AutismKB 2.0

Annotation Detail for FSCN1


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Basic Information Top
Gene Symbol:FSCN1 ( FLJ38511,SNL,p55 )
Gene Full Name: fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
Band: 7p22.1
Quick LinksEntrez ID:6624; OMIM: 602689; Uniprot ID:FSCN1_HUMAN; ENSEMBL ID: ENSG00000075618; HGNC ID: 11148
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2103Lymphoproliferative disorder
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in decreased expression of FSCN1 mRNAdecreases expression 15070760
15761015
20458559
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of FSCN1 mRNAaffects expression 17484886
C099555 CD 437 CD 437 results in decreased expression of FSCN1 mRNAdecreases expression 12958071
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of FSCN1 mRNAincreases expression 17403535
D016572 Cyclosporine Cyclosporine results in decreased expression of FSCN1 mRNAdecreases expression 20106945
C014347 decitabine decitabine affects the methylation of FSCN1 geneaffects methylation 17630775
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of FSCN1 mRNAaffects cotreatment|decreases expression 16054899
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of FSCN1 mRNAaffects cotreatment|decreases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of FSCN1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FSCN1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FSCN1 mRNAaffects cotreatment|increases expression 17942748
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of FSCN1 mRNAaffects cotreatment|decreases expression 16054899
D017239 Paclitaxel FSCN1 protein results in increased susceptibility to Paclitaxelincreases response to substance 16734730
C006253 pirinixic acid pirinixic acid results in increased expression of FSCN1 mRNAincreases expression 18301758
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of FSCN1 mRNAaffects cotreatment|decreases expression 17404688
C037219 quinoline quinoline analog results in increased expression of FSCN1 proteinincreases expression 18645022
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of FSCN1 mRNAaffects cotreatment|decreases expression 16054899
D013629 Tamoxifen Tamoxifen affects the expression of FSCN1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FSCN1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FSCN1 mRNAdecreases expression 15652763
D014212 Tretinoin Tretinoin results in decreased expression of FSCN1 mRNAdecreases expression 17218384
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8115322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.9819825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 6.9811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.9814692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.7816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7816835633
MESH:D000505 Alopecia Tretinoin 3.5815955085
MESH:D000544 Alzheimer Disease rosiglitazone 2.8419621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D001161 Arteriosclerosis Cyclophosphamide 10.0415014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.0411256880
MESH:D001169 Arthritis, Experimental Dexamethasone 12.1217659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 12.1215885639
MESH:D001169 Arthritis, Experimental Tretinoin 12.1216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2516292516
MESH:D001249 Asthma Tretinoin 2.3316456186
MESH:D001471 Barrett Esophagus Tretinoin 4.3616935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 21.6216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 21.6219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 21.6212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 21.6216206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.5315867366
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3117868700
MESH:D001930 Brain Injuries Progesterone 4.2215665606 15845082 15380490
MESH:D001943 Breast Neoplasms Cyclophosphamide 4.7117020986 18234424 15136595 17388661 16978400 11325840 12006526 18323546 15093573
MESH:D001943 Breast Neoplasms decitabine 4.7118320071 19208741
MESH:D001943 Breast Neoplasms Estradiol 4.7118497071 12948864 17261762 17289903 16675129 14630087 17018787 19861407
MESH:D001943 Breast Neoplasms Paclitaxel 4.7118323546 16244791 18234424 15136595 11325840 16273361 16115903 18223236
MESH:D001943 Breast Neoplasms Progesterone 4.7115562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 4.7119115204 19103187 20135344 18425577 19011961 19410462 16202921 19200415 18855134 17049068 11161223 20005174 18351453 17440819 15668708 19142967 19084267 19487384 18629630 17242785 19155303 19066611 20859285 20065188 17893378 19059307 18815881 17261762 19189212 18997820 20544844 18821012 19288272 20390343 15565566 19289846 19189210 18984771 19221464 16273361 19244106 16818667 21152245 16873071 21138602
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.7120435547
MESH:D001943 Breast Neoplasms Tretinoin 4.7116873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5516813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2911589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4316111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.743786805 16227642 16192424 15700767 16124888 15673190 16097048 15721981 16050911 16011737 18705752 10355542
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4719066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1316168501
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 16.8515553829 15073043 16217749 11135700 14691202
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 16.8518788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 16.8519701751
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.8516924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 16.8516313753
MESH:D006528 Carcinoma, Hepatocellular quinoline 16.85598648
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 16.8516924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 16.851917145
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.8516152834
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8519014326
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.5216201981
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0812490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.7219215824
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.7216096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418850075 16120746 18670907
MESH:D002386 Cataract Tretinoin 3.0717460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.4712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.4718566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5516129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis Cyclosporine 13.1519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.1516105132 15861022 17681005 11677210 16919318 17333356 17110522
MESH:D002779 Cholestasis pirinixic acid 13.1519176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7015340226 15668235 8697196 16354765 12621046
MESH:D002972 Cleft Palate Tretinoin 5.709407595
MESH:D003092 Colitis Tretinoin 3.6617035595
MESH:D003110 Colonic Neoplasms decitabine 3.9417616700
MESH:D003110 Colonic Neoplasms Dexamethasone 3.9415824018
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.5120501625
MESH:D015179 Colorectal Neoplasms decitabine 3.5118981723
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.5118802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0214669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1412609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.3810525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 5.3817728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.3815322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.3816925845 9142499 10589399 9224671 17551590 9125849 14991402 8800419 9664655 9211117
MESH:D003556 Cystitis Cyclophosphamide 4.9616413132 18372110 18093676 16614059 17979934 18433785 12161096 15643279 11948286 10498854 18710439 12913760 16989017 12388444 16651033 15276878 18295254 18483878 17010015 10700343
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0515213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3219031437
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.3712438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.2617446233
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.0311751995 10990075 15331540
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2118772604
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.4612642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4617107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.7119279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.7119279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.4517187935
MESH:D003967 Diarrhea Dexamethasone 3.667237001
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.6815998439 6884620 6623471 15027814 7440962 10092053 3786805 19336974 16227642 11566570 19085960 7120509 15968718 2869522 4309450 3732212 16177239 7179309 17522070 21278145 10915739 9327722
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.6820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D004485 Eczema Dexamethasone 4.4212438553
MESH:D004487 Edema Dexamethasone 16.1419703484
MESH:D004487 Edema pirinixic acid 16.1412083418
MESH:D004487 Edema rosiglitazone 16.1412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 16.1412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.8515322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.8518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 15.0912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 15.0917692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 15.0919031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.0919294695
MESH:D016889 Endometrial Neoplasms Estradiol 12.2619148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.2616202921 20544844 17893378 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 12.2616569247
MESH:D004715 Endometriosis Progesterone 8.8016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.809294722 10568697
MESH:D004802 Eosinophilia Cyclophosphamide 4.1811006010
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.7212903497
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.7216481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.7211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.729664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 36.4315073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 36.4317595544 16239168 12631006 61145 15959796 16045604 12795759 19224547
MESH:D005234 Fatty Liver Cyclosporine 36.4319224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 36.4315345470
MESH:D005234 Fatty Liver pirinixic acid 36.4320131406 19236843
MESH:D005234 Fatty Liver rosiglitazone 36.4319196556
MESH:D005234 Fatty Liver Tamoxifen 36.4319224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1519069698
MESH:D005355 Fibrosis Carbon Tetrachloride 20.8218705752
MESH:D005355 Fibrosis Cyclosporine 20.8212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.8220067830
MESH:D005355 Fibrosis Tretinoin 20.8217994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2216904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.188708960
MESH:D005909 Glioblastoma Tretinoin 2.9817312396
MESH:D018316 Gliosarcoma Cyclophosphamide 5.4811389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.0016376943 11014644 15172196
MESH:D006258 Head and Neck Neoplasms decitabine 7.7319215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.7316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4611294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.4614991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.5120558911
MESH:D006390 Hemangioendothelioma quinoline 5.87598648
MESH:D006394 Hemangiosarcoma quinoline 4.95598648
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3915720958
MESH:D006467 Hemophilia A Cyclophosphamide 5.2511918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.5114986274
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5519900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 8.1316221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.1312621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.057520565
MESH:D006558 Herpes Genitalis Estradiol 5.0015709030
MESH:D006689 Hodgkin Disease Cyclophosphamide 3.7516135485 17606976
MESH:D019584 Hot Flashes Estradiol 3.7217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.028697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia rosiglitazone 7.9512083418
MESH:D006930 Hyperalgesia Tretinoin 7.9516870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5016899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5316778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D006973 Hypertension Cyclosporine 8.4910903974
MESH:D006973 Hypertension Dexamethasone 8.4917042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.4918850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716945680 16569931
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.4118306037
MESH:D007154 Immune System Diseases Cyclophosphamide 5.3016076520
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3615869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Cyclophosphamide 11.147193160 16517039
