AutismKB 2.0

Annotation Detail for SPI1


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Basic Information Top
Gene Symbol:SPI1 ( OF,PU.1,SFPI1,SPI-1,SPI-A )
Gene Full Name: spleen focus forming virus (SFFV) proviral integration oncogene spi1
Band: 11p11.2
Quick LinksEntrez ID:6688; OMIM: 165170; Uniprot ID:SPI1_HUMAN; ENSEMBL ID: ENSG00000066336; HGNC ID: 11241
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05221Acute myeloid leukemia
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200171Validated targets of C-MYC transcriptional repression
200130C-MYB transcription factor network
200077Glucocorticoid receptor regulatory network
200018IL4-mediated signaling events
200191Regulation of retinoblastoma protein
Pathway IDPathway Name
P00036Interleukin signaling pathway
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers of haematopoietic and lymphoid tissues
Cancers
H00003Acute myeloid leukemia (AML)
Desease IDDesease Name
2011Leukoencephalopathy
2239Lymphoma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene affects the activity of SPI1 proteinaffects activity 20624995
C014347 decitabine decitabine affects the methylation of SPI1 promoteraffects methylation 17545613
C031927 hydroquinone hydroquinone results in increased phosphorylation of SPI1 proteinincreases phosphorylation 16642264
C027185 indirubin indirubin results in increased activity of SPI1 proteinincreases activity 16115123
C467566 pomalidomide pomalidomide results in decreased expression of SPI1 proteindecreases expression 16373662
C467566 pomalidomide pomalidomide results in increased expression of SPI1 mRNAincreases expression 15292067
D014212 Tretinoin Tretinoin inhibits the reaction [PML protein mutant form results in decreased expression of SPI1 mRNA]decreases expression|decreases reaction 16352814
D014212 Tretinoin Tretinoin inhibits the reaction [PML protein mutant form results in decreased expression of SPI1 protein]decreases expression|decreases reaction 16352814
D014212 Tretinoin Tretinoin inhibits the reaction [RARA protein mutant form results in decreased expression of SPI1 mRNA]decreases expression|decreases reaction 16352814
D014212 Tretinoin Tretinoin inhibits the reaction [RARA protein mutant form results in decreased expression of SPI1 protein]decreases expression|decreases reaction 16352814
D014212 Tretinoin Tretinoin promotes the reaction [CEBPB protein binds to SPI1 promoter]affects binding|increases reaction 16352814
D014212 Tretinoin Tretinoin promotes the reaction [POU2F1 protein binds to SPI1 promoter]affects binding|increases reaction 16352814
D014212 Tretinoin Tretinoin results in increased expression of SPI1 mRNAincreases expression 17218384
17361223
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D000505 Alopecia Tretinoin 3.8715955085
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.2516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3216292516
MESH:D001249 Asthma Tretinoin 2.4216456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7816935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9316197459 16206674
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9220146248 17474063
MESH:D001943 Breast Neoplasms decitabine 1.9219208741 18320071
MESH:D001943 Breast Neoplasms Tretinoin 1.9216873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.0516813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6816168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.911917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.9820419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.9819215824
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.9816051514 16096774
MESH:D002386 Cataract Tretinoin 3.2617460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.0516129372
MESH:D002822 Choriocarcinoma Tretinoin 5.6816461808
MESH:D002972 Cleft Palate Tretinoin 2.789407595
MESH:D003092 Colitis Tretinoin 4.1217035595
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.839224671 14991402 9142499 17551590 16925845 8800419 9211117 9664655 9125849 10589399
MESH:D004489 Edema, Cardiac Tretinoin 4.9918230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.6419294695
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3016569247
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005124 Eye Abnormalities Tretinoin 3.819664655 16938888
MESH:D005355 Fibrosis Tretinoin 3.9317994277
