AutismKB 2.0

Annotation Detail for SP3


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Basic Information Top
Gene Symbol:SP3 ( DKFZp686O1631,SPR2 )
Gene Full Name: Sp3 transcription factor
Band: 2q31.1
Quick LinksEntrez ID:6670; OMIM: 601804; Uniprot ID:SP3_HUMAN; ENSEMBL ID: ENSG00000172845; HGNC ID: 11208
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200072Regulation of Telomerase
No data
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Related Diseases/Disorders Top
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Desease IDDesease Name
1712Yersinia infection
2051Leukemia
2125Bladder cancer
2214Malignant glioma
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in decreased expression of SP3 mRNAdecreases expression 20435036
C006632 arsenic trioxide arsenic trioxide results in decreased expression of SP3 proteindecreases expression 20435036
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SP3 mRNAdecreases expression 19150397
D003474 Curcumin Curcumin results in decreased expression of SP3 proteindecreases expression 18593936
C014347 decitabine [decitabine co-treated with trichostatin A] promotes the reaction [SP3 protein binds to CLDN3 promoter]affects binding|affects cotreatment|increases reaction 17986852
C014347 decitabine decitabine promotes the reaction [SP3 protein binds to CIDEA promoter]affects binding|increases reaction 18033804
C014347 decitabine decitabine promotes the reaction [SP3 protein binds to CLDN3 promoter]affects binding|increases reaction 17986852
D011397 Promegestone mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP3 protein binds to HSD17B2 promoter]]affects binding|decreases reaction|increases reaction 16807381
D011397 Promegestone Promegestone promotes the reaction [SP3 protein binds to HSD17B2 promoter]affects binding|increases reaction 16807381
D011397 Promegestone Promegestone results in increased expression of SP3 mRNAincreases expression 16807381
D011397 Promegestone Promegestone results in increased expression of SP3 proteinincreases expression 16807381
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SP3 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of SP3 mRNA]affects reaction|decreases expression 15016801
C070081 fulvestrant fulvestrant promotes the reaction [SP3 protein binds to ESRRA promoter]affects binding|increases reaction 20211987
D005978 Glutathione Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP3 protein]decreases expression|decreases reaction 20435036
D006861 Hydrogen Peroxide Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP3 protein]decreases expression|decreases reaction 20435036
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of SP3 proteindecreases expression 20435036
C066851 mithramycin A mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP3 protein binds to HSD17B2 promoter]]affects binding|decreases reaction|increases reaction 16807381
C066851 mithramycin A mithramycin A inhibits the reaction [SP3 protein binds to HSD17B2 promoter]affects binding|decreases reaction 16807381
D026422 S-Nitrosoglutathione S-Nitrosoglutathione results in decreased activity of SP3 proteindecreases activity 14766015
D026422 S-Nitrosoglutathione S-Nitrosoglutathione results in increased activity of SP3 proteinincreases activity 14766015
D010634 Phenobarbital Phenobarbital results in increased expression of SP3 mRNAincreases expression 19270015
D010672 Phenytoin Phenytoin results in increased expression of SP3 mRNAincreases expression 14741686
C006253 pirinixic acid pirinixic acid results in increased expression of SP3 mRNAincreases expression 18301758
C017947 sodium arsenite sodium arsenite results in increased expression of SP3 mRNAincreases expression 12016162
D013629 Tamoxifen Tamoxifen promotes the reaction [SP3 protein binds to ESRRA promoter]affects binding|increases reaction 20211987
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SP3 mRNAaffects cotreatment|increases expression 17942748
C012589 trichostatin A [decitabine co-treated with trichostatin A] promotes the reaction [SP3 protein binds to CLDN3 promoter]affects binding|affects cotreatment|increases reaction 17986852
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4914745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.986195326
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 13.989677735 10563481 9118846 3425630 6195326 8986270
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.9811752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8917505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0518653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.9911798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.9914692618
MESH:D000230 Adenocarcinoma Fluorouracil 6.9917638652
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.9417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.9416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.9416835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8517306315 16712894
MESH:D019973 Alcohol-Related Disorders Curcumin 5.0317887948
MESH:D000544 Alzheimer Disease Curcumin 2.6015590663
