AutismKB 2.0

Annotation Detail for SMPD1


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Basic Information Top
Gene Symbol:SMPD1 ( ASM,ASMASE,NPD )
Gene Full Name: sphingomyelin phosphodiesterase 1, acid lysosomal
Band: 11p15.4
Quick LinksEntrez ID:6609; OMIM: 607608; Uniprot ID:ASM_HUMAN; ENSEMBL ID: ENSG00000166311; HGNC ID: 11120
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY3DJ-11281sphingomyelin metabolism
Pathway IDPathway Name
hsa00600Sphingolipid metabolism
hsa04142Lysosome
hsa01100Metabolic pathways
No data
Pathway IDPathway Name
200086TNF receptor signaling pathway
200067FAS (CD95) signaling pathway
200099IL2 signaling events mediated by PI3K
200100Ceramide signaling pathway
200056TRAIL signaling pathway
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00137Niemann-Pick disease
Lysosomal storage diseases
Genetic disorders
Desease IDDesease Name
1944Breast cancer
1972Histiocytosis
2111Systemic infection
2126Encephalopathies
2220Dermatitis
No data
No data
Desease Name
Niemann-Pick disease, type B
Niemann-Pick disease, type A
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C031278 2-chloroethyl ethyl sulfide 2-chloroethyl ethyl sulfide results in increased activity of SMPD1 proteinincreases activity 12815614
12717745
C031278 2-chloroethyl ethyl sulfide Acetylcysteine inhibits the reaction [2-chloroethyl ethyl sulfide results in increased activity of SMPD1 protein]decreases reaction|increases activity 12815614
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SMPD1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of SMPD1 mRNAaffects expression 17562736
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [2-chloroethyl ethyl sulfide results in increased activity of SMPD1 protein]decreases reaction|increases activity 12815614
D002995 Clofibric Acid Clofibric Acid affects the expression of SMPD1 mRNAaffects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of SMPD1 mRNAdecreases expression 20106945
D003891 Desipramine Desipramine results in decreased activity of SMPD1 proteindecreases activity 15781658
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of SMPD1 mRNAincreases expression 20387270
D004317 Doxorubicin Doxorubicin results in increased activity of SMPD1 proteinincreases activity 17520194
D004317 Doxorubicin [Doxorubicin results in increased activity of SMPD1 protein] promotes the reaction [TNFSF10 protein binds to TNFSF10 protein]affects binding|increases activity|increases reaction 17520194
D004317 Doxorubicin SMPD1 gene mutant form results in increased uptake of Doxorubicinincreases uptake 16439991
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SMPD1 mRNAdecreases expression 17108234
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of SMPD1 mRNAincreases expression 17616710
C006253 pirinixic acid pirinixic acid results in decreased expression of SMPD1 mRNAdecreases expression 20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of SMPD1 mRNA]decreases expression|increases reaction 20059764
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased activity of SMPD1 proteindecreases activity 19131362
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9611752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Doxorubicin 4.4517418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4514692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.823712494
MESH:D000236 Adenoma Diethylnitrosamine 6.826695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.9916434500 19052882 18056438 19061943 17162532 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.9916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.9916835633
MESH:D000419 Albuminuria Doxorubicin 4.6421441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.151440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.8314601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.8817150277
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8817474063
MESH:D001943 Breast Neoplasms Doxorubicin 1.8818628466 15994142 19526202 15634643 18234424 15692762 17983394 18382427 15939500 15567936 15136595 15668708 18695136 16595493 17369602 11325840 16096432 16935488 15993339 16826403 16115903 17426702 16264153 16322301
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002276 Carcinoid Tumor Doxorubicin 4.9416051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.677296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.673084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.6716540662 16935385 16698587 10672840 19701751 19919837 19822196 20514400 16807293 20214788 20084675 20432363 20007298 19208518 11831363 19383236 18785209 18056438 20935162 10737359 19335982 16328049 19394651 17978847 16779866 16502159 17428255 18978308 19539802 18494052 19519916 17761372 18210153 18691550 3581430 18393292 20524982 18971187 16830150 18665156 21159647 17055752 19052882 20101231 3084413 19171122 16878318 18788625 17138121 19418558 20727157 16288022 20512989 16569478 18506893 19107877 16681979 17173139 17162532
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.6716234567 18059187 16023760 17876044
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.677296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.671485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 5.2117015178
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 5.216189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.5816455267 17519947 18627295 15476868 17928571 16731534 17382496 17131338 16651473 16364871 15505089 17329180 17351982 17007740 17974986 16612575 16269455 17308081 15811867 17924179 16109756 16278810 16952015 16242529 15792986
