AutismKB 2.0

Annotation Detail for POLR3D


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Basic Information Top
Gene Symbol:POLR3D ( BN51T,RPC4,RPC53,TSBN51 )
Gene Full Name: polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
Band: 8p21.3
Quick LinksEntrez ID:661; OMIM: 187280; Uniprot ID:RPC4_HUMAN; ENSEMBL ID: ENSG00000168495; HGNC ID: 1080
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00240Pyrimidine metabolism
hsa03020RNA polymerase
hsa04623Cytosolic DNA-sensing pathway
hsa00230Purine metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Transcription
Pathway IDPathway Name
200045Validated targets of C-MYC transcriptional activation
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of POLR3D mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of POLR3D mRNAdecreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of POLR3D mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of POLR3D mRNAaffects expression 17562736
D016572 Cyclosporine Cyclosporine results in increased expression of POLR3D mRNAincreases expression 20106945
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in increased expression of POLR3D mRNAincreases expression 17951470
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.417525203
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.923712494
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7316705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.733581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.733084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.9814694615
MESH:D002386 Cataract Acetaminophen 7.9810977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.277505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2712371664
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.659022650 19486331
MESH:D002779 Cholestasis Cyclosporine 8.6519486331
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.4515095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.4318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2111906362 8156756 14531868 12868966 11298694 18759878 2524372 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.842952479 3621924
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.6518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.6518289764 6482804 18692083 9328219 8291058 16192314 9022650 11289319 1440618 18648102 6679447 7440962 9653073
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 9.6521346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.6512958197 16781746 12540782 19739265 11834606 11287661 12153990 14725611 11739529 17906064 10774834 16177239 11743745 18713872 19923254 10663392 15619225 19085960 12594235 11461765 19420014 17522070 14550746 16081117 16485898 16109766 16227642 18071297 17562736 10915739 19164858 12705907 14986274 19416960 11529661 15968718 19370779 11421492 16393943 12392966 2444490
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005234 Fatty Liver Cyclosporine 3.1819224547
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005355 Fibrosis Cyclosporine 3.5612168785 12639820
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.549022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.3415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.3418776723 8314463 10903974
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.9716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.976582329
MESH:D007680 Kidney Neoplasms Cyclosporine 13.9712371664
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.389327722 15034207
MESH:D008107 Liver Diseases Acetaminophen 1.6912969438 11587558 16611625 19014921 12587719 19784758 19460945 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.711399818 598648 3712494 6587162
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.3218551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5718481113 19348381
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.9912819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 16.994026338 6482804
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 16.9914694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7318551238
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.126587162 3712494 6582329 1399818 7505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3516049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.358074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
Pathway ID Pathway Name
KEGG:04623 Cytosolic DNA-sensing pathway
KEGG:01100 Metabolic pathways
KEGG:00230 Purine metabolism
KEGG:00240 Pyrimidine metabolism
KEGG:03020 RNA polymerase
REACT:1788 Transcription
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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