AutismKB 2.0

Annotation Detail for SOX5


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Basic Information Top
Gene Symbol:SOX5 ( L-SOX5,MGC35153 )
Gene Full Name: SRY (sex determining region Y)-box 5
Band: 12p12.1
Quick LinksEntrez ID:6660; OMIM: 604975; Uniprot ID:SOX5_HUMAN; ENSEMBL ID: ENSG00000134532; HGNC ID: 11201
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1860Brain tumor
1897Seminoma
2239Lymphoma
Desease Name
PHARMACOGENOMIC
response to antipsychotic treatment
AIDS
INFECTION
Desease Name
PR interval
Response to antipsychotic treatment
AIDS
Response to statin therapy
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SOX5 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SOX5 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SOX5 mRNAaffects expression 20382639
C006780 bisphenol A bisphenol A affects the expression of SOX5 mRNAaffects expression 20170705
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SOX5 mRNAaffects expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SOX5 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SOX5 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOX5 mRNAaffects cotreatment|increases expression 17942748
D009151 Mustard Gas Mustard Gas results in increased expression of SOX5 mRNAincreases expression 15674844
D013629 Tamoxifen Tamoxifen affects the expression of SOX5 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOX5 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1315322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001249 Asthma Mustard Gas 2.7610378619
MESH:D001281 Atrial Fibrillation marker/mechanism 20062060
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001768 Blister Mustard Gas 5.4419167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001862 Bone Resorption bisphenol A 4.0711985600
MESH:D001943 Breast Neoplasms bisphenol A 1.8517123778
MESH:D001943 Breast Neoplasms Tamoxifen 1.8521152245 19221464 16873071 19244106 17049068 16818667 19011961 18351453 19084267 19142967 19410462 19155303 16273361 18821012 19487384 18629630 20390343 19059307 17242785 15668708 19200415 18815881 20859285 15565566 17440819 16202921 21138602 17893378 17261762 18997820 19288272 19066611 19189212 18855134 20544844 19189210 19289846 11161223 20065188 19103187 20005174 20135344 19115204 18425577 18984771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8520435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.4415286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.2917687719 10378619
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0416124888 16192424 16011737 16050911 16097048 15700767 15673190 18705752 3786805 10355542 16227642 15721981
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.683084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6818788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6816924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.2717123778
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8620889678
MESH:D002659 Child Development Disorders, Pervasive marker/mechanism 20808228
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0216105132 17333356 11677210 16919318 15861022 17110522 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1816354765 15340226 8697196 12621046 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4311743745 17522070 14550746 16081117 14725611 11461765 19739265 18071297 12540782 17906064 10663392 10915739 12153990 16227642 16781746 19416960 18713872 10774834 15619225 12594235 11739529 11834606 11529661 15968718 14986274 17562736 12705907 19923254 16485898 16393943 2444490 19420014 19370779 11287661 12958197 16109766 19085960 12392966 16177239 19164858 11421492
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.436623471 10915739 11566570 21278145 6884620 7440962 3732212 15027814 15998439 7179309 15968718 16177239 7120509 16227642 4309450 19085960 3786805 2869522 19336974 9327722 17522070 10092053
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Mustard Gas 7.5311428647 11428631 11402378 9260866
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.5311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2216714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.7519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1716202921 17893378 20544844 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004890 Erythema Mustard Gas 5.449357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.3316239168 61145 15959796 12631006 19224547 16045604 17595544 12795759
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.3315345470
MESH:D005234 Fatty Liver Tamoxifen 14.3314986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Carbon Tetrachloride 9.4718705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.4720067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4310048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8319900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1516120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 18606429 16959395 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Mustard Gas 8.9011428647 9357497 16001271 17524151 11428620 8975870 11428631 11402378 9260866
MESH:D007249 Inflammation Tamoxifen 8.9019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.9012878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 3.4116393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3015629191 12587719
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2118625569
MESH:D008064 Lipidoses Tamoxifen 3.3017567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9117174718 11903743 16239168 11408273 21278145 17157831 16221502 16943688 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5516033810 13678700 18277467 17714472 18418968 12546737 14620537 17708605 14724832 12898905 17976157 17761835 17944888 18187930 15876570 12667390 12389079 18395914 16116963 18412020 16011737 18210741 17640975 15931870 14512876 16248980 18420326 15818738 12445421 17766677 16015684 15673190 15123356 12958196 17698563 15338365 18339082 16192424 12609069 17805973 18395095 17631135 15370692 17557913 18006644 12632512 18317297 16638106 18263696 12632514 17481882 17922224 12445418 15730626 17565644 18251166 14748882 18376398 15925388 15893842 20821823 12649538 18166357 12741479 15996030 18156304 18279442 17721639 18472332 18429990 11481614 10355542 15052691 16136751 18481824 18205269 15362042 15959796 14716833 14716496 12666154 18472094 15057751 17869086 16097048 18705752 17823541 18054572 17525996 12586293 17900296 15650968 16027843
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5512878042
MESH:D008107 Liver Diseases Acetaminophen 4.0519784758 16610002 12969438 11587558 19014921 16611625 12587719 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0517285989 16964402 15830285 16246199 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.0616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.0616899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.7919294768
MESH:D008113 Liver Neoplasms Tamoxifen 7.7916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1612151625
MESH:D008171 Lung Diseases Mustard Gas 3.5818161513 18702808
MESH:D008175 Lung Neoplasms Mustard Gas 3.538781369 3148597
MESH:D008175 Lung Neoplasms Tamoxifen 3.5318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5319555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7419196723 19196722 11731420 16827153 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219196722 19200415 19189210
MESH:D009421 Nervous System Malformations bisphenol A 10.3911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.3914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009503 Neutropenia Mustard Gas 4.1916761898 7688884
MESH:D010049 Ovarian Diseases bisphenol A 5.2711985600
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D011041 Poisoning Mustard Gas 4.0215727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.4810548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.4811118676 11222880 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4120887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.2416740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2415067354
MESH:D011537 Pruritus Ethinyl Estradiol 10.4915861022 16919318
MESH:D011537 Pruritus Mustard Gas 10.4918058305
MESH:D011629 Puberty, Precocious bisphenol A 5.0710548101
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9910334151 17266442 17620002 17894541 17720292
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012871 Skin Diseases Mustard Gas 2.7612880345 16961503 15451306
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.6516709447
MESH:D013088 Spermatocele Tamoxifen 12.6516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D019966 Substance-Related Disorders bisphenol A 4.2716045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.428653321 17572228 16712894
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014591 Uterine Diseases bisphenol A 5.3314652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36038
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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