AutismKB 2.0

Annotation Detail for SOS2


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Basic Information Top
Gene Symbol:SOS2 ( FLJ25596 )
Gene Full Name: son of sevenless homolog 2 (Drosophila)
Band: 14q21.3
Quick LinksEntrez ID:6655; OMIM: 601247; Uniprot ID:SOS2_HUMAN; ENSEMBL ID: ENSG00000100485; HGNC ID: 11188
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05160Hepatitis C
hsa04912GnRH signaling pathway
hsa04910Insulin signaling pathway
hsa04012ErbB signaling pathway
hsa04010MAPK signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04320Dorso-ventral axis formation
hsa04540Gap junction
hsa04630Jak-STAT signaling pathway
hsa04722Neurotrophin signaling pathway
hsa05211Renal cell carcinoma
hsa05223Non-small cell lung cancer
hsa05221Acute myeloid leukemia
hsa05220Chronic myeloid leukemia
hsa04810Regulation of actin cytoskeleton
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa05200Pathways in cancer
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Axon guidance
Signaling by Rho GTPases
No data
Pathway IDPathway Name
P00053T cell activation
P00018EGF receptor signaling pathway
P00005Angiogenesis
P00010B cell activation
P00048PI3 kinase pathway
P00047PDGF signaling pathway
P00021FGF signaling pathway
P00034Integrin signalling pathway
P00032Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
P00036Interleukin signaling pathway
P04393Ras Pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SOS2 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SOS2 mRNAaffects expression 16483693
D001554 Benzene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of SOS2 mRNAaffects cotreatment|increases expression 17905399
D002117 Calcitriol Calcitriol results in increased expression of SOS2 mRNAincreases expression 16002434
C065180 fluvastatin [zoledronic acid co-treated with fluvastatin] results in increased expression of SOS2 mRNAaffects cotreatment|increases expression 16996129
C030957 methylmercury II [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of SOS2 mRNAaffects cotreatment|increases expression 17905399
C004648 testosterone enanthate testosterone enanthate affects the expression of SOS2 mRNAaffects expression 17440010
D014241 Trichloroethylene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of SOS2 mRNAaffects cotreatment|increases expression 17905399
C088658 zoledronic acid [zoledronic acid co-treated with fluvastatin] results in increased expression of SOS2 mRNAaffects cotreatment|increases expression 16996129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D058186 Acute Kidney Injury zoledronic acid 4.6719715164
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.7720200999
MESH:D000741 Anemia, Aplastic Benzene 4.5317661222 11369114 14761424
MESH:D001855 Bone Marrow Diseases Benzene 5.5516183116
MESH:D001859 Bone Neoplasms zoledronic acid 5.1815867366 16121404 17312309 19442620 16778634 11697798
MESH:D001862 Bone Resorption zoledronic acid 4.9116769263 8053405 15845617 18496637 18404659 11869084
MESH:D001943 Breast Neoplasms Benzene 2.1417162533 11921183
MESH:D001943 Breast Neoplasms Calcitriol 2.1411237771
MESH:D001943 Breast Neoplasms Trichloroethylene 2.1415986119
MESH:D001943 Breast Neoplasms zoledronic acid 2.1416096432 18695136
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 1.7816705839
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 3.6019233551
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 3.9318507039
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6711237771
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.906135515
MESH:D003327 Coronary Disease fluvastatin 4.9316142594
MESH:D019465 Craniofacial Abnormalities Benzene 2.4515643154
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2818551238
MESH:D003872 Dermatitis Benzene 5.0215902427
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.5018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 4.507120509
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.1715138306
MESH:D005264 Femoral Fractures zoledronic acid 6.1116234978
MESH:D006402 Hematologic Diseases Benzene 4.8716183116
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.0617440010
MESH:D006930 Hyperalgesia zoledronic acid 4.4116769263
MESH:D006934 Hypercalcemia zoledronic acid 5.2518089816 19622757
MESH:D006973 Hypertension Benzene 3.1517940673
MESH:D006996 Hypocalcemia zoledronic acid 6.5112669777
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.1516705839
MESH:D007938 Leukemia Benzene 3.4814694614 18335105 17119257 15935818
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 4.9718089816
MESH:D007951 Leukemia, Myeloid Benzene 4.5217506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.7219478238
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.217678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.822876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Benzene 10.8212562636
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 10.827955063
MESH:D017563 Lung Diseases, Interstitial Benzene 5.1314698565
MESH:D008175 Lung Neoplasms Benzene 2.4212562636
MESH:D008223 Lymphoma Benzene 3.8817584886 17119257
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.7312562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 7.0711921183
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 7.0717312309
MESH:D008654 Mesothelioma zoledronic acid 3.8216675582
MESH:D009101 Multiple Myeloma Benzene 13.3517119195
MESH:D009101 Multiple Myeloma fluvastatin 13.3516996129
MESH:D009101 Multiple Myeloma zoledronic acid 13.3516996129 18089719 19621390
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.1518551238 7678174
MESH:D009362 Neoplasm Metastasis zoledronic acid 3.7119139120 17312309 15867366
MESH:D009369 Neoplasms Trichloroethylene 3.6411911487
MESH:D009436 Neural Tube Defects Benzene 3.8015643154
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.8216049721
MESH:D009784 Occupational Diseases Benzene 9.8215935809 17178637 16737584 17119257 15913788 15576619 15727169 17479406 15612468
MESH:D010014 Osteolysis zoledronic acid 5.6515867366
MESH:D010024 Osteoporosis zoledronic acid 4.1517882678
MESH:D010051 Ovarian Neoplasms Benzene 3.0212562636
MESH:D010146 Pain zoledronic acid 4.1016475674
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.0615572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.7012479363 16289102 15754350 18247401 16644109
MESH:D011471 Prostatic Neoplasms zoledronic acid 3.7019103299 12438248
MESH:D012512 Sarcoma, Ewing's zoledronic acid 5.1716121404
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6718551238
MESH:D013274 Stomach Neoplasms Benzene 2.4212562636
MESH:D013953 Thymus Neoplasms Benzene 5.2410850423
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3516049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6010091137
MESH:D014594 Uterine Neoplasms Benzene 4.5712562636
Pathway ID Pathway Name
KEGG:05221 Acute myeloid leukemia
REACT:18266 Axon guidance
KEGG:04662 B cell receptor signaling pathway
KEGG:04062 Chemokine signaling pathway
KEGG:05220 Chronic myeloid leukemia
KEGG:04320 Dorso-ventral axis formation
KEGG:05213 Endometrial cancer
KEGG:04012 ErbB signaling pathway
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04510 Focal adhesion
KEGG:04540 Gap junction
KEGG:05214 Glioma
KEGG:04912 GnRH signaling pathway
KEGG:05160 Hepatitis C
KEGG:04910 Insulin signaling pathway
KEGG:04630 Jak-STAT signaling pathway
KEGG:04010 MAPK signaling pathway
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04722 Neurotrophin signaling pathway
KEGG:05223 Non-small cell lung cancer
KEGG:05200 Pathways in cancer
KEGG:05215 Prostate cancer
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05211 Renal cell carcinoma
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
REACT:11061 Signalling by NGF
KEGG:04660 T cell receptor signaling pathway
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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