AutismKB 2.0

Annotation Detail for TRAK2


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Basic Information Top
Gene Symbol:TRAK2 ( ALS2CR3,CALS-C,GRIF-1,GRIF1,KIAA0549,OIP98 )
Gene Full Name: trafficking protein, kinesin binding 2
Band: 2q33.1
Quick LinksEntrez ID:66008; OMIM: 607334; Uniprot ID:TRAK2_HUMAN; ENSEMBL ID: ENSG00000115993; HGNC ID: 13206
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TRAK2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TRAK2 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of TRAK2 mRNAaffects expression 21346803
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of TRAK2 mRNAdecreases expression 16514628
D000082 Acetaminophen Acetaminophen affects the expression of TRAK2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TRAK2 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TRAK2 mRNAdecreases expression 20018196
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TRAK2 mRNAincreases expression 20382639
D004958 Estradiol Estradiol results in increased expression of TRAK2 mRNAincreases expression 16514628
C070081 fulvestrant fulvestrant results in decreased expression of TRAK2 mRNAdecreases expression 16514628
D017313 Fenretinide Fenretinide results in increased expression of TRAK2 mRNAincreases expression 16671099
D020849 Raloxifene Raloxifene results in decreased expression of TRAK2 mRNAdecreases expression 16514628
D014501 Uranium Uranium affects the expression of TRAK2 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of TRAK2 mRNAaffects expression 15672453
D014635 Valproic Acid Valproic Acid results in increased expression of TRAK2 mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of TRAK2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 8.897525203
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.898875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9619490988
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000230 Adenocarcinoma Estradiol 4.7211473722
MESH:D000230 Adenocarcinoma Fenretinide 4.7210697514
MESH:D000419 Albuminuria Raloxifene 4.6317308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5515800139
MESH:D000550 Amblyopia Valproic Acid 5.3017688650
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001008 Anxiety Disorders Valproic Acid 8.9317497229
MESH:D001008 Anxiety Disorders vinclozolin 8.9319015723
MESH:D001284 Atrophy fulvestrant 4.8811514358
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518396377 18775368 18316065 18177632 17688650 20603192 19460635 16609825 19232924 18985861 17507914 18558336 17157402 15238991 18940202
MESH:D001714 Bipolar Disorder Valproic Acid 3.0917594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.428888407
MESH:D001930 Brain Injuries Raloxifene 4.5216580743
MESH:D001932 Brain Neoplasms Fenretinide 4.3816187019
MESH:D001943 Breast Neoplasms Estradiol 2.0712948864 17261762 16675129 17018787 17289903 14630087 19861407 18497071
MESH:D001943 Breast Neoplasms Fenretinide 2.0716601279
MESH:D001943 Breast Neoplasms fulvestrant 2.0718984771
MESH:D001943 Breast Neoplasms Raloxifene 2.0717440819 17595753 15758505 16837676 17261762 17893378 17952589 16912660 15775269 15572757 17049068 17242785
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.9316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.9316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.933084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.9316924424
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 8.9316270382 17159502
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 3.1816274795
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.1017572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4615775269
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.4714694615
MESH:D002386 Cataract Acetaminophen 7.4710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.286135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.2820889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.2818566989
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.5316154183
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D003072 Cognition Disorders Raloxifene 4.6615800139
MESH:D015179 Colorectal Neoplasms Fenretinide 2.6817273769
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.1815095906
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.8916575769 17688650 8888407
MESH:D003456 Cryptorchidism vinclozolin 4.3814966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.0418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.0418551238
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1917474826
MESH:D003928 Diabetic Nephropathies Estradiol 9.0919279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.0915920148 17451421 17308373
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.1221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.1221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 12.1221346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.1212392966 11461765 14986274 10915739 11834606 14725611 12594235 11287661 12540782 19416960 19420014 10663392 17562736 18071297 18713872 17906064 19164858 12705907 11529661 19739265 16393943 12153990 19370779 16781746 14550746 10774834 16109766 19085960 16485898 11421492 15619225 12958197 16081117 16227642 15968718 16177239 17522070 11743745 11739529 19923254 2444490
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 12.121733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004421 Dystonia Valproic Acid 4.081851702
MESH:D004487 Edema Raloxifene 3.3715860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.0315845917
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 7.8419148513
MESH:D016889 Endometrial Neoplasms Estradiol 7.8419148513 11473722 18566989
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.1917275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.983922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9518234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.617562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.347750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.113659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0820426865