MESH:D000740 Anemia Fluorouracil 8.4816511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.4811748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6215885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7216807698
MESH:D050197 Atherosclerosis Curcumin 7.0318704882
MESH:D050197 Atherosclerosis Phenytoin 7.0315136057
MESH:D001284 Atrophy fulvestrant 4.7811514358
MESH:D001321 Autistic Disorder Glutathione 3.0218929414 19267885 19056591 16917939
MESH:D001327 Autoimmune Diseases Curcumin 4.4319761891
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.9216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.9219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.9212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D002545 Brain Ischemia Curcumin 4.2716770732
MESH:D001932 Brain Neoplasms Curcumin 3.8817596214
MESH:D001943 Breast Neoplasms Curcumin 2.9418593918 16243823 19250217 18462866
MESH:D001943 Breast Neoplasms decitabine 2.9418320071 19208741
MESH:D001943 Breast Neoplasms Fluorouracil 2.9418357371 19217205 16110121 18608205 15136595 16595493 16557594
MESH:D001943 Breast Neoplasms fulvestrant 2.9418984771
MESH:D001943 Breast Neoplasms Tamoxifen 2.9418855134 18425577 19142967 19244106 19155303 18984771 18629630 16818667 11161223 17893378 19103187 19200415 16273361 19066611 16202921 17440819 18351453 19487384 19059307 20544844 20135344 17049068 19189210 20859285 15668708 20390343 21152245 19189212 18815881 18821012 18997820 21138602 19221464 19289846 19115204 19410462 20005174 20065188 17242785 17261762 19011961 15565566 16873071 19288272 19084267
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9420435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2711589617
MESH:D002276 Carcinoid Tumor Fluorouracil 4.6116051944
MESH:D002277 Carcinoma Curcumin 13.6618593918
MESH:D002277 Carcinoma Fluorouracil 13.6617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 13.6616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4419066611
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.7715553829 16217749 11135700 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.7716332177 17971768 17045692 17088986 16799960 18930000
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.7720935162 17173139 20007298 1701930 6705139
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.7716507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.7716924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9518414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8219014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9918695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0612490120
MESH:D002294 Carcinoma, Squamous Cell Curcumin 14.1718462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 14.1719215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 14.1716757204 18986760 17066447 16280240
MESH:D002294 Carcinoma, Squamous Cell Glutathione 14.1717015178
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 14.1718572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3318670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.4716936243
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.5720889678
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.5720056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 11.464080065
MESH:D002493 Central Nervous System Diseases Phenytoin 11.464080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1016835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.5816105132 17333356 17681005 15861022 11677210 17110522 16919318
MESH:D002779 Cholestasis pirinixic acid 7.5819176532
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.8111748493
MESH:D002971 Cleft Lip Phenytoin 4.122227380
MESH:D002972 Cleft Palate Phenytoin 6.073877104 6862529 1687470 6856622 10789828 2227380
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0715340226 8697196 15668235 12621046 16354765
MESH:D003092 Colitis Curcumin 4.1116782535 18200517 16804969
MESH:D003103 Coloboma Curcumin 11.1218809619
MESH:D003103 Coloboma Phenytoin 11.129212184
MESH:D003110 Colonic Neoplasms Curcumin 5.8419359593 16340194
MESH:D003110 Colonic Neoplasms decitabine 5.8417616700
MESH:D003110 Colonic Neoplasms Fluorouracil 5.8417287894 16510598 17172411 17725105 17016597 15001691 17169374 16340194 17018589 18772588
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.4420501625
MESH:D015179 Colorectal Neoplasms decitabine 3.4418981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.4418383874 14970324 17695437 17094418 16303861 17016601 18509181 17594712 16331619 18949393 20501625 17255274 15148649 18288408 18802399 15289873 18448328 16524972 16391804 17401013 17454858 16282729
MESH:D000013 Congenital Abnormalities Phenytoin 9.1910627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.1914669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.8318497527
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8610525206
MESH:D019465 Craniofacial Abnormalities Phenytoin 3.868986270 19952982 9212184
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8620055451 10048152 15322242
MESH:D003550 Cystic Fibrosis Glutathione 4.4319747007
MESH:D007644 Darier Disease Fluorouracil 4.7316733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0315213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3019031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3918249437
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.3518403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3517107852
MESH:D003928 Diabetic Nephropathies Curcumin 8.8718204486
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.8719279558
OMIM:607208 DRAVET SYNDROME Phenytoin 5.3211748493
MESH:D003875 Drug Eruptions Phenytoin 5.4415024534
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7111462148
MESH:D004381 Duodenal Ulcer Curcumin 3.9817351913
MESH:D004421 Dystonia Phenobarbital 3.941851702
MESH:D004487 Edema pirinixic acid 6.3312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.3312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 15.0812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 15.0817654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 15.0819031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 13.8419294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 13.8419294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0020544844 19155303 17893378 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9610568697 9294722
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 5.1320235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 6.181399206 6251365
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.043659116
MESH:D004828 Epilepsies, Partial Phenobarbital 10.163922381 11558140
MESH:D004828 Epilepsies, Partial Phenytoin 10.1617116037 11558140
MESH:D004827 Epilepsy Phenobarbital 6.9220417680
MESH:D004827 Epilepsy Phenytoin 6.92821787 11434505 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.486401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 11.467750514
MESH:D017029 Epilepsy, Complex Partial Phenytoin 11.467750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 10.643659116
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 10.643659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1720426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.1712903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.1716785472 15173087 17638652 16337965 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005234 Fatty Liver arsenic trioxide 24.0015073043
MESH:D005234 Fatty Liver Curcumin 24.0019297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.0015345470
MESH:D005234 Fatty Liver pirinixic acid 24.0019236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 24.0019224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1916709447
MESH:D005313 Fetal Death Phenytoin 10.5310627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 10.5311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1219069698
MESH:D005355 Fibrosis Curcumin 8.5818705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.5820067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2016904648
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.6318462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6216452187
MESH:D005885 Gingival Hyperplasia Phenytoin 5.609029455
MESH:D019214 Gingival Overgrowth Phenytoin 6.1816390469 14659971
MESH:D005909 Glioblastoma Curcumin 7.4517596214
MESH:D005909 Glioblastoma trichostatin A 7.4518801729
MESH:D005910 Glioma Fluorouracil 2.8416145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006258 Head and Neck Neoplasms Curcumin 12.7818462866 18829502
MESH:D006258 Head and Neck Neoplasms decitabine 12.7819215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 12.7815162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3011294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5020558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006529 Hepatomegaly Phenobarbital 14.0216109766
MESH:D006529 Hepatomegaly pirinixic acid 14.0216221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.0216120746 15340226 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.9817701891
MESH:D006689 Hodgkin Disease sodium arsenite 3.1012676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.998697196 15340226 16959395 16354765 18606429
MESH:D006937 Hypercholesterolemia Curcumin 3.9918704882
MESH:D006943 Hyperglycemia pirinixic acid 3.1220558911
MESH:D020138 Hyperhomocysteinemia Phenytoin 4.6110459572
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4012013081
MESH:D007248 Infertility, Male decitabine 15.7217581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 15.7217937319
MESH:D007248 Infertility, Male fulvestrant 15.7211514358
MESH:D007248 Infertility, Male sodium arsenite 15.7215346721 12646999
MESH:D007249 Inflammation Curcumin 8.1418403477 17151092 16956363
MESH:D007249 Inflammation Tamoxifen 8.1419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.1412878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1818200517 18596194
MESH:D007333 Insulin Resistance pirinixic acid 2.5916306350
MESH:D007414 Intestinal Neoplasms Curcumin 4.1610783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007674 Kidney Diseases sodium arsenite 2.7620008137
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.2116518626
MESH:D007680 Kidney Neoplasms Fluorouracil 7.3216985049
MESH:D007680 Kidney Neoplasms Tamoxifen 7.3218625569
MESH:D007889 Leiomyoma Curcumin 4.5118555241
