AutismKB 2.0

Annotation Detail for SNAP25


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Basic Information Top
Gene Symbol:SNAP25 ( FLJ23079,RIC-4,RIC4,SEC9,SNAP,SNAP-25,bA416N4.2,dJ1068F16.2 )
Gene Full Name: synaptosomal-associated protein, 25kDa
Band: 20p12.2
Quick LinksEntrez ID:6616; OMIM: 600322; Uniprot ID:SNP25_HUMAN; ENSEMBL ID: ENSG00000132639; HGNC ID: 11132
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04130SNARE interactions in vesicular transport
Pathway IDPathway Name
Botulinum neurotoxicity
Synaptic Transmission
Diabetes pathways
Integration of energy metabolism
Pathway IDPathway Name
200160Effects of Botulinum toxin
Pathway IDPathway Name
P04378Beta2 adrenergic receptor signaling pathway
P00039Metabotropic glutamate receptor group III pathway
P04391Oxytocin receptor mediated signaling pathway
P04379Beta3 adrenergic receptor signaling pathway
P00001Adrenaline and noradrenaline biosynthesis
P04377Beta1 adrenergic receptor signaling pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P00044Nicotinic acetylcholine receptor signaling pathway
P04394Thyrotropin-releasing hormone receptor signaling pathway
P043745HT2 type receptor mediated signaling pathway
P00037Ionotropic glutamate receptor pathway
P04380Cortocotropin releasing factor receptor signaling pathway
P00002Alpha adrenergic receptor signaling pathway
P00040Metabotropic glutamate receptor group II pathway
P05734Synaptic vesicle trafficking
P043765HT4 type receptor mediated signaling pathway
P00043Muscarinic acetylcholine receptor 2 and 4 signaling pathway
P043755HT3 type receptor mediated signaling pathway
P043735HT1 type receptor mediated signaling pathway
Pathway IDPathway Name
500153Acetylcholine Neurotransmitter Release Cycle
500147Neurotransmitter Release Cycle
500148Norepinephrine Neurotransmitter Release Cycle
500149Serotonin Neurotransmitter Release Cycle
500151Dopamine Neurotransmitter Release Cycle
500150Glutamate Neurotransmitter Release Cycle
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1983Down syndrome
2069Schizophrenia
2190Attention deficit hyperactivity disorder
Desease Name
bipolar disorder
cognitive function
CHEMDEPENDENCY
ADHD
PSYCH
Weight Gain
attention deficit hyperactivity disorder depressive disorder, major
schizoaffective disorder
attention-deficit hyperactivity disorder
smoking cessation
schizophrenia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SNAP25 mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of SNAP25 proteindecreases expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in decreased expression of SNAP25 mRNAdecreases expression 18687144
C053541 bicalutamide bicalutamide results in increased expression of SNAP25 mRNAincreases expression 15790403
D019274 Botulinum Toxins, Type A Botulinum Toxins, Type A results in increased cleavage of SNAP25 proteinincreases cleavage 17666428
C096324 botulinum toxin type C botulinum toxin type C results in increased cleavage of SNAP25 proteinincreases cleavage 17666428
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of SNAP25 mRNAaffects cotreatment|increases expression 18636392
D003024 Clozapine SNAP25 gene SNP affects the susceptibility to Clozapineaffects response to substance 15823421
D003024 Clozapine Clozapine results in increased expression of SNAP25 mRNAincreases expression 15860345
C009160 cyclonite cyclonite results in increased expression of SNAP25 mRNAincreases expression 19417177
D005419 Flavonoids Flavonoids results in increased expression of SNAP25 mRNAincreases expression 18035473
D006220 Haloperidol SNAP25 gene SNP affects the susceptibility to Haloperidolaffects response to substance 15823421
D006220 Haloperidol Haloperidol affects the expression of SNAP25 mRNAaffects expression 15860345
C057416 KT 5720 KT 5720 inhibits the reaction [PRKACA protein results in increased phosphorylation of SNAP25 protein]decreases reaction|increases phosphorylation 14766180
C008493 methylselenic acid methylselenic acid results in increased expression of SNAP25 mRNAincreases expression 18548127
C076029 olanzapine SNAP25 gene SNP affects the susceptibility to olanzapineaffects response to substance 15823421
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of SNAP25 mRNAaffects cotreatment|increases expression 18636392
D018967 Risperidone SNAP25 gene SNP affects the susceptibility to Risperidoneaffects response to substance 15823421
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of SNAP25 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of SNAP25 mRNAdecreases expression 19244175
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of SNAP25 mRNAaffects cotreatment|decreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D055371 Acute Lung Injury Chlorine 4.3120601635
MESH:D000380 Agranulocytosis Clozapine 5.0414617031 12649775 16160616
MESH:D000544 Alzheimer Disease Ozone 2.4315513908
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5515570426
MESH:D020817 Asperger Syndrome Risperidone 5.4916401163
MESH:D001249 Asthma Ozone 2.6317854713 16373670
MESH:D001289 Attention Deficit Disorder with Hyperactivity Risperidone 4.7818349709
MESH:D001321 Autistic Disorder Haloperidol 2.6618080171 19368416
MESH:D001321 Autistic Disorder olanzapine 2.6618685284 17069543
MESH:D001321 Autistic Disorder Risperidone 2.6615994720 16379507 19154706 18278980 18775368 19368416 19232924 19013209 15930063 16948927 16601648 17069546 16730335 16239862 17929164 18349709 18080171 18026891 17019624 15543515 15492353
MESH:D001714 Bipolar Disorder marker/mechanism 14708030
MESH:D001714 Bipolar Disorder Risperidone 4.5119154706 18278980
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6618315731 16777450 18417511 17626835 14754758 19059883 15516495
MESH:D002012 Bruxism Botulinum Toxins, Type A 7.9116703933
MESH:D002100 Cachexia Ozone 4.7316183385
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.9216050911
MESH:D002375 Catalepsy Haloperidol 4.901977408 15215559
MESH:D002389 Catatonia olanzapine 6.2516772815 18071103
MESH:D003072 Cognition Disorders Clozapine 4.9517123785
MESH:D003092 Colitis Selenium 3.7717936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9119769572
MESH:D003556 Cystitis Botulinum Toxins, Type A 7.0212599022
MESH:D016757 Death, Sudden, Cardiac Haloperidol 11.4020210726
MESH:D016757 Death, Sudden, Cardiac Risperidone 11.4020210726
MESH:D003704 Dementia Haloperidol 10.4911575062
MESH:D003704 Dementia Risperidone 10.4911575062
MESH:D003866 Depressive Disorder marker/mechanism 14708030
MESH:D002658 Developmental Disabilities olanzapine 4.6817069543
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.9716402076
MESH:D006970 Disorders of Excessive Somnolence Clozapine 14.4515331141
MESH:D006970 Disorders of Excessive Somnolence Risperidone 14.4516379507
MESH:D053207 Diurnal Enuresis Risperidone 6.6817822346
MESH:D004314 Down Syndrome Risperidone 5.0418349709
MESH:D056486 Drug-Induced Liver Injury Selenium 2.1715131321
MESH:D050171 Dyslipidemias Clozapine 4.1716402076
MESH:D004417 Dyspnea Chlorine 4.6220016425
MESH:C538011 Eales disease Vitamin E 4.709068938
MESH:D005739 Gas Poisoning Chlorine 5.0120016425
MESH:D006330 Heart Defects, Congenital Vitamin E 2.9816080930
MESH:D006333 Heart Failure Selenium 3.0617162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6916863852 16490937
MESH:D019584 Hot Flashes Vitamin E 3.9714716179
MESH:D006943 Hyperglycemia Risperidone 5.1418278980
MESH:D006948 Hyperkinesis Clozapine 4.9016046005
MESH:D006963 Hyperphagia olanzapine 6.2217933447
MESH:D007249 Inflammation Flavonoids 2.6417296493
MESH:D007251 Influenza, Human Selenium 10.9616624496
MESH:D007251 Influenza, Human Vitamin E 10.9616624496
MESH:D007674 Kidney Diseases Vitamin E 2.7912488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.8716518626
MESH:D008064 Lipidoses Clozapine 3.9417567588
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008133 Long QT Syndrome olanzapine 4.7120210726
