinyl Estradiol |
4.81 | 17505938 |
| MESH:D000230 |
Adenocarcinoma |
|
Ethinyl Estradiol |
1.89 | 14692618 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
Tetrachlorodibenzodioxin |
4.12 | 16835633 |
| MESH:D000740 |
Anemia |
|
Tetrachlorodibenzodioxin |
3.39 | 11748828 |
| MESH:D001161 |
Arteriosclerosis |
|
Ethinyl Estradiol |
4.12 | 11256880 |
| MESH:D001169 |
Arthritis, Experimental |
|
Ethinyl Estradiol |
2.91 | 15885639 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
Tetrachlorodibenzodioxin |
3.53 | 12125929 |
| MESH:D001836 |
Body Weight Changes |
|
Tetrachlorodibenzodioxin |
4.66 | 15340226 |
| MESH:D001848 |
Bone Diseases, Developmental |
|
Tetrachlorodibenzodioxin |
3.02 | 15746008 |
| MESH:D001943 |
Breast Neoplasms |
|
Tetrachlorodibenzodioxin |
1.66 | 20435547 |
| MESH:D002277 |
Carcinoma |
|
Tetrachlorodibenzodioxin |
3.16 | 16835633 |
| MESH:D006332 |
Cardiomegaly |
|
Tetrachlorodibenzodioxin |
2.58 | 18670907 16120746 18850075 |
| MESH:D018281 |
Cholangiocarcinoma |
|
Tetrachlorodibenzodioxin |
3.58 | 16835633 |
| MESH:D002779 |
Cholestasis |
|
Ethinyl Estradiol |
3.20 | 17110522 17681005 16919318 15861022 11677210 16105132 17333356 |
| MESH:D002972 |
Cleft Palate |
|
Tetrachlorodibenzodioxin |
2.25 | 8697196 16354765 15668235 12621046 15340226 |
| MESH:D000013 |
Congenital Abnormalities |
|
Tetrachlorodibenzodioxin |
3.48 | 17141729 14669216 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Tetrachlorodibenzodioxin |
1.27 | 10048152 20055451 15322242 |
| MESH:D003924 |
Diabetes Mellitus, Type 2 |
|
Tetrachlorodibenzodioxin |
1.74 | 17107852 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Tetrachlorodibenzodioxin |
1.62 | 20420201 |
| MESH:D004362 |
Drug Toxicity |
|
Tetrachlorodibenzodioxin |
3.09 | 11462148 |
| MESH:D004487 |
Edema |
|
Tetrachlorodibenzodioxin |
2.85 | 12711302 11000095 |
| MESH:D004489 |
Edema, Cardiac |
|
Tetrachlorodibenzodioxin |
4.77 | 18230668 15322242 16714409 |
| MESH:D004681 |
Encephalomyelitis, Autoimmune, Experimental |
|
Ethinyl Estradiol |
3.77 | 12538720 |
| MESH:D004715 |
Endometriosis |
|
Tetrachlorodibenzodioxin |
3.47 | 9294722 10568697 |
| MESH:D005124 |
Eye Abnormalities |
|
Tetrachlorodibenzodioxin |
3.34 | 11564622 |
| MESH:D005234 |
Fatty Liver |
|
Ethinyl Estradiol |
3.29 | 15345470 |
| MESH:D005313 |
Fetal Death |
|
Tetrachlorodibenzodioxin |
4.11 | 11858732 |
| MESH:D005355 |
Fibrosis |
|
Tetrachlorodibenzodioxin |
3.60 | 20067830 |
| MESH:D006058 |
Gonadal Disorders |
|
Tetrachlorodibenzodioxin |
5.46 | 10696789 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Tetrachlorodibenzodioxin |
2.53 | 11294989 10048152 |
| MESH:D006470 |
Hemorrhage |
|
Tetrachlorodibenzodioxin |
3.82 | 11000095 |
| MESH:D006529 |
Hepatomegaly |
|
Tetrachlorodibenzodioxin |
