AutismKB 2.0

Annotation Detail for SMO


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SMO ( Gx,SMOH )
Gene Full Name: smoothened homolog (Drosophila)
Band: 7q32.1
Quick LinksEntrez ID:6608; OMIM: 601500; Uniprot ID:SMO_HUMAN; ENSEMBL ID: ENSG00000128602; HGNC ID: 11119
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04340Hedgehog signaling pathway
hsa05217Basal cell carcinoma
hsa05200Pathways in cancer
Pathway IDPathway Name
Signaling by GPCR
Pathway IDPathway Name
200144Signaling events mediated by the Hedgehog family
200147Hedgehog signaling events mediated by Gli proteins
Pathway IDPathway Name
P00025Hedgehog signaling pathway
Pathway IDPathway Name
500428Class B/2 (Secretin family receptors)
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
Skin cancers
H00039Basal cell carcinoma
Desease IDDesease Name
1759Skin cancer
1824Bone disease
2040Hyperglycemia
2106Pancreas cancer
2254Chondrosarcoma
No data
No data
Desease Name
Basal cell carcinoma, somatic
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SMO mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SMO mRNAaffects expression 16483693
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of SMO geneincreases mutagenesis 16724327
15755804
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of SMO mRNAincreases expression 17187413
D005472 Fluorouracil Fluorouracil results in decreased expression of SMO mRNAdecreases expression 18776995
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of SMO mRNAaffects cotreatment|increases expression 17183730
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of SMO mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of SMO mRNAdecreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of SMO mRNAincreases expression 17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of SMO mRNA]increases expression|increases reaction 17950772
D018038 Sodium Selenite Sodium Selenite results in decreased expression of SMO mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SMO mRNAincreases expression 17586704
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of SMO mRNAaffects cotreatment|increases expression 17183730
D002762 Cholecalciferol Cholecalciferol results in increased expression of SMO mRNAincreases expression 17170073
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 15.136195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 15.1311752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 15.138875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0419490988
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Fluorouracil 2.4517638652
MESH:D000236 Adenoma 2-Acetylaminofluorene 7.5510737359
MESH:D000236 Adenoma Ethylnitrosourea 7.556695378
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 6.186705139
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.2317620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.2316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.2316835633
MESH:D000550 Amblyopia Valproic Acid 5.4117688650
MESH:D000740 Anemia Fluorouracil 9.0317963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.0311748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6617497229
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518316065 19232924 18558336 15238991 17157402 20603192 17507914 16609825 18985861 18775368 18177632 18396377 18940202 19460635 17688650
MESH:D001327 Autoimmune Diseases Cholecalciferol 5.1716142846
MESH:D001714 Bipolar Disorder Valproic Acid 3.1317594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.2515746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.258888407
MESH:D001927 Brain Diseases Ethylnitrosourea 4.9814991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.3916357521 18412241 16651633 15144691 16436596
MESH:D001943 Breast Neoplasms Fluorouracil 2.0516557594 18357371 16595493 16110121 19217205 15136595 18608205
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0520435547
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8416051944
MESH:D002277 Carcinoma Fluorouracil 8.4817121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4816835633
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 6.753084413 6705139 10737359 17761372 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.753084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.7517971768 18930000 16332177 17088986 17045692 16799960
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.7520007298 1701930 20935162 17173139 6705139
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0618695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5218986760 17066447 16280240 16757204
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.8016003739
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.394080065
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.1617160924
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7420734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis pirinixic acid 2.9119176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8915894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415668235 15340226 12621046 8697196 16354765
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2515001691 18772588 16510598 17018589 17725105 17287894 17016597 17169374 17172411 16340194
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018949393 16282729 15289873 16303861 14970324 16391804 17255274 18509181 17594712 18448328 17016601 16331619 17094418 20501625 18288408 18383874 15148649 17695437 18802399 17454858 16524972 17401013
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5010048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5016575769 17688650 8888407
MESH:D007644 Darier Disease Fluorouracil 4.9516733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8716285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.222444490 11739529 16109766 11743745 19370779 18071297 16393943 19420014 14986274 14550746 16081117 18713872 16485898 11461765 17562736 17906064 12958197 11529661 16177239 19416960 17522070 19164858 11834606 12153990 19923254 12594235 16227642 19739265 15968718 10663392 19085960 12392966 12705907 10915739 11421492 11287661 16781746 12540782 14725611 10774834 15619225
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.2215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2220420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.221733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004421 Dystonia Phenobarbital 10.831851702
MESH:D004421 Dystonia Valproic Acid 10.831851702
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.1618357618
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 11.263659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 11.2617275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 10.563922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 10.5616628512 3922381
MESH:D004827 Epilepsy Phenobarbital 6.8420417680
MESH:D004827 Epilepsy Valproic Acid 6.8418234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 9.196401628