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9716243910 17334414
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 16.537505956
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 16.5318226522
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.5312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.532727394 7505956 17174075 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.5719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.5716835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 19.729022650 19486331
MESH:D002779 Cholestasis Cyclosporine 19.7219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 19.7217333356 11677210 16105132 17681005 16919318 15861022 17110522
MESH:D002779 Cholestasis pirinixic acid 19.7219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 15340226 15668235 12621046 8697196
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D003550 Cystic Fibrosis Acetylcysteine 4.4519747007
MESH:D003866 Depressive Disorder Desipramine 5.1515014590 3690436
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9018759878 11906362 12868966 11298694 14531868 8970840 8156756 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.582952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2817107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 15.589022650 9328219 6679447 18692083 18289764 1440618 18648102 7440962 6482804 16192314 11289319 9653073 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.5811743745 16177239 11739529 14986274 12153990 2444490 19420014 19923254 14725611 16081117 19416960 16109766 11529661 17522070 10663392 15968718 11461765 19164858 12392966 11834606 11287661 11421492 16485898 16227642 18713872 12958197 10774834 12594235 19370779 17906064 17562736 19085960 18071297 15619225 16781746 10915739 14550746 19739265 12540782 16393943 12705907
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 15.5811287661
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.5819107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 15.5817416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.5820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Doxorubicin 8.3118602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.3111462148
MESH:D004409 Dyskinesia, Drug-Induced Desipramine 6.323690436
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.5017359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.2918037988
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.713581430
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.7115878914 15150132 16704527 16805852 15264214 15547733 16510608 15623463 15547721
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 19.4419224547
MESH:D005234 Fatty Liver Diethylnitrosamine 19.4420387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.4415345470
MESH:D005234 Fatty Liver pirinixic acid 19.4420131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.7019069698
MESH:D005355 Fibrosis Cyclosporine 8.8312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8320067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D005909 Glioblastoma Doxorubicin 3.4017150277
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.5815692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.5416330681 16495754 16879835 17875725 12587719 16144979 16707910 16244371 16244372 18006777 14766674 17888722 18674790
MESH:D006333 Heart Failure Doxorubicin 7.2117481944
MESH:D006333 Heart Failure pirinixic acid 7.2120558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.9815692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.616705139
MESH:D006529 Hepatomegaly pirinixic acid 8.6118467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6115340226 16120746 12621046
MESH:D006689 Hodgkin Disease Doxorubicin 3.4815147373 18501091 17606976
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1818606429 8697196 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Diethylnitrosamine 5.0318785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0312200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.158074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 10.3012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.308314463 18776723 10903974
MESH:D007674 Kidney Diseases Doxorubicin 10.3015369732 15699352 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.2316707910
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.506582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5012371664
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.2916085563
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8718407596 18522880 19638242 18665156 20032147
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.249327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.4916595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4912878042
MESH:D008107 Liver Diseases Acetaminophen 3.9712969438 12587719 19784758 16610002 16611625 11587558 19460945 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9717034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms Clofibric Acid 10.9317602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.9320118626 19690152 19294768 16942905 19499222 21047994 19090486 20492335 18648771 20405173 19812893 9163691 20101389 19073162 12771043 19833225 19551842 18754104 19254457 19427195 2862719 19426721 15175105 18644402 19638242 20583210 20137499 19256749 12112319 19255062 20501860 19996281 19642983 10737359 20452335 20434301 2422723 15885732 21071580 18977376 19850985 21278145 21167192 18978307
