Annotation Detail for SPTA1
Basic Information
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| Pathway ID | Pathway Name |
|---|
| Axon guidance |
| Desease ID | Desease Name |
|---|
| Circulatory system diseases |
| Hematologic diseases |
| H00230 | Hereditary spherocytosis |
| H00231 | Hereditary elliptocytosis |
| Desease ID | Desease Name |
|---|
| 1999 | Thalassemia |
| 2239 | Lymphoma |
| 1882 | Malaria |
| Desease Name |
|---|
| HEMATOLOGICAL |
| other erythrocyte phenotypes |
| Desease Name |
|---|
| Other erythrocyte phenotypes |
| Glycated hemoglobin levels |
| Desease Name |
|---|
| Pyropoikilocytosis |
| Spherocytosis, type 3 |
| Elliptocytosis-2 |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C027132 |
1-anilino-8-naphthalenesulfonate |
1-anilino-8-naphthalenesulfonate binds to [SPTA1 protein binds to SPTB protein] | affects binding | 15492010
|
| C029728 |
4-phenylenediamine |
4-phenylenediamine results in increased expression of SPTA1 mRNA | increases expression | 16314067
|
| D020122 |
tert-Butylhydroperoxide |
tert-Butylhydroperoxide results in increased degradation of [SPTA1 protein binds to SPTB protein] | affects binding|increases degradation | 15040847
|
| D004137 |
Dinitrochlorobenzene |
Dinitrochlorobenzene results in increased expression of SPTA1 mRNA | increases expression | 16314067
|
| C479799 |
(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide |
(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide results in decreased expression of SPTA1 mRNA | decreases expression | 15528975
|
| D019791 |
Guanidine |
Guanidine affects the folding of [SPTA1 protein binds to SPTB protein] | affects binding|affects folding | 15711878
|
| D019791 |
Guanidine |
Guanidine inhibits the reaction [prodan binds to [SPTA1 protein binds to SPTB protein]] | affects binding|decreases reaction | 15711878
|
| C029938 |
nickel sulfate |
nickel sulfate results in increased expression of SPTA1 mRNA | increases expression | 16314067
|
| C038517 |
prodan |
Guanidine inhibits the reaction [prodan binds to [SPTA1 protein binds to SPTB protein]] | affects binding|decreases reaction | 15711878
|
| C038517 |
prodan |
prodan binds to [SPTA1 protein binds to SPTB protein] | affects binding | 15492010
|
| C038517 |
prodan |
Urea inhibits the reaction [prodan binds to [SPTA1 protein binds to SPTB protein]] | affects binding|decreases reaction | 15711878
|
| D014508 |
Urea |
Urea affects the folding of [SPTA1 protein binds to SPTB protein] | affects binding|affects folding | 15711878
|
| D014508 |
Urea |
Urea inhibits the reaction [prodan binds to [SPTA1 protein binds to SPTB protein]] | affects binding|decreases reaction | 15711878
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D055371 |
Acute Lung Injury |
|
nickel sulfate |
4.53 | 16100012 19131640 12718980 11954676 |
| MESH:D001943 |
Breast Neoplasms |
|
(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide |
4.02 | 15528975 |
| MESH:D003093 |
Colitis, Ulcerative |
|
Dinitrochlorobenzene |
3.91 | 17373747 19159591 |
| MESH:D017449 |
Dermatitis, Allergic Contact |
|
4-phenylenediamine |
13.60 | 11298694 16533241 19470301 18759875 11906362 16823706 |
| MESH:D017449 |
Dermatitis, Allergic Contact |
|
Dinitrochlorobenzene |
13.60 | 15491423 |
| MESH:D017449 |
Dermatitis, Allergic Contact |
|
nickel sulfate |
13.60 | 16823706 16780908 11298694 |
| MESH:D003877 |
Dermatitis, Contact |
|
4-phenylenediamine |
5.56 | 11531941 |
| MESH:D004612 |
Elliptocytosis, Hereditary |
marker/mechanism |
|
| |
| MESH:D008175 |
Lung Neoplasms |
|
(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide |
3.57 | 15528975 |
| MESH:D008545 |
Melanoma |
|
Dinitrochlorobenzene |
3.22 | 12202904 17334785 |
| MESH:D010051 |
Ovarian Neoplasms |
|
(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide |
4.16 | 15528975 |
| OMIM:266140 |
PYROPOIKILOCYTOSIS, HEREDITARY |
marker/mechanism |
|
| |
| MESH:D012878 |
Skin Neoplasms |
|
tert-Butylhydroperoxide |
2.77 | 8532709 |
| OMIM:270970 |
SPHEROCYTOSIS, TYPE 3 |
marker/mechanism |
|
| |
PharmGKB Accession:PA36101
| Releated disease ID |
Related disease Name |
| PA446155 | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
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