AutismKB 2.0

Annotation Detail for SPP2


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Basic Information Top
Gene Symbol:SPP2 ( SPP24 )
Gene Full Name: secreted phosphoprotein 2, 24kDa
Band: 2q37.1
Quick LinksEntrez ID:6694; OMIM: 602637; Uniprot ID:SPP24_HUMAN; ENSEMBL ID: ENSG00000072080; HGNC ID: 11256
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SPP2 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SPP2 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SPP2 mRNAaffects expression 16483693
C095105 bexarotene bexarotene results in decreased expression of SPP2 mRNAdecreases expression 16648578
C006780 bisphenol A bisphenol A results in increased expression of SPP2 mRNAincreases expression 17912697
D002104 Cadmium Cadmium results in increased expression of SPP2 mRNAincreases expression 17327699
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of SPP2 mRNAincreases expression 17327699
D002118 Calcium Calcium affects the expression of SPP2 mRNAaffects expression 15913539
D016572 Cyclosporine Cyclosporine results in decreased expression of SPP2 mRNAdecreases expression 20106945
D003687 Dehydroepiandrosterone Dehydroepiandrosterone results in decreased expression of SPP2 mRNAdecreases expression 17823450
D004958 Estradiol Estradiol results in decreased expression of SPP2 mRNAdecreases expression 20106945
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SPP2 mRNAaffects binding|decreases expression|increases activity 19710929
D018038 Sodium Selenite Sodium Selenite results in decreased expression of SPP2 mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SPP2 mRNAincreases expression 15644576
D014501 Uranium Uranium affects the expression of SPP2 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of SPP2 mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8714514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma Estradiol 2.1011473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.9716835633
MESH:D000309 Adrenal Insufficiency Dehydroepiandrosterone 5.7817302879
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D050197 Atherosclerosis Cadmium 3.6415687053
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D001862 Bone Resorption bisphenol A 3.8711985600
MESH:D001943 Breast Neoplasms bexarotene 1.9716344269 16818667
MESH:D001943 Breast Neoplasms bisphenol A 1.9717123778
MESH:D001943 Breast Neoplasms Estradiol 1.9717261762 16675129 17289903 12948864 14630087 19861407 18497071 17018787
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.543084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.5421507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5416924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.0117123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.2316247446
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3718850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002471 Cell Transformation, Neoplastic Cadmium 11.2817332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.2812371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.2818566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Cyclosporine 7.7619486331
MESH:D002779 Cholestasis pirinixic acid 7.7619176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1012621046 15340226 16354765 15668235 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.7816285004
MESH:D003922 Diabetes Mellitus, Type 1 Dehydroepiandrosterone 3.6916616286
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4119279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.1616177239 12705907 19923254 12153990 11287661 11529661 19420014 11739529 19739265 12540782 19164858 18713872 14986274 10663392 16081117 10915739 16109766 11743745 11421492 10774834 16227642 18071297 12392966 14550746 2444490 17906064 16485898 11461765 15619225 19370779 14725611 19416960 11834606 16393943 16781746 17522070 12594235 19085960 15968718 17562736 12958197
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.1615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.1620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004487 Edema pirinixic acid 6.5512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9318230668 16714409 15322242
MESH:D016889 Endometrial Neoplasms Estradiol 2.9819148513 18566989 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0210568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Cyclosporine 7.5819224547
MESH:D005234 Fatty Liver pirinixic acid 7.5820131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005355 Fibrosis Cyclosporine 8.5312639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.5320067830
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.3119772884 18467677 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.3115340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.0615709030
MESH:D019584 Hot Flashes Estradiol 3.7817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.088697196 18606429 16354765 16959395 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006973 Hypertension Cyclosporine 4.9510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9518850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8612200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 17.6716393666
MESH:D007333 Insulin Resistance Estradiol 17.6716393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 17.6716306350
MESH:D007333 Insulin Resistance Sodium Selenite 17.6714714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Acetaminophen 19.0912587719 15629191
MESH:D007674 Kidney Diseases Cadmium 19.0916962696 16226777 16322080
MESH:D007674 Kidney Diseases Cadmium Chloride 19.0916962696
MESH:D007674 Kidney Diseases Cyclosporine 19.098314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 19.0915618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.2812371664
MESH:D007680 Kidney Neoplasms Estradiol 7.2815610895
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 5.0816316344
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.3814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3812878042
MESH:D008107 Liver Diseases Acetaminophen 1.6319784758 19460945 11587558 12969438 16610002 19014921 12587719 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2417185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 10.7518177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms Dehydroepiandrosterone 10.7518709148
MESH:D008113 Liver Neoplasms pirinixic acid 10.7516377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.7516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.998603461
MESH:D008114 Liver Neoplasms, Experimental Dehydroepiandrosterone 9.998603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.9912151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4914755239
MESH:D008175 Lung Neoplasms bexarotene 3.4917849452
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4911884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0614737004
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.1611161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 10.2315591091 19196722 19196723
MESH:D008325 Mammary Neoplasms, Experimental Dehydroepiandrosterone 10.2316457693
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.2316891317 17203775 11807958 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.5119453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.2616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.2616411023
MESH:D009369 Neoplasms pirinixic acid 1.9517405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.8119196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2919348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 16.4211399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 16.4211399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.4214600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D010024 Osteoporosis Calcium 3.7817882678
MESH:D015663 Osteoporosis, Postmenopausal Dehydroepiandrosterone 5.0316397352
MESH:D010049 Ovarian Diseases bisphenol A 5.0111985600
MESH:D010051 Ovarian Neoplasms Estradiol 2.2219401270
MESH:D010146 Pain Acetaminophen 2.3916870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.4015687053
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2212371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.5810548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.5811118676 11399792 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.5720887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.5720887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1216740699
MESH:D011471 Prostatic Neoplasms Cadmium 2.1217075824
MESH:D011471 Prostatic Neoplasms Estradiol 2.1216740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.1218760546
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D011629 Puberty, Precocious bisphenol A 4.8110548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0416192470
MESH:D019966 Substance-Related Disorders bisphenol A 4.0016684133 16045194
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013978 Tibial Fractures Estradiol 4.7219048282
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D014591 Uterine Diseases bisphenol A 5.0414652134
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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