3.54 | 16120746 15340226 12621046 |
| MESH:D006869 |
Hydronephrosis |
|
Tetrachlorodibenzodioxin |
4.91 | 15340226 16959395 16354765 18606429 8697196 |
| MESH:D006973 |
Hypertension |
|
Tetrachlorodibenzodioxin |
2.03 | 18670907 18850075 |
| MESH:D007021 |
Hypospadias |
|
Ethinyl Estradiol |
4.46 | 16569931 16945680 |
| MESH:D007247 |
Infertility, Female |
|
Ethinyl Estradiol |
3.99 | 12013081 |
| MESH:D007248 |
Infertility, Male |
|
Ethinyl Estradiol |
2.76 | 17937319 |
| MESH:D007249 |
Inflammation |
|
Tetrachlorodibenzodioxin |
2.04 | 12200463 12878042 |
| MESH:D007569 |
Jaw Abnormalities |
|
Tetrachlorodibenzodioxin |
3.82 | 16580747 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Tetrachlorodibenzodioxin |
1.25 | 12878042 |
| MESH:D008113 |
Liver Neoplasms |
|
Tetrachlorodibenzodioxin |
1.84 | 16984957 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
Tetrachlorodibenzodioxin |
2.35 | 12151625 |
| MESH:D008175 |
Lung Neoplasms |
|
Tetrachlorodibenzodioxin |
1.24 | 11884234 19555203 |
| MESH:D017202 |
Myocardial Ischemia |
|
Tetrachlorodibenzodioxin |
3.38 | 12213967 |
| MESH:D009410 |
Nerve Degeneration |
|
Rotenone |
4.22 | 18619942 15790535 17356569 |
| MESH:D009421 |
Nervous System Malformations |
|
Tetrachlorodibenzodioxin |
3.80 | 14600291 |
| MESH:D016584 |
Panic Disorder |
|
Ethinyl Estradiol |
4.22 | 11578682 |
| MESH:D010300 |
Parkinson Disease |
|
Rotenone |
3.10 | 15451049 19232380 11535288 18191903 19114014 18619942 11445065 16412576 16140633 |
| MESH:D020734 |
Parkinsonian Disorders |
|
Rotenone |
4.52 | 15927086 18197244 15574749 15795934 |
| MESH:D010382 |
Peliosis Hepatis |
|
Tetrachlorodibenzodioxin |
5.12 | 12520081 |
| MESH:D017119 |
Porphyria Cutanea Tarda |
|
Tetrachlorodibenzodioxin |
4.14 | 18163543 |
| MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
Tetrachlorodibenzodioxin |
3.93 | 11896295 11222880 11118676 11399792 |
| MESH:D011537 |
Pruritus |
|
Ethinyl Estradiol |
4.05 | 16919318 15861022 |
| MESH:D015619 |
Respiratory System Abnormalities |
|
Tetrachlorodibenzodioxin |
4.42 | 18990726 |
| MESH:D012878 |
Skin Neoplasms |
|
Tetrachlorodibenzodioxin |
2.21 | 16192470 |
| MESH:D013088 |
Spermatocele |
|
Ethinyl Estradiol |
4.81 | 16709447 |
| MESH:D019851 |
Thrombophilia |
|
Ethinyl Estradiol |
4.15 | 11994571 |
| MESH:D013927 |
Thrombosis |
|
Ethinyl Estradiol |
3.57 | 15669648 |
| MESH:D013959 |
Thyroid Diseases |
|
Tetrachlorodibenzodioxin |
4.77 | 12697716 |
| MESH:D014594 |
Uterine Neoplasms |
|
Ethinyl Estradiol |
3.88 | 14692618 |
| MESH:D054079 |
Vascular Malformations |
|
Tetrachlorodibenzodioxin |
5.46 | 12125929 |
| MESH:D020246 |
Venous Thrombosis |
|
Ethinyl Estradiol |
4.02 | 14671159 15869587 |
| MESH:D019282 |
Wasting Syndrome |
|
Tetrachlorodibenzodioxin |
5.12 | 15886252 |
Related Pathway Information