MESH:D005909 Glioblastoma Tretinoin 3.1917312396
MESH:D006258 Head and Neck Neoplasms decitabine 8.5119215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.5116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.1420471113
MESH:D006330 Heart Defects, Congenital Tretinoin 7.1414991402 9664655
MESH:D006930 Hyperalgesia Tretinoin 3.4616870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9916778211
MESH:D006968 Hypersensitivity, Delayed indirubin 6.4511275354
MESH:D007248 Infertility, Male decitabine 3.4017581917
MESH:D007410 Intestinal Diseases Tretinoin 4.1817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2315992940 17551590
MESH:D007938 Leukemia decitabine 6.8918980019 19235587
MESH:D007938 Leukemia Tretinoin 6.8917143497
MESH:D007951 Leukemia, Myeloid therapeutic 17361223
MESH:D007951 Leukemia, Myeloid decitabine 10.6718454857 17236224 19117987
MESH:D007951 Leukemia, Myeloid Tretinoin 10.6716932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.1219010910 18704418 18206229 17679729 19387464 18460780
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.1217596541 16294345 19850784
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.9818055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3417301526 19035177 16788101 15748426 16935935 16331271 17361223 19642359 19075265 17506722 17339181 17217047 17649720 16140955 17107899 16766008 16891316 17712046 17294898 9834237 16823087 19029980 17368321 12679006 19225113
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.539224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8116248980 18397230
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1320195826 21137059
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5720064080 20135361 20869020 6695378 20464547 18569708 17053015 18816296 18520028
MESH:D008223 Lymphoma decitabine 3.6419470736
MESH:D008527 Medulloblastoma Tretinoin 2.8817453147
MESH:D008545 Melanoma decitabine 3.5616505122 17785578
MESH:D008545 Melanoma Tretinoin 3.5616752155
MESH:D008591 Meningomyelocele Tretinoin 4.8416940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D009101 Multiple Myeloma decitabine 3.5618172295
MESH:D009190 Myelodysplastic Syndromes decitabine 8.0219010910 18608210 19157545 16882708
MESH:D009190 Myelodysplastic Syndromes Tretinoin 8.0217596541
MESH:D009369 Neoplasms Benzo(a)pyrene 9.1011141357
MESH:D009369 Neoplasms decitabine 9.1017925555 19116145 19470736
MESH:D009369 Neoplasms Tretinoin 9.1016594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.169125849
MESH:D009436 Neural Tube Defects Tretinoin 3.249142499
MESH:D010051 Ovarian Neoplasms decitabine 5.2319259094 19331143
MESH:D010051 Ovarian Neoplasms Tretinoin 5.2316936753
MESH:D010146 Pain Tretinoin 3.1616870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.6919294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.6915976015
MESH:D055728 Primary Myelofibrosis decitabine 5.1517616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9217292933
MESH:D011507 Proteinuria Tretinoin 3.9516636307
MESH:D011625 Pterygium Tretinoin 5.2616723453
MESH:D012208 Rhabdomyosarcoma decitabine 12.1419155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 12.1416116481 16283617
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.1119755658 10029692
MESH:D012878 Skin Neoplasms Tretinoin 6.1116467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.5020155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 3.5019037991
MESH:D013274 Stomach Neoplasms Tretinoin 3.5017261132
MESH:D013964 Thyroid Neoplasms decitabine 8.1117967635
MESH:D013964 Thyroid Neoplasms Tretinoin 8.1116026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.0916051514
MESH:D014376 Tuberculosis Tretinoin 3.4116040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.4717053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.4719087683 17616700
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9816129372
MESH:D014604 Uveal Neoplasms decitabine 14.6317785578
MESH:D014604 Uveal Neoplasms Tretinoin 14.6316752155
MESH:D014820 Vitiligo Tretinoin 4.4416761959
MESH:D009396 Wilms Tumor Tretinoin 4.2516287080
Pathway ID Pathway Name
KEGG:05221 Acute myeloid leukemia
KEGG:04380 Osteoclast differentiation
KEGG:05200 Pathways in cancer
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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