MESH:D007938 Leukemia arsenic trioxide 10.3815070760
MESH:D007938 Leukemia Curcumin 10.3818462866
MESH:D007938 Leukemia decitabine 10.3819235587 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.5612560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 9.5616106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.3819077051
MESH:D007951 Leukemia, Myeloid decitabine 9.3817236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.1919850784 16968895 16467208 20471514 17050201
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.1918704418 19387464 19010910 18206229 18460780 17679729
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 6.1918206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4118055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1719035177 16330433 17712046 17217047 19075265 16891316 16331271 15213294 12018890 19225113 16112521 12679006 12712474 16966277 11468182 17649720 17107899 17869043 19642359 15622746 15336539 11161223 9834237 16823087 15748426
MESH:D015458 Leukemia, T-Cell arsenic trioxide 11.5016882451
MESH:D015458 Leukemia, T-Cell Curcumin 11.5016106398
MESH:D008064 Lipidoses Tamoxifen 3.1117567588 15342952
MESH:D008103 Liver Cirrhosis Phenobarbital 2.8621047994
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 4.8818006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8815474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.8818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8812878042
MESH:D008107 Liver Diseases Curcumin 6.6716956363
MESH:D008107 Liver Diseases Phenobarbital 6.6719363144
MESH:D008107 Liver Diseases Phenytoin 6.6714986274
MESH:D008113 Liver Neoplasms arsenic trioxide 21.5414682389
MESH:D008113 Liver Neoplasms Fluorouracil 21.5418383874 17045692 15113037 16603448
MESH:D008113 Liver Neoplasms Phenobarbital 21.5415975961 8742319 21047994 19812893 19482888 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 21.5420007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 21.5416712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 21.5416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.5416984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.5820377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.5817172636 6150874 18308698 1399818 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.5812151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3015213294
MESH:D008171 Lung Diseases sodium arsenite 3.1319095001
MESH:D008175 Lung Neoplasms arsenic trioxide 8.4611798837 19825857
MESH:D008175 Lung Neoplasms Curcumin 8.4618462866 19359593 16243823
MESH:D008175 Lung Neoplasms Fluorouracil 8.4615246190
MESH:D008175 Lung Neoplasms sodium arsenite 8.4616712894 17077188 17306315 15276417 19931552
MESH:D008175 Lung Neoplasms Tamoxifen 8.4618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.4611884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7315086387
MESH:D008223 Lymphoma Curcumin 7.6118462866
MESH:D008223 Lymphoma decitabine 7.6119470736
MESH:D016399 Lymphoma, T-Cell Curcumin 4.6316173963
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.5811731420 14580682 16827153 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.4919453300
MESH:D008545 Melanoma Curcumin 9.7018462866 17885582
MESH:D008545 Melanoma decitabine 9.7016505122 17785578
MESH:D008545 Melanoma sodium arsenite 9.7019082730 16487513
MESH:D008545 Melanoma Tamoxifen 9.7019393235 12393984
MESH:D008545 Melanoma trichostatin A 9.7016505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1215990972
MESH:D008569 Memory Disorders Curcumin 4.0917263510
MESH:D008607 Mental Retardation Phenytoin 3.659212184
MESH:D009062 Mouth Neoplasms Fluorouracil 3.5816757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 16.9315949261 11468182 19417148 14977855 19549372
MESH:D009101 Multiple Myeloma Curcumin 16.9319372569
MESH:D009101 Multiple Myeloma decitabine 16.9318172295
MESH:D009101 Multiple Myeloma trichostatin A 16.9318172295
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.8617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.4416239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.3816105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 7.3818608210 16882708 19010910 19157545
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 12.2917484760
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 12.2917484760
MESH:D009224 Myotonia Congenita Phenytoin 5.351896199
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 10.1116624393
MESH:D009361 Neoplasm Invasiveness Curcumin 10.1118495463
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4919410462
MESH:D009369 Neoplasms decitabine 11.6119470736 19116145 17925555
MESH:D009369 Neoplasms Fluorouracil 11.6118600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 11.6117405874
MESH:D009369 Neoplasms sodium arsenite 11.6111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6020056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 10.6612497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.6619200415 19196722 19189210
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1514600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.5718462866
