AutismKB 2.0

Annotation Detail for BNIP1


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Basic Information Top
Gene Symbol:BNIP1 ( NIP1,SEC20,TRG-8 )
Gene Full Name: BCL2/adenovirus E1B 19kDa interacting protein 1
Band: 5q35.1
Quick LinksEntrez ID:662; OMIM: 603291; Uniprot ID:SEC20_HUMAN; ENSEMBL ID: ENSG00000113734; HGNC ID: 1082
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04130SNARE interactions in vesicular transport
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of BNIP1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of BNIP1 mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A results in increased expression of BNIP1 mRNAincreases expression 19371625
D016572 Cyclosporine Cyclosporine results in increased expression of BNIP1 mRNAincreases expression 20106945
D004280 Dobutamine Dobutamine results in increased expression of BNIP1 proteinincreases expression 15052282
D004317 Doxorubicin [Doxorubicin co-treated with Razoxane] results in increased expression of BNIP1 proteinaffects cotreatment|increases expression 12714334
D004317 Doxorubicin Doxorubicin results in increased expression of BNIP1 proteinincreases expression 12714334
D015025 Zearalenone Zearalenone results in increased expression of BNIP1 mRNAincreases expression 19371625
D019833 Genistein Genistein results in increased expression of BNIP1 mRNAincreases expression 19371625
D007545 Isoproterenol Isoproterenol results in increased expression of BNIP1 proteinincreases expression 15052282
D009921 Metaproterenol Metaproterenol results in increased expression of BNIP1 proteinincreases expression 15052282
C016340 o,p'-DDT o,p'-DDT results in increased expression of BNIP1 mRNAincreases expression 19371625
D011929 Razoxane [Doxorubicin co-treated with Razoxane] results in increased expression of BNIP1 proteinaffects cotreatment|increases expression 12714334
D011929 Razoxane Razoxane results in increased expression of BNIP1 proteinincreases expression 12714334
C059514 resveratrol resveratrol results in increased expression of BNIP1 mRNAincreases expression 19371625
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D058186 Acute Kidney Injury resveratrol 3.9316538975
MESH:D000230 Adenocarcinoma Doxorubicin 4.7017418594
MESH:D000230 Adenocarcinoma Genistein 4.7011473722
MESH:D000236 Adenoma resveratrol 3.3615688382
MESH:D000419 Albuminuria Doxorubicin 4.6421441931
MESH:D000544 Alzheimer Disease resveratrol 2.5816183991 16162502
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001169 Arthritis, Experimental resveratrol 3.5517115116
MESH:D050197 Atherosclerosis resveratrol 3.3216873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.8314601052
MESH:D001862 Bone Resorption bisphenol A 3.9411985600
MESH:D001919 Bradycardia Isoproterenol 5.306740701
MESH:D002545 Brain Ischemia resveratrol 4.4017600658
MESH:D001932 Brain Neoplasms Doxorubicin 3.8817150277
MESH:D001943 Breast Neoplasms bisphenol A 2.0317123778
MESH:D001943 Breast Neoplasms Doxorubicin 2.0311325840 18695136 18234424 15939500 15668708 16264153 17426702 18628466 19526202 16096432 17369602 15993339 16595493 15136595 17983394 16826403 15634643 15692762 16115903 18382427 16322301 15567936 16935488 15994142
MESH:D001943 Breast Neoplasms Genistein 2.0317200150 16873071 16541309
MESH:D001943 Breast Neoplasms resveratrol 2.0317651959 17534123 16393696
MESH:D002276 Carcinoid Tumor Doxorubicin 4.9416051944
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.713084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.7116234567 17876044 18059187 16023760
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.7116924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 6.7116227395 19321006
MESH:D002278 Carcinoma in Situ bisphenol A 5.1117123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.7116675471
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.191485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 5.016189445
MESH:D002294 Carcinoma, Squamous Cell resveratrol 5.0116227395
MESH:D006332 Cardiomegaly Isoproterenol 4.217544033 11179087
MESH:D009202 Cardiomyopathies Doxorubicin 8.7316952015 15505089 16278810 16269455 17928571 17308081 17007740 18627295 16455267 17519947 15792986 17351982 15811867 17924179 16612575 16651473 16242529 16109756 17131338 15476868 17329180 16731534 16364871 17382496 17974986
MESH:D009202 Cardiomyopathies Razoxane 8.7317519947
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9716243910 17334414
MESH:D002318 Cardiovascular Diseases Genistein 7.7016332659
MESH:D002318 Cardiovascular Diseases resveratrol 7.7015458977
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5812371664
MESH:D002779 Cholestasis Cyclosporine 2.9719486331
MESH:D003092 Colitis resveratrol 4.2316474422
MESH:D003110 Colonic Neoplasms Genistein 3.9817182828
MESH:D003110 Colonic Neoplasms resveratrol 3.9816338953
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.7518259882 18802399
MESH:D015179 Colorectal Neoplasms resveratrol 2.7516550006
MESH:D003327 Coronary Disease resveratrol 3.8016507316
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.8416873680
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5016647724
MESH:D003928 Diabetic Nephropathies resveratrol 4.0316286809
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9616485898 11287661 19370779 16109766 19164858 12705907 17562736 18713872 10663392 18071297 16393943 16081117 2444490 19739265 11529661 16781746 19923254 10915739 12392966 17906064 12540782 16177239 12153990 19416960 12594235 11739529 14550746 11743745 19085960 11461765 11421492 14725611 14986274 12958197 19420014 15619225 16227642 11834606 10774834 15968718 17522070
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 3.9617416283
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Doxorubicin 3.7318602426
MESH:D004487 Edema resveratrol 3.458985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.1217872969
MESH:D004714 Endometrial Hyperplasia Genistein 4.7116402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.8517359293
MESH:D016889 Endometrial Neoplasms Genistein 7.8511473722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.2918037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.9517923197
MESH:D005234 Fatty Liver Cyclosporine 2.9419224547
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.7019069698
MESH:D005355 Fibrosis Cyclosporine 3.2412168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D005909 Glioblastoma Doxorubicin 7.5117150277
MESH:D005909 Glioblastoma Genistein 7.5116598420
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.5815692506
MESH:D006331 Heart Diseases Doxorubicin 8.5918006777 17888722 17875725 16244371 16495754 16707910 16244372 12587719 16144979 16330681 16879835 14766674 18674790
MESH:D006331 Heart Diseases Razoxane 8.5917875725
MESH:D006333 Heart Failure Dobutamine 12.5117440445
MESH:D006333 Heart Failure Doxorubicin 12.5117481944
MESH:D006333 Heart Failure Isoproterenol 12.5118097624
MESH:D006390 Hemangioendothelioma Razoxane 6.5415380572
MESH:D006394 Hemangiosarcoma Doxorubicin 3.9815692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006561 Herpes Simplex resveratrol 4.3016876885
MESH:D006689 Hodgkin Disease Doxorubicin 3.4815147373 18501091 17606976
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006937 Hypercholesterolemia resveratrol 4.0917188708
MESH:D006949 Hyperlipidemias resveratrol 4.1116873680
MESH:D006973 Hypertension Cyclosporine 2.1210903974
MESH:D006984 Hypertrophy Isoproterenol 5.2712791704
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.3817488730
MESH:D007022 Hypotension Isoproterenol 4.886740701
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.7517600658
MESH:D007249 Inflammation resveratrol 2.8816366677
MESH:D007251 Influenza, Human resveratrol 4.6816624496
MESH:D007333 Insulin Resistance bisphenol A 3.3416393666
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 10.3012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.308314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 10.3015369732 16775033 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.2316707910
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8012371664
MESH:D007938 Leukemia Genistein 3.0617468513 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.2916085563
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.6316087638
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.7516595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.7517823541
MESH:D008107 Liver Diseases Acetaminophen 1.6519014921 16611625 19460945 12969438 12587719 11587558 16610002 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms resveratrol 2.7320405173 19812893 19321006 19073162
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.0616842330 17085340
MESH:D008133 Long QT Syndrome Dobutamine 4.8019353679
MESH:D008171 Lung Diseases Dobutamine 4.5816638327
MESH:D008175 Lung Neoplasms Doxorubicin 2.1417418594 6189445
MESH:D008223 Lymphoma Doxorubicin 3.5216098063
MESH:D016393 Lymphoma, B-Cell resveratrol 4.3917088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 9.1117654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 9.1114749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.6715621674
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.3615688416
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 10.4115458769
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.4114578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 10.418985016 11606380
