AutismKB 2.0

Annotation Detail for SP1


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Basic Information Top
Gene Symbol:SP1 ( - )
Gene Full Name: Sp1 transcription factor
Band: 12q13.13
Quick LinksEntrez ID:6667; OMIM: 189906; Uniprot ID:SP1_HUMAN; ENSEMBL ID: ENSG00000185591; HGNC ID: 11205
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
hsa04350TGF-beta signaling pathway
No data
Pathway IDPathway Name
200030HIF-2-alpha transcription factor network
200171Validated targets of C-MYC transcriptional repression
200002Regulation of nuclear SMAD2/3 signaling
200027E2F transcription factor network
200130C-MYB transcription factor network
200158IL2 signaling events mediated by STAT5
200120FOXM1 transcription factor network
200172HIF-1-alpha transcription factor network
200073FOXA2 and FOXA3 transcription factor networks
200072Regulation of Telomerase
200018IL4-mediated signaling events
200118AP-1 transcription factor network
200044Validated transcriptional targets of AP1 family members Fra1 and Fra2
200101Direct p53 effectors
200194FOXA1 transcription factor network
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1712Yersinia infection
1740Alzheimer's disease
1826Cystic fibrosis
1850Herpes
1919Corneal disease
1934Cancer
2042Thrombophlebitis
2069Schizophrenia
2258Keratoconus
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C492909 1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane SP1 protein affects the reaction [1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane results in increased expression of CDKN1A protein]affects reaction|increases expression 15345676
C477819 15-deoxyprostaglandin J2 15-deoxyprostaglandin J2 results in decreased expression of SP1 proteindecreases expression 15908479
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of SP1 mRNAdecreases expression 18648102
C090942 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin promotes the reaction [SP1 protein binds to PLAT promoter]]affects binding|decreases reaction|increases reaction 18419748
C054852 7-hydroxystaurosporine 7-hydroxystaurosporine results in increased expression of SP1 mRNAincreases expression 14653808
C054852 7-hydroxystaurosporine 7-hydroxystaurosporine results in increased expression of SP1 proteinincreases expression 14653808
C054852 7-hydroxystaurosporine 7-hydroxystaurosporine results in increased expression of SP1 mRNAincreases expression 14653808
C054852 7-hydroxystaurosporine 7-hydroxystaurosporine results in increased expression of SP1 proteinincreases expression 14653808
D000079 Acetaldehyde SP1 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]increases expression|increases reaction 16025520
D000082 Acetaminophen Acetaminophen affects the expression of SP1 mRNAaffects expression 17562736
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Sodium Selenite results in decreased expression of SP1 protein]decreases expression|decreases reaction 16928829
D012436 S-Adenosylmethionine S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]affects binding|decreases reaction|increases reaction 15983038
D012436 S-Adenosylmethionine S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]affects binding|decreases reaction|increases reaction 15983038
D012436 S-Adenosylmethionine S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter]affects binding|decreases reaction 15983038
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SP1 mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of SP1 mRNAdecreases expression 17442060
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of SP1 proteindecreases expression 17442060
D000643 Ammonium Chloride Ammonium Chloride results in decreased phosphorylation of SP1 proteindecreases phosphorylation 17442060
C006632 arsenic trioxide arsenic trioxide inhibits the reaction [SP1 protein binds to CYTL1 promoter]affects binding|decreases reaction 15761015
C006632 arsenic trioxide arsenic trioxide inhibits the reaction [SP1 protein binds to MYC promoter]affects binding|decreases reaction 15761015
C006632 arsenic trioxide arsenic trioxide inhibits the reaction [SP1 protein binds to TERT promoter]affects binding|decreases reaction 15761015
C006632 arsenic trioxide arsenic trioxide inhibits the reaction [SP1 protein results in increased expression of TERT mRNA]decreases reaction|increases expression 11714746
C006632 arsenic trioxide arsenic trioxide results in decreased activity of SP1 proteindecreases activity 11714746
C006632 arsenic trioxide arsenic trioxide results in decreased expression of SP1 mRNAdecreases expression 20435036
C006632 arsenic trioxide arsenic trioxide results in decreased expression of SP1 proteindecreases expression 20435036
C006632 arsenic trioxide arsenic trioxide results in increased oxidation of and results in decreased activity of SP1 proteindecreases activity|increases oxidation 15761015
D001194 Asbestos Asbestos results in increased expression of SP1increases expression 15636197
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of SP1 mRNAaffects expression 17331233
D001374 Azacitidine Azacitidine promotes the reaction [SP1 protein binds to KIR2DL2 promoter]affects binding|increases reaction 18945643
D001374 Azacitidine Azacitidine promotes the reaction [SP1 protein binds to KIR2DL4 promoter]affects binding|increases reaction 18945643
D001374 Azacitidine Azacitidine promotes the reaction [SP1 protein binds to AQP5 promoter]affects binding|increases reaction 17198683
D001564 Benzo(a)pyrene Benzo(a)pyrene affects the activity of SP1 proteinaffects activity 20624995
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [SP1 protein binds to ARNT promoter]affects binding|increases reaction 14529614
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of and results in increased activity of SP1 proteinincreases activity|increases phosphorylation 14529614
C070515 bisindolylmaleimide I bisindolylmaleimide I results in increased expression of SP1 mRNAincreases expression 14653808
C070515 bisindolylmaleimide I bisindolylmaleimide I results in increased expression of SP1 proteinincreases expression 14653808
C099555 CD 437 CD 437 results in increased expression of SP1 proteinincreases expression 15059897
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased activity of SP1 proteinincreases activity 16159668
D004390 Chlorpyrifos Chlorpyrifos affects the expression of SP1 mRNAaffects expression 17452286
D003474 Curcumin Curcumin results in decreased expression of SP1 proteindecreases expression 18347134
18593936
C014347 decitabine [decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to CLDN3 promoter]affects binding|affects cotreatment|increases reaction 17986852
C014347 decitabine [[decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to SLC25A1 promoter]] which results in increased expression of SLC25A1 mRNAaffects binding|affects cotreatment|increases expression|increases reaction 18706393
C014347 decitabine decitabine promotes the reaction [SP1 protein binds to CIDEA promoter]affects binding|increases reaction 18033804
C014347 decitabine decitabine promotes the reaction [SP1 protein binds to CLDN3 promoter]affects binding|increases reaction 17986852
C014347 decitabine decitabine promotes the reaction [SP1 protein binds to SLC25A1 promoter]affects binding|increases reaction 18706393
C014347 decitabine decitabine results in increased expression of SP1 mRNAincreases expression 19027835
C014347 decitabine decitabine results in increased expression of SP1 proteinincreases expression 19027835
C014347 decitabine decitabine results in increased expression of SP1 mRNAincreases expression 15251184
C014347 decitabine [Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of SP1 mRNAaffects cotreatment|increases expression 15251184
C007262 deoxynivalenol deoxynivalenol promotes the reaction [SP1 protein binds to MLL promoter]affects binding|increases reaction 19438726
C007262 deoxynivalenol deoxynivalenol results in increased phosphorylation of SP1 proteinincreases phosphorylation 19438726
C007262 deoxynivalenol SP1 protein promotes the reaction [deoxynivalenol results in increased expression of MLL mRNA]increases expression|increases reaction 19438726
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of SP1 mRNAincreases expression 16714842
D011397 Promegestone mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]]affects binding|decreases reaction|increases reaction 16807381
D011397 Promegestone Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]affects binding|increases reaction 16807381
D011397 Promegestone Promegestone results in increased expression of SP1 mRNAincreases expression 16807381
D011397 Promegestone Promegestone results in increased expression of SP1 proteinincreases expression 16807381
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide promotes the reaction [SP1 protein binds to CAD promoter]affects binding|increases reaction 16675542
D004317 Doxorubicin Doxorubicin affects the activity of SP1 proteinaffects activity 17108358
D004317 Doxorubicin Doxorubicin promotes the reaction [SP1 protein binds to BIRC5 promoter]affects binding|increases reaction 17124180
D004317 Doxorubicin Doxorubicin promotes the reaction [SP1 protein binds to ESR1 promoter]affects binding|increases reaction 19351845
D004317 Doxorubicin Doxorubicin promotes the reaction [TP53 protein binds to SP1 protein]affects binding|increases reaction 19351845
D004958 Estradiol Estradiol promotes the reaction [ESR1 protein binds to SP1 protein]affects binding|increases reaction 16675542
D004958 Estradiol Estradiol promotes the reaction [SP1 protein binds to VDR promoter]affects binding|increases reaction 17088408