MESH:D005234 Fatty Liver Raloxifene 8.1417473493
MESH:D005234 Fatty Liver Valproic Acid 8.1419224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 4.9516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.178888407 18558336
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9816973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3616417039
MESH:D005909 Glioblastoma Fenretinide 3.9116187019
MESH:D006331 Heart Diseases Raloxifene 3.5511110106
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D019584 Hot Flashes Estradiol 3.8117088409
MESH:D006849 Hydrocephalus Valproic Acid 4.9217688650
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006973 Hypertension Raloxifene 2.8715787275 17577099
MESH:D007248 Infertility, Male fulvestrant 7.1911514358
MESH:D007248 Infertility, Male vinclozolin 7.1916467254
MESH:D007333 Insulin Resistance Estradiol 2.9816393666 16627594
MESH:D007674 Kidney Diseases Acetaminophen 5.9415629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.9415618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.5416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.5416705839
MESH:D007680 Kidney Neoplasms Estradiol 12.5415610895
MESH:D007889 Leiomyoma Raloxifene 4.5316973256
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1517596541 16294345
MESH:D007972 Leukoplakia, Oral Fenretinide 6.1116707609
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7816417039
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814659978 14716833
MESH:D008107 Liver Diseases Acetaminophen 1.6311587558 12969438 19014921 16610002 12587719 16611625 19784758 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2617185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.167678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.566135515 2876784 2876786
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3217228818
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.3817203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 6.3810697514
MESH:D020149 Manganese Poisoning Estradiol 4.5519453300
MESH:D008545 Melanoma Fenretinide 2.8316270382
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008881 Migraine Disorders Valproic Acid 3.2118765137 18803445
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.6215863610
MESH:D009062 Mouth Neoplasms Fenretinide 4.3416274795
MESH:D009101 Multiple Myeloma Raloxifene 3.4616497877
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.068888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1717596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3016810080
MESH:D009232 Myxoma Raloxifene 5.6216343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.5218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.5218551238 7678174
MESH:D009369 Neoplasms Fenretinide 3.3117353921 15958647
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7817289903
MESH:D009421 Nervous System Malformations Estradiol 3.6911399458 16427766
MESH:D009436 Neural Tube Defects Valproic Acid 3.1416359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.7316303764
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.3216049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.3216049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 15.3214694615
MESH:D010024 Osteoporosis Raloxifene 3.4115775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2615758505 15579764 17823083 17893378
MESH:D010051 Ovarian Neoplasms Estradiol 5.1619401270
MESH:D010051 Ovarian Neoplasms Fenretinide 5.1616133793
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010190 Pancreatic Neoplasms Fenretinide 3.3615580305
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.8920603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.8918220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.9818220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9120887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.7116740699
MESH:D011471 Prostatic Neoplasms Fenretinide 2.7117024972
MESH:D011471 Prostatic Neoplasms Raloxifene 2.7116536755 15731164 16220300
MESH:D011472 Prostatitis vinclozolin 4.9818629315
MESH:D019310 Pseudolymphoma Valproic Acid 4.6011422049 12752131
MESH:D011693 Purpura Raloxifene 5.6215770314
MESH:D012162 Retinal Degeneration Fenretinide 4.4216303925
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2119155313
MESH:D012559 Schizophrenia Valproic Acid 2.0719110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 9.9318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.9318551238
MESH:D012640 Seizures Valproic Acid 9.9317978042 14763951 1511512 16876388 11044598 15475178 11738929 3137016
MESH:D012878 Skin Neoplasms Fenretinide 3.5016467112
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8019490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6012833885
MESH:D020521 Stroke Raloxifene 3.8416837676
MESH:D013978 Tibial Fractures Estradiol 13.9219048282
MESH:D013978 Tibial Fractures Raloxifene 13.9219048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.3017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.573119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.0716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.0716049721
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 12.0716720286
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 12.0717572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.688888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.1610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.1610091137
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 4.5916154183
MESH:D054556 Venous Thromboembolism Raloxifene 5.2716837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.6216343187
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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