MESH:D008171 Lung Diseases Ozone 7.478266340 19066396
MESH:D008171 Lung Diseases Vitamin E 7.4716863852
MESH:D055370 Lung Injury Asbestos, Crocidolite 9.2017365036
MESH:D055370 Lung Injury Ozone 9.2020417186
MESH:D008175 Lung Neoplasms Ozone 2.618597069 7614698
MESH:D008175 Lung Neoplasms Vitamin E 2.6111062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.7515318939
MESH:D001523 Mental Disorders Clozapine 18.8116856516
MESH:D001523 Mental Disorders Haloperidol 18.8116856516
MESH:D001523 Mental Disorders olanzapine 18.8116856516
MESH:D001523 Mental Disorders Risperidone 18.8116856516 16596465
MESH:D008607 Mental Retardation Risperidone 4.1018349709
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.3116966607 16166281 18303189
MESH:D008654 Mesothelioma Selenium 6.3115107826
MESH:D008659 Metabolic Diseases olanzapine 5.3719142110
MESH:D024821 Metabolic Syndrome X Clozapine 10.1219142101
MESH:D024821 Metabolic Syndrome X Risperidone 10.1219142101
MESH:D008679 Metaplasia Ozone 5.1110496685
MESH:D019964 Mood Disorders Risperidone 5.8217019624
MESH:D053206 Nocturnal Enuresis Risperidone 6.3317822346
MESH:D009765 Obesity Clozapine 5.3819142110 18515891
MESH:D009765 Obesity olanzapine 5.3818515891
MESH:D010538 Peritonitis Ozone 4.1216369182
MESH:D010954 Plasmacytoma Selenium 4.8915087411
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.8810923243
MESH:D011014 Pneumonia Ozone 4.3918007984 18929643 18381685
MESH:D011471 Prostatic Neoplasms bicalutamide 2.8219240160 15638997 17914592 18487222 19011039
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.8216205645
MESH:D011471 Prostatic Neoplasms Vitamin E 2.8215084515
MESH:D011595 Psychomotor Agitation Haloperidol 11.7711575062
MESH:D011595 Psychomotor Agitation olanzapine 11.7718685284
MESH:D011618 Psychotic Disorders marker/mechanism 14708030
MESH:D011618 Psychotic Disorders Clozapine 9.1115331141
MESH:D011618 Psychotic Disorders Haloperidol 9.1111575062
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0215814490 17365031 17322281 17975199
MESH:D012120 Respiration Disorders Chlorine 5.2118579056
MESH:D012559 Schizophrenia Clozapine 8.0820580759 17123785 11151749 18855531 20107430 20452607 17726453 20521326 18806925 19369910 16141801 11763009 17667964 20168265 20521320
MESH:D012559 Schizophrenia Haloperidol 8.0820107430 19369910 18513383 1830565
MESH:D012559 Schizophrenia olanzapine 8.0820107430 20521326 17726453
MESH:D012559 Schizophrenia Risperidone 8.0820107430 18278980 19154706
MESH:D012640 Seizures cyclonite 4.5219417177
MESH:D012871 Skin Diseases Vitamin E 2.4418709164
MESH:D012893 Sleep Disorders Risperidone 5.5018278980
MESH:D020521 Stroke Vitamin E 3.5016517955
MESH:D017180 Tachycardia, Ventricular Haloperidol 17.5820210726
MESH:D017180 Tachycardia, Ventricular olanzapine 17.5820210726
MESH:D017180 Tachycardia, Ventricular Risperidone 17.5820210726
MESH:D005879 Tourette Syndrome Risperidone 5.9319154706
MESH:D015430 Weight Gain Clozapine 16.5320107430 20521320 16141801 16402076 17502770 20564506
MESH:D015430 Weight Gain olanzapine 16.5320107430 17933447 19434072
MESH:D015430 Weight Gain Risperidone 16.5316379507 20564506
MESH:D015431 Weight Loss Clozapine 5.0717933447
Pathway ID Pathway Name
REACT:11184 Botulinum neurotoxicity
REACT:15380 Diabetes pathways
REACT:1505 Integration of energy metabolism
KEGG:04130 SNARE interactions in vesicular transport
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35980
    • No data
    Releated disease ID Related disease Name
    PA447197Attention Deficit Disorder with Hyperactivity
    Releated drug ID Related drug Name
    PA451898vitamin c
    PA10090l-glutamine
    PA450197l-leucine
    PA448976choline
    PA450464methylphenidate
    PA449396dopamine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00083 inhibitor Botulinum Toxin Type A Anti-Wrinkle Agents;Antidystonic Agents;Neuromuscular Blocking Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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