AutismKB 2.0

Annotation Detail for SNX1


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Basic Information Top
Gene Symbol:SNX1 ( HsT17379,MGC8664,SNX1A,Vps5 )
Gene Full Name: sorting nexin 1
Band: 15q22.31
Quick LinksEntrez ID:6642; OMIM: 601272; Uniprot ID:SNX1_HUMAN; ENSEMBL ID: ENSG00000028528; HGNC ID: 11172
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SNX1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SNX1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SNX1 mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of SNX1 mRNAdecreases expression 15336504
D004041 Dietary Fats Dietary Fats results in increased expression of SNX1 mRNAincreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SNX1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SNX1 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in increased expression of SNX1 mRNAincreases expression 18035473
D019833 Genistein Genistein results in increased expression of SNX1 mRNAincreases expression 16169203
C008493 methylselenic acid methylselenic acid results in increased expression of SNX1 mRNAincreases expression 18548127
D009532 Nickel MT1 affects the reaction [Nickel affects the expression of SNX1 mRNA]affects expression|affects reaction 16166738
D009532 Nickel MT2 affects the reaction [Nickel affects the expression of SNX1 mRNA]affects expression|affects reaction 16166738
C041786 palm oil palm oil results in increased expression of SNX1 mRNAincreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of SNX1 mRNAdecreases expression 17426115
D012643 Selenium Selenium results in increased expression of SNX1 mRNAincreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of SNX1 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SNX1 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9015322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D055371 Acute Lung Injury Nickel 9.3516166738
MESH:D055371 Acute Lung Injury pirinixic acid 9.3518653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3814692618
MESH:D000230 Adenocarcinoma Genistein 4.3811473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.0716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.0716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001161 Arteriosclerosis Dietary Fats 10.0515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.0511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.8619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.8612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001943 Breast Neoplasms Dietary Fats 2.0020435547
MESH:D001943 Breast Neoplasms Genistein 2.0016541309 17200150 16873071
MESH:D001943 Breast Neoplasms Nickel 2.0015986119
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.5816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.583084413
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.5816924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3816120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Genistein 3.3216332659
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8116919318 15861022 16105132 17110522 17681005 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 7.8119176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7915894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1116354765 15668235 8697196 12621046 15340226
MESH:D003092 Colitis Selenium 3.8217936198
MESH:D003110 Colonic Neoplasms Genistein 2.2917182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0618551238
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.9917244072 19470301 17100760
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003877 Dermatitis, Contact Nickel 4.672952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8016285004
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3517107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.1018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.1010774834 19739265 12392966 19370779 12958197 18713872 19085960 11743745 16781746 11287661 16109766 17906064 11834606 11739529 14986274 17562736 15968718 11529661 16177239 12153990 17522070 14550746 12705907 10663392 15619225 12540782 14725611 16393943 11421492 19164858 16081117 2444490 16227642 18071297 11461765 19923254 19416960 10915739 12594235 16485898 19420014
MESH:D056486 Drug-Induced Liver Injury Selenium 12.1015131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.1015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.1020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4718367378
MESH:D004487 Edema pirinixic acid 6.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2212538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.6416402032
MESH:D016889 Endometrial Neoplasms Genistein 3.3811473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.059294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Dietary Fats 13.2317967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.2315345470
MESH:D005234 Fatty Liver pirinixic acid 13.2320131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005355 Fibrosis Dietary Fats 8.7618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.7620067830
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D005909 Glioblastoma Genistein 3.2816598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3410048152 11294989
MESH:D006333 Heart Failure pirinixic acid 7.0120558911
MESH:D006333 Heart Failure Selenium 7.0117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly pirinixic acid 8.4018467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.4016120746 12621046 15340226
MESH:D015658 HIV Infections Nickel 3.8317263646
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1116959395 8697196 16354765 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6221332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6521332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9118670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5017937319
MESH:D007249 Inflammation Dietary Fats 12.1320412841
MESH:D007249 Inflammation Flavonoids 12.1317296493
MESH:D007249 Inflammation Nickel 12.1316166738
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.1312200463 12878042
MESH:D007251 Influenza, Human Selenium 4.2616624496
MESH:D007333 Insulin Resistance Dietary Fats 12.4418457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 12.4416306350
MESH:D007333 Insulin Resistance Sodium Selenite 12.4414714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2115629191 12587719
MESH:D007676 Kidney Failure, Chronic Selenium 3.9116518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.0016705839
MESH:D007938 Leukemia Genistein 3.0418980019 17468513
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8918296743
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.4417823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6312587719 12969438 16610002 19460945 19014921 16611625 19784758 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2617185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 4.2816377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.2816984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1212151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2319555203 11884234
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0914737004
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.2212929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.2215318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008654 Mesothelioma Selenium 2.8015107826
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009203 Myocardial Infarction Genistein 5.7117141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.7119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.4617141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.4616411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9118551238
MESH:D009369 Neoplasms pirinixic acid 1.9617405874
MESH:D009421 Nervous System Malformations Genistein 9.7316427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7314600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D009765 Obesity Dietary Fats 4.4519632207 11836018 18674790 20132043 21332399 20518802 18457598 17217161 16723640
MESH:D009765 Obesity pirinixic acid 4.4520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.4516049721 12819281
MESH:D010024 Osteoporosis Genistein 3.2719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1216169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6119005980
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010954 Plasmacytoma Selenium 4.9515087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2411896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Genistein 2.7115378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.7116205645
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.7118760546
MESH:D011537 Pruritus Ethinyl Estradiol 3.3615861022 16919318
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5518551238
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.638532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0016709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.2916049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.3710091137
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D015430 Weight Gain Dietary Fats 3.7616723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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