AutismKB 2.0

Annotation Detail for SOX9


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Basic Information Top
Gene Symbol:SOX9 ( CMD1,CMPD1,SRA1 )
Gene Full Name: SRY (sex determining region Y)-box 9
Band: 17q24.3
Quick LinksEntrez ID:6662; OMIM: 608160; Uniprot ID:SOX9_HUMAN; ENSEMBL ID: ENSG00000125398; HGNC ID: 11204
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
1940Ovarian disease
2025Polyarthritis
No data
No data
Desease Name
Campomelic dysplasia
Acampomelic campomelic dysplasia
Campomelic dysplasia with autosomal sex reversal
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of SOX9 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of SOX9 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SOX9 mRNAaffects expression 16483693
D016718 Arachidonic Acid Arachidonic Acid results in decreased expression of SOX9 mRNAdecreases expression 16704987
D001151 Arsenic SOX9 mRNA results in decreased susceptibility to Arsenicdecreases response to substance 17976673
D001374 Azacitidine Azacitidine affects the expression of SOX9 mRNAaffects expression 18033690
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of SOX9 mRNAincreases expression 15336504
C014347 decitabine decitabine results in increased expression of SOX9 mRNAincreases expression 19151715
D003907 Dexamethasone Dexamethasone promotes the reaction [BMP2 protein results in increased expression of SOX9 mRNA]increases expression|increases reaction 17502159
D003907 Dexamethasone Dexamethasone promotes the reaction [TGFB1 protein results in increased expression of SOX9 mRNA]increases expression|increases reaction 17502159
D002117 Calcitriol Calcitriol results in decreased expression of SOX9 mRNAdecreases expression 16002434
D004958 Estradiol Estradiol affects the expression of SOX9 mRNAaffects expression 14699072
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SOX9 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of SOX9 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of SOX9 mRNAincreases expression 19619570
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of SOX9 mRNAaffects cotreatment|decreases expression 17404688
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOX9 mRNAaffects cotreatment|increases expression 17942748
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of SOX9 mRNAaffects cotreatment|increases expression 17183730
C475919 hydroxytamoxifen hydroxytamoxifen results in decreased expression of SOX9 mRNAdecreases expression 16849584
D015735 Mifepristone Mifepristone results in increased expression of SOX9 mRNAincreases expression 17584828
D016226 Phosphorus, Dietary Phosphorus, Dietary affects the expression of SOX9 mRNAaffects expression 16311027
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SOX9 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of SOX9 mRNAincreases expression 18445702
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of SOX9 mRNAaffects cotreatment|decreases expression 17404688
D011374 Progesterone Progesterone results in decreased expression of SOX9 mRNAdecreases expression 17404688
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of SOX9 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of SOX9 mRNAdecreases expression 19244175
D013629 Tamoxifen Tamoxifen affects the expression of SOX9 mRNAaffects expression 14699072
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SOX9 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SOX9 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SOX9 mRNAincreases expression 19619570
15056799
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOX9 mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin results in increased expression of SOX9 mRNAincreases expression 16480812
D014212 Tretinoin Tretinoin results in decreased expression of SOX9 mRNAdecreases expression 16505366
D014212 Tretinoin Tretinoin results in decreased expression of SOX9 proteindecreases expression 15961395
C034613 triacsin C triacsin C results in decreased expression of SOX9 mRNAdecreases expression 16704987
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of SOX9 mRNAaffects cotreatment|increases expression 17183730
D014801 Vitamin A [RARA gene mutant form co-treated with Vitamin A] results in decreased expression of SOX9 mRNAaffects cotreatment|decreases expression 16397886
D014801 Vitamin A RARG gene mutant form inhibits the reaction [[RARA gene mutant form co-treated with Vitamin A] results in decreased expression of SOX9 mRNA]affects cotreatment|decreases expression|decreases reaction 16397886
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of SOX9 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of SOX9 mRNAdecreases expression 19244175
C063449 zileuton zileuton results in increased expression of SOX9 mRNAincreases expression 19544365
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.5511752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.558875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 9.6919490988
MESH:D000015 Abnormalities, Multiple Vitamin A 9.6910992263
MESH:D000138 Acidosis Ammonium Chloride 3.3318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 11.3317505938
MESH:D000152 Acne Vulgaris zileuton 11.3320436887
MESH:D055371 Acute Lung Injury pirinixic acid 8.6918653653
MESH:D055371 Acute Lung Injury zileuton 8.6917118201
MESH:D000230 Adenocarcinoma Estradiol 4.0211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.0214692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.623712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.1416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.1416835633
MESH:D018246 Adrenocortical Adenoma Arsenic 4.9817306315
MESH:D000505 Alopecia Tretinoin 3.4415955085
MESH:D000550 Amblyopia Valproic Acid 5.0017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.3211748828
MESH:D000740 Anemia Vitamin A 8.3216960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.6016960172
MESH:D000799 Angioedema Acetaminophen 3.6110982225
MESH:C536377 Anonychia congenita marker/mechanism 19639023
MESH:D001008 Anxiety Disorders Valproic Acid 3.3917497229
MESH:D020261 Arsenic Poisoning Arsenic 2.8018414634 16835338 16251483 12569548
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2411256880
MESH:D001169 Arthritis, Experimental Dexamethasone 11.4717659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.4715885639
MESH:D001169 Arthritis, Experimental Tretinoin 11.4716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Tretinoin 7.7716456186
MESH:D001249 Asthma Vitamin A 7.7716732791
MESH:D001249 Asthma zileuton 7.7710181070 10764316 20332717 9620945 8598621 17944539 19214143
MESH:D001250 Asthma, Exercise-Induced zileuton 5.3710984370
MESH:D050197 Atherosclerosis Arsenic 3.1219371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 2.2018445737
MESH:D001321 Autistic Disorder Arachidonic Acid 2.2018582451
MESH:D001321 Autistic Disorder Valproic Acid 2.2018985861 17688650 16609825 18316065 18940202 20603192 19460635 17507914 18558336 18775368 18177632 18396377 17157402 15238991 19232924
MESH:D001471 Barrett Esophagus Tretinoin 4.1816935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.791440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 2.9617594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.0819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.0812125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.0816206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.5415746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.548888407
MESH:D001929 Brain Edema zileuton 5.6519309543
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1117868700
MESH:D001930 Brain Injuries Progesterone 4.0315665606 15845082 15380490
MESH:D001943 Breast Neoplasms Calcitriol 3.6211237771
MESH:D001943 Breast Neoplasms decitabine 3.6218320071 19208741
MESH:D001943 Breast Neoplasms Estradiol 3.6212948864 17018787 16675129 17289903 17261762 18497071 14630087 19861407
MESH:D001943 Breast Neoplasms Progesterone 3.6216175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tamoxifen 3.6219115204 20390343 15565566 19289846 18855134 19288272 18821012 21138602 19103187 19487384 19189210 15668708 19142967 21152245 20135344 19200415 18997820 20859285 19066611 17261762 20065188 19011961 19084267 17049068 18629630 17440819 20005174 16873071 16202921 19410462 18815881 17893378 17242785 19059307 19244106 20544844 18425577 18351453 18984771 19221464 16818667 19189212 11161223 19155303 16273361
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6220435547
MESH:D001943 Breast Neoplasms Tretinoin 3.6216166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity zileuton 4.6212388339 12654629 12794006
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 12.2616813970
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 12.2617377406 17426644
MESH:D055036 Campomelic Dysplasia marker/mechanism
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2316111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.7116050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6216835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4617687452 15504454
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2819066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9316168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 10.887296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.883084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 10.8817306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.8816924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 10.8816924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 10.881917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.577296757
MESH:D002294 Carcinoma, Squamous Cell Arsenic 10.2717687452 18922899 15504454
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 10.2711237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 10.2719215824
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.2716096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 8.8418640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.8417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2418850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.2915738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.1216973168 18022660
MESH:D002386 Cataract Acetaminophen 6.7810977129
MESH:D002386 Cataract Tretinoin 6.7817460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.147505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.1418566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3616129372
MESH:D002659 Child Development Disorders, Pervasive marker/mechanism 20868653
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6320734317
MESH:D015362 Child Nutrition Disorders Vitamin A 5.2416153327
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9716835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 17.919022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 17.9117681005 17333356 17110522 15861022 16105132 16919318 11677210
MESH:D002779 Cholestasis pirinixic acid 17.9119176532
MESH:D002779 Cholestasis Vitamin A 17.9116175620
MESH:D002822 Choriocarcinoma Tretinoin 4.9316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.3612621046 15668235 16354765 8697196 15340226
MESH:D002972 Cleft Palate Tretinoin 9.369407595
MESH:D002972 Cleft Palate Vitamin A 9.3616054864
MESH:D003092 Colitis Selenium 8.7517936198
MESH:D003092 Colitis Tretinoin 8.7517035595
MESH:D003110 Colonic Neoplasms decitabine 8.0717616700
MESH:D003110 Colonic Neoplasms Dexamethasone 8.0715824018
MESH:D003110 Colonic Neoplasms Vitamin A 8.0717219422 16267017
MESH:D003110 Colonic Neoplasms zileuton 8.0718927292
MESH:D015179 Colorectal Neoplasms Azacitidine 2.8419934284
MESH:D015179 Colorectal Neoplasms decitabine 2.8418981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8714669216 17141729
MESH:D019465 Craniofacial Abnormalities marker/mechanism 11807034
MESH:D019465 Craniofacial Abnormalities Dexamethasone 9.1317728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 9.1315322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 9.139125849 9211117 10589399 16925845 17551590 9142499 8800419 9664655 9224671 14991402
MESH:D019465 Craniofacial Abnormalities Valproic Acid 9.1316575769 17688650 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin A 9.1310992263
MESH:D019465 Craniofacial Abnormalities Vitamin E 9.1319769572
MESH:D003665 Decompression Sickness zileuton 5.9918309904
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1419031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 6.3112868966 8970840 14531868 11298694 11906362 2524372 18759878 8156756
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 6.3112438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.283621924 2952479
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.4416506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6117107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.2019279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.2019279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2717187935
MESH:D003967 Diarrhea Dexamethasone 3.487237001
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 14.356679447 18648102 18289764 11289319 16192314 8291058 7440962 6482804 1440618 9653073 9022650 18692083 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.3511743745 19164858 10663392 15619225 10774834 2444490 16781746 12594235 12540782 12392966 11739529 18071297 12153990 14986274 14550746 10915739 11529661 16109766 18713872 19420014 11461765 16485898 19416960 19923254 14725611 16393943 11421492 19739265 11287661 15968718 19085960 12958197 17906064 16227642 16177239 12705907 11834606 19370779 17522070 17562736 16081117
MESH:D056486 Drug-Induced Liver Injury Selenium 14.3515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.3520420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 14.3519641884 1733752
MESH:D056486 Drug-Induced Liver Injury zileuton 14.3517944539
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5911462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.5716146918
MESH:D004421 Dystonia Valproic Acid 3.841851702
MESH:C538011 Eales disease Vitamin A 12.359068938
MESH:C538011 Eales disease Vitamin E 12.359068938
MESH:D004480 Ectromelia Vitamin A 5.5916054864
MESH:D004485 Eczema Dexamethasone 4.2412438553
MESH:D004487 Edema Arachidonic Acid 19.519831321 9599246 11698051 15177302 16716910 7990266
MESH:D004487 Edema Dexamethasone 19.5119703484
MESH:D004487 Edema pirinixic acid 19.5112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 19.5111000095 12711302
MESH:D004487 Edema zileuton 19.5117118201 7812673 8273558 9831321 7990266 19703484 11698051
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1718230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.1718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 20.1215138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 20.1212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 20.1217692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 20.1219031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.8819294695
MESH:D016889 Endometrial Neoplasms Estradiol 11.5718566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.5716202921 17893378 19155303 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 11.5716569247
MESH:D004715 Endometriosis Mifepristone 14.1816134523
MESH:D004715 Endometriosis Progesterone 14.1816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 14.189294722 10568697
MESH:D019446 Endotoxemia zileuton 5.1315328337
MESH:D004802 Eosinophilia zileuton 4.698621850 10764316
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.933659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.693922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.8220417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.407562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.077750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.843659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.053581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.289664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 17.0715345470
MESH:D005234 Fatty Liver pirinixic acid 17.0719236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 17.0719224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 17.0719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D005315 Fetal Diseases Valproic Acid 4.6616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.9118558336 8888407
MESH:D005327 Fetal Resorption Vitamin A 5.1316054864
MESH:D005334 Fever Arachidonic Acid 4.4611852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.796705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3014745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9519069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.8720067830
MESH:D005355 Fibrosis Tretinoin 7.8717994277
MESH:D005534 Foot Diseases Arsenic 5.336392382
MESH:D005596 Fractures, Closed zileuton 5.6119544365
MESH:D005756 Gastritis Acetaminophen 3.4416983495
MESH:D005909 Glioblastoma Tretinoin 2.8617312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.827505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006228 Hand Deformities, Congenital marker/mechanism 19639023
MESH:D006258 Head and Neck Neoplasms decitabine 7.3219215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.3216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 15.0410048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 15.049664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin A 15.0410992263 16080930
MESH:D006330 Heart Defects, Congenital Vitamin E 15.0416080930
MESH:D006333 Heart Failure pirinixic acid 6.4920558911
MESH:D006333 Heart Failure Selenium 6.4917162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.306705139
MESH:D006529 Hepatomegaly pirinixic acid 13.2719176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.2712621046 15340226 16120746
MESH:D006529 Hepatomegaly zileuton 13.278661344
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 9.247520565
MESH:D006548 Hernia, Diaphragmatic Vitamin A 9.2416490937 16877224 15707848 16863852 16292552 17436238
MESH:D006548 Hernia, Diaphragmatic Vitamin E 9.2416490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.8015709030
MESH:D015658 HIV Infections Vitamin A 3.7016960176
MESH:D006679 HIV Seropositivity Vitamin A 5.3717209195
MESH:D019584 Hot Flashes Estradiol 9.2817088409
MESH:D019584 Hot Flashes Vitamin E 9.2814716179
MESH:D006849 Hydrocephalus Valproic Acid 4.6417688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8118606429 15340226 16959395 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 7.0316870215
MESH:D006930 Hyperalgesia Tretinoin 7.0316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3416778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9920558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.2617050553
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7115034207
MESH:D006973 Hypertension Arsenic 8.189931084 11953799 16076760
MESH:D006973 Hypertension Dexamethasone 8.1817042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.1818670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.4016612254
MESH:D006976 Hypertension, Pulmonary zileuton 4.5014726295
MESH:D006986 Hypervitaminosis A Vitamin A 5.9416054864
MESH:D006987 Hypesthesia Arsenic 5.3316093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5816945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 11.1015869954
MESH:D020244 Infarction, Middle Cerebral Artery zileuton 11.1019309543
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2512013081
MESH:D007248 Infertility, Male decitabine 6.2217581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.2217937319
MESH:D007249 Inflammation Arachidonic Acid 18.4517371808 15177302 9831321
MESH:D007249 Inflammation Dexamethasone 18.4511099482 8960868
MESH:D007249 Inflammation Progesterone 18.4515869954
MESH:D007249 Inflammation Tamoxifen 18.4519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.4512200463 12878042
MESH:D007249 Inflammation zileuton 18.458960868 18309904 18295198 9831321 7812673 17118201 8621850 18059327
MESH:D015212 Inflammatory Bowel Diseases zileuton 4.0615339030
MESH:D007251 Influenza, Human Selenium 10.1916624496
MESH:D007251 Influenza, Human Vitamin E 10.1916624496
MESH:D007333 Insulin Resistance Estradiol 6.7116627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.7116306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5417994277
MESH:D019586 Intracranial Hypertension Vitamin A 5.5915955940
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.799022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2517551590 15992940
MESH:D007642 Keratosis Arsenic 4.7612749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 9.2815629191 12587719
MESH:D007674 Kidney Diseases Estradiol 9.2815618244
MESH:D007674 Kidney Diseases Vitamin E 9.2812488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.6816518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 11.346582329
MESH:D007680 Kidney Neoplasms Estradiol 11.3415610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.3418625569
MESH:D007938 Leukemia Azacitidine 9.9619148494
MESH:D007938 Leukemia decitabine 9.9618980019 19235587
MESH:D007938 Leukemia Tretinoin 9.9617143497
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive zileuton 4.6119503090 19823023
MESH:D007951 Leukemia, Myeloid Azacitidine 14.9319077051
MESH:D007951 Leukemia, Myeloid decitabine 14.9319117987 17236224 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 14.9319285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 8.4418720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute decitabine 8.4418206229 19010910 19387464 17679729 18704418 18460780
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 8.4416294345 17596541 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 8.4416294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2318055864
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.9819299654
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.2717339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.2717301526 16331271 17217047 17107899 17361223 16788101 16935935 15748426 19029980 17368321 12679006 9834237 19225113 17339181 17506722 16823087 16891316 16140955 17294898 19642359 19035177 17649720 19075265 17712046 16766008
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.979224671
MESH:D017880 Limb Deformities, Congenital Vitamin A 7.9716054864
MESH:D008064 Lipidoses Tamoxifen 2.9915342952 17567588
MESH:D008103 Liver Cirrhosis Vitamin A 3.7516256175
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0615034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 12.7416718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 12.7414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 12.7415474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 12.7418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 12.7412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 12.7416248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 12.7416248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 12.7416169303
MESH:D008107 Liver Diseases Acetaminophen 6.3219460945 16611625 16610002 19784758 11587558 12969438 12587719 19014921
MESH:D008107 Liver Diseases Arsenic 6.3211134558
MESH:D008107 Liver Diseases Vitamin A 6.3216175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 4.9316762690
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0417185352 16871587
MESH:D008113 Liver Neoplasms Arsenic 9.9716368122
MESH:D008113 Liver Neoplasms pirinixic acid 9.9716377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 9.9716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.9716984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.113712494 1399818 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.1112151625
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 9.1117113696
MESH:D008171 Lung Diseases Vitamin A 7.2816863852
MESH:D008171 Lung Diseases Vitamin E 7.2816863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.0317228818
MESH:D008175 Lung Neoplasms Arsenic 8.1817306315 17976673 19168569
MESH:D008175 Lung Neoplasms Azacitidine 8.1821224363
MESH:D008175 Lung Neoplasms Dexamethasone 8.1811195469 15824018
MESH:D008175 Lung Neoplasms Tamoxifen 8.1818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.1819555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 8.1811062179
MESH:D008223 Lymphoma decitabine 3.2619470736
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5319428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.0717203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.0717203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 13.0715318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.0714580682 16827153 19196722 19196723 11731420
MESH:D020149 Manganese Poisoning Estradiol 11.8719453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.8719453300
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma decitabine 4.8817785578 16505122
MESH:D008545 Melanoma Tamoxifen 4.8812393984 19393235
MESH:D008545 Melanoma Tretinoin 4.8816752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9515990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3419513568
MESH:D008591 Meningomyelocele Tretinoin 4.2016940565
MESH:D008654 Mesothelioma Selenium 2.7015107826
MESH:D008881 Migraine Disorders Valproic Acid 3.0318803445 18765137
MESH:D009006 Monosomy Azacitidine 5.8519299654
MESH:D009101 Multiple Myeloma Azacitidine 16.0519549372 18443271
MESH:D009101 Multiple Myeloma decitabine 16.0518172295
MESH:D009101 Multiple Myeloma Dexamethasone 16.0515867202 15744524 16118317
MESH:D009101 Multiple Myeloma Vitamin A 16.0516374440
MESH:D009135 Muscular Diseases pirinixic acid 3.2816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.828888407
MESH:D009190 Myelodysplastic Syndromes Azacitidine 21.7119805378 18720364 17596541 17611569
MESH:D009190 Myelodysplastic Syndromes decitabine 21.7116882708 19010910 19157545 18608210
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 21.719809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 21.7117596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 21.7117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0519151258
MESH:D017202 Myocardial Ischemia Arsenic 8.4115371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.4112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.6716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.6716411023
MESH:D009298 Nasal Polyps zileuton 5.9910665187
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.393581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.3919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms decitabine 7.6119116145 19470736 17925555
MESH:D009369 Neoplasms pirinixic acid 7.6117405874
MESH:D009369 Neoplasms Tretinoin 7.6116946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7719200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5017289903
MESH:D009421 Nervous System Malformations Estradiol 15.0611399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.0614600291
MESH:D009421 Nervous System Malformations Tretinoin 15.069125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 21.226679447
MESH:D009436 Neural Tube Defects Arsenic 21.2216620997
MESH:D009436 Neural Tube Defects Tretinoin 21.229142499
MESH:D009436 Neural Tube Defects Valproic Acid 21.2216359493 8888407
MESH:D009436 Neural Tube Defects Vitamin A 21.2217400914
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6918514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.1617056641
MESH:D009765 Obesity pirinixic acid 1.7620558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.224026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.793988306
MESH:D010051 Ovarian Neoplasms Arsenic 17.9217306315
