AutismKB 2.0

Annotation Detail for ZBTB10


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Basic Information Top
Gene Symbol:ZBTB10 ( FLJ12752,RINZF )
Gene Full Name: zinc finger and BTB domain containing 10
Band: 8q21.13
Quick LinksEntrez ID:65986; OMIM: NA; Uniprot ID:ZBT10_HUMAN; ENSEMBL ID: ENSG00000205189; HGNC ID: 30953
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ZBTB10 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ZBTB10 mRNAaffects expression 16483693
D001151 Arsenic Arsenic affects the expression of ZBTB10 mRNAaffects expression 18414638
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of ZBTB10 mRNAincreases expression 18687144
D003010 Clorgyline Clorgyline results in increased expression of ZBTB10 mRNAincreases expression 19691856
D016572 Cyclosporine Cyclosporine results in increased expression of ZBTB10 mRNAincreases expression 20106945
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ZBTB10 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of ZBTB10 mRNAdecreases expression 19619570
D005576 Forskolin Forskolin results in decreased expression of ZBTB10 mRNAdecreases expression 16751804
D007657 Ketone Bodies Ketone Bodies results in decreased expression of ZBTB10 mRNAdecreases expression 16807920
D008628 Mercury Mercury results in increased expression of ZBTB10 mRNAincreases expression 16823088
D015741 Metribolone Metribolone results in increased expression of ZBTB10 mRNAincreases expression 17010675
16751804
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ZBTB10 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ZBTB10 mRNAdecreases expression 19619570
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0011752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000230 Adenocarcinoma Estradiol 2.1211473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.3917306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D020261 Arsenic Poisoning Arsenic 2.8916835338 12569548 18414634 16251483
MESH:D050197 Atherosclerosis Arsenic 3.3112928151 19371607
MESH:D001321 Autistic Disorder Mercury 2.7717497416
MESH:D001327 Autoimmune Diseases Mercury 5.0116634805
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Estradiol 1.9317018787 12948864 18497071 16675129 17261762 19861407 17289903 14630087
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6515504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7512907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.7516507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7516924424
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7217687452 15504454 18922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1818640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.4810334427
MESH:D002318 Cardiovascular Diseases Arsenic 3.5219152805 17938729 15738583
MESH:D002340 Carotid Artery Diseases Arsenic 4.4118022660 16973168
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8218566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 3.0019486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415340226 12621046 15668235 8697196 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.9316823706
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5119279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0816714409 18230668 15322242
MESH:D016889 Endometrial Neoplasms Estradiol 3.0511473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 2.9619224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Cyclosporine 8.9512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005534 Foot Diseases Arsenic 5.736392382
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3810048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0316120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2216354765 8697196 18606429 15340226 16959395
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5617050553
MESH:D006973 Hypertension Arsenic 8.809931084 16076760 11953799
MESH:D006973 Hypertension Cyclosporine 8.8010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.8018850075 18670907
MESH:D006987 Hypesthesia Arsenic 5.7316093927
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9112878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.0316627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007642 Keratosis Arsenic 5.1412749816 16930632
MESH:D007674 Kidney Diseases Cyclosporine 10.518314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 10.5115618244
MESH:D007674 Kidney Diseases Mercury 10.5117934191
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5812371664
MESH:D007680 Kidney Neoplasms Estradiol 7.5815610895
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6217339181
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.2914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2912878042
MESH:D008107 Liver Diseases Arsenic 2.5611134558
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.6915890375 2125692 9163691 18177683
MESH:D008113 Liver Neoplasms Arsenic 7.6916368122
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6916984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.038603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0312151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.1617365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5114755239
MESH:D008175 Lung Neoplasms Arsenic 3.5117976673 19168569 17306315
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5119555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6211408345 17203775 16891317 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2218303189 16966607 16166281
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D017202 Myocardial Ischemia Arsenic 9.3015371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.3012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3616810080
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.8911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.8914600291
MESH:D009436 Neural Tube Defects Arsenic 3.5216620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.4917056641
MESH:D010051 Ovarian Neoplasms Arsenic 5.0617306315
MESH:D010051 Ovarian Neoplasms Estradiol 5.0619401270
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3016093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.146392382 16905509 15371236
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.0310923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411118676 11222880 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.7216140617
MESH:D011471 Prostatic Neoplasms Clorgyline 2.7219691856
MESH:D011471 Prostatic Neoplasms Estradiol 2.7216740699
MESH:D011507 Proteinuria Arsenic 4.1221343184
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0615814490 17975199 17365031 17322281
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012871 Skin Diseases Arsenic 2.7715952646 6392382 17938729 17453740 17548696 18709164 17050553 16353154 19834688 16759981 16702368
MESH:D012878 Skin Neoplasms Arsenic 5.8717029826 16251483 17976673 15504454 17050553 19538983
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8716192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.8515987713 17306315 19429237 17976673 18640142 19322015 11144890
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014652 Vascular Diseases Arsenic 4.8917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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