AutismKB 2.0

Annotation Detail for SRD5A1


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Basic Information Top
Gene Symbol:SRD5A1 ( S5AR 1 )
Gene Full Name: steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
Band: 5p15.31
Quick LinksEntrez ID:6715; OMIM: 184753; Uniprot ID:S5A1_HUMAN; ENSEMBL ID: ENSG00000145545; HGNC ID: 11284
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-378androgen biosynthesis
Pathway IDPathway Name
hsa00140Steroid hormone biosynthesis
Pathway IDPathway Name
Hormone biosynthesis
Metabolism of lipids and lipoproteins
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
METABOLIC
hirsutism polycystic ovary syndrome
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C031563 17-N,N-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one 17-N,N-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one results in decreased activity of SRD5A1 proteindecreases activity 8142312
C014024 2,4,5,2',4',5'-hexachlorobiphenyl [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of SRD5A1 mRNAaffects cotreatment|decreases expression 16984957
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SRD5A1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SRD5A1 mRNAaffects expression 21346803
C023035 3,4,5,3',4'-pentachlorobiphenyl [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of SRD5A1 mRNAaffects cotreatment|decreases expression 16984957
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SRD5A1 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SRD5A1 mRNAaffects expression 16483693
D000728 Androgens Androgens results in decreased expression of SRD5A1 mRNAdecreases expression 17628001
C006632 arsenic trioxide arsenic trioxide results in decreased expression of SRD5A1 mRNAdecreases expression 19769630
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of SRD5A1 mRNAaffects cotreatment|decreases expression 18164116
C095105 bexarotene bexarotene results in decreased expression of SRD5A1 mRNAdecreases expression 16648578
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of SRD5A1 mRNAdecreases expression 18178546
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SRD5A1 mRNAaffects cotreatment|affects expression 17602206
D003687 Dehydroepiandrosterone SRD5A1 protein affects the metabolism of Dehydroepiandrosteroneaffects metabolic processing 15261307
C020735 dibutyldichlorotin dibutyldichlorotin results in decreased activity of SRD5A1 proteindecreases activity 12231121
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of SRD5A1 mRNAaffects cotreatment|decreases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SRD5A1 mRNAaffects cotreatment|affects expression 17602206
D004317 Doxorubicin SRD5A1 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
C108373 dutasteride dutasteride results in decreased activity of SRD5A1 proteindecreases activity 16806904
C108373 dutasteride dutasteride results in decreased expression of SRD5A1 mRNAdecreases expression 16806904
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of SRD5A1 mRNAaffects cotreatment|increases expression 17347304
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SRD5A1 mRNAincreases expression 16940010
D018120 Finasteride Finasteride results in decreased activity of SRD5A1 proteindecreases activity 8142312
D018120 Finasteride Finasteride results in decreased activity of SRD5A1 proteindecreases activity 17499997
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of SRD5A1 mRNAaffects cotreatment|increases expression 17347304
D015725 Fluconazole Fluconazole results in decreased expression of SRD5A1 mRNAdecreases expression 16643972
C521787 ganoderol B ganoderol B results in decreased activity of SRD5A1 proteindecreases activity 17499997
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of SRD5A1 mRNAincreases expression 16849584
D007213 Indomethacin Indomethacin results in increased expression of SRD5A1 mRNAincreases expression 18299717
D007529 Isoflavones [selenomethylselenocysteine co-treated with Isoflavones] results in decreased activity of SRD5A1 proteinaffects cotreatment|decreases activity 19025659
C015329 lycopene lycopene results in decreased expression of SRD5A1 mRNAdecreases expression 15084515
D008942 Mitoxantrone SRD5A1 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of SRD5A1 mRNAdecreases expression 17681415
D010634 Phenobarbital Phenobarbital results in increased expression of SRD5A1 mRNAincreases expression 19363144
C032727 piperidine piperidine analog results in decreased activity of SRD5A1 proteindecreases activity 10896124
C032727 piperidine piperidine analog results in decreased activity of SRD5A1 proteindecreases activity 10896124
D010936 Plant Extracts Plant Extracts results in decreased activity of SRD5A1 proteindecreases activity 8142312
D011374 Progesterone SRD5A1 protein affects the metabolism of Progesteroneaffects metabolic processing 15555913
D011374 Progesterone SRD5A1 protein affects the metabolism of Progesteroneaffects metabolic processing 15261307
C045950 propiconazole propiconazole results in decreased expression of SRD5A1 mRNAdecreases expression 16643972
C002979 selenomethylselenocysteine [selenomethylselenocysteine co-treated with Isoflavones] results in decreased activity of SRD5A1 proteinaffects cotreatment|decreases activity 19025659
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of SRD5A1 mRNAaffects expression 20067830
D013749 Tetrachlorodibenzodioxin AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SRD5A1 mRNA]decreases expression|decreases reaction 16984957
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SRD5A1 mRNAdecreases expression 18796159
16984957
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SRD5A1 mRNAdecreases expression 16054898
18178546
18465118
D019772 Topotecan SRD5A1 protein affects the susceptibility to Topotecanaffects response to substance 16217747
C032910 triadimefon triadimefon results in decreased expression of SRD5A1 mRNAdecreases expression 19423681
C011559 tributyltin tributyltin results in decreased activity of SRD5A1 proteindecreases activity 12231121
D014747 Vinblastine SRD5A1 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
D015032 Zinc Zinc results in increased expression of SRD5A1 mRNAincreases expression 18172885
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 11.7018926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 11.706195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.7011752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 9.0018287403
MESH:D000138 Acidosis Ethanol 9.0011192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4917505938
MESH:D000169 Acrodermatitis Zinc 4.9617202136 17190629 16889938
MESH:D000230 Adenocarcinoma arsenic trioxide 9.1219825857 11798837
MESH:D000230 Adenocarcinoma Doxorubicin 9.1217418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.1214692618
MESH:D000230 Adenocarcinoma Indomethacin 9.1216537180
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 13.823712494
MESH:D000236 Adenoma beta-Naphthoflavone 13.8219389873
MESH:D000236 Adenoma Diethylnitrosamine 13.826695378 10737359
MESH:D000236 Adenoma Indomethacin 13.8211497255
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 21.3116628245
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 21.3119061943 17162532 19052882 16434500 18056438 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 21.3117620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 21.3116835633
MESH:D000309 Adrenal Insufficiency Dehydroepiandrosterone 5.3317302879
MESH:D000419 Albuminuria Doxorubicin 4.1221441931
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.8715451039 15451040
MESH:D000505 Alopecia Isoflavones 4.3717569567
MESH:D016301 Alveolar Bone Loss Indomethacin 4.9217225004
MESH:D000544 Alzheimer Disease Androgens 8.5817182789 17917157
MESH:D000544 Alzheimer Disease Indomethacin 8.5817627676 15579461
MESH:D000544 Alzheimer Disease Plant Extracts 8.5816962711
MESH:D000544 Alzheimer Disease Zinc 8.5817119284 16325427 16580781 16410023
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5711748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.4816916123
MESH:D000853 Anophthalmos Ethanol 4.3915513904
MESH:D001008 Anxiety Disorders Ethanol 3.6611141031
MESH:D001014 Aortic Aneurysm Indomethacin 4.4310231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.4410388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0311256880
MESH:D018771 Arthralgia Indomethacin 4.722160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.5915885639
MESH:D001169 Arthritis, Experimental Plant Extracts 6.5914686799
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.7111248219
MESH:D001249 Asthma Zinc 2.8117085522
MESH:D001477 Bartter Syndrome Indomethacin 4.5510684365
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.571440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 7.6516206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.6512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4715746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.2514601052
MESH:D001929 Brain Edema Indomethacin 4.5711481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8917868700
MESH:D001930 Brain Injuries Progesterone 9.6115665606 15845082 15380490
MESH:D001930 Brain Injuries Zinc 9.6117109824
MESH:D002545 Brain Ischemia Indomethacin 9.0512524144
MESH:D002545 Brain Ischemia Plant Extracts 9.0516041641
MESH:D001932 Brain Neoplasms Doxorubicin 3.4317150277
MESH:D001943 Breast Neoplasms Androgens 5.3017018787
MESH:D001943 Breast Neoplasms bexarotene 5.3016344269 16818667
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.3017474063
MESH:D001943 Breast Neoplasms Doxorubicin 5.3018628466 15993339 17983394 16935488 11325840 15994142 16096432 15136595 17369602 18382427 16115903 15668708 19526202 18695136 16595493 15939500 15692762 16322301 18234424 15567936 16826403 16264153 15634643 17426702
MESH:D001943 Breast Neoplasms dutasteride 5.3016806904
MESH:D001943 Breast Neoplasms Indomethacin 5.3017401462
MESH:D001943 Breast Neoplasms Progesterone 5.3016175315 17614352 15562024
MESH:D001943 Breast Neoplasms selenomethylselenocysteine 5.3018855134
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.3020435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9211589617
MESH:D002056 Burns Ethanol 9.9416374292
MESH:D002056 Burns Indomethacin 9.9410459503
MESH:D002057 Burns, Chemical Plant Extracts 4.889625245
MESH:D002100 Cachexia Indomethacin 4.5615625704 16537180 11239499 15141370
MESH:D002276 Carcinoid Tumor Doxorubicin 4.3616051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4516835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 21.0516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 21.0516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 21.053581430 7296757
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 21.0516217749 14691202 15073043 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 21.0518665156 18494052 20514400 17761372 19208518 3084413 16328049 16779866 19539802 20524982 18788625 19052882 10672840 11831363 19418558 18506893 17173139 18978308 16935385 19171122 18971187 20101231 10737359 18056438 16878318 19701751 20727157 17138121 16502159 18691550 19919837 16681979 16569478 19335982 17978847 16830150 20214788 3581430 16288022 20007298 17055752 17428255 20935162 19107877 19383236 20512989 16540662 19822196 16807293 18393292 18210153 19519916 16698587 19394651 20084675 18785209 17162532 21159647 20432363
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 21.0518059187 17876044 16023760 16234567
MESH:D006528 Carcinoma, Hepatocellular Ethanol 21.0515289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 21.0516391822
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 21.051701930 20007298 17173139 20935162 6705139
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 21.0518834353
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.2811053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.9111352223 14736730 18791128
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.0616247446
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.4219014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 13.597296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 13.5916201981 1485588
MESH:D002292 Carcinoma, Renal Cell Indomethacin 13.5917341418
MESH:D002292 Carcinoma, Renal Cell Vinblastine 13.591485588
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.7312490120
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 6.876189445
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 6.8712636206 15482327
MESH:D002294 Carcinoma, Squamous Cell Zinc 6.8716543248
MESH:D006332 Cardiomegaly Ethanol 10.0419332462
MESH:D006332 Cardiomegaly Plant Extracts 10.0417645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.0418850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.2317924179 17329180 17974986 15476868 16731534 17131338 17928571 16242529 16278810 17519947 16109756 17308081 15505089 16612575 16952015 16455267 15792986 16269455 15811867 17351982 17382496 16651473 16364871 17007740 18627295
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.7817334414 16243910
MESH:D002318 Cardiovascular Diseases Isoflavones 6.8617689850
MESH:D002318 Cardiovascular Diseases Zinc 6.8616936243
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 9.396135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 9.397505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 9.397505956 17174075 21159647 2727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.824080065
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 14.0716628245
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 14.0719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 14.0716835633
MESH:D002764 Cholecystitis Indomethacin 4.7211181007
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 6.7719486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 6.7717681005 16919318 16105132 17110522 11677210 15861022 17333356
MESH:D002971 Cleft Lip Ethanol 3.3415513904
MESH:D002972 Cleft Palate Ethanol 12.5715513904
MESH:D002972 Cleft Palate Fluconazole 12.5716781842
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 12.578697196 15340226 15668235 12621046 16354765
MESH:D002972 Cleft Palate triadimefon 12.5716781842
MESH:D003110 Colonic Neoplasms Indomethacin 2.5115786552 15637740 15936596 11260862 15963497 15625704
MESH:D015179 Colorectal Neoplasms arsenic trioxide 5.9420501625
MESH:D015179 Colorectal Neoplasms Doxorubicin 5.9418802399 18259882
MESH:D015179 Colorectal Neoplasms Indomethacin 5.9418059344 17054584 11197048 12606626
MESH:D015179 Colorectal Neoplasms Isoflavones 5.9417116718
MESH:D015179 Colorectal Neoplasms Vinblastine 5.9418802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6917141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.7612609071
MESH:D018352 Coronavirus Infections Indomethacin 5.2717302372
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 8.6917686920
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 8.6910525206
MESH:D019465 Craniofacial Abnormalities Ethanol 8.6910194807 11873399 19302082 15513904 11198716 15451040 15451039
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 8.6920055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities triadimefon 8.6915834900 16875885
MESH:D019465 Craniofacial Abnormalities Zinc 8.6919302082
MESH:D016638 Critical Illness Androgens 5.6216670151
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.4618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.4618551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.6915213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.4011298694 18759878 8970840 8156756 14531868 12868966 2524372 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.093621924 2952479
MESH:D003920 Diabetes Mellitus Zinc 3.8316479319
MESH:D003922 Diabetes Mellitus, Type 1 Dehydroepiandrosterone 3.5516616286
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.8020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.8017107852
MESH:D003928 Diabetic Nephropathies Plant Extracts 4.0419706694
MESH:D003929 Diabetic Neuropathies Progesterone 4.0617187935
MESH:D003967 Diarrhea Indomethacin 3.397237001 7907874
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 19.5618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 19.5618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 19.566679447 18648102 18692083 1440618 7440962 9653073 16192314 11289319 9328219 18289764 9022650 6482804 8291058
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 19.5617851650
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 19.5619107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 19.5617416283
MESH:D056486 Drug-Induced Liver Injury Ethanol 19.5611566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 19.5620420201
MESH:D004362 Drug Toxicity Doxorubicin 7.0118602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.0111462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.7118446180 18043480 12774134 16326151 17190690 16133044
MESH:D004381 Duodenal Ulcer Indomethacin 3.7211535926 17202747 17045617 10671773 11991626 11595415 17329845 11595431 16699067 17351913 17151854
MESH:D004421 Dystonia Phenobarbital 3.601851702
MESH:D004487 Edema Indomethacin 13.3216100529 8985016 7907874 7990266 8273558 19703484 10653021
MESH:D004487 Edema perfluorooctanoic acid 13.3217259670 12083418
MESH:D004487 Edema Plant Extracts 13.3212787963
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.3211000095 12711302
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 10.9117686920
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.9118230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.6412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 7.6417692515
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.1617359293
MESH:D004715 Endometriosis Indomethacin 13.0815652904
MESH:D004715 Endometriosis Progesterone 13.0816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 13.089294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 12.5518037988
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 12.5515268973
MESH:D019446 Endotoxemia Indomethacin 4.0618509659
MESH:D004751 Enteritis Indomethacin 4.3017763956 10567023 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.5517980183
MESH:D004802 Eosinophilia Indomethacin 3.6311298111
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.683659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.423922381 11558140
MESH:D004827 Epilepsy Phenobarbital 6.1620417680
MESH:D004827 Epilepsy Plant Extracts 6.1619439326 19700373
MESH:D004832 Epilepsy, Absence Phenobarbital 3.176401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.827750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.583659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6616302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 12.423581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 12.4212903497
MESH:D004938 Esophageal Neoplasms Ethanol 12.4216704527
MESH:D004938 Esophageal Neoplasms Indomethacin 12.4211005569
MESH:D004938 Esophageal Neoplasms Zinc 12.4216543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6811564622
MESH:D005234 Fatty Liver arsenic trioxide 25.6115073043
MESH:D005234 Fatty Liver Diethylnitrosamine 25.6121071580 20387270
MESH:D005234 Fatty Liver Ethanol 25.6118620774 19236843 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.6115345470
MESH:D005234 Fatty Liver Fish Oils 25.6118620774
MESH:D005234 Fatty Liver Plant Extracts 25.6115975614
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.2117920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.8616946407 15513904 10194807 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0211858732
MESH:D005334 Fever Indomethacin 3.7411852909 10431976 17627676
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.576705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.1519069698
MESH:D005354 Fibrosarcoma Indomethacin 4.4510962813
MESH:D005355 Fibrosis Indomethacin 7.4017994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.4020067830
MESH:D005499 Folliculitis Indomethacin 4.7211298111
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.8416904648
MESH:D005756 Gastritis Ethanol 16.5915046732
MESH:D005756 Gastritis Indomethacin 16.5915046732
MESH:D005756 Gastritis Zinc 16.5917241300
MESH:D005909 Glioblastoma Doxorubicin 6.4717150277
MESH:D005909 Glioblastoma Indomethacin 6.4712870263
MESH:D005910 Glioma Indomethacin 3.0416487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.9311849393
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.637505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1410696789
MESH:D006073 Gout Indomethacin 4.9111248219
MESH:D006130 Growth Disorders Zinc 3.6717217573
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.0415692506
MESH:D006258 Head and Neck Neoplasms Indomethacin 7.0415482327
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 6.1920471113 17686920
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1911294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 7.0317875725 16879835 16330681 18674790 18006777 16707910 16244371 16495754 16144979 16244372 12587719 14766674 17888722
MESH:D006331 Heart Diseases Mitoxantrone 7.0316019553
MESH:D006333 Heart Failure Doxorubicin 10.4317481944
MESH:D006333 Heart Failure Plant Extracts 10.4318097624
MESH:D006333 Heart Failure Zinc 10.4317162251
MESH:D006335 Heart Injuries Zinc 5.3217074742
MESH:D016481 Helicobacter Infections Zinc 4.1317241300
MESH:D006394 Hemangiosarcoma Doxorubicin 3.5115692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9411000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.1715633222
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.106705139
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.2615135802
MESH:D006527 Hepatolenticular Degeneration Zinc 4.2617276780
MESH:D006529 Hepatomegaly perfluorooctanoic acid 22.603609246
MESH:D006529 Hepatomegaly Phenobarbital 22.6016109766
MESH:D006529 Hepatomegaly propiconazole 22.6017178689 17178688
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 22.6016120746 15340226 12621046
MESH:D006529 Hepatomegaly triadimefon 22.6017178689 17178688
MESH:D006561 Herpes Simplex Plant Extracts 4.1910715843
MESH:D006628 Hirsutism Androgens 5.6316914592 17019078
MESH:D015658 HIV Infections Plant Extracts 3.4412878215
MESH:D006689 Hodgkin Disease Doxorubicin 6.5817606976 18501091 15147373
MESH:D006689 Hodgkin Disease Vinblastine 6.5818501091 18180244
MESH:D019584 Hot Flashes Isoflavones 9.2917290160 14716179
MESH:D019584 Hot Flashes Plant Extracts 9.2917454163 16566672 14716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5915340226 16354765 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Ethanol 11.2818783367
MESH:D006930 Hyperalgesia Indomethacin 11.2812727271
MESH:D006930 Hyperalgesia perfluorooctanoic acid 11.2812083418
MESH:D034321 Hyperamylasemia Indomethacin 5.2717883296
MESH:D017588 Hyperandrogenism Androgens 5.2817019078
MESH:D006940 Hyperemia Indomethacin 4.5612524144
MESH:D020138 Hyperhomocysteinemia Plant Extracts 4.0916484555
MESH:D006949 Hyperlipidemias Fish Oils 13.3715752949
MESH:D006949 Hyperlipidemias Indomethacin 13.3717546600
MESH:D006949 Hyperlipidemias Plant Extracts 13.3715268973 15975614
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.5115034207
MESH:D006968 Hypersensitivity, Delayed Fish Oils 5.0511484837
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3816945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 4.5718306037 10574470
MESH:D007079 Ileitis Indomethacin 4.9116133968 10647630 10651667
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.9216133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.9715869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.1917937319
MESH:D007249 Inflammation Diethylnitrosamine 16.8118785209
MESH:D007249 Inflammation Indomethacin 16.8112568917 7812673 3291741
MESH:D007249 Inflammation perfluorooctanoic acid 16.8112083418
MESH:D007249 Inflammation Plant Extracts 16.8116366677 15997105 12787963 19332304
MESH:D007249 Inflammation Progesterone 16.8115869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 16.8112200463 12878042
MESH:D007410 Intestinal Diseases Indomethacin 3.9015610444 11713966 10210152 11686837 18236018 11855677 17329856 15831440 17994277
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.2312351151 12584176 12628509
MESH:D019586 Intracranial Hypertension Indomethacin 4.9215241188
MESH:D007511 Ischemia Zinc 4.2016584753
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.578074119 9022650
MESH:D007569 Jaw Abnormalities Ethanol 15.0315513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 15.0316580747
MESH:D007569 Jaw Abnormalities triadimefon 15.0315992940 15834900
MESH:D007579 Jejunal Diseases Indomethacin 4.5716133968 10574470 18306037
MESH:D007674 Kidney Diseases Doxorubicin 8.7815699352 16775033 15369732
MESH:D007674 Kidney Diseases Indomethacin 8.7817190690
MESH:D007674 Kidney Diseases Zinc 8.7816960431
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.8616707910
MESH:D007676 Kidney Failure, Chronic Zinc 8.8616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 10.3216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 10.3216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 10.326582329
MESH:D007859 Learning Disorders Ethanol 3.7815451040
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.5512228301 10320625 11703811
MESH:D007938 Leukemia arsenic trioxide 2.6015070760
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.7016085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.5918172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4017077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.8616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 7.4614633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 7.4610785260 15631656 16572323
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.3719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7720471514 16467208 16968895 19850784 17050201
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 3.7718360721