MESH:D008113 Liver Neoplasms pirinixic acid 10.9316377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9316984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.543712494 6587162 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.5418282651 18544905 18253720 9362446 3124819 17854601 18164116 2563599 18093689 19009564 19519916 16267830 19126423 18079962 17942915 17174075 19539802 16842330 19004024 21159647 18775883 18308698
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 14.5417085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.5412151625
MESH:D008171 Lung Diseases 2-chloroethyl ethyl sulfide 8.4816252256 18675330 12815614
MESH:D008171 Lung Diseases Acetylcysteine 8.4812815614
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4721163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 3.4717418594 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4711884234 19555203
MESH:D008223 Lymphoma Doxorubicin 3.5216098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.8617654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.6715621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.0815458769
MESH:D008545 Melanoma Doxorubicin 2.3016827129
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D001523 Mental Disorders Desipramine 5.2416856516
MESH:D008654 Mesothelioma Doxorubicin 3.0917638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5815792986
MESH:D052016 Mucositis Doxorubicin 4.9117415656
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction Doxorubicin 5.8119429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 5.8119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 13.893581430
MESH:D009362 Neoplasm Metastasis Acetylcysteine 13.8914720322
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 13.899029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 13.8918259882
MESH:D009369 Neoplasms pirinixic acid 1.9817405874
MESH:D009401 Nephrosis Doxorubicin 4.8716899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.5419348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.5415640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.766679447
MESH:D009436 Neural Tube Defects Acetylcysteine 7.7619446573
MESH:D009447 Neuroblastoma Doxorubicin 3.3015555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009542 Niemann-Pick Diseases marker/mechanism 12631268
MESH:D052536 Niemann-Pick Disease, Type A marker/mechanism
MESH:D052537 Niemann-Pick Disease, Type B marker/mechanism
MESH:D009765 Obesity 2-chloroethyl ethyl sulfide 5.0616289378
MESH:D009765 Obesity pirinixic acid 5.0620558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.506482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D012516 Osteosarcoma Doxorubicin 4.1815930896
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4516540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010300 Parkinson Disease Desipramine 4.4110965161
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.2917983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.2917638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.1912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.192563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5416888761 15897917 16729912 18437689 16868541 15749863
MESH:D011537 Pruritus Ethinyl Estradiol 3.4316919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D051437 Renal Insufficiency Doxorubicin 4.3317922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D012128 Respiratory Distress Syndrome, Adult 2-chloroethyl ethyl sulfide 10.1816292752 12210543 18257742
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 10.1812210543
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012509 Sarcoma Doxorubicin 4.0615675481 16767912 17203757 18313854 17710206 15625365
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.3416326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.9117846226
MESH:D012878 Skin Neoplasms Doxorubicin 5.8115692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8116192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.6717203757 15625365 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6318456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.6317575124 12958204
MESH:D013276 Stomach Ulcer Acetylcysteine 4.0717918041
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.376582329 3712494 1399818 7505956 6587162
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.377505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 12.3717909728 16010429
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.288074119
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.2817653716
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.3317638931 17334414 17678736 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
Pathway ID Pathway Name
KEGG:04142 Lysosome
KEGG:01100 Metabolic pathways
KEGG:00600 Sphingolipid metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35969
    • No data
    Releated disease ID Related disease Name
    PA445118Niemann-Pick Diseases
    Releated drug ID Related drug Name
    PA449780glutathione
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01151 inhibitor Desipramine Antidepressants;Adrenergic Uptake Inhibitors;Enzyme Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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