AutismKB 2.0

Annotation Detail for SPRR2D


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Basic Information Top
Gene Symbol:SPRR2D ( - )
Gene Full Name: small proline-rich protein 2D
Band: 1q21.3
Quick LinksEntrez ID:6703; OMIM: NA; Uniprot ID:SPR2D_HUMAN; ENSEMBL ID: ENSG00000163216; HGNC ID: 11264
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C105260 4-tert-octylphenol 4-tert-octylphenol results in increased expression of SPRR2D mRNAincreases expression 20438831
C006780 bisphenol A bisphenol A results in increased expression of SPRR2D mRNAincreases expression 20438831
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of SPRR2D mRNAincreases expression 15171707
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SPRR2D mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SPRR2D mRNAdecreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SPRR2D mRNAaffects cotreatment|decreases expression 17942748
C006253 pirinixic acid pirinixic acid results in increased expression of SPRR2D mRNAincreases expression 20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of SPRR2D mRNA]increases expression|increases reaction 20059764
D013629 Tamoxifen Tamoxifen affects the expression of SPRR2D mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of SPRR2D mRNAaffects expression 16611356
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SPRR2D mRNAaffects cotreatment|decreases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SPRR2D mRNAdecreases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2411752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.2616835633
MESH:D000686 Amyloidosis Diethylstilbestrol 4.8115469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.7319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001862 Bone Resorption bisphenol A 4.1411985600
MESH:D001943 Breast Neoplasms bisphenol A 1.9917123778
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.9917129689 15324884
MESH:D001943 Breast Neoplasms Tamoxifen 1.9917440819 20859285 20544844 19066611 19189212 18629630 17893378 20065188 15565566 18997820 19200415 18425577 16202921 17049068 18815881 20135344 15668708 16818667 19084267 19289846 19115204 19244106 16873071 19410462 19221464 18855134 19011961 18351453 21152245 19487384 19189210 19142967 16273361 17242785 19059307 19155303 19288272 17261762 20390343 19103187 21138602 18984771 20005174 11161223 18821012
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 3.2715948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.2716924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.3817123778
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5016120746 18670907 18850075
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.4216105132 17333356 17681005 17110522 16919318 11677210 15861022
MESH:D002779 Cholestasis pirinixic acid 8.4219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2016354765 12621046 15340226 15668235 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.8916002989 12952375
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7219279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema pirinixic acid 7.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0619031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 5.0916402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 8.1415700306 16804899
MESH:D016889 Endometrial Neoplasms Tamoxifen 8.1419155303 17893378 20544844 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.7415345470
MESH:D005234 Fatty Liver pirinixic acid 14.7419236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 14.7419224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 8.7216002989 16513791 16611131 15751030 16534752
MESH:D052776 Female Urogenital Diseases Tamoxifen 8.7216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.3416452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4610048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly pirinixic acid 9.4816221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.4815340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4915340226 16354765 8697196 18606429 16959395
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.7914722030 12960047
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 12.4716002989
MESH:D007021 Hypospadias Ethinyl Estradiol 12.4716569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 4.6815036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Tamoxifen 5.3219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3212200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 7.8816393666
MESH:D007333 Insulin Resistance pirinixic acid 7.8816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 8.3516762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Tamoxifen 8.3518625569
MESH:D007859 Learning Disorders Diethylstilbestrol 4.4217184923
MESH:D008064 Lipidoses Tamoxifen 3.3517567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008113 Liver Neoplasms Diethylstilbestrol 11.4416712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 11.4416377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 11.4416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.4416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.3118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3119555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.5515166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.6615700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.9616002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7914580682 19196722 11731420 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms Diethylstilbestrol 5.4415313581
MESH:D009369 Neoplasms pirinixic acid 5.4417405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419200415 19196722 19189210
MESH:D009421 Nervous System Malformations bisphenol A 18.4316427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 18.4311399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 18.4314600291
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010049 Ovarian Diseases bisphenol A 5.3811985600
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.6114722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 5.0315687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 18.7410548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 18.7417184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 18.7411222880 11118676 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.5816740699
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.5817136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5815067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D011629 Puberty, Precocious bisphenol A 5.1810548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013088 Spermatocele Diethylstilbestrol 22.9216709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 22.9216709447
MESH:D013088 Spermatocele Tamoxifen 22.9216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D019966 Substance-Related Disorders bisphenol A 4.3816684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.5216452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.528653321 17572228 16712894
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.3016175088
MESH:D014591 Uterine Diseases bisphenol A 15.3414652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 15.3414652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 10.5915809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.5914692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.7916002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8215869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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