MESH:D004832 Epilepsy, Absence Valproic Acid 9.196426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 11.777750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 11.777750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 11.003659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 11.003659116
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4716785472 16337965 16481741 15173087 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver pirinixic acid 8.0919236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 8.0914986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005315 Fetal Diseases Valproic Acid 5.0616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.2618558336 8888407
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0920067830
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005909 Glioblastoma Ethylnitrosourea 3.9016436596
MESH:D005910 Glioma Ethylnitrosourea 6.4818412241 16357521 16651633
MESH:D005910 Glioma Fluorouracil 6.4816145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4615162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3810048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.496705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.516705139
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Phenobarbital 15.2216109766
MESH:D006529 Hepatomegaly pirinixic acid 15.2216221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.2216120746 12621046 15340226
MESH:D006849 Hydrocephalus Valproic Acid 5.0217688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.228697196 18606429 16959395 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7616612254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9112878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 7.5416306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.5414714311
MESH:D007569 Jaw Abnormalities marker/mechanism 16580747
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2615629191 12587719
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 8.1417379185
MESH:D007680 Kidney Neoplasms Fluorouracil 8.1416985049
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9521047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1612878042
MESH:D008107 Liver Diseases Acetaminophen 4.0116611625 16610002 12969438 19014921 19460945 11587558 12587719 19784758
MESH:D008107 Liver Diseases Phenobarbital 4.0119363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 14.6718001218 16273603 14678523 10672840 10737359 11376686
MESH:D008113 Liver Neoplasms Fluorouracil 14.6717045692 18383874 16603448 15113037
MESH:D008113 Liver Neoplasms Phenobarbital 14.678742319 15975961 19812893 19482888 21047994 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 14.6720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.6716984957
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 10.32534488 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.3217172636 1399818 18308698 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.3212151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4417228818
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 5.0211376686
MESH:D008175 Lung Neoplasms Ethylnitrosourea 5.026695378 17703301 16019985 16271038
MESH:D008175 Lung Neoplasms Fluorouracil 5.0215246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0219555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9515086387
MESH:D008223 Lymphoma Ethylnitrosourea 4.0215790496
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1814737004
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.1915375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.5810767621 10838139 18041768
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008579 Meningioma Ethylnitrosourea 6.1617943659
MESH:D008881 Migraine Disorders Valproic Acid 3.2718765137 18803445
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7116757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.148888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6317484760
MESH:D009369 Neoplasms Fluorouracil 5.1518600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 5.1517405874
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.5416707424
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.2016359493 8888407
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.5716651423 16003739 17160924
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5116436463
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.1617160924
MESH:D010018 Osteomalacia Phenobarbital 4.5217016548
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.4716929163 15113037 19003803 16500647
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4716965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.722563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.9811399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.9820603192
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.7317024972
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.7318626508 19082440
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.7318760546
MESH:D019310 Pseudolymphoma Phenobarbital 12.7812752131
MESH:D019310 Pseudolymphoma Valproic Acid 12.7812752131 11422049
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1115538739 18286688 18722050 16160472
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2919155313
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures Phenobarbital 6.2516876388 3137016 11442880 4039156
MESH:D012640 Seizures Valproic Acid 6.253137016 16876388 1511512 17978042 15475178 14763951 11044598 11738929
MESH:D003294 Seizures, Febrile Phenobarbital 4.986407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7112833885
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0016951190 18567086 19015929 15786421 16424979 17498489 17522103 19084572 18396642 17172411
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.3115790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.141399818
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0916280240
MESH:D014178 Translocation, Genetic Valproic Acid 5.4117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.673119515
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 3.3015867355 1399818 15289314
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.788888407
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.9816803524
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
Pathway ID Pathway Name
KEGG:05217 Basal cell carcinoma
KEGG:04340 Hedgehog signaling pathway
KEGG:05200 Pathways in cancer
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35968
    • Releated gene ID Related gene Name
    PA162400269PTCH1
    Releated disease ID Related disease Name
    PA443557Brain Neoplasms
    PA444898Medulloblastoma
    PA445062Neoplasms
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01047 agonist Trisyn Anti-inflammatory Agents;Anti-Allergic Agents;Glucocorticoids
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved