AutismKB 2.0

Annotation Detail for SPN


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Basic Information Top
Gene Symbol:SPN ( CD43,GPL115,LSN )
Gene Full Name: sialophorin
Band: 16p11.2
Quick LinksEntrez ID:6693; OMIM: 182160; Uniprot ID:LEUK_HUMAN; ENSEMBL ID: ENSG00000197471; HGNC ID: 11249
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04514Cell adhesion molecules (CAMs)
Pathway IDPathway Name
Hemostasis
No data
No data
Pathway IDPathway Name
500308Basigin interactions
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of SPN mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SPN mRNAaffects expression 16483693
D001285 Atropine SPN protein results in increased susceptibility to Atropineincreases response to substance 18711009
D000431 Ethanol Ethanol results in decreased expression of SPN mRNAdecreases expression 17920746
D008790 Metoprolol SPN protein results in decreased susceptibility to Metoprololdecreases response to substance 18711009
D011224 Prazosin SPN protein results in decreased susceptibility to Prazosindecreases response to substance 18711009
D020849 Raloxifene Raloxifene affects the expression of SPN mRNAaffects expression 16079270
D014294 Trimethaphan SPN protein results in decreased susceptibility to Trimethaphandecreases response to substance 18711009
C025643 vinclozolin vinclozolin affects the expression of SPN mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.847525203
MESH:D000014 Abnormalities, Drug-Induced Ethanol 9.8417676605 18926900
MESH:D000138 Acidosis Ammonium Chloride 11.4418287403
MESH:D000138 Acidosis Ethanol 11.4411192467
MESH:D000419 Albuminuria Raloxifene 4.8317451421 17308373
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.6415451040 15451039
MESH:D000544 Alzheimer Disease Raloxifene 2.5815800139
MESH:D000853 Anophthalmos Ethanol 5.0815513904
MESH:D001008 Anxiety Disorders Ethanol 9.5711141031
MESH:D001008 Anxiety Disorders vinclozolin 9.5719015723
MESH:D001930 Brain Injuries Raloxifene 4.7316580743
MESH:D001943 Breast Neoplasms Atropine 2.9512762645
MESH:D001943 Breast Neoplasms Raloxifene 2.9515758505 16912660 17242785 17261762 17952589 15572757 17893378 15775269 16837676 17049068 17595753 17440819
MESH:D002056 Burns Ethanol 4.9116374292
MESH:D006528 Carcinoma, Hepatocellular Ethanol 2.4115763234 15289165 18788625
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.2717572228
MESH:D006332 Cardiomegaly Ethanol 3.5419332462
MESH:D002311 Cardiomyopathy, Dilated Metoprolol 4.7919477965
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5815775269
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.7414694615
MESH:D002971 Cleft Lip Ethanol 3.6815513904
MESH:D002972 Cleft Palate Ethanol 3.2515513904
MESH:D003072 Cognition Disorders Raloxifene 4.8815800139
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.3415095906
MESH:D019465 Craniofacial Abnormalities Ethanol 2.3310194807 15451039 11873399 19302082 15451040 11198716 15513904
MESH:D003456 Cryptorchidism vinclozolin 4.5814966744
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3417474826
MESH:D003928 Diabetic Nephropathies Raloxifene 4.1215920148 17308373 17451421
MESH:D003967 Diarrhea Atropine 5.1910867622
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.9521346803
MESH:D056486 Drug-Induced Liver Injury Ethanol 6.9511566570
MESH:D056486 Drug-Induced Liver Injury Prazosin 6.9518071297
MESH:D004381 Duodenal Ulcer Atropine 5.5311595415
MESH:D004487 Edema Raloxifene 3.5415860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.2315845917
MESH:D004938 Esophageal Neoplasms Ethanol 2.7916704527
MESH:D005234 Fatty Liver Ethanol 8.8919236843 16409862 18620774
MESH:D005234 Fatty Liver Raloxifene 8.8917473493
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.9817920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.5816946407 15451040 10194807 15513904
MESH:D005756 Gastritis Ethanol 5.0115046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6216417039
MESH:D006331 Heart Diseases Raloxifene 3.6711110106
MESH:D006930 Hyperalgesia Ethanol 9.1618783367
MESH:D006930 Hyperalgesia Prazosin 9.1612727271
MESH:D006973 Hypertension Raloxifene 2.9317577099 15787275
MESH:D007248 Infertility, Male vinclozolin 3.1716467254
MESH:D007569 Jaw Abnormalities Ethanol 4.6115513904
MESH:D007859 Learning Disorders Ethanol 4.4715451040
MESH:D007889 Leiomyoma Raloxifene 4.7216973256
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0216417039
MESH:D017880 Limb Deformities, Congenital Ethanol 3.9617676605
MESH:D008103 Liver Cirrhosis Ethanol 3.4715289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.3818295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.3118166357
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.9117207112 17347304
MESH:D008133 Long QT Syndrome Metoprolol 5.5719353679
MESH:D008569 Memory Disorders Ethanol 4.4218411066 15451040
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.8715863610
MESH:D009101 Multiple Myeloma Raloxifene 3.5816497877
MESH:D009203 Myocardial Infarction Metoprolol 4.8118072171
MESH:D009216 Myopia Atropine 5.1112601066
MESH:D009232 Myxoma Raloxifene 5.8716343187
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 4.2914694615
MESH:D010024 Osteoporosis Raloxifene 3.5115775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4517823083 15579764 15758505 17893378
MESH:D010190 Pancreatic Neoplasms Ethanol 3.0312384795
MESH:D011041 Poisoning Atropine 5.3717849254 18072136
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.1818220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.2218220299
MESH:D011471 Prostatic Neoplasms Raloxifene 3.5716536755 15731164 16220300
MESH:D011472 Prostatitis vinclozolin 5.2218629315
MESH:D011693 Purpura Raloxifene 5.8715770314
MESH:D012640 Seizures Atropine 7.2311218047 17157343 12660363
MESH:D012640 Seizures Ethanol 7.239754883
MESH:D013274 Stomach Neoplasms Ethanol 2.3118456281
MESH:D013276 Stomach Ulcer Atropine 8.7011595415
MESH:D013276 Stomach Ulcer Ethanol 8.7011906479 16755016 17918041 17189318 9562338 9211565
MESH:D020521 Stroke Raloxifene 3.9816837676
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.459754883
MESH:D013978 Tibial Fractures Raloxifene 5.5319048282
MESH:D016171 Torsades de Pointes Metoprolol 6.3119353679
MESH:D014202 Tremor Atropine 6.0417594079
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.8817572228
MESH:D054556 Venous Thromboembolism Raloxifene 5.5316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.8716343187
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
REACT:604 Hemostasis
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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