MESH:D008545 Melanoma Doxorubicin 3.6316827129
MESH:D008545 Melanoma resveratrol 3.6317992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008654 Mesothelioma Doxorubicin 3.0917638057
MESH:D008659 Metabolic Diseases resveratrol 4.4617112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5815792986
MESH:D052016 Mucositis Doxorubicin 4.9117415656
MESH:D009101 Multiple Myeloma resveratrol 3.5216267019 17049120 17164350 16490592 17935668 14749477
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.9917962980
MESH:D009203 Myocardial Infarction Doxorubicin 13.9215857846 19429709
MESH:D009203 Myocardial Infarction Genistein 13.9217141266
MESH:D009203 Myocardial Infarction Isoproterenol 13.9216538859 16697266 19172585 17052832 16584858 15740881 19595682
MESH:D009203 Myocardial Infarction resveratrol 13.9216456233 17125593 17015251 16317513 16525036 17188708
MESH:D017202 Myocardial Ischemia Dobutamine 9.9712447174
MESH:D017202 Myocardial Ischemia resveratrol 9.9717015251 17125593
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7217141266
MESH:D009205 Myocarditis resveratrol 4.8817322642
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.9818259882
MESH:D009374 Neoplasms, Experimental resveratrol 4.108985016
MESH:D009401 Nephrosis Doxorubicin 4.8716636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.5419348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.5416889571 15640375
MESH:D009421 Nervous System Malformations bisphenol A 10.2011399458 16427766
MESH:D009421 Nervous System Malformations Genistein 10.2016427766
MESH:D009447 Neuroblastoma Doxorubicin 3.3015555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.5818514411
MESH:D019636 Neurodegenerative Diseases resveratrol 8.5817652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.4917929310
MESH:D010024 Osteoporosis Genistein 3.3019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 10.4516169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 10.4517513867
MESH:D012516 Osteosarcoma Doxorubicin 4.1815930896
MESH:D010049 Ovarian Diseases bisphenol A 5.1111985600
MESH:D010051 Ovarian Neoplasms Genistein 2.6219005980
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D003557 Phyllodes Tumor Doxorubicin 5.2917983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.2917638057
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.2710548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 10.2716679765
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1216740699
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.1216888761 16729912 15749863 16868541 15897917 18437689
MESH:D011471 Prostatic Neoplasms Genistein 2.1216925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms resveratrol 2.1215767336 17804756 16731767 17675339 17718901 17636462
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D011629 Puberty, Precocious bisphenol A 4.9010548101
MESH:D011654 Pulmonary Edema Isoproterenol 5.3810903255
MESH:D051437 Renal Insufficiency Doxorubicin 4.3317922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.7216325855
MESH:D015427 Reperfusion Injury resveratrol 3.3116317513 16314181 17058453 17520802 15827377
MESH:D012509 Sarcoma Doxorubicin 4.0617710206 15625365 16767912 17203757 18313854 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.3414601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.9117846226
MESH:D012878 Skin Neoplasms Doxorubicin 6.1715692506
MESH:D012878 Skin Neoplasms resveratrol 6.178985016 15837718
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.6715625365 16767912 17203757
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.5616321402
MESH:D019966 Substance-Related Disorders bisphenol A 4.1016684133 16045194
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.4317909728 16010429
MESH:D014062 Tongue Neoplasms resveratrol 4.2916227395
MESH:D016171 Torsades de Pointes Dobutamine 5.4619353679
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.7917653716
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.1817473185
MESH:D014591 Uterine Diseases bisphenol A 5.1414652134
MESH:D014594 Uterine Neoplasms resveratrol 4.2317044934
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 17.9317638931 17678736 16364871 17334414
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 17.9318097624
MESH:D018487 Ventricular Dysfunction, Left resveratrol 17.9317488730
MESH:D020257 Ventricular Remodeling Isoproterenol 5.8018097624
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
Pathway ID Pathway Name
KEGG:04130 SNARE interactions in vesicular transport
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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