AutismKB 2.0

Annotation Detail for BPHL


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:BPHL ( BPH-RP,MCNAA,MGC125930,MGC41865,VACVASE )
Gene Full Name: biphenyl hydrolase-like (serine hydrolase)
Band: 6p25.2
Quick LinksEntrez ID:670; OMIM: 603156; Uniprot ID:BPHL_HUMAN; ENSEMBL ID: ENSG00000137274; HGNC ID: 1094
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of BPHL mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of BPHL mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of BPHL proteinaffects expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of BPHL mRNAincreases expression 17484886
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of BPHL mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of BPHL mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of BPHL mRNAaffects cotreatment|affects expression 17602206
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of BPHL mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of BPHL mRNAincreases expression 17426115
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000236 Adenoma Diethylnitrosamine 2.9810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.2417162532 19052882 18056438 19061943 17620307 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2416434500
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0815673190 16050911 15700767 16192424 15721981 18705752 16227642 16124888 3786805 16097048 10355542 16011737
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.2116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.213084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 9.2112907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.2118788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.2120101231 3084413 20524982 3581430 20007298 17138121 17162532 17428255 16681979 19701751 20935162 18506893 18691550 18785209 18056438 19335982 20432363 18393292 18971187 20514400 18494052 20084675 16779866 18788625 11831363 17978847 19418558 19052882 21159647 19171122 10737359 19394651 18665156 17173139 19107877 18210153 19383236 17761372 19822196 19519916 16830150 16288022 16569478 19539802 18978308 16878318 16935385 16807293 16502159 19919837 20727157 16328049 16698587 20512989 19208518 16540662 17055752 10672840 20214788
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.106135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.1012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.1017174075 2727394 7505956 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D002779 Cholestasis Cyclosporine 8.3519486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.4818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.4811421492 17906064 17522070 12540782 16781746 18071297 14725611 10663392 12958197 11287661 12705907 12153990 14986274 14550746 11461765 11529661 19416960 10915739 19739265 16109766 16227642 19370779 11834606 10774834 12392966 11739529 19923254 16177239 2444490 19085960 17562736 15619225 12594235 16485898 19164858 16081117 18713872 16393943 11743745 19420014 15968718
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.4816177239 2869522 17522070 10092053 4309450 6884620 21278145 15027814 10915739 7179309 19085960 7440962 9327722 11566570 15968718 6623471 7120509 16227642 3732212 3786805 19336974 15998439
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.4819107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.8715959796 17595544 12795759 12631006 16045604 19224547 16239168 61145
MESH:D005234 Fatty Liver Cyclosporine 20.8719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 20.8721071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 20.8719236843 20131406
MESH:D005355 Fibrosis Carbon Tetrachloride 9.7118705752
MESH:D005355 Fibrosis Cyclosporine 9.7112168785 12639820
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.3019772884 18467677 19176532 16221962
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007249 Inflammation Diethylnitrosamine 2.4818785209
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2215629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.2218776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.9516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9512371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.0116943688 17157831 16221502 17334410 16239168 11903743 11408273 17174718 21278145
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 7.0118522880 20032147 18407596 18665156 19638242
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3817976157 18210741 18187930 16248980 16011737 18412020 16033810 17565644 12958196 18166357 16097048 18481824 13678700 16638106 17766677 14724832 17900296 17481882 18205269 17698563 11481614 18006644 18279442 16116963 15052691 15673190 17721639 17944888 18156304 18054572 10355542 15893842 14716833 17823541 18263696 12546737 15876570 15650968 17640975 12389079 15959796 18277467 12445421 14620537 12667390 20821823 17525996 18472094 16192424 17922224 12632512 18317297 17631135 14716496 18420326 12649538 18418968 17805973 12609069 12445418 18395095 12666154 16027843 14748882 15818738 14512876 17708605 15925388 12586293 17869086 18429990 16136751 12898905 15931870 12632514 18705752 17714472 15057751 15730626 18395914 12741479 15370692 15362042 16015684 18376398 18472332 17761835 15338365 17557913 15123356 18339082 18251166 15996030
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3815474484
MESH:D008107 Liver Diseases Acetaminophen 6.7819784758 12587719 19014921 11587558 19460945 16611625 12969438 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.7816246199 15720792 15830285 17285989 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 6.7817034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.1816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.1816899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 19.047678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 19.049163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 19.0419294768
MESH:D008113 Liver Neoplasms Clofibric Acid 19.0417602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 19.0418648771 21047994 19254457 19812893 20434301 19499222 20101389 18754104 19255062 12771043 19850985 20452335 15175105 9163691 19294768 19638242 19996281 10737359 20583210 19256749 18977376 19426721 21167192 12112319 20118626 20405173 19642983 18644402 16942905 20492335 20501860 19690152 21071580 21278145 19427195 20137499 15885732 19833225 19090486 2422723 2862719 19073162 19551842 18978307
MESH:D008113 Liver Neoplasms pirinixic acid 19.0416377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 15.322876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 15.328603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 15.3215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 15.3219126423 19009564 19004024 18079962 18253720 18544905 18164116 19539802 9362446 18093689 2563599 18775883 19519916 17942915 21159647 3124819 17174075 16267830 18308698 16842330 18282651 17854601
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.5514755239
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5521163286 20512841 6695378 20970405
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2018551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.659029167 3581430
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.8618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.8620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6616049721
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4916540662
MESH:D011230 Precancerous Conditions Cyclosporine 9.6712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.672563599
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6918551238
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.167505956
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3716049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03380 - L-Tyrosinamide
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved