AutismKB 2.0

Annotation Detail for MRPS34


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Basic Information Top
Gene Symbol:MRPS34 ( MGC2616,MRP-S12,MRP-S34,MRPS12 )
Gene Full Name: mitochondrial ribosomal protein S34
Band: 16p13.3
Quick LinksEntrez ID:65993; OMIM: 611994; Uniprot ID:RT34_HUMAN; ENSEMBL ID: ENSG00000074071; HGNC ID: 16618
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MRPS34 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MRPS34 mRNAaffects expression 21346803
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MRPS34 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MRPS34 mRNAaffects cotreatment|affects expression 17602206
D018038 Sodium Selenite Sodium Selenite results in increased expression of MRPS34 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MRPS34 mRNAincreases expression 18796159
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3115322242 14514962 11752688
MESH:D000236 Adenoma Diethylnitrosamine 3.0110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.6518056438 19052882 17162532 19061943 16434500 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.6516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9417474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.8016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8016705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.8016569478 17761372 10672840 16540662 16878318 19383236 18978308 19418558 19919837 10737359 19701751 16681979 20727157 16830150 18788625 17978847 16328049 17428255 18210153 16807293 16502159 16779866 18506893 17162532 19052882 19519916 18393292 19822196 3084413 18056438 19208518 18665156 20214788 19107877 17055752 20101231 20514400 3581430 16935385 20935162 19539802 18971187 19171122 20512989 16288022 20432363 17138121 20007298 17173139 18494052 18691550 18785209 19335982 19394651 11831363 20524982 16698587 21159647 20084675
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.396135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.397505956 17174075 21159647 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 10.2919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 10.2916835633
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1715894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2116354765 15340226 8697196 12621046 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.3218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.3218551238
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0616285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.4320387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4317107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.8621346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.8621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.8619107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.8615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.8620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4216714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.6416302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Diethylnitrosamine 3.5120387270 21071580
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3116120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 16959395 15340226 18606429 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D007249 Inflammation Diethylnitrosamine 5.3818785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3812200463 12878042
MESH:D007333 Insulin Resistance Sodium Selenite 3.4714714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.2716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.2716705839
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9819638242 18407596 18522880 18665156 20032147
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1617034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.557678174
MESH:D008113 Liver Neoplasms Clofibric Acid 11.5517602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.5515175105 19090486 20101389 19850985 18644402 15885732 19499222 20405173 19426721 19812893 19254457 20452335 21278145 19833225 18648771 18978307 19642983 20501860 21167192 19255062 19294768 20434301 18754104 16942905 19690152 21047994 21071580 19996281 18977376 20492335 2862719 10737359 19638242 9163691 20137499 12112319 12771043 20583210 19551842 19256749 2422723 19073162 20118626 19427195
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.5516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.872876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.8719539802 18093689 9362446 2563599 16267830 18775883 19009564 3124819 16842330 18164116 18308698 18544905 18282651 19004024 21159647 18079962 19126423 17174075 18253720 19519916 17942915 17854601
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.8712151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.336695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3319555203 11884234
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.4114737004
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.9418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.947678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.679029167 3581430
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.6120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.6420387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.9216049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.9216049721
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5116540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.842563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3418760546
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.5618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.5618551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.227505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3616049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.5810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.5810091137
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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