AutismKB 2.0

Annotation Detail for SMARCC1


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Basic Information Top
Gene Symbol:SMARCC1 ( BAF155,CRACC1,Rsc8,SRG3,SWI3 )
Gene Full Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
Band: 3p21.31
Quick LinksEntrez ID:6599; OMIM: 601732; Uniprot ID:SMRC1_HUMAN; ENSEMBL ID: ENSG00000173473; HGNC ID: 11104
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200077Glucocorticoid receptor regulatory network
200102Regulation of Androgen receptor activity
Pathway IDPathway Name
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
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Desease IDDesease Name
1831Prostate cancer
2237Neoplasm metastasis
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SMARCC1 mRNAaffects expression 17562736
D001151 Arsenic Arsenic affects the expression of SMARCC1 mRNAaffects expression 18414638
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SMARCC1 mRNAdecreases expression 20064835
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of SMARCC1 mRNAdecreases expression 15336504
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SMARCC1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMARCC1 mRNAaffects cotreatment|increases expression 17942748
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of SMARCC1 mRNAaffects cotreatment|increases expression 17183730
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of SMARCC1 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of SMARCC1 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMARCC1 mRNAaffects cotreatment|increases expression 17942748
D014501 Uranium Uranium affects the expression of SMARCC1 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of SMARCC1 mRNAaffects expression 15672453
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of SMARCC1 mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid Valproic Acid results in decreased expression of SMARCC1 mRNAdecreases expression 19101580
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of SMARCC1 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of SMARCC1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.8314514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.838875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0419490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2620464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2614692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.3917306315
MESH:D000550 Amblyopia Valproic Acid 5.4117688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6617497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8912569548 16251483 18414634 16835338
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D050197 Atherosclerosis Arsenic 3.3119371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8520603192 19460635 18396377 18177632 18985861 19232924 15238991 17688650 18316065 18775368 18558336 17157402 18940202 17507914 16609825
MESH:D001714 Bipolar Disorder Valproic Acid 3.1317594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.2515746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.258888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8820146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0716050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6517687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.063084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.0617306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.8118922899 17687452 15504454
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8120419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1818640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.5217938729 15738583 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.4118022660 16973168
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7420734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9516919318 17333356 16105132 17110522 11677210 15861022 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1416354765 8697196 15340226 12621046 15668235
MESH:D003092 Colitis Selenium 3.9217936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8320055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.838888407 17688650 16575769
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8319769572
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2110663392 11287661 14986274 18071297 19164858 19739265 16081117 14725611 16227642 11461765 11834606 14550746 11743745 12705907 12594235 17906064 16109766 17522070 11739529 11529661 10774834 12540782 12958197 11421492 16393943 10915739 18713872 19416960 12153990 16781746 12392966 15968718 16485898 19420014 19085960 2444490 19923254 16177239 15619225 19370779 17562736
MESH:D056486 Drug-Induced Liver Injury Selenium 9.2115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2120420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.211733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004421 Dystonia Valproic Acid 4.171851702
MESH:C538011 Eales disease Vitamin E 4.889068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0815322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.293659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.093922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9918234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.686426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.447750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.223659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.1115345470
MESH:D005234 Fatty Liver Valproic Acid 8.1119224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005315 Fetal Diseases Valproic Acid 5.0616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.268888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0920067830
MESH:D005534 Foot Diseases Arsenic 5.736392382
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.4220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.4211294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 11.4216080930
MESH:D006333 Heart Failure Selenium 3.1417162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0316120746 12621046 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.1514716179
MESH:D006849 Hydrocephalus Valproic Acid 5.0217688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2215340226 8697196 18606429 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5617050553
MESH:D006973 Hypertension Arsenic 5.3516076760 11953799 9931084
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3518850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7616612254
MESH:D006987 Hypesthesia Arsenic 5.7316093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9112878042 12200463
MESH:D007251 Influenza, Human Selenium 11.5516624496
MESH:D007251 Influenza, Human Vitamin E 11.5516624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007642 Keratosis Arsenic 5.1416930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 6.1715629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.1712488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9916518626
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6217339181
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3712878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3716169303
MESH:D008107 Liver Diseases Acetaminophen 4.1519784758 16610002 19014921 12587719 19460945 12969438 11587558 16611625
MESH:D008107 Liver Diseases Arsenic 4.1511134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms Arsenic 7.6516368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.6520195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1712151625
MESH:D008171 Lung Diseases Vitamin E 3.2516863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4417228818
MESH:D008175 Lung Neoplasms Arsenic 4.9417306315 17976673 19168569
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9418569708 20064080 18816296 6695378 18520028 17053015 20869020 20464547 20135361
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9411884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 4.9411062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8315318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008654 Mesothelioma Selenium 2.8315107826
MESH:D008881 Migraine Disorders Valproic Acid 3.2718765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.148888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2117596541
MESH:D017202 Myocardial Ischemia Arsenic 9.3015371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.3012213967
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2211141357
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009436 Neural Tube Defects Arsenic 7.6816620997
MESH:D009436 Neural Tube Defects Valproic Acid 7.6816359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.4917056641
MESH:D010051 Ovarian Neoplasms Arsenic 2.7717306315
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3016093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1415371236 16905509 6392382
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.9811896295 11222880 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.9820603192
MESH:D011471 Prostatic Neoplasms Arsenic 2.5716140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5717292933
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5715084515
MESH:D011507 Proteinuria Arsenic 4.1221343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.7112752131 11422049
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2919155313
MESH:D012559 Schizophrenia Valproic Acid 2.0819110320 15737665
MESH:D012640 Seizures Valproic Acid 2.8115475178 1511512 11738929 16876388 17978042 14763951 11044598 3137016
MESH:D012871 Skin Diseases Arsenic 5.1218709164 17050553 16759981 17453740 6392382 19834688 17548696 15952646 16702368 17938729 16353154
MESH:D012871 Skin Diseases Vitamin E 5.1218709164
MESH:D012878 Skin Neoplasms Arsenic 13.9716251483 17976673 17050553 19538983 17029826 15504454
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.9719755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.978532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.9716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7112833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Vitamin E 3.6116517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D014178 Translocation, Genetic Valproic Acid 5.4117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.673119515
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.3018640142 19322015 19429237 17306315 17976673 15987713 11144890
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3017053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.788888407
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014652 Vascular Diseases Arsenic 4.8917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6515869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35954
    • No data
    No data
    Releated drug ID Related drug Name
    PA448547beclomethasone
    PA164754818betamethasone
    PA448681budesonide
    PA164781399ciclesonide
    PA164776996desonide
    PA449247dexamethasone
    PA449661flunisolide
    PA449686fluticasone propionate
    PA452347glucocorticoids
    PA449905hydrocortisone
    PA450466methylprednisolone
    PA450541mometasone
    PA164777035paramethasone
    PA451096prednisolone
    PA451100prednisone
    PA164752251rimexolone
    PA451749triamcinolone
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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