AutismKB 2.0

Annotation Detail for GRAMD3


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Basic Information Top
Gene Symbol:GRAMD3 ( FLJ21313,NS3TP2 )
Gene Full Name: GRAM domain containing 3
Band: 5q23.2
Quick LinksEntrez ID:65983; OMIM: NA; Uniprot ID:GRAM3_HUMAN; ENSEMBL ID: ENSG00000155324; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of GRAMD3 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GRAMD3 proteinaffects expression 20106945
C006632 arsenic trioxide arsenic trioxide results in increased expression of GRAMD3 mRNAincreases expression 15070760
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GRAMD3 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in decreased expression of GRAMD3 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of GRAMD3 mRNAdecreases expression 18042831
D004958 Estradiol Estradiol results in decreased expression of GRAMD3 mRNAdecreases expression 20106945
C041786 palm oil palm oil results in decreased expression of GRAMD3 mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GRAMD3 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of GRAMD3 mRNAincreases expression 18301758
D018038 Sodium Selenite Sodium Selenite results in decreased expression of GRAMD3 mRNAdecreases expression 18175754
D014284 Triiodothyronine Triiodothyronine results in decreased expression of GRAMD3 mRNAdecreases expression 19228888
C025643 vinclozolin vinclozolin affects the expression of GRAMD3 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4819825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 4.4811473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D001008 Anxiety Disorders vinclozolin 3.7319015723
MESH:D001161 Arteriosclerosis Dietary Fats 4.0315238619
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.3716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.3719483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.1420435547
MESH:D001943 Breast Neoplasms Estradiol 2.1416675129 12948864 17018787 17289903 17261762 14630087 19861407 18497071
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4511589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7116705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.7112619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.7115073043 14691202 11135700 16217749 15553829
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7116924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2212490120
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.636135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.6320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.6312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.6318566989
MESH:D002779 Cholestasis Cyclosporine 8.0319486331
MESH:D002779 Cholestasis pirinixic acid 8.0319176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8915894690
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8810525206
MESH:D003456 Cryptorchidism vinclozolin 4.4714966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1618551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2115213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8716285004
MESH:D003928 Diabetic Nephropathies Estradiol 3.5119279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.0718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.0715131321
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D016889 Endometrial Neoplasms Estradiol 3.0518566989 11473722 19148513
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5420426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5412903497
MESH:D005234 Fatty Liver arsenic trioxide 19.7115073043
MESH:D005234 Fatty Liver Cyclosporine 19.7119224547
MESH:D005234 Fatty Liver Dietary Fats 19.7117967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver pirinixic acid 19.7119236843 20131406
MESH:D005355 Fibrosis Cyclosporine 9.1612639820 12168785
MESH:D005355 Fibrosis Dietary Fats 9.1618296743
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3916904648
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4716417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006529 Hepatomegaly pirinixic acid 3.1319176532 19772884 16221962 18467677
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006973 Hypertension Cyclosporine 2.1310903974
MESH:D007248 Infertility, Male vinclozolin 3.1116467254
MESH:D007249 Inflammation Dietary Fats 2.4820412841
MESH:D007333 Insulin Resistance Dietary Fats 18.2211836018 18457598
MESH:D007333 Insulin Resistance Estradiol 18.2216627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 18.2216306350
MESH:D007333 Insulin Resistance Sodium Selenite 18.2214714311
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 6.148314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.1415618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.9116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.9112371664
MESH:D007680 Kidney Neoplasms Estradiol 12.9115610895
MESH:D007938 Leukemia arsenic trioxide 2.8815070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1516467208 17050201 19850784 20471514 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2817107899 12018890 16891316 19225113 19075265 12679006 15213294 11161223 16112521 15622746 11468182 17217047 19642359 9834237 12712474 17712046 19035177 16331271 17649720 15336539 16823087 15748426 16966277 17869043 16330433
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4816882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8916417039
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9318296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3315474484
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.027678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.029163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms arsenic trioxide 11.0214682389
MESH:D008113 Liver Neoplasms pirinixic acid 11.0220007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.276135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.278603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.2720377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4315213294
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.5514755239
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5511798837 19825857
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1814737004
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6217203775 11807958 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1814977855 19417148 15949261 11468182 19549372
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2016105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.5316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.5316411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0118551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0916624393
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 3.7811399458 16427766
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1810525206
MESH:D009765 Obesity Dietary Fats 4.5221332399 20132043 17217161 16723640 11836018 18457598 20518802 18674790 19632207
MESH:D009765 Obesity pirinixic acid 4.5220558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5316049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.9319769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 4.9319401270
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5615580305
MESH:D010235 Paraganglioma arsenic trioxide 4.2819927285
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.0518220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.0918220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5619131511
MESH:D011471 Prostatic Neoplasms Estradiol 2.5616740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5618760546
MESH:D011472 Prostatitis vinclozolin 5.0918629315
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0916646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6118551238
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1719014326
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1115213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2116049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.2112973940 20435036 12845720 11780464
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4710091137
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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