MESH:D007248 Infertility, Male decitabine 11.1417581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.1417937319
MESH:D007249 Inflammation Dexamethasone 15.6511099482 8960868
MESH:D007249 Inflammation Progesterone 15.6515869954
MESH:D007249 Inflammation rosiglitazone 15.6512083418
MESH:D007249 Inflammation Tamoxifen 15.6519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.6512878042 12200463
MESH:D007333 Insulin Resistance Estradiol 12.2216627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 12.2216306350
MESH:D007333 Insulin Resistance rosiglitazone 12.2216306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7317994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.8016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.8015992940 17551590
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.4118306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4115604871
MESH:D007674 Kidney Diseases Cyclosporine 5.8518776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 5.8515618244
MESH:D007680 Kidney Neoplasms Cyclosporine 12.1612371664
MESH:D007680 Kidney Neoplasms Estradiol 12.1615610895
MESH:D007680 Kidney Neoplasms Tamoxifen 12.1618625569
MESH:D007938 Leukemia arsenic trioxide 14.8215070760
MESH:D007938 Leukemia Cyclophosphamide 14.8210602166
MESH:D007938 Leukemia decitabine 14.8219235587 18980019
MESH:D007938 Leukemia Tretinoin 14.8217143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.4817802794 17008537 18172266 18587576 17296974 17658394
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7517077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 8.5114633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 8.5110373061
MESH:D007951 Leukemia, Myeloid arsenic trioxide 15.7719077051
MESH:D007951 Leukemia, Myeloid decitabine 15.7717236224 19117987 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 15.7716932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.1116467208 19850784 20471514 16968895 17050201
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.1119010910 18704418 18460780 19387464 17679729 18206229
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.1119850784 16294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4318055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.5417649720 15748426 16966277 17869043 16823087 12679006 19225113 11161223 19075265 17217047 11468182 17712046 16112521 15622746 9834237 16330433 17107899 12018890 16891316 12712474 15213294 16331271 19642359 15336539 19035177
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.5419225113 17712046 17301526 16891316 16766008 9834237 16140955 19035177 17368321 17649720 15748426 19075265 16331271 17339181 19029980 17361223 17107899 19642359 16935935 17506722 17217047 16788101 17294898 16823087 12679006
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3116882451
MESH:D007970 Leukopenia Cyclophosphamide 4.9311830472 10052129
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.279224671
MESH:D008064 Lipidoses Tamoxifen 3.1217567588 15342952
MESH:D008080 Liposarcoma Paclitaxel 4.7817353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7817174718 11408273 11903743 16221502 21278145 16943688 17334410 16239168 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 13.2012958196 17708605 16011737 18054572 18187930 16638106 16033810 18006644 18205269 15673190 16097048 12666154 17900296 18317297 13678700 17922224 17766677 17481882 10355542 18705752 15052691 12649538 17565644 14620537 17721639 18472094 18279442 15338365 18156304 15818738 15893842 15730626 11481614 14748882 15876570 15370692 14716833 15925388 18263696 12389079 15959796 17761835 14724832 12632514 12445421 17823541 17640975 14716496 17525996 18412020 12667390 16136751 18418968 18395914 17631135 12898905 16192424 18166357 12632512 18277467 18420326 12445418 15650968 17557913 18395095 17698563 20821823 18472332 12609069 17805973 17976157 17869086 17944888 15057751 18251166 14512876 17714472 16248980 12586293 18481824 12741479 16015684 18339082 12546737 15996030 15931870 15123356 16116963 18429990 18210741 18376398 16027843 15362042
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 13.2016718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 13.2014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 13.2015474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 13.2015980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 13.2018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 13.2012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 13.2018397230 16248980
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0715720792 16964402 16246199 17285989 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6516899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 14.0614682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.0619294768
MESH:D008113 Liver Neoplasms pirinixic acid 14.0615890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 14.0616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.0616984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.6520377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.6512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.6512151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 4.8211798837 19825857
MESH:D008175 Lung Neoplasms Dexamethasone 4.8215824018 11195469
MESH:D008175 Lung Neoplasms Tamoxifen 4.8218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8211884234 19555203
MESH:D008223 Lymphoma Cyclophosphamide 7.7612854902
MESH:D008223 Lymphoma decitabine 7.7619470736
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.5516675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 8.9711911406
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 8.9714749477
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7219428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 14.0711408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 14.0717203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 14.0716827153
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 14.0714580682 19196722 11731420 16827153 19196723
MESH:D020149 Manganese Poisoning Estradiol 12.5519453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.5519453300
MESH:D008527 Medulloblastoma Tretinoin 2.7717453147
MESH:D008545 Melanoma decitabine 7.2717785578 16505122
MESH:D008545 Melanoma Paclitaxel 7.2712040289 12025231 16342250
MESH:D008545 Melanoma Tamoxifen 7.2712393984 19393235
MESH:D008545 Melanoma Tretinoin 7.2716752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1515990972
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.7616388313
MESH:D008591 Meningomyelocele Tretinoin 4.3916940565
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.3417261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7616801185
MESH:D009101 Multiple Myeloma arsenic trioxide 17.0511468182 19417148 15949261 19549372 14977855
MESH:D009101 Multiple Myeloma decitabine 17.0518172295
MESH:D009101 Multiple Myeloma Dexamethasone 17.0515867202 16118317 15744524
MESH:D009101 Multiple Myeloma Paclitaxel 17.0514749477
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 17.3816882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 17.3819010910 16882708 19157545 18608210
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 17.389809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 17.3817596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1316411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9216624393
MESH:D009362 Neoplasm Metastasis Paclitaxel 9.6715867366
MESH:D009362 Neoplasm Metastasis quinoline 9.67598648
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.6719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5019410462
MESH:D009369 Neoplasms Cyclophosphamide 11.7318854779
MESH:D009369 Neoplasms decitabine 11.7319116145 17925555 19470736
MESH:D009369 Neoplasms pirinixic acid 11.7317405874
MESH:D009369 Neoplasms Tretinoin 11.7316594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9719189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7017289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2418481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 16.1011399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.1014600291
MESH:D009421 Nervous System Malformations Tretinoin 16.109125849
MESH:D009436 Neural Tube Defects arsenic trioxide 7.2010525206
MESH:D009436 Neural Tube Defects Tretinoin 7.209142499
MESH:D009447 Neuroblastoma Cyclophosphamide 3.6216115947 15176712 8761367
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.8512837982 8761367
MESH:D009503 Neutropenia Cyclophosphamide 4.288291058
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D009845 Oligospermia Cyclophosphamide 4.6816517039
MESH:D010014 Osteolysis Paclitaxel 4.9415867366
MESH:D010051 Ovarian Neoplasms arsenic trioxide 22.7519769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms CD 437 22.7517474084
MESH:D010051 Ovarian Neoplasms decitabine 22.7519331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 22.7519401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 22.7511161223
MESH:D010051 Ovarian Neoplasms Progesterone 22.7516525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 22.7516936753
MESH:D010146 Pain Cyclophosphamide 6.9218093676 12161096
MESH:D010146 Pain Tretinoin 6.9216870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 12.2615580305
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 12.2611332152
MESH:D010190 Pancreatic Neoplasms decitabine 12.2619294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 12.2615976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010235 Paraganglioma arsenic trioxide 4.1219927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1812371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 7.7321297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 7.7321297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1611222880 11118676 11399792 11896295
MESH:D055728 Primary Myelofibrosis decitabine 4.6917616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8420887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8819131511
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 1.8817136230
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.8817136230 17172428 16729912 16356831
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011507 Proteinuria Tretinoin 3.5616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.2815861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011625 Pterygium Tretinoin 4.7616723453
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.2616636934
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.9711700416 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012208 Rhabdomyosarcoma decitabine 10.8119155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.8116116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8418045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9216646077
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.7816636934
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4916192470
MESH:D012878 Skin Neoplasms Tretinoin 5.4916467112
MESH:D013088 Spermatocele Ethinyl Estradiol 11.4716709447
MESH:D013088 Spermatocele Tamoxifen 11.4716709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.4816517039
MESH:D013119 Spinal Cord Injuries Progesterone 10.7516503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.7519457130
MESH:D013272 Stomach Diseases Dexamethasone 4.2915472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.7317007042
MESH:D013274 Stomach Neoplasms decitabine 4.7319037991
MESH:D013274 Stomach Neoplasms Paclitaxel 4.7318506536 18396642
MESH:D013274 Stomach Neoplasms Tretinoin 4.7317261132
MESH:D013276 Stomach Ulcer Dexamethasone 3.4515138204
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.0212837982
MESH:D024801 Tauopathies Paclitaxel 4.7816930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.8319014326
MESH:D013964 Thyroid Neoplasms decitabine 11.8317967635
MESH:D013964 Thyroid Neoplasms Tretinoin 11.8317045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.6619048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.7516051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9315213294
MESH:D014376 Tuberculosis Tretinoin 3.2016040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 15.6620435036 12845720 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms CD 437 15.6616720286
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 15.6614692829
MESH:D001749 Urinary Bladder Neoplasms decitabine 15.6617616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.668653321 16712894 17572228
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6416129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D014604 Uveal Neoplasms decitabine 12.7317785578
MESH:D014604 Uveal Neoplasms Tretinoin 12.7316752155
MESH:D014605 Uveitis Cyclosporine 11.671336536
MESH:D014605 Uveitis Dexamethasone 11.671336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.0216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D009396 Wilms Tumor Tretinoin 3.9316287080
MESH:D014985 Xerophthalmia Cyclosporine 4.4117120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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