AutismKB 2.0

Annotation Detail for SORD


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Basic Information Top
Gene Symbol:SORD ( SORD1 )
Gene Full Name: sorbitol dehydrogenase
Band: 15q21.1
Quick LinksEntrez ID:6652; OMIM: 182500; Uniprot ID:DHSO_HUMAN; ENSEMBL ID: ENSG00000140263; HGNC ID: 11184
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-4101sorbitol degradation I
Pathway IDPathway Name
hsa01100Metabolic pathways
hsa00051Fructose and mannose metabolism
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035208 2-amino-4,6-dinitrotoluene 2-amino-4,6-dinitrotoluene affects the expression of SORD mRNAaffects expression 21346803
C004726 2-dichlorobenzene 2-dichlorobenzene results in increased activity of SORD proteinincreases activity 3012827
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SORD mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of SORD mRNAaffects expression 17562736
D000082 Acetaminophen ABCC2 protein affects the reaction [Acetaminophen results in increased activity of SORD protein]affects reaction|increases activity 16271353
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SORD mRNAaffects expression 16483693
C015001 arsenite arsenite results in increased expression of SORD mRNAincreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in increased expression of SORD mRNA]affects reaction|increases expression 18929588
C095105 bexarotene bexarotene results in decreased expression of SORD mRNAdecreases expression 16648578
C032036 bromobenzene bromobenzene results in increased activity of SORD proteinincreases activity 3012827
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of SORD mRNAincreases expression 15336504
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased activity of SORD proteinincreases activity 16928893
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased activity of SORD proteinincreases activity 17177172
D002251 Carbon Tetrachloride Dimethyl Sulfoxide inhibits the reaction [Carbon Tetrachloride results in increased activity of SORD protein]decreases reaction|increases activity 17177172
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of SORD proteinincreases expression 17374462
C007164 cumene hydroperoxide cumene hydroperoxide results in increased activity of SORD proteinincreases activity 16928893
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide inhibits the reaction [Carbon Tetrachloride results in increased activity of SORD protein]decreases reaction|increases activity 17177172
D004726 Endosulfan Endosulfan results in decreased activity of SORD proteindecreases activity 11692196
D004726 Endosulfan Endosulfan results in increased activity of SORD proteinincreases activity 8588293
D005632 Fructose Fructose results in increased glycation of SORD proteinincreases glycation 8761460
D005632 Fructose [Fructose results in increased glycation of SORD protein] which results in decreased activity of SORD proteindecreases activity|increases glycation 8761460
D019833 Genistein Genistein results in decreased expression of SORD mRNAdecreases expression 15378649
D005947 Glucose Glucose results in increased expression of SORD mRNAincreases expression 16805838
D010656 Phenylephrine Phenylephrine results in decreased expression of SORD mRNAdecreases expression 18158353
D013311 Streptozocin Streptozocin results in decreased expression of and results in decreased activity of SORD proteindecreases activity|decreases expression 8761460
D013311 Streptozocin Streptozocin results in increased expression of SORD mRNAincreases expression 8761460
D013311 Streptozocin Streptozocin results in increased glycation of SORD proteinincreases glycation 8761460
D014303 Trinitrotoluene Trinitrotoluene affects the expression of SORD mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 2-amino-4,6-dinitrotoluene 9.157525203
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 9.157525203
MESH:D000138 Acidosis Ammonium Chloride 3.5018287403
MESH:D000230 Adenocarcinoma Genistein 2.4611473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.713712494
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.0517460149
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.961440618 11289319
MESH:D001919 Bradycardia Phenylephrine 4.4815306635
MESH:D001943 Breast Neoplasms bexarotene 2.5616818667 16344269
MESH:D001943 Breast Neoplasms Genistein 2.5617200150 16873071 16541309
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7218705752 16011737 16227642 15700767 15673190 15721981 3786805 10355542 16050911 16124888 16097048 16192424
MESH:D002276 Carcinoid Tumor Streptozocin 5.5516051944
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.487296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.483084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.4818788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.4816924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.2016247446
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.647296757
MESH:D006332 Cardiomegaly Phenylephrine 3.5011179087 15728586 16170337 11754973 17124262 17287366
MESH:D002318 Cardiovascular Diseases Genistein 3.2616332659
MESH:D002386 Cataract Acetaminophen 7.3810977129
MESH:D002386 Cataract Trinitrotoluene 7.3814694615 15817613
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.717505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.109022650 19486331
MESH:D003110 Colonic Neoplasms arsenite 3.9415037631
MESH:D003110 Colonic Neoplasms Genistein 3.9417182828
MESH:D000013 Congenital Abnormalities 2-amino-4,6-dinitrotoluene 9.8615095906
MESH:D000013 Congenital Abnormalities Trinitrotoluene 9.8615095906
MESH:D003327 Coronary Disease Fructose 4.4318504504
MESH:D003490 Cyanosis Endosulfan 11.587900959
MESH:D003490 Cyanosis Trinitrotoluene 11.5818551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7418759878 11298694 8156756 2524372 14531868 11906362 12868966 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.432952479 3621924
MESH:D003920 Diabetes Mellitus Streptozocin 4.6716285004
MESH:D003921 Diabetes Mellitus, Experimental Fructose 8.9118603373
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 8.911374869 7637645 2177838 19298542 19496084 6379147 12083368 19960420 19586609 16684804 8740154 15862027 18603373 12644472 17874149 15298345 11260395 17442507 12093613 15831366 18715473 16286809 11055810 12446591
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.6118603373
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 7.4018603373
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 7.4016647724
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 7.4019586609 19647726
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.6616025228
MESH:D003928 Diabetic Nephropathies Streptozocin 4.6119960420 19682444
MESH:D003930 Diabetic Retinopathy Streptozocin 5.3617662242
MESH:D056486 Drug-Induced Liver Injury 2-amino-4,6-dinitrotoluene 15.0421346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 15.0411289319 16192314 9653073 9328219 6679447 18692083 18289764 7440962 18648102 1440618 9022650 8291058 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.0411743745 17906064 19370779 16109766 11461765 17522070 18713872 19923254 18071297 15968718 17562736 2444490 15619225 11834606 11739529 12958197 10663392 16081117 14725611 19164858 16393943 16227642 10915739 12594235 12392966 14986274 11529661 16177239 12705907 19085960 19416960 11421492 16781746 19420014 12540782 10774834 12153990 11287661 19739265 14550746 16485898
MESH:D056486 Drug-Induced Liver Injury bromobenzene 15.0412628495 10092053
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 15.0421278145 15968718 17522070 3732212 7179309 9327722 6884620 7440962 10915739 16227642 4309450 11566570 2869522 19336974 3786805 10092053 15998439 19085960 16177239 6623471 15027814 7120509
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 15.0421346803 18551238
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004417 Dyspnea Endosulfan 5.227900959 3388749
MESH:D004646 Emphysema Endosulfan 6.507900959
MESH:D018159 Endolymphatic Hydrops Dimethyl Sulfoxide 6.5120641076
MESH:D004714 Endometrial Hyperplasia Genistein 4.5316402032
MESH:D016889 Endometrial Neoplasms Genistein 3.3211473722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.093581430
MESH:D005234 Fatty Liver arsenite 13.0318296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.0312795759 16045604 12631006 61145 15959796 16239168 19224547 17595544
MESH:D005234 Fatty Liver Fructose 13.0318641190 18395287 19196556
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.966705139
MESH:D005355 Fibrosis arsenite 14.7018296743
MESH:D005355 Fibrosis Carbon Tetrachloride 14.7018705752
MESH:D005355 Fibrosis Fructose 14.7018504504
MESH:D005756 Gastritis Acetaminophen 3.6216983495
MESH:D005909 Glioblastoma Genistein 3.2216598420
MESH:D018149 Glucose Intolerance Fructose 5.2619165636
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.977505956
MESH:D034381 Hearing Loss Dimethyl Sulfoxide 5.1120641076
MESH:D006331 Heart Diseases Streptozocin 4.2312093613
MESH:D006470 Hemorrhage Endosulfan 5.237900959
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.016705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.0119110552 19900420
MESH:D006529 Hepatomegaly Trinitrotoluene 4.1715817613
MESH:D006930 Hyperalgesia Acetaminophen 2.6516870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4716899240
MESH:D006946 Hyperinsulinism Fructose 4.8419008412 18563319 14757778 18360027 15752949
MESH:D006949 Hyperlipidemias Fructose 4.6915752949
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8815034207
MESH:D006973 Hypertension Fructose 5.8514573337 16843071 14568997 14633139 19008412
MESH:D006973 Hypertension Phenylephrine 5.858949925 12717712
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0215338365
MESH:D015228 Hypertriglyceridemia Fructose 5.0219342510 19799862
MESH:D006984 Hypertrophy Phenylephrine 4.4918502941 12791704
MESH:D007248 Infertility, Male Endosulfan 7.418588293 9432128
MESH:D007248 Infertility, Male Trinitrotoluene 7.4112150543
MESH:D007333 Insulin Resistance Fructose 4.2018981581 14633139 19799862 19586609 17133782 18563319 14757778 14573337 18057795 19008412 19342510
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.969022650 8074119