D004958 Estradiol Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [SP1 protein binds to CYP1A1 promoter]]affects binding|increases reaction 16675542
D004958 Estradiol Estradiol results in increased activity of SP1 proteinincreases activity 17088408
D004958 Estradiol Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to SP1 protein]]affects binding|decreases reaction|increases reaction 16675542
D004958 Estradiol U 0126 inhibits the reaction [Estradiol results in increased activity of SP1 protein]decreases reaction|increases activity 17088408
D004958 Estradiol Estradiol promotes the reaction [[SP1 protein binds to VEGFA promoter] which results in increased expression of VEGFA mRNA]affects binding|increases expression|increases reaction 15774498
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SP1 mRNAdecreases expression 16954407
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased activity of SP1 proteinincreases activity 15878629
D004997 Ethinyl Estradiol SP1 protein promotes the reaction [Ethinyl Estradiol results in increased expression of AGER mRNA]increases expression|increases reaction 15878629
D005047 Etoposide Etoposide results in increased phosphorylation of SP1 proteinincreases phosphorylation 17441964
D005047 Etoposide PRKDC protein promotes the reaction [Etoposide results in increased phosphorylation of SP1 protein]increases phosphorylation|increases reaction 17441964
D005047 Etoposide wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of SP1 protein]decreases reaction|increases phosphorylation 17441964
D005472 Fluorouracil Fluorouracil promotes the reaction [[TP53 protein binds to SP1 protein] which binds to CDKN1A promoter]affects binding|increases reaction 15489892
D005472 Fluorouracil SP1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]affects cotreatment|affects response to substance 18927307
D005492 Folic Acid Folic Acid inhibits the reaction [SP1 protein binds to IGF1R promoter]affects binding|decreases reaction 16728583
C070081 fulvestrant fulvestrant promotes the reaction [SP1 protein binds to ESRRA promoter]affects binding|increases reaction 20211987
D019833 Genistein Genistein promotes the reaction [SP1 protein binds to VDR promoter]affects binding|increases reaction 17088408
D019833 Genistein Genistein results in increased activity of SP1 proteinincreases activity 17088408
D019833 Genistein U 0126 inhibits the reaction [Genistein results in increased activity of SP1 protein]decreases reaction|increases activity 17088408
D005978 Glutathione Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP1 protein]decreases expression|decreases reaction 20435036
C086566 glycitein glycitein promotes the reaction [SP1 protein binds to VDR promoter]affects binding|increases reaction 17088408
C086566 glycitein glycitein results in increased activity of SP1 proteinincreases activity 17088408
C086566 glycitein U 0126 inhibits the reaction [glycitein results in increased activity of SP1 protein]decreases reaction|increases activity 17088408
D006861 Hydrogen Peroxide Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP1 protein]decreases expression|decreases reaction 20435036
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of SP1 proteindecreases expression 20435036
D006861 Hydrogen Peroxide SB 203580 inhibits the reaction [Hydrogen Peroxide promotes the reaction [SP1 protein results in increased expression of CAV1 protein]]decreases reaction|increases expression|increases reaction 17108117
D006861 Hydrogen Peroxide Hydrogen Peroxide inhibits the reaction [SP1 protein binds to AHR promoter]affects binding|decreases reaction 20478378
D006861 Hydrogen Peroxide Hydrogen Peroxide promotes the reaction [SP1 protein binds to CAV1 promoter]affects binding|increases reaction 17108117
D006861 Hydrogen Peroxide Hydrogen Peroxide promotes the reaction [SP1 protein results in increased expression of CAV1 protein]increases expression|increases reaction 17108117
C016517 indole-3-carbinol indole-3-carbinol analog inhibits the reaction [SP1 protein binds to CDK6 promoter]affects binding|decreases reaction 20570586
C016517 indole-3-carbinol indole-3-carbinol results in decreased activity of SP1 proteindecreases activity 16082211
C051890 irinotecan irinotecan analog results in decreased expression of SP1 mRNAdecreases expression 18927307
C051890 irinotecan irinotecan results in increased phosphorylation of SP1 proteinincreases phosphorylation 17441964
C051890 irinotecan SP1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]affects cotreatment|affects response to substance 18927307
D007545 Isoproterenol EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA]affects cotreatment|affects reaction|increases expression 10710348
D007545 Isoproterenol [Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNAaffects cotreatment|increases expression 10710348
D008070 Lipopolysaccharides Sodium Selenite inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of SP1 protein]affects cotreatment|decreases reaction|increases activity 15650415
C008493 methylselenic acid methylselenic acid inhibits the reaction [SP1 protein binds to BIRC5 promoter]affects binding|decreases reaction 17876054
C100075 mibolerone mibolerone promotes the reaction [SP1 protein binds to AR protein]affects binding|increases reaction 15661808
C100075 mibolerone Quercetin promotes the reaction [mibolerone promotes the reaction [SP1 protein binds to AR protein]]affects binding|increases reaction 15661808
C066851 mithramycin A mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]]affects binding|decreases reaction|increases reaction 16807381
C066851 mithramycin A mithramycin A inhibits the reaction [SP1 protein binds to CDKN1A promoter]affects binding|decreases reaction 15489892
C066851 mithramycin A mithramycin A inhibits the reaction [SP1 protein binds to HSD17B2 promoter]affects binding|decreases reaction 16807381
C066851 mithramycin A mithramycin A inhibits the reaction [[TP53 protein binds to SP1 protein] which results in increased expression of BBC3 mRNA]affects binding|decreases reaction|increases expression 15489892
C066851 mithramycin A mithramycin A inhibits the reaction [[TP53 protein binds to SP1 protein] which results in increased expression of CDKN1A mRNA]affects binding|decreases reaction|increases expression 15489892
C066851 mithramycin A mithramycin A inhibits the reaction [SP1 protein binds to AHR promoter]affects binding|decreases reaction 20478378
C066851 mithramycin A mithramycin A results in decreased activity of SP1 proteindecreases activity 17124180
18980244
D009532 Nickel Nickel results in increased activity of SP1 proteinincreases activity 19403854
D026422 S-Nitrosoglutathione S-Nitrosoglutathione results in increased activity of SP1 proteinincreases activity 14766015
C069741 norcantharidin norcantharidin results in decreased activity of SP1 proteindecreases activity 19616522
C069741 norcantharidin SP1 protein affects the reaction [norcantharidin results in decreased expression of MMP9 mRNA]affects reaction|decreases expression 19616522
C090046 olomoucine olomoucine results in increased expression of SP1 proteinincreases expression 14653808
C090046 olomoucine olomoucine results in increased expression of SP1 mRNAincreases expression 14653808
C090046 olomoucine olomoucine results in increased expression of SP1 proteinincreases expression 14653808
C030110 oxaliplatin oxaliplatin inhibits the reaction [SP1 protein binds to DUT promoter]affects binding|decreases reaction 19015155
D010656 Phenylephrine EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA]affects cotreatment|affects reaction|increases expression 10710348
D010656 Phenylephrine [Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNAaffects cotreatment|increases expression 10710348
D008926 Plicamycin Plicamycin results in decreased activity of SP1 proteindecreases activity 15946989
D008926 Plicamycin Plicamycin results in decreased activity of SP1 proteindecreases activity 16291751
15690306
C107773 pterostilbene SP1 protein affects the reaction [[pterostilbene co-treated with Quercetin] results in increased expression of SOD2 protein]affects cotreatment|affects reaction|increases expression 18852136
D011794 Quercetin 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin promotes the reaction [SP1 protein binds to PLAT promoter]]affects binding|decreases reaction|increases reaction 18419748
D011794 Quercetin Quercetin inhibits the reaction [SP1 protein binds to BIRC5 promoter]affects binding|decreases reaction 18377872
D011794 Quercetin Quercetin inhibits the reaction [SP1 protein promotes the reaction [AR protein results in increased expression of HK2 mRNA]]decreases reaction|increases expression|increases reaction 15661808
D011794 Quercetin Quercetin inhibits the reaction [SP1 protein promotes the reaction [AR protein results in increased expression of KLK3 mRNA]]decreases reaction|increases expression|increases reaction 15661808
D011794 Quercetin Quercetin inhibits the reaction [SP1 protein results in increased expression of AR mRNA]decreases reaction|increases expression 15661808
D011794 Quercetin Quercetin promotes the reaction [AR protein binds to SP1 protein]affects binding|increases reaction 15661808
D011794 Quercetin Quercetin promotes the reaction [mibolerone promotes the reaction [SP1 protein binds to AR protein]]affects binding|increases reaction 15661808
D011794 Quercetin Quercetin promotes the reaction [SP1 protein binds to PLAT promoter]affects binding|increases reaction 18419748
D011794 Quercetin Quercetin results in decreased expression of SP1 proteindecreases expression 18377872
D011794 Quercetin Quercetin results in increased activity of SP1 proteinincreases activity 18980244
D011794 Quercetin SP1 protein affects the reaction [[pterostilbene co-treated with Quercetin] results in increased expression of SOD2 protein]affects cotreatment|affects reaction|increases expression 18852136
D011794 Quercetin SP1 protein promotes the reaction [Quercetin results in increased expression of TNFRSF10B mRNA]increases expression|increases reaction 18980244
C059514 resveratrol resveratrol inhibits the reaction [TNF protein results in increased activity of SP1 protein]decreases reaction|increases activity 16614140
C059514 resveratrol resveratrol promotes the reaction [SP1 protein binds to DDIT3 promoter]affects binding|increases reaction 17049495
C059514 resveratrol resveratrol results in increased activity of SP1 proteinincreases activity 17049495
C059514 resveratrol resveratrol results in increased expression of SP1 proteinincreases expression 16456233
C104586 roscovitine roscovitine results in increased expression of SP1 proteinincreases expression 14653808
C104586 roscovitine roscovitine results in increased expression of SP1 mRNAincreases expression 14653808
C104586 roscovitine roscovitine results in increased expression of SP1 proteinincreases expression 14653808
C089730 rosiglitazone rosiglitazone results in decreased expression of SP1 proteindecreases expression 15908479
C093642 SB 203580 SB 203580 inhibits the reaction [Hydrogen Peroxide promotes the reaction [SP1 protein results in increased expression of CAV1 protein]]decreases reaction|increases expression|increases reaction 17108117
D018038 Sodium Selenite Acetylcysteine inhibits the reaction [Sodium Selenite results in decreased expression of SP1 protein]decreases expression|decreases reaction 16928829
D018038 Sodium Selenite [Sodium Selenite results in decreased activity of SP1 protein] which results in decreased expression of AR proteindecreases activity|decreases expression 16928829
D018038 Sodium Selenite Sodium Selenite results in decreased expression of and results in decreased activity of SP1 proteindecreases activity|decreases expression 16928829
D018038 Sodium Selenite Sodium Selenite inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of SP1 protein]affects cotreatment|decreases reaction|increases activity 15650415
D013629 Tamoxifen Tamoxifen promotes the reaction [[ESR1 protein binds to SP1 protein] which binds to E2F1 promoter]affects binding|increases reaction 20215421
D013629 Tamoxifen Tamoxifen promotes the reaction [[[ESR1 protein binds to SP1 protein] which binds to E2F1 promoter] which results in increased expression of E2F1 mRNA]affects binding|increases expression|increases reaction 20215421
D013629 Tamoxifen Tamoxifen promotes the reaction [SP1 protein binds to ESR1 protein]affects binding|increases reaction 20215421
D013629 Tamoxifen Tamoxifen promotes the reaction [SP1 protein binds to ESRRA promoter]affects binding|increases reaction 20211987
D013629 Tamoxifen Tamoxifen promotes the reaction [[SP1 protein binds to PEMT promoter] which results in decreased expression of PEMT mRNA]affects binding|decreases expression|increases reaction 20150657
C076852 terameprocol terameprocol inhibits the reaction [SP1 protein results in increased expression of ABCB1 mRNA]decreases reaction|increases expression 16544145
C076852 terameprocol terameprocol results in decreased activity of SP1 proteindecreases activity 16544145
D013749 Tetrachlorodibenzodioxin Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [SP1 protein binds to CYP1A1 promoter]]affects binding|increases reaction 16675542
D013749 Tetrachlorodibenzodioxin [SP1 protein binds to CYP1B1 enhancer] promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]affects binding|increases expression|increases reaction 12801909
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to SP1 protein]]affects binding|decreases reaction|increases reaction 16675542
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of SP1 mRNAaffects cotreatment|increases expression 15251184
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SP1 mRNAdecreases expression 14708085
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the activity of SP1 proteinaffects activity 11926288
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate promotes the reaction [SP1 protein binds to CDKN1A promoter]affects binding|increases reaction 15978937
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased activity of SP1 proteinincreases activity 15978937
D014212 Tretinoin Tretinoin promotes the reaction [SP1 protein binds to FOLR2 promoter]affects binding|increases reaction 16740727
D014212 Tretinoin Tretinoin promotes the reaction [SP1 protein binds to HAS2 promoter]affects binding|increases reaction 17307735
D014212 Tretinoin Tretinoin promotes the reaction [SP1 protein binds to PDK4 promoter]affects binding|increases reaction 16757381
D014212 Tretinoin Tretinoin results in increased activity of SP1 proteinincreases activity 16757381
D014212 Tretinoin trichostatin A promotes the reaction [Tretinoin promotes the reaction [SP1 protein binds to FOLR2 promoter]]affects binding|increases reaction 16740727
D014212 Tretinoin Tretinoin results in increased activity of SP1 proteinincreases activity 17097063
C012589 trichostatin A [decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to CLDN3 promoter]affects binding|affects cotreatment|increases reaction 17986852
C012589 trichostatin A [[decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to SLC25A1 promoter]] which results in increased expression of SLC25A1 mRNAaffects binding|affects cotreatment|increases expression|increases reaction 18706393
C012589 trichostatin A SP1 protein affects the reaction [trichostatin A affects the expression of GDF15 mRNA]affects expression|affects reaction 18801729
C012589 trichostatin A trichostatin A affects the expression of SP1 mRNAaffects expression 18801729
C012589 trichostatin A trichostatin A affects the expression of SP1 proteinaffects expression 18801729
C012589 trichostatin A trichostatin A promotes the reaction [SP1 protein binds to PDK4 promoter]affects binding|increases reaction 16757381
C012589 trichostatin A trichostatin A promotes the reaction [SP1 protein binds to SLC25A1 promoter]affects binding|increases reaction 18706393
C012589 trichostatin A trichostatin A promotes the reaction [Tretinoin promotes the reaction [SP1 protein binds to FOLR2 promoter]]affects binding|increases reaction 16740727
C012589 trichostatin A trichostatin A results in increased activity of SP1 proteinincreases activity 16757381
C057693 troglitazone troglitazone results in decreased expression of SP1 proteindecreases expression 15908479
C113580 U 0126 U 0126 inhibits the reaction [Estradiol results in increased activity of SP1 protein]decreases reaction|increases activity 17088408
C113580 U 0126 U 0126 inhibits the reaction [Genistein results in increased activity of SP1 protein]decreases reaction|increases activity 17088408
C113580 U 0126 U 0126 inhibits the reaction [glycitein results in increased activity of SP1 protein]decreases reaction|increases activity 17088408
C009687 wortmannin wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of SP1 protein]decreases reaction|increases phosphorylation 17441964
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.8614745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.2015322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 2.8918287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.2617505938
MESH:D000168 Acrocephalosyndactylia U 0126 4.8217694057
MESH:D058186 Acute Kidney Injury Folic Acid 7.0217003819 16316344 16595132
MESH:D058186 Acute Kidney Injury resveratrol 7.0216538975
MESH:D055371 Acute Lung Injury Lipopolysaccharides 7.5218653653 11850527
MESH:D055371 Acute Lung Injury Nickel 7.5216166738
MESH:D000230 Adenocarcinoma arsenic trioxide 17.3319825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 17.3320127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 17.3317418594
MESH:D000230 Adenocarcinoma Estradiol 17.3311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 17.3314692618
MESH:D000230 Adenocarcinoma Fluorouracil 17.3317638652
MESH:D000230 Adenocarcinoma Genistein 17.3311473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 12.493712494
MESH:D000236 Adenoma Benzo(a)pyrene 12.496695378
MESH:D000236 Adenoma Folic Acid 12.4916963246
MESH:D000236 Adenoma resveratrol 12.4915688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 2.7116835633
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 3.6911874814 17119214 16611668
MESH:D000419 Albuminuria Doxorubicin 3.9021441931
MESH:D019973 Alcohol-Related Disorders Curcumin 4.4017887948
MESH:D000505 Alopecia Tretinoin 3.0715955085
MESH:D000544 Alzheimer Disease Curcumin 7.7715590663
MESH:D000544 Alzheimer Disease Folic Acid 7.7717116317
MESH:D000544 Alzheimer Disease resveratrol 7.7716162502 16183991
MESH:D000544 Alzheimer Disease rosiglitazone 7.7719621015
MESH:D000686 Amyloidosis Diethylstilbestrol 3.8415469931
MESH:D000740 Anemia Fluorouracil 6.7315504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 6.7311748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.6317084956
MESH:D000799 Angioedema Acetaminophen 3.1610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.4219183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.5317460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.8111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 9.6615885639
MESH:D001169 Arthritis, Experimental resveratrol 9.6617115116
MESH:D001169 Arthritis, Experimental Tretinoin 9.6616412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.0216807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.0216292516
MESH:D001249 Asthma Acetaldehyde 4.469600491
MESH:D001249 Asthma Tretinoin 4.4616456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.3015336622
MESH:D050197 Atherosclerosis Asbestos 8.7018795166
MESH:D050197 Atherosclerosis Curcumin 8.7018704882
MESH:D050197 Atherosclerosis resveratrol 8.7016873680 17967414
MESH:D001284 Atrophy fulvestrant 4.2111514358
MESH:D001321 Autistic Disorder Acetaminophen 2.4918445737
MESH:D001321 Autistic Disorder Folic Acid 2.4921388746
MESH:D001321 Autistic Disorder Glutathione 2.4916917939 19267885 18929414 19056591
MESH:D001321 Autistic Disorder S-Adenosylmethionine 2.4919056591 16917939
MESH:D001327 Autoimmune Diseases Curcumin 8.6919761891
MESH:D001327 Autoimmune Diseases Quercetin 8.6919761891
MESH:D001471 Barrett Esophagus Tretinoin 3.7616935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.331440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 11.8516206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 11.8512125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 11.8516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3015746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 9.8914601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 9.8914601052
MESH:D001919 Bradycardia Isoproterenol 8.736740701
MESH:D001919 Bradycardia Phenylephrine 8.7315306635
MESH:D002545 Brain Ischemia Curcumin 8.1016770732
MESH:D002545 Brain Ischemia resveratrol 8.1017600658
MESH:D001932 Brain Neoplasms Curcumin 7.0117596214
MESH:D001932 Brain Neoplasms Doxorubicin 7.0117150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 17.2217474063 20146248
MESH:D001943 Breast Neoplasms Curcumin 17.2216243823 19250217 18593918 18462866
MESH:D001943 Breast Neoplasms decitabine 17.2218320071 19208741
MESH:D001943 Breast Neoplasms Diethylstilbestrol 17.2217129689 15324884
MESH:D001943 Breast Neoplasms Doxorubicin 17.2218628466 15567936 11325840 16322301 17983394 15993339 17369602 16826403 16096432 16595493 19526202 16264153 16115903 15692762 15136595 15994142 15668708 17426702 15939500 18695136 18382427 16935488 15634643 18234424
MESH:D001943 Breast Neoplasms Estradiol 17.2218497071 14630087 19861407 16675129 17018787 12948864 17289903 17261762
MESH:D001943 Breast Neoplasms Etoposide 17.2216322251
MESH:D001943 Breast Neoplasms Fluorouracil 17.2216110121 19217205 18608205 16595493 16557594 15136595 18357371
MESH:D001943 Breast Neoplasms Folic Acid 17.2216777985
MESH:D001943 Breast Neoplasms fulvestrant 17.2218984771
MESH:D001943 Breast Neoplasms Genistein 17.2216541309 17200150 16873071
MESH:D001943 Breast Neoplasms indole-3-carbinol 17.2216082211
MESH:D001943 Breast Neoplasms Nickel 17.2215986119
MESH:D001943 Breast Neoplasms Quercetin 17.2218628248
MESH:D001943 Breast Neoplasms resveratrol 17.2217651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tamoxifen 17.2217261762 19189210 19084267 11161223 17049068 19066611 19410462 19289846 21138602 15565566 16273361 19115204 17242785 18984771 20390343 18997820 19200415 16818667 16873071 18629630 19011961 15668708 20859285 19155303 17440819 19189212 19059307 19103187 19288272 16202921 19487384 17893378 21152245 18821012 20065188 20005174 18815881 18351453 18425577 19244106 20135344 19142967 19221464 20544844 18855134
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 17.2220435547
MESH:D001943 Breast Neoplasms Tretinoin 17.2216873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.9216813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.7011589617
MESH:D002105 Cadmium Poisoning Quercetin 4.8616962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.7916111702
MESH:D002276 Carcinoid Tumor Doxorubicin 10.0816051944
MESH:D002276 Carcinoid Tumor Fluorouracil 10.0816051944
MESH:D002277 Carcinoma Curcumin 10.8218593918
MESH:D002277 Carcinoma Fluorouracil 10.8217121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 10.8216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.8519066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.4716168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 25.193581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 25.193084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 25.1915553829 16217749 14691202 15073043 11135700
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 25.1916924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 25.1916234567 17876044 16023760 18059187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 25.1916924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 25.1916332177 16799960 17088986 18930000 17045692 17971768
MESH:D006528 Carcinoma, Hepatocellular Genistein 25.1916924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 25.1919519916 12508355
MESH:D006528 Carcinoma, Hepatocellular resveratrol 25.1919321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 25.1916924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 25.191917145
MESH:D018827 Carcinoma, Lewis Lung resveratrol 3.9216675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.7018414057
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.3017234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.1919014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 8.657296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 8.651485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 8.6518695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.5212490120
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 28.9117015178
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 28.9120419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 28.9118462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 28.9119215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 28.916189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 28.9116280240 18986760 16757204 17066447
MESH:D002294 Carcinoma, Squamous Cell Glutathione 28.9117015178
MESH:D002294 Carcinoma, Squamous Cell resveratrol 28.9116227395
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 28.9118922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 28.9116051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.0317572228
MESH:D006332 Cardiomegaly Isoproterenol 12.9811179087 7544033
MESH:D006332 Cardiomegaly Phenylephrine 12.9811754973 11179087 15728586 16170337 17287366 17124262
MESH:D006332 Cardiomegaly Quercetin 12.9819794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 12.9818850075 16120746 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.0617382496 17519947 17928571 17329180 17924179 17131338 16952015 16455267 15792986 15505089 16612575 17007740 17974986 15476868 16269455 16242529 16278810 16651473 16731534 17351982 15811867 16109756 17308081 16364871 18627295
MESH:D002310 Cardiomyopathy, Alcoholic Acetaldehyde 5.7910525098
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.6717334414 16243910
MESH:D002318 Cardiovascular Diseases Folic Acid 13.3716755160
MESH:D002318 Cardiovascular Diseases Genistein 13.3716332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 13.3716936243
MESH:D002318 Cardiovascular Diseases resveratrol 13.3715458977
MESH:D002386 Cataract Acetaminophen 5.7810977129
MESH:D002386 Cataract Tretinoin 5.7817460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 8.507505956
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 8.5018226522
MESH:D002471 Cell Transformation, Neoplastic Estradiol 8.5018566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.9216129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.5916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 6.1419486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 6.1415861022 17110522 11677210 17333356 16105132 17681005 16919318
MESH:D002822 Choriocarcinoma Tretinoin 4.4716461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.0915894690
MESH:D002971 Cleft Lip Folic Acid 3.5921254359
MESH:D002972 Cleft Palate Folic Acid 7.948946559 21254359
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 7.9416354765 12621046 8697196 15668235 15340226
MESH:D002972 Cleft Palate Tretinoin 7.949407595
MESH:D003092 Colitis Curcumin 12.3218200517 16782535 16804969
MESH:D003092 Colitis resveratrol 12.3216474422
MESH:D003092 Colitis Tretinoin 12.3217035595
MESH:D003103 Coloboma Curcumin 3.9418809619
MESH:D003110 Colonic Neoplasms Curcumin 17.3919359593 16340194
MESH:D003110 Colonic Neoplasms decitabine 17.3917616700
MESH:D003110 Colonic Neoplasms Fluorouracil 17.3917018589 17725105 17172411 18772588 17169374 16510598 16340194 15001691 17016597 17287894
MESH:D003110 Colonic Neoplasms Genistein 17.3917182828
MESH:D003110 Colonic Neoplasms irinotecan 17.3917287894 17725105
MESH:D003110 Colonic Neoplasms oxaliplatin 17.3916004971 16510598 16024531
MESH:D003110 Colonic Neoplasms Quercetin 17.3917191121 11134977 19056647 17148506 16640504 19440933 15741050
MESH:D003110 Colonic Neoplasms resveratrol 17.3916338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 17.6820501625
MESH:D015179 Colorectal Neoplasms Azacitidine 17.6819934284
MESH:D015179 Colorectal Neoplasms decitabine 17.6818981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 17.6818259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 17.6816331619 18802399 15289873 17695437 17454858 20501625 18448328 16391804 17401013 15148649 18949393 16282729 18509181 16524972 14970324 17255274 17016601 18288408 17594712 18383874 17094418 16303861
MESH:D015179 Colorectal Neoplasms Folic Acid 17.6817087956 17116713 16963246 16985020 17245555
MESH:D015179 Colorectal Neoplasms irinotecan 17.6817159606 16391804 15273666 17454858 18259882 18509181 16303861
MESH:D015179 Colorectal Neoplasms oxaliplatin 17.6817255274 18448328 17594712 17401013 17695437 18509181
MESH:D015179 Colorectal Neoplasms pterostilbene 17.6818852136
MESH:D015179 Colorectal Neoplasms Quercetin 17.6818095365 18852136
MESH:D015179 Colorectal Neoplasms resveratrol 17.6816550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.4914669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.2418497527
MESH:D003327 Coronary Disease resveratrol 3.2916507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.5512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.1710525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.1720055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.1710589399 9125849 8800419 14991402 17551590 9142499 9664655 16925845 9224671 9211117
MESH:D003456 Cryptorchidism Diethylstilbestrol 3.9216002989 12952375
MESH:D003550 Cystic Fibrosis Acetylcysteine 7.2719747007
MESH:D003550 Cystic Fibrosis Glutathione 7.2719747007
MESH:D007644 Darier Disease Fluorouracil 4.1216733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.4715213294
MESH:D003711 Demyelinating Diseases Tamoxifen 3.7119031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 5.142524372 8970840 8156756 11298694 14531868 11906362 18759878 12868966
MESH:D017449 Dermatitis, Allergic Contact Nickel 5.1417244072 17100760 19470301
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 7.482952479 3621924
MESH:D003877 Dermatitis, Contact Nickel 7.482952479
MESH:D003920 Diabetes Mellitus rosiglitazone 7.5217446233
MESH:D003920 Diabetes Mellitus Sodium Selenite 7.5216285004
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 6.7119496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 6.7116873680
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 14.3018403477
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 14.3016886840
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 14.3016647724
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 14.3012642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 14.3017107852
MESH:D003924 Diabetes Mellitus, Type 2 troglitazone 14.3016023994
MESH:D003925 Diabetic Angiopathies troglitazone 4.9812601628
MESH:D003928 Diabetic Nephropathies Curcumin 16.7518204486
MESH:D003928 Diabetic Nephropathies Estradiol 16.7519279558
MESH:D003928 Diabetic Nephropathies resveratrol 16.7516286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 16.7519279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 17.6316192314 8291058 6679447 9653073 7440962 9022650 18289764 9328219 6482804 1440618 11289319 18692083 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 17.6312153990 12392966 14550746 14986274 11529661 19420014 12540782 19164858 10663392 10774834 11739529 16485898 19923254 17562736 11743745 16393943 18713872 16227642 15619225 19416960 2444490 10915739 14725611 11287661 19739265 17906064 16781746 11461765 18071297 19085960 19370779 11421492 17522070 16109766 16177239 11834606 12705907 12594235 16081117 12958197 15968718
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 17.6311287661
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 17.6317851650
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 17.6317416283
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 17.6315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.6320420201
MESH:D056486 Drug-Induced Liver Injury troglitazone 17.6314986274
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.4119426721
MESH:D004362 Drug Toxicity Doxorubicin 6.3918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.3911462148
MESH:D004381 Duodenal Ulcer Curcumin 3.4217351913
MESH:D004487 Edema bisindolylmaleimide I 15.398273558
MESH:D004487 Edema resveratrol 15.398985016
MESH:D004487 Edema rosiglitazone 15.3912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 15.3911000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 15.397812673 11698051 8113982 16716910 15177302 8273558 9599246
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 9.6715322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 9.6718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 11.6812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 11.6817872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 11.6819031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 11.7519294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 11.7519294695
MESH:D018159 Endolymphatic Hydrops Dimethyl Sulfoxide 5.8820641076
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 9.6616402032
MESH:D004714 Endometrial Hyperplasia Genistein 9.6616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 27.8916804899 15700306
MESH:D016889 Endometrial Neoplasms Doxorubicin 27.8917359293
MESH:D016889 Endometrial Neoplasms Estradiol 27.8919148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Folic Acid 27.8917301261
MESH:D016889 Endometrial Neoplasms Genistein 27.8911473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 27.8920544844 17893378 16202921 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 27.8916569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.4410568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.4718037988
MESH:D019446 Endotoxemia Lipopolysaccharides 3.7315821434 17637181 15328337
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.1917923197
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 8.463581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 8.4612903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 8.4616530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 8.4616785472 17638652 15173087 16481741 16337965
MESH:D017889 Exfoliation Syndrome Folic Acid 4.8216504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.1011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.109664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 18.3215073043
MESH:D005234 Fatty Liver Curcumin 18.3219297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.3215345470
MESH:D005234 Fatty Liver rosiglitazone 18.3219196556
MESH:D005234 Fatty Liver Tamoxifen 18.3214986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 6.7316534752 16002989 16611131 16513791 15751030
MESH:D052776 Female Urogenital Diseases Tamoxifen 6.7316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.8011858732
MESH:D005334 Fever Lipopolysaccharides 3.439205823 11852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.336705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.8614745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 9.2119069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 9.2119069698
MESH:D005355 Fibrosis Curcumin 15.8618705752
MESH:D005355 Fibrosis Quercetin 15.8619474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.8620067830
MESH:D005355 Fibrosis Tretinoin 15.8617994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 9.8916904648
MESH:D005706 Gallbladder Neoplasms norcantharidin 9.8916681930
MESH:D005756 Gastritis Acetaminophen 9.0016983495
MESH:D005756 Gastritis Folic Acid 9.0017171786
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.0418462866
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.2816452187
MESH:D005901 Glaucoma Folic Acid 4.4516504073
MESH:D005909 Glioblastoma Curcumin 21.7017596214
MESH:D005909 Glioblastoma Doxorubicin 21.7017150277
MESH:D005909 Glioblastoma Genistein 21.7016598420
MESH:D005909 Glioblastoma Quercetin 21.7019804834
MESH:D005909 Glioblastoma Tretinoin 21.7017312396
MESH:D005909 Glioblastoma trichostatin A 21.7018801729
MESH:D005910 Glioma Fluorouracil 5.1216145905
MESH:D005910 Glioma Quercetin 5.1217643826
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 4.4715173396 16524712
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.417505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.9110696789
MESH:D006258 Head and Neck Neoplasms Curcumin 19.1118462866 18829502
MESH:D006258 Head and Neck Neoplasms decitabine 19.1119215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 19.1115692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 19.1118337622 15162350 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 19.1116096774
MESH:D034381 Hearing Loss Dimethyl Sulfoxide 4.5920641076
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.4716084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 12.7120471113
MESH:D006330 Heart Defects, Congenital Folic Acid 12.7116524890 17286298
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 12.7111294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 12.719664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 3.0016707910 16879835 18006777 14766674 18674790 16244371 17875725 17888722 12587719 16144979 16330681 16495754 16244372
MESH:D006333 Heart Failure Doxorubicin 6.1817481944
MESH:D006333 Heart Failure Isoproterenol 6.1818097624
MESH:D006394 Hemangiosarcoma Doxorubicin 3.3015692506
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.7916366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.7311000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 2.886705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.2512621046 15340226 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.3817701891
MESH:D006558 Herpes Genitalis Estradiol 4.3515709030
MESH:D006561 Herpes Simplex Etoposide 7.8810809021
MESH:D006561 Herpes Simplex resveratrol 7.8816876885
MESH:D015658 HIV Infections Nickel 3.4317263646
MESH:D006679 HIV Seropositivity Folic Acid 4.8217209195
MESH:D006689 Hodgkin Disease Doxorubicin 5.8715147373 18501091 17606976
MESH:D006689 Hodgkin Disease Etoposide 5.8716135485 17606976 15147373 16200630 18180244
MESH:D019584 Hot Flashes Estradiol 3.0717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.3616354765 18606429 16959395 8697196 15340226
MESH:D006930 Hyperalgesia Acetaminophen 14.2816870215
MESH:D006930 Hyperalgesia oxaliplatin 14.2817418472
MESH:D006930 Hyperalgesia rosiglitazone 14.2812083418
MESH:D006930 Hyperalgesia Tretinoin 14.2816870215
MESH:D006937 Hypercholesterolemia Curcumin 7.3818704882
MESH:D006937 Hypercholesterolemia resveratrol 7.3817188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.9116778211
MESH:D006943 Hyperglycemia Quercetin 3.4418262572 11834736
MESH:D020138 Hyperhomocysteinemia Folic Acid 3.9216395265 16433478 16397167 16865747 16755160
MESH:D006949 Hyperlipidemias resveratrol 3.4116873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 8.6615034207
MESH:D006965 Hyperplasia Diethylstilbestrol 8.6612960047 14722030
MESH:D006973 Hypertension Phenylephrine 6.908949925 12717712
MESH:D006973 Hypertension Quercetin 6.9018356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 6.9018850075 18670907
MESH:D006984 Hypertrophy Isoproterenol 8.9812791704
MESH:D006984 Hypertrophy Phenylephrine 8.9818502941 12791704
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.7117488730
MESH:D007021 Hypospadias Diethylstilbestrol 9.0716002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.0716945680 16569931
MESH:D007022 Hypotension Isoproterenol 4.186740701
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 3.9917600658
MESH:D007246 Infertility Diethylstilbestrol 3.7215036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.8412013081
MESH:D007248 Infertility, Male decitabine 8.5717581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 8.5717937319
MESH:D007248 Infertility, Male fulvestrant 8.5711514358
MESH:D007249 Inflammation bisindolylmaleimide I 25.328273558
MESH:D007249 Inflammation Curcumin 25.3216956363 18403477 17151092
MESH:D007249 Inflammation Lipopolysaccharides 25.3217255318 9205823 17963957 12878042 17237260
MESH:D007249 Inflammation Nickel 25.3216166738
MESH:D007249 Inflammation resveratrol 25.3216366677
MESH:D007249 Inflammation rosiglitazone 25.3212083418
MESH:D007249 Inflammation Tamoxifen 25.3219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 25.3212200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 25.3215177302 7562506 8273558 11698051 7812673
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.8918596194 18200517
MESH:D007251 Influenza, Human Quercetin 8.9316624496
MESH:D007251 Influenza, Human resveratrol 8.9316624496
MESH:D007333 Insulin Resistance Estradiol 9.7516627594 16393666
MESH:D007333 Insulin Resistance rosiglitazone 9.7516306350
MESH:D007333 Insulin Resistance Sodium Selenite 9.7514714311
MESH:D007410 Intestinal Diseases Tretinoin 3.1217994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.6310783313
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.0117255318
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.339022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 7.9216580747
MESH:D007569 Jaw Abnormalities Tretinoin 7.9217551590 15992940
MESH:D007627 Keloid Quercetin 4.3017086741
MESH:D007674 Kidney Diseases Acetaminophen 10.9512587719 15629191
MESH:D007674 Kidney Diseases Doxorubicin 10.9515369732 16775033 15699352
MESH:D007674 Kidney Diseases Estradiol 10.9515618244
MESH:D007674 Kidney Diseases Quercetin 10.9516962696
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.1116707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 8.1116518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 17.496582329
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 17.4915003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 17.4915610895
MESH:D007680 Kidney Neoplasms Fluorouracil 17.4916985049
MESH:D007680 Kidney Neoplasms Tamoxifen 17.4918625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.4117184923
MESH:D007889 Leiomyoma Curcumin 3.9518555241
MESH:D007938 Leukemia arsenic trioxide 28.2815070760
MESH:D007938 Leukemia Azacitidine 28.2819148494
MESH:D007938 Leukemia Curcumin 28.2818462866
MESH:D007938 Leukemia decitabine 28.2819235587 18980019
MESH:D007938 Leukemia Genistein 28.2817468513 18980019
MESH:D007938 Leukemia Quercetin 28.2817468513
MESH:D007938 Leukemia roscovitine 28.2816275999
MESH:D007938 Leukemia Tretinoin 28.2817143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 11.9516085563
MESH:D004915 Leukemia, Erythroblastic, Acute troglitazone 11.9516085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 7.7517077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 7.7516106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 9.5216972261
MESH:D007948 Leukemia, Monocytic, Acute U 0126 9.5216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 2.9114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 17.8919077051
MESH:D007951 Leukemia, Myeloid Azacitidine 17.8919077051
MESH:D007951 Leukemia, Myeloid decitabine 17.8919117987 17236224 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 17.8919285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 9.8017050201 19850784 20471514 16968895 16467208
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 9.8018720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute decitabine 9.8019387464 17679729 18206229 18704418 19010910 18460780
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 9.8016294345 17596541 19850784
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 9.8018206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.7818055864
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.5719299654
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 10.0516891316 17712046 12018890 17107899 12679006 16331271 15622746 19035177 15213294 15748426 17869043 9834237 19225113 19642359 11161223 17217047 16966277 17649720 19075265 11468182 16112521 16330433 16823087 12712474 15336539
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 10.0516087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 10.0517361223 17368321 16788101 17506722 16766008 17301526 16331271 19075265 19642359 16891316 15748426 16935935 19035177 19225113 17339181 19029980 16140955 12679006 17217047 17712046 17107899 9834237 17649720 16823087 17294898
MESH:D015458 Leukemia, T-Cell arsenic trioxide 9.5916882451
MESH:D015458 Leukemia, T-Cell Curcumin 9.5916106398
MESH:D007970 Leukopenia Lipopolysaccharides 4.0315821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.819224671
MESH:D008064 Lipidoses Tamoxifen 2.6615342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.7415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 20.2718705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Dimethyl Sulfoxide 20.2711682029
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 20.2716439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 20.2714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 20.2717823541
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 20.2712878042
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 20.2712741479
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 20.2717347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental S-Adenosylmethionine 20.2715983038
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 20.2718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 20.2712878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 20.2716248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 7.5512587719 12969438 19460945 19784758 16611625 19014921 11587558 16610002
MESH:D008107 Liver Diseases Chlorpyrifos 7.5515991261
MESH:D008107 Liver Diseases Curcumin 7.5516956363
MESH:D008107 Liver Diseases Folic Acid 7.5516877991
MESH:D017114 Liver Failure, Acute Acetaminophen 2.6516871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 20.4414682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.4421137059 20195826
MESH:D008113 Liver Neoplasms Diethylstilbestrol 20.4415890375 16712894
MESH:D008113 Liver Neoplasms Fluorouracil 20.4417045692 16603448 18383874 15113037
MESH:D008113 Liver Neoplasms Quercetin 20.4418980244
MESH:D008113 Liver Neoplasms resveratrol 20.4419321006 19073162 20405173 19812893
MESH:D008113 Liver Neoplasms Tamoxifen 20.4416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.4416984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.866587162 3712494 1399818 598648
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 13.8620377131
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 13.8617085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Quercetin 13.8619519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.8612151625
MESH:D008133 Long QT Syndrome arsenic trioxide 2.8315213294
MESH:D008171 Lung Diseases Acetylcysteine 3.5812815614
MESH:D055370 Lung Injury Asbestos, Crocidolite 7.1417365036
MESH:D055370 Lung Injury Lipopolysaccharides 7.1421114838
MESH:D008175 Lung Neoplasms Acetaldehyde 19.9117372256
MESH:D008175 Lung Neoplasms arsenic trioxide 19.9111798837 19825857
MESH:D008175 Lung Neoplasms Asbestos 19.9112111688
MESH:D008175 Lung Neoplasms Azacitidine 19.9121224363
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 19.9120464547 20064080 18520028 6695378 18569708 20869020 17053015 20135361 18816296
MESH:D008175 Lung Neoplasms Curcumin 19.9118462866 16243823 19359593
MESH:D008175 Lung Neoplasms Doxorubicin 19.9117418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 19.9115246190
MESH:D008175 Lung Neoplasms Quercetin 19.9116280456
MESH:D008175 Lung Neoplasms Tamoxifen 19.9118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 19.9119555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 19.9111807781
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.1215086387
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.1117718048
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.4815166399
MESH:D008223 Lymphoma Curcumin 18.1518462866
MESH:D008223 Lymphoma decitabine 18.1519470736
MESH:D008223 Lymphoma Diethylstilbestrol 18.1515700306
MESH:D008223 Lymphoma Doxorubicin 18.1516098063
MESH:D008223 Lymphoma Etoposide 18.1512556972 12854902
MESH:D016393 Lymphoma, B-Cell resveratrol 8.2117088997
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 8.2114737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 7.0317654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 7.0314749477
MESH:D016399 Lymphoma, T-Cell Curcumin 9.3916173963
MESH:D016399 Lymphoma, T-Cell Doxorubicin 9.3915621674
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.8316002989
MESH:D015674 Mammary Neoplasms, Animal resveratrol 7.7815688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 7.7819428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 21.4315458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 21.4317203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 21.4312929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 21.438985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 21.4316827153
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 21.4314580682 16827153 19196723 19196722 11731420
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 21.438985016
MESH:D020149 Manganese Poisoning Estradiol 10.3719453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.3719453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.0216832597
MESH:D008527 Medulloblastoma Tretinoin 2.4717453147
MESH:D008545 Melanoma Curcumin 12.7417885582 18462866
MESH:D008545 Melanoma decitabine 12.7417785578 16505122
MESH:D008545 Melanoma Doxorubicin 12.7416827129
MESH:D008545 Melanoma resveratrol 12.7417992120
MESH:D008545 Melanoma Tamoxifen 12.7419393235 12393984
MESH:D008545 Melanoma Tretinoin 12.7416752155
MESH:D008545 Melanoma trichostatin A 12.7416505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.5115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 2.9119513568
MESH:D008569 Memory Disorders Curcumin 3.5217263510
MESH:D008591 Meningomyelocele Tretinoin 3.7716940565
MESH:D008654 Mesothelioma Asbestos 8.5518310086 16564556 16919927 18709470 16319530
MESH:D008654 Mesothelioma Asbestos, Crocidolite 8.5516966607 18303189 16166281
MESH:D008654 Mesothelioma Doxorubicin 8.5517638057
MESH:D008659 Metabolic Diseases resveratrol 3.7717112576
MESH:D024821 Metabolic Syndrome X rosiglitazone 3.8217261469
MESH:D028361 Mitochondrial Diseases Doxorubicin 3.8915792986
MESH:D009006 Monosomy Azacitidine 5.4019299654
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 6.7616381670
MESH:D009062 Mouth Neoplasms Fluorouracil 6.7618986760 16757204
MESH:D052016 Mucositis Doxorubicin 10.1917415656
MESH:D052016 Mucositis irinotecan 10.1917159606
MESH:D009101 Multiple Myeloma arsenic trioxide 21.7911468182 14977855 19417148 19549372 15949261
MESH:D009101 Multiple Myeloma Azacitidine 21.7918443271 19549372
MESH:D009101 Multiple Myeloma Curcumin 21.7919372569
MESH:D009101 Multiple Myeloma decitabine 21.7918172295
MESH:D009101 Multiple Myeloma resveratrol 21.7917049120 16490592 17935668 17164350 14749477 16267019
MESH:D009101 Multiple Myeloma trichostatin A 21.7918172295
MESH:D009134 Muscular Atrophy, Spinal Curcumin 10.1817962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 10.1817962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 3.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 14.1216105982 16882451
MESH:D009190 Myelodysplastic Syndromes Azacitidine 14.1218720364 17596541 19805378 17611569
MESH:D009190 Myelodysplastic Syndromes decitabine 14.1216882708 18608210 19010910 19157545
MESH:D009190 Myelodysplastic Syndromes Tretinoin 14.1217596541
MESH:D009203 Myocardial Infarction Doxorubicin 14.3715857846 19429709
MESH:D009203 Myocardial Infarction Genistein 14.3717141266
MESH:D009203 Myocardial Infarction Isoproterenol 14.3717052832 19172585 16538859 16584858 16697266 19595682 15740881
MESH:D009203 Myocardial Infarction Quercetin 14.3719595682
MESH:D009203 Myocardial Infarction resveratrol 14.3716317513 17188708 17125593 16525036 17015251 16456233
MESH:D017202 Myocardial Ischemia resveratrol 7.1917015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.1912213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 11.2116810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 11.2117141266
MESH:D015428 Myocardial Reperfusion Injury Quercetin 11.2119207477
MESH:D009205 Myocarditis resveratrol 4.0917322642
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 8.2116624393
MESH:D009361 Neoplasm Invasiveness Curcumin 8.2118495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 18.293581430
MESH:D009362 Neoplasm Metastasis Acetylcysteine 18.2914720322
MESH:D009362 Neoplasm Metastasis Doxorubicin 18.2918259882
MESH:D009362 Neoplasm Metastasis irinotecan 18.2918259882
MESH:D009362 Neoplasm Metastasis norcantharidin 18.2915711181
MESH:D009362 Neoplasm Metastasis Tamoxifen 18.2919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.2519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 18.2111141357
MESH:D009369 Neoplasms decitabine 18.2119470736 17925555 19116145
MESH:D009369 Neoplasms Diethylstilbestrol 18.2115313581
MESH:D009369 Neoplasms Fluorouracil 18.2118600527 18239605 16928823
MESH:D009369 Neoplasms Quercetin 18.2115185748
MESH:D009369 Neoplasms terameprocol 18.2115958646
MESH:D009369 Neoplasms Tretinoin 18.2116946489 16594593
MESH:D009374 Neoplasms, Experimental resveratrol 3.368985016
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 8.5712497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 8.5719200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.0717289903
MESH:D009401 Nephrosis Doxorubicin 4.1116636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.4315640375 16889571
MESH:D009421 Nervous System Malformations Diethylstilbestrol 24.0211399458
MESH:D009421 Nervous System Malformations Estradiol 24.0216427766 11399458
MESH:D009421 Nervous System Malformations Genistein 24.0216427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 24.0214600291
MESH:D009421 Nervous System Malformations Tretinoin 24.029125849
MESH:D009423 Nervous System Neoplasms Curcumin 4.9418462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 17.826679447
MESH:D009436 Neural Tube Defects Acetylcysteine 17.8219446573
MESH:D009436 Neural Tube Defects arsenic trioxide 17.8210525206
MESH:D009436 Neural Tube Defects Folic Acid 17.8217438019
MESH:D009436 Neural Tube Defects Tretinoin 17.829142499
MESH:D009447 Neuroblastoma Doxorubicin 5.8515555623
MESH:D009447 Neuroblastoma irinotecan 5.858761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.5018514411
MESH:D019636 Neurodegenerative Diseases resveratrol 6.5017652729
MESH:D017599 Neuroectodermal Tumors irinotecan 4.068761367
MESH:D020078 Neurogenic Inflammation Quercetin 8.6317929310
MESH:D020078 Neurogenic Inflammation resveratrol 8.6317929310
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 6.7015081274
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 6.7016436463
MESH:D009503 Neutropenia Folic Acid 3.8916322990
MESH:D009765 Obesity Curcumin 2.5519297423
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 2.834026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.333988306
MESH:D010024 Osteoporosis Curcumin 5.8718719352
MESH:D010024 Osteoporosis Genistein 5.8719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 13.3116169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 13.3119495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 13.3117513867
MESH:D012516 Osteosarcoma Doxorubicin 3.5615930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 29.9612452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms CD 437 29.9617474084
MESH:D010051 Ovarian Neoplasms Curcumin 29.9618462866 19020741
MESH:D010051 Ovarian Neoplasms decitabine 29.9619331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 29.9619401270
MESH:D010051 Ovarian Neoplasms Genistein 29.9619005980
MESH:D010051 Ovarian Neoplasms Quercetin 29.9619005980
MESH:D010051 Ovarian Neoplasms Tretinoin 29.9616936753
MESH:D010051 Ovarian Neoplasms trichostatin A 29.9619331143
MESH:D010051 Ovarian Neoplasms U 0126 29.9616211241
MESH:D010146 Pain Acetaminophen 4.7816870215
MESH:D010146 Pain Tretinoin 4.7816870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 28.0715580305
MESH:D010190 Pancreatic Neoplasms Curcumin 28.0719401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms decitabine 28.0719294695
MESH:D010190 Pancreatic Neoplasms Etoposide 28.0719003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 28.0719003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Quercetin 28.0716965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 28.0715976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 28.0715976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 28.0719294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.0611578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 11.867296757
MESH:D010212 Papilloma Hydrogen Peroxide 11.8612065085
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 11.8618922899 12065085 8330346 18404319
MESH:D010235 Paraganglioma arsenic trioxide 3.5419927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.5612520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.796228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.4717983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.4814722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.0116977796 15687265
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.2410923243
MESH:D010997 Pleural Neoplasms Doxorubicin 4.4717638057
MESH:D011014 Pneumonia Lipopolysaccharides 3.8911605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.9218163543
MESH:D011230 Precancerous Conditions Quercetin 3.4119056647
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 12.4517184923
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 12.4516679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 12.4511896295 11222880 11399792 11118676
MESH:D055728 Primary Myelofibrosis decitabine 10.2517616702
MESH:D055728 Primary Myelofibrosis trichostatin A 10.2517616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.2820887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 8.9319131511
MESH:D011471 Prostatic Neoplasms Azacitidine 8.9318324645
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 8.9317292933
MESH:D011471 Prostatic Neoplasms Curcumin 8.9318156803 12497104 11398177 10851300 18226269 18769126 15129424
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 8.9317136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Doxorubicin 8.9316729912 15897917 16868541 18437689 16888761 15749863
MESH:D011471 Prostatic Neoplasms Estradiol 8.9316740699
MESH:D011471 Prostatic Neoplasms Etoposide 8.9317172428
MESH:D011471 Prostatic Neoplasms Fluorouracil 8.9319082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 8.9315378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms methylselenic acid 8.9316205645
MESH:D011471 Prostatic Neoplasms Quercetin 8.9314715546 17292933
MESH:D011471 Prostatic Neoplasms resveratrol 8.9317675339 17636462 16731767 15767336 17804756 17718901
MESH:D011471 Prostatic Neoplasms roscovitine 8.9316140939
MESH:D011471 Prostatic Neoplasms Sodium Selenite 8.9318760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 8.9315067354
MESH:D011471 Prostatic Neoplasms trichostatin A 8.9319789329 18798265
MESH:D011507 Proteinuria Tretinoin 2.9916636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.6515861022 16919318
MESH:D011625 Pterygium Tretinoin 4.1216723453
MESH:D011654 Pulmonary Edema Isoproterenol 4.5710903255
MESH:D011656 Pulmonary Emphysema Curcumin 3.9319168576
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 5.2317365031 17322281 15814490 17975199
MESH:D011658 Pulmonary Fibrosis troglitazone 5.2318162602
MESH:D012004 Rectal Neoplasms Fluorouracil 3.4416160472 18286688 15538739 18722050
MESH:D051437 Renal Insufficiency Doxorubicin 8.3417922066
MESH:D051437 Renal Insufficiency Folic Acid 8.3415728788
MESH:D051436 Renal Insufficiency, Chronic resveratrol 4.9016325855
MESH:D015427 Reperfusion Injury resveratrol 2.9015827377 16314181 17058453 17520802 16317513
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 7.4412210543
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 7.4410666014 18379247
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.2610835634
MESH:D012135 Respiratory Sounds Chlorpyrifos 3.9917119214 11874814 16611668
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2018990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.2116611668 17119214
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 2.863692021
MESH:D012208 Rhabdomyosarcoma decitabine 8.8819155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 8.8816283617 16116481
MESH:D012220 Rhinitis Acetaldehyde 4.1617050345
MESH:D012509 Sarcoma Curcumin 7.6118462866
MESH:D012509 Sarcoma Doxorubicin 7.6115625365 18313854 16767912 17203757 17710206 15675481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 19.4716646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 19.4714601052 16326096
MESH:D012512 Sarcoma, Ewing's Etoposide 19.4714601052
MESH:D012512 Sarcoma, Ewing's roscovitine 19.4716230394
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.1217846226
MESH:D012554 Schistosomiasis japonica Quercetin 4.8616862918
MESH:D012559 Schizophrenia Folic Acid 2.7916641680
MESH:D018805 Sepsis Curcumin 3.5218389075
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.406418539
MESH:D012852 Sinusitis Phenylephrine 4.037327846
MESH:D012871 Skin Diseases Folic Acid 3.0418709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 21.5910029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 21.5915692506
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 21.5912065085
MESH:D012878 Skin Neoplasms resveratrol 21.598985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 21.5916192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 21.5911807781 12065085 18404319 8330346 8985016
MESH:D012878 Skin Neoplasms Tretinoin 21.5916467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 3.9117203757 15625365 16767912
MESH:D013088 Spermatocele Diethylstilbestrol 16.1916709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 16.1916709447
MESH:D013088 Spermatocele Tamoxifen 16.1916709447
MESH:D013118 Spinal Cord Diseases Folic Acid 4.8216361298
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.3719457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 10.7417007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 10.7420155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 10.7419037991
MESH:D013274 Stomach Neoplasms Fluorouracil 10.7418567086 17172411 18396642 17522103 16424979 19015929 16951190 19084572 17498489 15786421
MESH:D013274 Stomach Neoplasms Folic Acid 10.7417171786
MESH:D013274 Stomach Neoplasms irinotecan 10.7415723263
MESH:D013274 Stomach Neoplasms Tretinoin 10.7417261132
MESH:D013274 Stomach Neoplasms troglitazone 10.7415930296
MESH:D013276 Stomach Ulcer Acetylcysteine 5.7617918041
MESH:D013276 Stomach Ulcer Curcumin 5.7616631530 19188055
MESH:D020521 Stroke Folic Acid 3.7916517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 3.8916321402
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.5815821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.0011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.5815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.2212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 16.921399818 3712494 6582329 6587162 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 16.9219014326
MESH:D013964 Thyroid Neoplasms decitabine 16.9217967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 16.9216010429 17909728
MESH:D013964 Thyroid Neoplasms Tretinoin 16.9217045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.0019048282
MESH:D014062 Tongue Neoplasms Fluorouracil 13.1716280240
MESH:D014062 Tongue Neoplasms resveratrol 13.1716227395
MESH:D014062 Tongue Neoplasms Tretinoin 13.1716051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.2915213294
MESH:D014376 Tuberculosis Tretinoin 2.7816040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 30.638074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 30.6312845720 20435036 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 30.6317053015
MESH:D001749 Urinary Bladder Neoplasms CD 437 30.6316720286
MESH:D001749 Urinary Bladder Neoplasms Curcumin 30.6318593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 30.6319087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 30.6317306315 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 30.6317653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 30.6316720314
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 30.6317572228 16712894 8653321
MESH:D014565 Urogenital Neoplasms Curcumin 4.5918462866
MESH:D014581 Urticaria Acetaminophen 2.3610982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 23.4516175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 23.4516803524
MESH:D002583 Uterine Cervical Neoplasms indole-3-carbinol 23.4516082211
MESH:D002583 Uterine Cervical Neoplasms resveratrol 23.4517473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 23.4516129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.4814652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 12.3915809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 12.3914692618
MESH:D014594 Uterine Neoplasms resveratrol 12.3917044934
MESH:D014604 Uveal Neoplasms decitabine 10.5617785578
MESH:D014604 Uveal Neoplasms Tretinoin 10.5616752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.7816002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.9314671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 13.5217638931 16364871 17678736 17334414
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 13.5218097624
MESH:D018487 Ventricular Dysfunction, Left resveratrol 13.5217488730
MESH:D020257 Ventricular Remodeling Isoproterenol 5.0218097624
MESH:D014820 Vitiligo Tretinoin 3.4216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.5615886252
MESH:D009396 Wilms Tumor Tretinoin 3.3916287080
Pathway ID Pathway Name
KEGG:05016 Huntington's disease
KEGG:04350 TGF-beta signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36042
    • No data
    No data
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA451578tacrolimus
    PA164768822chlorotrianisene
    PA164754789conjugated estrogens
    PA164745534dienestrol
    PA449307diethylstilbestrol
    PA449503estradiol
    PA449509estrogens
    PA449512estrone
    PA449527ethinyl estradiol
    PA451581tamoxifen
    PA449748gemcitabine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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