AutismKB 2.0

Annotation Detail for SNCB


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Basic Information Top
Gene Symbol:SNCB ( - )
Gene Full Name: synuclein, beta
Band: 5q35.2
Quick LinksEntrez ID:6620; OMIM: 602569; Uniprot ID:SYUB_HUMAN; ENSEMBL ID: ENSG00000074317; HGNC ID: 11140
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Desease IDDesease Name
Nervous system diseases
Neurodegenerative diseases
H00066Lewy body dementia
Desease IDDesease Name
1709Parkinson disease
1860Brain tumor
1890Lipoidosis
No data
No data
Desease Name
Dementia, Lewy body
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SNCB mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SNCB mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of SNCB proteinincreases expression 16483693
D005419 Flavonoids Flavonoids results in increased expression of SNCB mRNAincreases expression 18035473
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SNCB mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid NCF1 protein promotes the reaction [pirinixic acid results in decreased expression of SNCB mRNA]decreases expression|increases reaction 17950772
C006253 pirinixic acid pirinixic acid results in decreased expression of SNCB mRNAdecreases expression 17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of SNCB mRNA]decreases expression|increases reaction 17950772
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SNCB mRNAincreases expression 15328365
D024505 Tocopherols Tocopherols results in increased expression of SNCB mRNAincreases expression 17654050
C025643 vinclozolin vinclozolin affects the expression of SNCB mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2414514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.2616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8619015723
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.7319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.208697196 15340226 16354765 15668235 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003456 Cryptorchidism vinclozolin 4.6714966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7819739265 16485898 11287661 16393943 19416960 19085960 17906064 14550746 16781746 11743745 12153990 19164858 14725611 11834606 12705907 16177239 18071297 12594235 17522070 10774834 11461765 16227642 11421492 17562736 12958197 18713872 10915739 12392966 10663392 16109766 11739529 11529661 19420014 14986274 16081117 19370779 2444490 15968718 19923254 12540782 15619225
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema pirinixic acid 7.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3518230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver pirinixic acid 3.0420131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.3316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.7416417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly pirinixic acid 9.4816221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.4815340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916959395 15340226 18606429 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D007248 Infertility, Male vinclozolin 3.2116467254
MESH:D007249 Inflammation Flavonoids 5.4217296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4212200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D020961 Lewy Body Disease marker/mechanism
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1316417039
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.2015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2012878042
MESH:D008107 Liver Diseases Acetaminophen 1.6812587719 16611625 19460945 16610002 11587558 12969438 19784758 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 4.5415890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 4.2417927505
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008654 Mesothelioma Tocopherols 4.2015878867
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.8411399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.8418042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.3318220299
MESH:D011471 Prostatic Neoplasms Tocopherols 4.5612504091
MESH:D011472 Prostatitis vinclozolin 5.3318629315
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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