MESH:D009436 Neural Tube Defects arsenic trioxide 12.0510525206
MESH:D009436 Neural Tube Defects Phenytoin 12.059118846
MESH:D009436 Neural Tube Defects sodium arsenite 12.0512854658
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3916436463
MESH:D009765 Obesity Curcumin 4.5519297423
MESH:D009765 Obesity pirinixic acid 4.5520558911
MESH:D010018 Osteomalacia Phenobarbital 11.8717016548
MESH:D010018 Osteomalacia Phenytoin 11.8717016548
MESH:D010024 Osteoporosis Curcumin 3.4318719352
MESH:D010051 Ovarian Neoplasms arsenic trioxide 14.7916624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Curcumin 14.7919020741 18462866
MESH:D010051 Ovarian Neoplasms decitabine 14.7919331143 19259094
MESH:D010051 Ovarian Neoplasms sodium arsenite 14.7917306315 15276417
MESH:D010051 Ovarian Neoplasms trichostatin A 14.7919331143
MESH:D010146 Pain Phenytoin 3.9215215642
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 20.2115580305
MESH:D010190 Pancreatic Neoplasms Curcumin 20.2117440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms decitabine 20.2119294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 20.2115113037 16929163 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 20.2116965848
MESH:D010190 Pancreatic Neoplasms trichostatin A 20.2119294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6211578682
MESH:D010212 Papilloma Hydrogen Peroxide 4.0212065085
MESH:D010235 Paraganglioma arsenic trioxide 4.1019927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D017689 Polydactyly Phenytoin 4.989212184
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.562563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1311222880 11896295 11399792 11118676
MESH:D055728 Primary Myelofibrosis decitabine 12.2117616702
MESH:D055728 Primary Myelofibrosis trichostatin A 12.2117616702
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8919131511
MESH:D011471 Prostatic Neoplasms Curcumin 1.8910851300 11398177 12497104 18226269 18156803 15129424 18769126
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8919082440 18626508
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8916039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011471 Prostatic Neoplasms trichostatin A 1.8919789329 18798265
MESH:D011537 Pruritus Ethinyl Estradiol 3.2516919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 12.3712752131
MESH:D019310 Pseudolymphoma Phenytoin 12.3712752131 1419762 8603615
MESH:D011656 Pulmonary Emphysema Curcumin 4.4719168576
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9516160472 18286688 15538739 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.3519058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.9618379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.3419155313
MESH:D012509 Sarcoma Curcumin 4.0618462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9016646077
MESH:D012640 Seizures Phenobarbital 6.2211442880 3137016 4039156 16876388
MESH:D012640 Seizures Phenytoin 6.2211044598 3137016 16876388 3691417 10029267 15946322 9844417 19919933
MESH:D003294 Seizures, Febrile Phenobarbital 4.766407741
MESH:D018805 Sepsis Curcumin 4.0218389075
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 9.3112065085
MESH:D012878 Skin Neoplasms sodium arsenite 9.3118572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.3116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.3716709447
MESH:D013088 Spermatocele Tamoxifen 11.3716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9819457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7412854658
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 5.0920235791
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4117007042
MESH:D013274 Stomach Neoplasms decitabine 3.4119037991
MESH:D013274 Stomach Neoplasms Fluorouracil 3.4118396642 19084572 17522103 17498489 16951190 17172411 19015929 15786421 16424979 18567086
MESH:D013276 Stomach Ulcer Curcumin 3.4419188055 16631530
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.7319014326
MESH:D013964 Thyroid Neoplasms decitabine 11.7317967635
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.731399818
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9316280240
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9015213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 15.5511780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Curcumin 15.5518593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 15.5519087683 17616700
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 15.5516712894 17306315 11723127 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.5516712894 17572228 8653321
MESH:D014565 Urogenital Neoplasms Curcumin 5.2018462866
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.2816803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.2811813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2314692618
MESH:D014604 Uveal Neoplasms decitabine 4.8617785578
MESH:D014652 Vascular Diseases sodium arsenite 4.3617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36045
    • No data
    No data
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA451578tacrolimus
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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