Annotation Detail for SIGLEC1
Basic Information Top
| Gene Symbol: | SIGLEC1 ( CD169,DKFZp667F058,FLJ00051,FLJ00055,FLJ00073,FLJ00411,FLJ32150,SIGLEC-1,SN,dJ1009E24.1 ) |
|---|---|
| Gene Full Name: | sialic acid binding Ig-like lectin 1, sialoadhesin |
| Band: | 20p13 |
| Quick Links | Entrez ID:6614; OMIM: 600751; Uniprot ID:SN_HUMAN; ENSEMBL ID: ENSG00000088827; HGNC ID: 11127 |
| Relate to Another Database: | SFARIGene; denovo-db |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D005472 | Fluorouracil | [Fluorouracil co-treated with irinotecan] results in increased expression of SIGLEC1 mRNA | affects cotreatment|increases expression | 16391804 |
| C051890 | irinotecan | [Fluorouracil co-treated with irinotecan] results in increased expression of SIGLEC1 mRNA | affects cotreatment|increases expression | 16391804 |
| D015215 | Zidovudine | [Zidovudine co-treated with IFNA1 protein] results in increased expression of SIGLEC1 mRNA | affects cotreatment|increases expression | 20370541 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000163 | Acquired Immunodeficiency Syndrome | Zidovudine | 5.48 | 9612607 | |
| MESH:D000230 | Adenocarcinoma | Fluorouracil | 2.50 | 17638652 | |
| MESH:D000740 | Anemia | Fluorouracil | 4.16 | 16511603 15504547 17963324 | |
| MESH:D001943 | Breast Neoplasms | Fluorouracil | 2.43 | 16595493 18608205 19217205 16557594 18357371 16110121 15136595 | |
| MESH:D002276 | Carcinoid Tumor | Fluorouracil | 5.53 | 16051944 | |
| MESH:D002277 | Carcinoma | Fluorouracil | 3.93 | 17121937 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Fluorouracil | 2.12 | 17971768 17045692 16332177 18930000 16799960 17088986 | |
| MESH:D002292 | Carcinoma, Renal Cell | Fluorouracil | 3.18 | 18695887 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Fluorouracil | 2.58 | 18986760 16757204 16280240 17066447 | |
| MESH:D003110 | Colonic Neoplasms | Fluorouracil | 4.17 | 17016597 17725105 17287894 16510598 17169374 15001691 17018589 17172411 18772588 16340194 | |
| MESH:D003110 | Colonic Neoplasms | irinotecan | 4.17 | 17725105 17287894 | |
| MESH:D015179 | Colorectal Neoplasms | Fluorouracil | 2.81 | 17016601 16524972 15148649 17695437 16331619 18802399 18288408 18383874 18949393 20501625 17454858 16282729 18509181 16303861 14970324 17094418 17255274 17401013 17594712 15289873 16391804 18448328 | |
| MESH:D015179 | Colorectal Neoplasms | irinotecan | 2.81 | 17159606 15273666 18259882 17454858 16391804 16303861 18509181 | |
| MESH:D007644 | Darier Disease | Fluorouracil | 5.53 | 16733453 | |
| MESH:D004362 | Drug Toxicity | Zidovudine | 4.33 | 15040536 | |
| MESH:D004938 | Esophageal Neoplasms | Fluorouracil | 2.53 | 16481741 16337965 16785472 15173087 17638652 | |
| MESH:D005234 | Fatty Liver | Zidovudine | 4.39 | 18299183 | |
| MESH:D005910 | Glioma | Fluorouracil | 3.00 | 16145905 | |
| MESH:D006258 | Head and Neck Neoplasms | Fluorouracil | 3.67 | 18337622 15162350 15102660 | |
| MESH:D006402 | Hematologic Diseases | Zidovudine | 5.24 | 12579204 | |
| MESH:D015658 | HIV Infections | Zidovudine | 3.69 | 17358032 11698656 11363243 20032539 11141242 | |
| MESH:D007680 | Kidney Neoplasms | Fluorouracil | 9.09 | 16985049 | |
| MESH:D007680 | Kidney Neoplasms | Zidovudine | 9.09 | 12579204 | |
| MESH:D015459 | Leukemia-Lymphoma, Adult T-Cell | Zidovudine | 4.90 | 20370541 | |
| MESH:D008113 | Liver Neoplasms | Fluorouracil | 2.61 | 17045692 15113037 16603448 18383874 | |
| MESH:D008175 | Lung Neoplasms | Fluorouracil | 2.90 | 15246190 | |
| MESH:D008175 | Lung Neoplasms | Zidovudine | 2.90 | 18800350 | |
| MESH:D008178 | Lupus Erythematosus, Cutaneous | Fluorouracil | 5.53 | 15086387 | |
| MESH:D048629 | Micronuclei, Chromosome-Defective | Zidovudine | 6.71 | 17358032 | |
| MESH:D009062 | Mouth Neoplasms | Fluorouracil | 3.98 | 18986760 16757204 | |
| MESH:D052016 | Mucositis | irinotecan | 5.75 | 17159606 | |
| MESH:D009362 | Neoplasm Metastasis | irinotecan | 3.31 | 18259882 | |
| MESH:D009369 | Neoplasms | Fluorouracil | 2.79 | 18600527 18239605 16928823 | |
| MESH:D009447 | Neuroblastoma | irinotecan | 3.67 | 8761367 | |
| MESH:D017599 | Neuroectodermal Tumors | irinotecan | 5.47 | 8761367 | |
| MESH:D020258 | Neurotoxicity Syndromes | Fluorouracil | 3.72 | 16436463 | |
| MESH:D010190 | Pancreatic Neoplasms | Fluorouracil | 2.78 | 16500647 16929163 19003803 15113037 | |
| MESH:D011471 | Prostatic Neoplasms | Fluorouracil | 3.34 | 19082440 18626508 | |
| MESH:D012004 | Rectal Neoplasms | Fluorouracil | 4.43 | 18722050 18286688 15538739 16160472 | |
| MESH:D013274 | Stomach Neoplasms | Fluorouracil | 3.73 | 19084572 18396642 19015929 16951190 17172411 17522103 17498489 16424979 18567086 15786421 | |
| MESH:D013274 | Stomach Neoplasms | irinotecan | 3.73 | 15723263 | |
| MESH:D013274 | Stomach Neoplasms | Zidovudine | 3.73 | 17696246 | |
| MESH:D014062 | Tongue Neoplasms | Fluorouracil | 4.44 | 16280240 | |
| MESH:D002583 | Uterine Cervical Neoplasms | Fluorouracil | 4.33 | 16803524 | |
| MESH:D014625 | Vaginal Neoplasms | Zidovudine | 5.41 | 12579204 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:04514 | Cell adhesion molecules (CAMs) |