AutismKB 2.0

Annotation Detail for DST


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DST ( BP240,BPA,BPAG1,CATX-15,CATX15,D6S1101,DKFZp564B2416,DMH,DT,FLJ46791,KIAA0465,KIAA1470,MACF2 )
Gene Full Name: dystonin
Band: 6p12.1
Quick LinksEntrez ID:667; OMIM: 113810; Uniprot ID:DYST_HUMAN; ENSEMBL ID: ENSG00000151914; HGNC ID: 1090
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1925Pemphigoid, Bullous
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DST mRNAaffects expression 21346803
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of DST mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of DST mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DST mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DST mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of DST mRNAdecreases expression 12419474
D003010 Clorgyline Clorgyline results in increased expression of DST mRNAincreases expression 19691856
D002945 Cisplatin DST protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DST mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of DST mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of DST mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of DST mRNAincreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of DST mRNAdecreases expression 17557909
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of DST geneincreases mutagenesis 16724327
D005472 Fluorouracil DST protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
C070081 fulvestrant fulvestrant results in increased expression of DST mRNAincreases expression 16202921
D007213 Indomethacin Indomethacin results in decreased expression of DST mRNAdecreases expression 16984733
C051890 irinotecan irinotecan analog results in decreased expression of DST mRNAdecreases expression 18927307
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of DST mRNAdecreases expression 17616710
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of DST mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of DST mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of DST mRNAincreases expression 18445702
D011374 Progesterone Progesterone results in decreased expression of DST mRNAdecreases expression 18070364
D012645 Selenomethionine Selenomethionine affects the expression of DST mRNAaffects expression 17222674
D013629 Tamoxifen Tamoxifen results in increased expression of DST mRNAincreases expression 16202921
D013629 Tamoxifen Tamoxifen affects the expression of DST mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DST mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DST mRNAincreases expression 19619570
C025643 vinclozolin vinclozolin affects the expression of DST mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4014745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.796195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.7915322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7917505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.8217670903 12690470 15814532
MESH:D055371 Acute Lung Injury pirinixic acid 2.9718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 16.6320127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 16.6311798837 17638652
MESH:D000230 Adenocarcinoma Estradiol 16.6311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 16.6314692618
MESH:D000230 Adenocarcinoma Fluorouracil 16.6317638652
MESH:D000230 Adenocarcinoma Indomethacin 16.6316537180
MESH:D000236 Adenoma Benzo(a)pyrene 10.846695378
MESH:D000236 Adenoma Ethylnitrosourea 10.846695378
MESH:D000236 Adenoma Indomethacin 10.8411497255
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.4017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.4016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.4016835633
MESH:D016301 Alveolar Bone Loss Indomethacin 5.2217225004
MESH:D000544 Alzheimer Disease Indomethacin 2.6717627676 15579461
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.0110965797
MESH:D000740 Anemia Fluorouracil 8.2417963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.2411748828
MESH:D000799 Angioedema Acetaminophen 3.6910982225
MESH:D001008 Anxiety Disorders vinclozolin 3.5219015723
MESH:D001014 Aortic Aneurysm Indomethacin 4.7010231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 11.2119183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 11.2110388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3111256880
MESH:D018771 Arthralgia Indomethacin 5.022160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5715885639
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.7911248219
MESH:D001284 Atrophy fulvestrant 4.7011514358
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001477 Bartter Syndrome Indomethacin 4.8310684365
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.7314601052
MESH:D001927 Brain Diseases Ethylnitrosourea 4.7514991843
MESH:D001929 Brain Edema Indomethacin 4.8711481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1917868700
MESH:D001930 Brain Injuries Progesterone 4.1115665606 15380490 15845082
MESH:D002545 Brain Ischemia Indomethacin 4.2712524144
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.1615144691 16357521 16436596 16651633 18412241
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.6917474063 20146248
MESH:D001943 Breast Neoplasms Cisplatin 5.6919526202 18382427
MESH:D001943 Breast Neoplasms Estradiol 5.6914630087 16675129 17018787 17289903 17261762 12948864 19861407 18497071
MESH:D001943 Breast Neoplasms Fluorouracil 5.6919217205 16595493 18608205 16110121 16557594 18357371 15136595
MESH:D001943 Breast Neoplasms fulvestrant 5.6918984771
MESH:D001943 Breast Neoplasms Indomethacin 5.6917401462
MESH:D001943 Breast Neoplasms Progesterone 5.6915562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 5.6919189210 19200415 20544844 17261762 17893378 21152245 19142967 16273361 19011961 17440819 19221464 19103187 19189212 20390343 18815881 20005174 19115204 19487384 16873071 18984771 19410462 20859285 18351453 19059307 21138602 19244106 11161223 19288272 16202921 16818667 17049068 18629630 15565566 20135344 18855134 18821012 15668708 17242785 19084267 18425577 20065188 19155303 19066611 18997820 19289846
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.6920435547
MESH:D002056 Burns Indomethacin 4.5510459503
MESH:D002100 Cachexia Indomethacin 4.8511239499 16537180 15141370 15625704
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3116111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.5216051944
MESH:D002277 Carcinoma Fluorouracil 7.7817121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.7816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3519066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 16.5116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.513084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 16.5117982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.5116924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 16.5117971768 16332177 18930000 16799960 17088986 17045692
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 16.5116391822
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 16.5117173139 20935162 20007298 6705139 1701930
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 16.5116924424
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.5711053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.2011352223 14736730 18791128
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.9816685392 12023789
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.5218695887
MESH:D002292 Carcinoma, Renal Cell Indomethacin 6.5217341418
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.4820419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 10.4817066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.4816757204 17066447 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 10.4815482327 12636206
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.4910977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.216135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.2120889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.2118566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 15.2116003739
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.104080065
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.8317160924
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0316835633
MESH:D002764 Cholecystitis Indomethacin 5.0211181007
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3716105132 11677210 16919318 17333356 17681005 17110522 15861022
MESH:D002779 Cholestasis pirinixic acid 7.3719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.048697196 12621046 16354765 15668235 15340226
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.6020423518
MESH:D003110 Colonic Neoplasms Fluorouracil 5.7917169374 16340194 17172411 17725105 18772588 16510598 17016597 15001691 17287894 17018589
MESH:D003110 Colonic Neoplasms Indomethacin 5.7915786552 11260862 15963497 15936596 15625704 15637740
MESH:D003110 Colonic Neoplasms irinotecan 5.7917725105 17287894
MESH:D015179 Colorectal Neoplasms Cisplatin 4.7415273666
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.7416331619 17094418 16303861 14970324 16524972 18383874 18509181 17401013 20501625 17255274 17695437 15148649 18802399 18448328 17454858 17016601 18949393 17594712 16282729 18288408 15289873 16391804
MESH:D015179 Colorectal Neoplasms Indomethacin 4.7418059344 12606626 17054584 11197048
MESH:D015179 Colorectal Neoplasms irinotecan 4.7416391804 17159606 17454858 16303861 15273666 18259882 18509181
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9314669216 17141729
MESH:D018352 Coronavirus Infections Indomethacin 5.5717302372
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 10048152 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.1914966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8718551238
MESH:D007644 Darier Disease Fluorouracil 4.6416733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2119031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6317107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.4119279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.4119279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.3417187935
MESH:D003967 Diarrhea Indomethacin 3.657907874 7237001
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 5.8521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.8519164858 19739265 18713872 11461765 19370779 19416960 10663392 10915739 16485898 11287661 12594235 12958197 11529661 17522070 12392966 17906064 11743745 16081117 11739529 16177239 16393943 19085960 12153990 18071297 12540782 16109766 19923254 15968718 2444490 14725611 17562736 16781746 14550746 12705907 16227642 10774834 19420014 11834606 14986274 15619225 11421492
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.8520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D004362 Drug Toxicity Cisplatin 7.8112231392 15033597 12649298 19839026
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.8111462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.0017190690 16133044 18043480 18446180 16326151 12774134
MESH:D004381 Duodenal Ulcer Indomethacin 3.9917151854 17351913 17329845 11991626 10671773 17202747 17045617 11535926 11595415 16699067 11595431
MESH:D004421 Dystonia Phenobarbital 3.861851702
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.8318357618
MESH:D004487 Edema Indomethacin 10.658273558 7907874 10653021 16100529 19703484 7990266 8985016
MESH:D004487 Edema pirinixic acid 10.6512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.4712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 14.4717692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.4719031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.0618566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.0619155303 16202921 20544844 17893378
MESH:D004715 Endometriosis Indomethacin 14.5315652904
MESH:D004715 Endometriosis Progesterone 14.5316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 14.5310568697 9294722
MESH:D019446 Endotoxemia Indomethacin 4.3518509659
MESH:D004751 Enteritis Indomethacin 4.5910567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.8317980183
MESH:D004802 Eosinophilia Indomethacin 3.9011298111
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.963659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.723922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.416401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.107750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.873659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 13.4220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 13.4216530937
MESH:D004938 Esophageal Neoplasms Cisplatin 13.4216481741 15173087 16785472 15464296 17638652
MESH:D004938 Esophageal Neoplasms Fluorouracil 13.4216337965 17638652 16481741 15173087 16785472
MESH:D004938 Esophageal Neoplasms Indomethacin 13.4211005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.2415345470
MESH:D005234 Fatty Liver pirinixic acid 12.2420131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 12.2419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005334 Fever Indomethacin 3.9811852909 10431976 17627676
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0319069698
MESH:D005354 Fibrosarcoma Indomethacin 4.7410962813
MESH:D005355 Fibrosis Indomethacin 8.3217994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.3220067830
MESH:D005499 Folliculitis Indomethacin 5.0211298111
MESH:D005756 Gastritis Acetaminophen 10.6416983495
MESH:D005756 Gastritis Indomethacin 10.6415046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7816973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1516417039
MESH:D005909 Glioblastoma Ethylnitrosourea 7.3016436596
MESH:D005909 Glioblastoma Indomethacin 7.3012870263
MESH:D005910 Glioma Ethylnitrosourea 9.7216357521 16651633 18412241
MESH:D005910 Glioma Fluorouracil 9.7216145905
MESH:D005910 Glioma Indomethacin 9.7218371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.1611849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006073 Gout Indomethacin 5.2011248219
MESH:D006258 Head and Neck Neoplasms Cisplatin 12.4915102660 15464296
MESH:D006258 Head and Neck Neoplasms Fluorouracil 12.4915102660 18337622 15162350
MESH:D006258 Head and Neck Neoplasms Indomethacin 12.4915482327
MESH:D034381 Hearing Loss Cisplatin 4.1719898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.2915464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1810048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4420558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.4315633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.5315135802
MESH:D006529 Hepatomegaly Phenobarbital 13.5116109766
MESH:D006529 Hepatomegaly pirinixic acid 13.5119772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.5112621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8815709030
MESH:D006689 Hodgkin Disease Cisplatin 3.4716170182 16200630
MESH:D019584 Hot Flashes Estradiol 3.6017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.898697196 16354765 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 7.4316870215
MESH:D006930 Hyperalgesia Indomethacin 7.4312727271
MESH:D034321 Hyperamylasemia Indomethacin 5.5717883296
MESH:D006940 Hyperemia Indomethacin 4.8512524144
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D006949 Hyperlipidemias Indomethacin 4.0217546600
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8518850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6616945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 4.8718306037 10574470
MESH:D007079 Ileitis Indomethacin 5.2010651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.2216133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2515869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.7317937319
MESH:D007248 Infertility, Male fulvestrant 10.7311514358
MESH:D007248 Infertility, Male vinclozolin 10.7316467254
MESH:D007249 Inflammation Indomethacin 11.347812673 3291741 12568917
MESH:D007249 Inflammation Progesterone 11.3415869954
MESH:D007249 Inflammation Tamoxifen 11.3419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.3412200463 12878042
MESH:D007333 Insulin Resistance Estradiol 6.8716627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.8716306350
MESH:D007410 Intestinal Diseases Indomethacin 4.1715610444 17994277 10210152 17329856 11686837 11713966 18236018 15831440 11855677
MESH:D019586 Intracranial Hypertension Indomethacin 5.2215241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007579 Jejunal Diseases Indomethacin 4.8710574470 18306037 16133968
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.9915464296
MESH:D007674 Kidney Diseases Acetaminophen 13.7712587719 15629191
MESH:D007674 Kidney Diseases Cisplatin 13.7712649298 18289764 12231392 19839026 15190930
MESH:D007674 Kidney Diseases Estradiol 13.7715618244
MESH:D007674 Kidney Diseases Indomethacin 13.7717190690
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 22.0316705839
MESH:D007680 Kidney Neoplasms Estradiol 22.0315610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 22.0317379185
MESH:D007680 Kidney Neoplasms Fluorouracil 22.0316985049
MESH:D007680 Kidney Neoplasms Tamoxifen 22.0318625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.6411231351
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.7810320625 12228301 11703811
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.8110785260 16572323 15631656
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6118360721
MESH:D007964 Leukocytosis Indomethacin 5.2216537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.5717980183
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5816417039
MESH:D008064 Lipidoses Tamoxifen 3.0517567588 15342952
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.5711479899
MESH:D008103 Liver Cirrhosis Phenobarbital 2.8121047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.5314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 6.5318194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.5318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5312878042
MESH:D008107 Liver Diseases Acetaminophen 3.8019460945 12969438 12587719 16610002 11587558 16611625 19014921 19784758
MESH:D008107 Liver Diseases Phenobarbital 3.8019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 21.037678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.0320195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 21.0317045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms Phenobarbital 21.0319812893 19482888 15975961 21047994 8742319 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 21.0320007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 21.0316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.0316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.256135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.251399818 18308698 17172636 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.2512151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.4220135361 18816296 18520028 18569708 17053015 20464547 6695378 20869020 20064080
MESH:D008175 Lung Neoplasms Cisplatin 10.426189445 11798837 17225452
MESH:D008175 Lung Neoplasms Ethylnitrosourea 10.4216271038 17703301 16019985 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 10.4215246190
MESH:D008175 Lung Neoplasms Indomethacin 10.4216537180 11497255 11053908
MESH:D008175 Lung Neoplasms Tamoxifen 10.4218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.4211884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6415086387
MESH:D008223 Lymphoma Ethylnitrosourea 3.8315790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.9015375218
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6119428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.5117203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 13.5110767621 18041768 10838139
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.5117203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.5116827153 11731420 19196723 14580682 19196722
MESH:D020149 Manganese Poisoning Estradiol 12.1419453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.1419453300
MESH:D008545 Melanoma Cisplatin 3.3912374674 17761969 18332650 12393984 12883367 16432458 11135225 17023156 18176117 18505091 16809738 15577323 16248763
MESH:D008545 Melanoma Tamoxifen 3.3919393235 12393984
MESH:D018328 Melanoma, Amelanotic Cisplatin 11.0015990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 11.0015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4219513568
MESH:D008579 Meningioma Ethylnitrosourea 5.8317943659
MESH:D008654 Mesothelioma Cisplatin 3.1917638057
MESH:D008881 Migraine Disorders Indomethacin 3.5711903285
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 13.7516381670
MESH:D009062 Mouth Neoplasms Fluorouracil 13.7516757204 18986760
MESH:D009062 Mouth Neoplasms Indomethacin 13.7512636206
MESH:D052016 Mucositis irinotecan 4.8617159606
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.8616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.8616411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3217484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.717678174 18551238
MESH:D009362 Neoplasm Metastasis Indomethacin 9.2911053908 11239499 16537180
MESH:D009362 Neoplasm Metastasis irinotecan 9.2918259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.2919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4719410462
MESH:D009369 Neoplasms Benzo(a)pyrene 11.2611141357
MESH:D009369 Neoplasms Cisplatin 11.2616773208
MESH:D009369 Neoplasms Fluorouracil 11.2616928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 11.2617405874
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 9.0516707424
MESH:D009374 Neoplasms, Experimental Indomethacin 9.0510663608 15625704
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8519200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5817289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.3415464296
MESH:D009421 Nervous System Malformations Estradiol 8.9716427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.9714600291
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.2616651423 16003739 17160924
MESH:D009447 Neuroblastoma Cisplatin 6.978761367
MESH:D009447 Neuroblastoma irinotecan 6.978761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.9918514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 7.9912349958
MESH:D017599 Neuroectodermal Tumors Cisplatin 10.968761367
MESH:D017599 Neuroectodermal Tumors irinotecan 10.968761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3416436463
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.026374098
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3016049721
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.8317160924
MESH:D010003 Osteoarthritis Indomethacin 3.587009135
MESH:D010018 Osteomalacia Phenobarbital 4.2117016548
MESH:D010051 Ovarian Neoplasms Cisplatin 7.6819769630 17225452 6897625 15464296
MESH:D010051 Ovarian Neoplasms Estradiol 7.6819401270
MESH:D010051 Ovarian Neoplasms Progesterone 7.6817393432 16525653
MESH:D010146 Pain Acetaminophen 6.3816870215
MESH:D010146 Pain Indomethacin 6.3813679232 17627676 3291741 17440234
MESH:D010149 Pain, Postoperative Indomethacin 4.5318702446 12538197
MESH:D010190 Pancreatic Neoplasms Cisplatin 8.4019003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.4016500647 19003803 15113037 16929163
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.4016965848
MESH:D010195 Pancreatitis Indomethacin 3.7815028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5411578682
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.5716537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.9812349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.5711903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010437 Peptic Ulcer Indomethacin 5.0011148446
MESH:D010518 Periodontitis Indomethacin 4.7617225004
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.1615464296
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.3511550810
MESH:D010997 Pleural Neoplasms Cisplatin 5.1917638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.492563599
MESH:D047928 Premature Birth Indomethacin 4.9817000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.9811222880 11118676 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.9818042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.7818220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7520887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Clorgyline 1.8819691856
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8818626508 19082440
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011472 Prostatitis vinclozolin 4.7818629315
MESH:D011507 Proteinuria Indomethacin 4.0211849393
MESH:D011537 Pruritus Ethinyl Estradiol 3.1616919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.3412752131
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8816160472 18722050 18286688 15538739
MESH:D051437 Renal Insufficiency Cisplatin 4.2615464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.3119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8018045962
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.2814601052
MESH:D012640 Seizures 2,6-dinitrotoluene 5.5918551238
MESH:D012640 Seizures Phenobarbital 5.593137016 4039156 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.676407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.9919755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.998532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.9916192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.1915464296
MESH:D013088 Spermatocele Ethinyl Estradiol 11.0616709447
MESH:D013088 Spermatocele Tamoxifen 11.0616709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.3616503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.3619457130
MESH:D013272 Stomach Diseases Indomethacin 4.2718545984 16280098 16113693 10192188 17207306 16184426 10215738 18209964 17160473 17638125 15038085 10486359 15472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 6.262093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 6.2617522103 18396642 15958060
MESH:D013274 Stomach Neoplasms Fluorouracil 6.2616951190 17498489 18396642 16424979 18567086 17522103 19015929 15786421 19084572 17172411
MESH:D013274 Stomach Neoplasms Indomethacin 6.2615609394
MESH:D013274 Stomach Neoplasms irinotecan 6.2615723263
MESH:D013276 Stomach Ulcer Indomethacin 3.4517627676 12787963 17895592 11523592 17977527 18209962 1323529 12500499 16631530 18181030 15104355 11595431 16397915 11145282 11906479 11729361 12077510 18299717 15138204 17654042 17918041 15255614 10423059 16169175 16150113 16252198 14567935 18237397 12498302 18726076 17135157 18193104 16755016 10878458 11595415 17657623 12467913 16934674 10750652 18087811 18431645 18543354
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 4.7915864552
MESH:D013736 Testicular Neoplasms Cisplatin 4.4917225452 15464296
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0215669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.0115790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms Indomethacin 7.0214736730 18791128 11352223
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.021399818
MESH:D013978 Tibial Fractures Estradiol 4.5319048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8516280240
MESH:D014456 Ulcer Indomethacin 4.7417380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.4516049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.4517053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 11.4515464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.458653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1710091137
MESH:D014581 Urticaria Acetaminophen 2.8310982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 9.2016803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.2016803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1514692618
MESH:D014625 Vaginal Neoplasms Cisplatin 4.4615577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4014671159 15869587
MESH:D014839 Vomiting Cisplatin 11.0311897121
MESH:D014839 Vomiting Indomethacin 11.0311897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
Pathway ID Pathway Name
REACT:20676 Cell junction organization
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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