AutismKB 2.0

Annotation Detail for SNTB1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SNTB1 ( 59-DAP,A1B,BSYN2,DAPA1B,FLJ22442,MGC111389,SNT2,SNT2B1,TIP-43 )
Gene Full Name: syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
Band: 8q24.12
Quick LinksEntrez ID:6641; OMIM: 600026; Uniprot ID:SNTB1_HUMAN; ENSEMBL ID: ENSG00000172164; HGNC ID: 11168
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SNTB1 mRNAincreases expression 18648102
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SNTB1 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SNTB1 mRNAdecreases expression 20064835
20106945
D005472 Fluorouracil Fluorouracil results in increased expression of SNTB1 mRNAincreases expression 16510598
C006253 pirinixic acid pirinixic acid results in increased expression of SNTB1 mRNAincreases expression 18301758
D014212 Tretinoin Tretinoin results in increased expression of SNTB1 mRNAincreases expression 16054129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.6220464547 20127859
MESH:D000230 Adenocarcinoma Fluorouracil 4.6217638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.153712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.156695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000505 Alopecia Tretinoin 3.8715955085
MESH:D000740 Anemia Fluorouracil 4.0216511603 15504547 17963324
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.2516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3216292516
MESH:D001249 Asthma Tretinoin 2.4216456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7816935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.0819483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.0816206674 16197459
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9120146248 17474063
MESH:D001943 Breast Neoplasms Fluorouracil 1.9119217205 16557594 15136595 18608205 18357371 16110121 16595493
MESH:D001943 Breast Neoplasms Tretinoin 1.9116166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.0516813970
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1916051944
MESH:D002277 Carcinoma Fluorouracil 3.8217121937
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6816168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.937296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.9312619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.9317045692 16332177 16799960 17971768 18930000 17088986
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.931917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.927296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.9218695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.9720419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.9718986760 16757204 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.9716096774 16051514
MESH:D002386 Cataract Tretinoin 3.2617460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.967505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.0516129372
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.6219486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.6219176532
MESH:D002822 Choriocarcinoma Tretinoin 5.6816461808
MESH:D002972 Cleft Palate Tretinoin 2.789407595
MESH:D003092 Colitis Tretinoin 4.1217035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2717016597 15001691 17172411 17725105 17287894 18772588 17018589 16510598 17169374 16340194
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017094418 17695437 17454858 18448328 16391804 16282729 17016601 20501625 18288408 16524972 18949393 18802399 17255274 16303861 17401013 16331619 18509181 14970324 15148649 17594712 15289873 18383874
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8310589399 9224671 17551590 16925845 9664655 8800419 14991402 9125849 9211117 9142499
MESH:D007644 Darier Disease Fluorouracil 5.2516733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2111298694 11906362 18759878 12868966 8970840 2524372 14531868 8156756
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.843621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0311289319 1440618 16192314 18289764 18692083 18648102 9328219 6679447 8291058 9022650 6482804 9653073 7440962
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004489 Edema, Cardiac Tretinoin 4.9918230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3016569247
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.623581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.6216530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.6215173087 16481741 17638652 16785472 16337965
MESH:D005124 Eye Abnormalities Tretinoin 3.8116938888 9664655
MESH:D005234 Fatty Liver pirinixic acid 3.0920131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005355 Fibrosis Tretinoin 3.9317994277
MESH:D005909 Glioblastoma Tretinoin 3.1917312396
MESH:D005910 Glioma Fluorouracil 2.9716145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.4715102660 15162350 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.4716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.1420471113
MESH:D006330 Heart Defects, Congenital Tretinoin 7.1414991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006529 Hepatomegaly pirinixic acid 3.4116221962 18467677 19772884 19176532
MESH:D006930 Hyperalgesia Tretinoin 3.4616870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9916778211
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007410 Intestinal Diseases Tretinoin 4.1817994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.549022650 8074119
MESH:D007569 Jaw Abnormalities Tretinoin 4.2315992940 17551590
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.386582329
MESH:D007680 Kidney Neoplasms Fluorouracil 8.3816985049
MESH:D007938 Leukemia Tretinoin 2.9017143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0216932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1216294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3419035177 16935935 15748426 17649720 17339181 19029980 17712046 16823087 17368321 17294898 17107899 12679006 16788101 19225113 9834237 17301526 17217047 16140955 16891316 17506722 16766008 19075265 17361223 16331271 19642359
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.539224671
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.389327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4215474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.4216248980 18397230
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.5515890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.5520195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 11.5517045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 11.5520007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.571399818 3712494 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.578603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.6214755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6220869020 17053015 18569708 18520028 6695378 20464547 20135361 18816296 20064080
MESH:D008175 Lung Neoplasms Fluorouracil 3.6215246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.2515086387
MESH:D008527 Medulloblastoma Tretinoin 2.8817453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.8416940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.3416381670
MESH:D009062 Mouth Neoplasms Fluorouracil 9.3416757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009369 Neoplasms Benzo(a)pyrene 13.0111141357
MESH:D009369 Neoplasms Fluorouracil 13.0116928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 13.0117405874
MESH:D009369 Neoplasms Tretinoin 13.0116946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.169125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.876679447
MESH:D009436 Neural Tube Defects Tretinoin 7.879142499
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6416436463
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.726482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4216936753
MESH:D010146 Pain Tretinoin 3.1616870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.6519003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.6515976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1617292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.1618626508 19082440
MESH:D011507 Proteinuria Tretinoin 3.9516636307
MESH:D011625 Pterygium Tretinoin 5.2616723453
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3018722050 18286688 15538739 16160472
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4516116481 16283617
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.1110029692 19755658
MESH:D012878 Skin Neoplasms Tretinoin 6.1116467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.492093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 3.4916951190 19015929 18396642 17172411 17498489 17522103 16424979 15786421 18567086 19084572
MESH:D013274 Stomach Neoplasms Tretinoin 3.4917261132
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.943712494 6587162 7505956 6582329 1399818
MESH:D013964 Thyroid Neoplasms Tretinoin 7.9417045167 16026305
MESH:D014062 Tongue Neoplasms Fluorouracil 10.8616280240
MESH:D014062 Tongue Neoplasms Tretinoin 10.8616051514
MESH:D014376 Tuberculosis Tretinoin 3.4116040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.318074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3117053015
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 10.4816803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 10.4816129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.1316752155
MESH:D014820 Vitiligo Tretinoin 4.4416761959
MESH:D009396 Wilms Tumor Tretinoin 4.2516287080
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved