AutismKB 2.0

Annotation Detail for SP100


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Basic Information Top
Gene Symbol:SP100 ( DKFZp686E07254,FLJ00340,FLJ34579 )
Gene Full Name: SP100 nuclear antigen
Band: 2q37.1
Quick LinksEntrez ID:6672; OMIM: 604585; Uniprot ID:SP100_HUMAN; ENSEMBL ID: ENSG00000067066; HGNC ID: 11206
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2011Leukoencephalopathy
2151Neuroblastoma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SP100 mRNAdecreases expression 20713471
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of SP100 mRNAincreases expression 15003993
14729362
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SP100 mRNAaffects expression 17484886
D002945 Cisplatin SP100 protein results in decreased susceptibility to Cisplatindecreases response to substance 16734730
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SP100 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of SP100 mRNAincreases expression 19619570
C059514 resveratrol BCL2 protein inhibits the reaction [resveratrol promotes the reaction [PML protein binds to SP100 protein]]affects binding|decreases reaction|increases reaction 19631782
C059514 resveratrol resveratrol promotes the reaction [PML protein binds to SP100 protein]affects binding|increases reaction 19631782
D012643 Selenium Selenium results in decreased expression of SP100 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SP100 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SP100 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SP100 mRNAincreases expression 20106945
16704738
D014810 Vitamin E Vitamin E results in decreased expression of SP100 mRNAdecreases expression 19244175
C111237 vorinostat vorinostat promotes the reaction [PML protein binds to SP100 protein]affects binding|increases reaction 19631782
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0814514962 15322242 11752688
MESH:D058186 Acute Kidney Injury Cisplatin 9.4615814532 12690470 17670903
MESH:D058186 Acute Kidney Injury resveratrol 9.4616538975
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.3620464547 20127859
MESH:D000230 Adenocarcinoma Cisplatin 7.3611798837 17638652
MESH:D000230 Adenocarcinoma Estradiol 7.3611473722
MESH:D000236 Adenoma Benzo(a)pyrene 7.116695378
MESH:D000236 Adenoma resveratrol 7.1115688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000544 Alzheimer Disease resveratrol 2.6016183991 16162502
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001169 Arthritis, Experimental resveratrol 3.6017115116
MESH:D050197 Atherosclerosis resveratrol 3.3716873680 17967414
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.1514601052
MESH:D002545 Brain Ischemia resveratrol 4.5217600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.0420146248 17474063
MESH:D001943 Breast Neoplasms Cisplatin 3.0419526202 18382427
MESH:D001943 Breast Neoplasms Estradiol 3.0414630087 19861407 17289903 12948864 17261762 17018787 16675129 18497071
MESH:D001943 Breast Neoplasms resveratrol 3.0416393696 17534123 17651959
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.0420435547
MESH:D001943 Breast Neoplasms vorinostat 3.0416144943
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.6616011737 15700767 3786805 18705752 10355542 15721981 16050911 16124888 16192424 15673190 16227642 16097048
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.6616050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.8218788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.8217982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.8216924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 6.8216227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.8316675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0916685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.8920419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 7.896189445 18337622 17066447
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.8916227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases resveratrol 3.5915458977
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8818566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1616354765 8697196 12621046 15340226 15668235
MESH:D003092 Colitis resveratrol 10.3816474422
MESH:D003092 Colitis Selenium 10.3817936198
MESH:D003110 Colonic Neoplasms resveratrol 2.4816338953
MESH:D015179 Colorectal Neoplasms Cisplatin 2.8315273666
MESH:D015179 Colorectal Neoplasms resveratrol 2.8316550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.8516507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5219769572
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.9116873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Estradiol 9.5319279558
MESH:D003928 Diabetic Nephropathies resveratrol 9.5316286809
MESH:D003967 Diarrhea vorinostat 4.6920479100
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.4715998439 10092053 11566570 15968718 3786805 10915739 19085960 2869522 3732212 15027814 7120509 6884620 7440962 16227642 19336974 7179309 6623471 21278145 16177239 4309450 17522070 9327722
MESH:D056486 Drug-Induced Liver Injury Selenium 6.4715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4720420201
MESH:D004362 Drug Toxicity Cisplatin 8.6015033597 12231392 12649298 19839026
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.6011462148
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004487 Edema resveratrol 7.448985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.2217872969
MESH:D016889 Endometrial Neoplasms Estradiol 3.0911473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.0617923197
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.7416530937
MESH:D004938 Esophageal Neoplasms Cisplatin 4.7417638652 16481741 15173087 15464296 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005221 Fatigue vorinostat 5.8320479100
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.3417595544 15959796 16239168 16045604 61145 19224547 12631006 12795759
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.3318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3320067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.8215464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.4519898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.5615464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.5920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.5911294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 11.5916080930
MESH:D006333 Heart Failure Selenium 3.1717162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1116120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D006561 Herpes Simplex resveratrol 4.4216876885
MESH:D006689 Hodgkin Disease Cisplatin 3.7416170182 16200630
MESH:D019584 Hot Flashes Estradiol 10.9517088409
MESH:D019584 Hot Flashes Vitamin E 10.9514716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3118606429 16354765 15340226 8697196 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006937 Hypercholesterolemia resveratrol 4.1817188708
MESH:D006949 Hyperlipidemias resveratrol 4.2116873680
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.4617488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.8617600658
MESH:D007249 Inflammation resveratrol 5.3416366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3412878042 12200463
MESH:D007251 Influenza, Human resveratrol 20.2616624496
MESH:D007251 Influenza, Human Selenium 20.2616624496
MESH:D007251 Influenza, Human Vitamin E 20.2616624496
MESH:D007333 Insulin Resistance Estradiol 3.0716627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.4115464296
MESH:D007674 Kidney Diseases Cisplatin 10.7212231392 12649298 15190930 18289764 19839026
MESH:D007674 Kidney Diseases Estradiol 10.7215618244
MESH:D007674 Kidney Diseases Vitamin E 10.7212488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007680 Kidney Neoplasms Estradiol 3.1215610895
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.0611231351
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.6816087638
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8911903743 17157831 16943688 21278145 11408273 16221502 17174718 16239168 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.0918277467 17557913 18395095 16248980 18472094 17805973 18339082 12586293 17698563 17708605 17922224 12445418 18187930 15818738 16116963 17761835 15362042 18210741 12649538 16015684 14620537 17721639 17640975 15730626 15123356 18376398 15959796 18429990 14716833 15673190 17944888 12632514 12445421 18395914 18006644 12546737 12666154 12898905 18166357 18251166 15925388 16027843 18481824 18054572 17766677 18279442 13678700 10355542 15931870 18205269 18705752 17714472 16136751 18412020 14748882 15338365 17823541 15996030 15057751 12741479 16097048 18418968 18472332 16192424 12632512 17631135 12958196 17481882 16638106 17900296 18420326 15052691 17869086 14724832 14512876 14716496 15876570 12667390 15893842 15650968 11481614 18156304 16033810 18317297 18263696 12389079 20821823 16011737 17565644 15370692 17525996 17976157 12609069
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0912878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.0916169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1216246199 16964402 15830285 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8516899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1920195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.1919294768
MESH:D008113 Liver Neoplasms resveratrol 11.1919073162 19321006 20405173 19812893
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1012151625
MESH:D008171 Lung Diseases Vitamin E 3.2916863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0020464547 18569708 18520028 20064080 17053015 20869020 18816296 6695378 20135361
MESH:D008175 Lung Neoplasms Cisplatin 5.006189445 11798837 17225452
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0019555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 5.0011062179
MESH:D016393 Lymphoma, B-Cell resveratrol 4.4817088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.0114749477
MESH:D016410 Lymphoma, T-Cell, Cutaneous vorinostat 5.9020479100
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.4815688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.6511408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 10.658985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.6515318939
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008545 Melanoma Cisplatin 3.7415577323 18505091 18176117 18332650 12393984 17761969 12883367 11135225 16809738 17023156 12374674 16432458 16248763
MESH:D008545 Melanoma resveratrol 3.7417992120
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.0115990972
MESH:D008654 Mesothelioma Cisplatin 6.5617638057
MESH:D008654 Mesothelioma Selenium 6.5615107826
MESH:D008659 Metabolic Diseases resveratrol 4.5517112576
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009101 Multiple Myeloma resveratrol 3.5816267019 17164350 14749477 16490592 17935668 17049120
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.1117962980
MESH:D009203 Myocardial Infarction resveratrol 3.0917188708 16525036 17015251 17125593 16456233 16317513
MESH:D017202 Myocardial Ischemia resveratrol 9.4717125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.4712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4116810080
MESH:D009205 Myocarditis resveratrol 5.0017322642
MESH:D009325 Nausea vorinostat 5.7920479100
MESH:D009369 Neoplasms Benzo(a)pyrene 5.4411141357
MESH:D009369 Neoplasms Cisplatin 5.4416773208
MESH:D009374 Neoplasms, Experimental resveratrol 4.218985016
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.7615464296
MESH:D009421 Nervous System Malformations Estradiol 10.1416427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1414600291
MESH:D009447 Neuroblastoma Cisplatin 3.538761367
MESH:D019636 Neurodegenerative Diseases resveratrol 3.9517652729
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.938761367
MESH:D020078 Neurogenic Inflammation resveratrol 4.5817929310
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.4417513867
MESH:D010051 Ovarian Neoplasms Cisplatin 5.1615464296 17225452 6897625 19769630
MESH:D010051 Ovarian Neoplasms Estradiol 5.1619401270
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.0419003803
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.5115464296
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D010997 Pleural Neoplasms Cisplatin 5.6117638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 10.4016679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.4011222880 11118676 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8717292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8716740699
MESH:D011471 Prostatic Neoplasms resveratrol 1.8717804756 17718901 17636462 17675339 15767336 16731767
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8715084515
MESH:D011471 Prostatic Neoplasms vorinostat 1.8717218635
MESH:D051437 Renal Insufficiency Cisplatin 4.6215464296
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.8516325855
MESH:D015427 Reperfusion Injury resveratrol 3.3516314181 15827377 16317513 17058453 17520802
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.6314601052
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 14.1810029692 19755658
MESH:D012878 Skin Neoplasms resveratrol 14.1815837718 8985016
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 14.188532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.1816192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.6115464296
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.5820155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 2.5815958060 17522103 18396642
MESH:D020521 Stroke Vitamin E 3.6616517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.6416321402
MESH:D013736 Testicular Neoplasms Cisplatin 4.8115464296 17225452
MESH:D013921 Thrombocytopenia vorinostat 5.1320479100
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D014062 Tongue Neoplasms resveratrol 4.3716227395
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.4117053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.4115464296 12973940 17225452
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 10.2716803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 10.2717473185
MESH:D014594 Uterine Neoplasms resveratrol 4.3317044934
MESH:D014625 Vaginal Neoplasms Cisplatin 4.8215577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.5217488730
MESH:D014839 Vomiting Cisplatin 4.9811897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
Pathway ID Pathway Name
REACT:6900 Signaling in Immune system
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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