MESH:D010051 Ovarian Neoplasms decitabine 17.9219259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 17.9219401270
MESH:D010051 Ovarian Neoplasms Mifepristone 17.9216525653
MESH:D010051 Ovarian Neoplasms Progesterone 17.9217393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 17.9216936753
MESH:D010146 Pain Acetaminophen 10.3316870215
MESH:D010146 Pain Tretinoin 10.3316870215
MESH:D010146 Pain zileuton 10.3315935457
MESH:D010190 Pancreatic Neoplasms decitabine 5.1019294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.1015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.267296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.9616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.7615371236 6392382 16905509
MESH:D010538 Peritonitis zileuton 5.0317371808
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.246228378
MESH:D010855 Pierre Robin Syndrome marker/mechanism 19234473
MESH:D010954 Plasmacytoma Selenium 4.6615087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.4221297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.7011896295 11222880 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.7020603192
MESH:D055728 Primary Myelofibrosis decitabine 4.5017616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5515572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6820887781
MESH:D011471 Prostatic Neoplasms Arsenic 1.8816140617
MESH:D011471 Prostatic Neoplasms Azacitidine 1.8818324645
MESH:D011471 Prostatic Neoplasms Calcitriol 1.8818247401 16289102 16644109 15754350 12479363
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8815084515
MESH:D011507 Proteinuria Arsenic 8.5721343184
MESH:D011507 Proteinuria Tretinoin 8.5716636307
MESH:D011537 Pruritus Ethinyl Estradiol 9.1516919318 15861022
MESH:D011537 Pruritus zileuton 9.1519657356 17827870
MESH:D019310 Pseudolymphoma Valproic Acid 4.3111422049 12752131
MESH:D011625 Pterygium Tretinoin 4.5616723453
MESH:D011654 Pulmonary Edema zileuton 5.1918309904
MESH:D015427 Reperfusion Injury pirinixic acid 6.5719058328
MESH:D015427 Reperfusion Injury zileuton 6.5715266012 9865762
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.8111700416 18379247
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.5716877224
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.213692021
MESH:D012208 Rhabdomyosarcoma decitabine 17.2919155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 17.2916116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 17.2919155313
MESH:D012220 Rhinitis zileuton 4.6420332717
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7818045962
MESH:D012559 Schizophrenia Valproic Acid 2.0419110320 15737665
MESH:D012640 Seizures Valproic Acid 2.5917978042 14763951 11044598 11738929 1511512 16876388 15475178 3137016
MESH:D012852 Sinusitis zileuton 5.2910665187
MESH:D012871 Skin Diseases Arsenic 7.7316702368 17050553 19834688 17938729 16759981 17548696 6392382 18709164 15952646 16353154 17453740
MESH:D012871 Skin Diseases Vitamin A 7.7318709164
MESH:D012871 Skin Diseases Vitamin E 7.7318709164
MESH:D012878 Skin Neoplasms Arsenic 12.6917976673 19538983 17029826 17050553 16251483 15504454
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.698532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.6916192470
MESH:D012878 Skin Neoplasms Tretinoin 12.6916467112
MESH:D020181 Sleep Apnea, Obstructive zileuton 5.6319118273
MESH:D013088 Spermatocele Ethinyl Estradiol 10.7916709447
MESH:D013088 Spermatocele Tamoxifen 10.7916709447
MESH:D013119 Spinal Cord Injuries Progesterone 17.3015862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 17.3019457130
MESH:D013119 Spinal Cord Injuries zileuton 17.3018059327
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.3112833885
MESH:D013272 Stomach Diseases Dexamethasone 4.0915472012
MESH:D013274 Stomach Neoplasms decitabine 2.4919037991
MESH:D013274 Stomach Neoplasms Tretinoin 2.4917261132
MESH:D013276 Stomach Ulcer Dexamethasone 3.2915138204
MESH:D020521 Stroke Vitamin E 3.3416517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.006587162 1399818 3712494 7505956 6582329
MESH:D013964 Thyroid Neoplasms decitabine 11.0017967635
MESH:D013964 Thyroid Neoplasms Tretinoin 11.0017045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.4519048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.5916051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.0017262798
MESH:D014376 Tuberculosis Tretinoin 3.0916040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.293119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.218074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 11.2117306315 17976673 19322015 19429237 11144890 18640142 15987713
MESH:D001749 Urinary Bladder Neoplasms decitabine 11.2119087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.2117572228 8653321 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.428888407
MESH:D014581 Urticaria Acetaminophen 2.7710982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4816129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0814692618
MESH:D014604 Uveal Neoplasms decitabine 12.0617785578
MESH:D014604 Uveal Neoplasms Tretinoin 12.0616752155
MESH:D014605 Uveitis Dexamethasone 4.591336536
MESH:D014652 Vascular Diseases Arsenic 4.5117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3314671159 15869587
MESH:D014802 Vitamin A Deficiency Vitamin A 5.0616175781 16960172 16146918
MESH:D014820 Vitiligo Tretinoin 3.8416761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D009396 Wilms Tumor Tretinoin 3.7816287080
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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