MESH:D007674 Kidney Diseases 2-dichlorobenzene 10.258440869
MESH:D007674 Kidney Diseases Acetaminophen 10.2515629191 12587719
MESH:D007674 Kidney Diseases Streptozocin 10.2512093613
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.916582329
MESH:D007859 Learning Disorders Endosulfan 5.048157075
MESH:D007938 Leukemia Genistein 2.9917468513 18980019
MESH:D008103 Liver Cirrhosis arsenite 6.7118296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.7117334410 11903743 21278145 16943688 11408273 16221502 17157831 16239168 17174718
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.159327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.7118420326 12649538 14724832 12958196 15057751 18412020 16033810 18156304 12609069 15362042 15052691 15925388 17944888 16027843 18263696 18279442 18705752 17761835 11481614 15818738 20821823 17766677 18166357 16638106 17976157 17631135 15893842 18006644 18472332 17708605 14748882 14716496 15959796 14620537 17565644 15996030 16097048 12898905 15650968 17922224 18481824 15876570 12586293 16248980 16015684 12445421 18277467 18418968 16011737 17640975 18395095 17869086 14716833 12546737 17900296 12632514 16116963 18429990 12741479 18205269 18317297 17823541 15338365 17525996 12666154 17481882 15730626 15370692 14512876 15673190 12445418 17557913 18376398 18187930 18251166 18472094 15931870 13678700 17714472 16192424 12667390 18054572 16136751 17805973 10355542 12389079 12632512 17721639 17698563 18210741 18339082 15123356 18395914
MESH:D008106 Liver Cirrhosis, Experimental Dimethyl Sulfoxide 3.7111682029
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.7117823541
MESH:D008107 Liver Diseases 2-dichlorobenzene 6.658661352 8440869 1949037 1853346
MESH:D008107 Liver Diseases Acetaminophen 6.6519784758 12587719 12969438 19014921 16611625 16610002 11587558 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.6515720792 16246199 17285989 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.2116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.2116899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.2019294768
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.783712494 6587162 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.7812014681 15583823
MESH:D008175 Lung Neoplasms arsenite 2.9316809336
MESH:D008175 Lung Neoplasms bexarotene 2.9317849452
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.0811161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 6.2515591091 19196722 19196723
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.2512929590 14578162
MESH:D008545 Melanoma Glucose 3.0614993021
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D024821 Metabolic Syndrome X Fructose 4.7618497449 17098227 19165636 16815490 17261469
MESH:D009203 Myocardial Infarction Genistein 2.8317141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.6117141266
MESH:D009336 Necrosis Trinitrotoluene 4.7018551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.443581430
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.7319196722
MESH:D009389 Neovascularization, Pathologic arsenite 4.3515738583
MESH:D009421 Nervous System Malformations Genistein 3.9716427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.876679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8118514411
MESH:D009765 Obesity Fructose 3.4117707055 18585860
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.024026338 6482804
MESH:D009784 Occupational Diseases Trinitrotoluene 9.0212819281 17852074 14694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.963988306
MESH:D010024 Osteoporosis Genistein 3.2119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.0216169203
MESH:D010051 Ovarian Neoplasms Genistein 2.5819005980
MESH:D010146 Pain Acetaminophen 2.3416870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 9.567296757
MESH:D010212 Papilloma cumene hydroperoxide 9.5617234724 12065085
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.416228378
MESH:D011471 Prostatic Neoplasms Genistein 3.4915378649 15256057 16925846
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.323692021
MESH:D012640 Seizures Endosulfan 6.617539098 10698677
MESH:D012640 Seizures Trinitrotoluene 6.6118551238
MESH:D012852 Sinusitis Phenylephrine 4.647327846
MESH:D012878 Skin Neoplasms cumene hydroperoxide 9.718532709 12065085 17234724
MESH:D012878 Skin Neoplasms Glucose 9.7114993021
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.718532709
MESH:D013163 Splenomegaly Trinitrotoluene 5.1415817613
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.836582329 6587162 1399818 7505956 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.258074119
MESH:D014581 Urticaria Acetaminophen 2.9110982225
Pathway ID Pathway Name
KEGG:00051 Fructose and mannose metabolism
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36021
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    DB01907 - Nicotinamide-Adenine-Dinucleotide
    DB04478 - Cp-166572, 2-Hydroxymethyl-4-(4-N,N-Dimethylaminosulfonyl-1-Piperazino)-Pyrimidine
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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