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 2.9211161223 17107899 12679006 16330433 16891316 16112521 19225113 17712046 16966277 9834237 17217047 15748426 17869043 16331271 15622746 12712474 15213294 19075265 17649720 19035177 11468182 16823087 19642359 12018890 15336539
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.9316882451
MESH:D007964 Leukocytosis Indomethacin 4.9216537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.2717980183
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.798812269
MESH:D017880 Limb Deformities, Congenital Ethanol 3.4917676605
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.2711479899
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 13.7218665156 18522880 18407596 19638242 20032147
MESH:D008103 Liver Cirrhosis Ethanol 13.7215289165
MESH:D008103 Liver Cirrhosis Phenobarbital 13.7221047994
MESH:D008103 Liver Cirrhosis Plant Extracts 13.7217157831
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.6518295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.9115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.0616439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 6.0618166357
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 6.0618194892
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 6.0615479170
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.0612878042
MESH:D008107 Liver Diseases Diethylnitrosamine 14.1417034775
MESH:D008107 Liver Diseases Fluconazole 14.1414966256
MESH:D008107 Liver Diseases Phenobarbital 14.1419363144
MESH:D008107 Liver Diseases Plant Extracts 14.1417034775
MESH:D008107 Liver Diseases propiconazole 14.1419363144
MESH:D008107 Liver Diseases triadimefon 14.1419363144
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.2217347304 17207112
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 42.7616835634 18644402
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 42.767678174
MESH:D008113 Liver Neoplasms arsenic trioxide 42.7614682389
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 42.7619389873 21295105
MESH:D008113 Liver Neoplasms Clofibric Acid 42.7617602206
MESH:D008113 Liver Neoplasms Dehydroepiandrosterone 42.7618709148
MESH:D008113 Liver Neoplasms Diethylnitrosamine 42.7619073162 2862719 19812893 18977376 20405173 19642983 19255062 18648771 18644402 19551842 18754104 21071580 19427195 19254457 15885732 12112319 21047994 19090486 19996281 20101389 20501860 12771043 20583210 19294768 19850985 15175105 19426721 2422723 19256749 20137499 18978307 20118626 20434301 21278145 16942905 10737359 20492335 20452335 19499222 9163691 21167192 19638242 19690152 19833225
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 42.7614757943 18709148
MESH:D008113 Liver Neoplasms Phenobarbital 42.7619482888 8742319 15975961 21047994 19812893 19073162
MESH:D008113 Liver Neoplasms Plant Extracts 42.7619168119
MESH:D008113 Liver Neoplasms propiconazole 42.7619028983
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 42.7616984957
MESH:D008113 Liver Neoplasms triadimefon 42.7619028983
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 42.332876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 42.336587162 1399818 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 42.3320377131
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 42.3318164116
MESH:D008114 Liver Neoplasms, Experimental Dehydroepiandrosterone 42.338603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 42.3316267830 19126423 19009564 18093689 2563599 18253720 19519916 17854601 19539802 18164116 9362446 19004024 16842330 18079962 17942915 21159647 17174075 18775883 3124819 18308698 18282651 18544905
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 42.3316842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 42.3317172636 18308698 6150874 2563599 1399818
MESH:D008114 Liver Neoplasms, Experimental propiconazole 42.3317178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 42.3312151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 42.3317178689
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0115213294
MESH:D008171 Lung Diseases Fluconazole 4.5214966256
MESH:D008175 Lung Neoplasms arsenic trioxide 9.6619825857 11798837
MESH:D008175 Lung Neoplasms bexarotene 9.6617849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 9.6620512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Doxorubicin 9.666189445 17418594
MESH:D008175 Lung Neoplasms Indomethacin 9.6611053908 11497255 16537180
MESH:D008175 Lung Neoplasms Plant Extracts 9.6620869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 9.6611884234 19555203
MESH:D008223 Lymphoma Doxorubicin 3.1416098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.4317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.1315621674
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.7111161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 19.8219196723 15591091 19196722
MESH:D008325 Mammary Neoplasms, Experimental Dehydroepiandrosterone 19.8216457693
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 19.8215458769
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 19.8217203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental selenomethylselenocysteine 19.8215318939
MESH:D008325 Mammary Neoplasms, Experimental Zinc 19.8212773700
MESH:D008545 Melanoma Doxorubicin 3.5016827129
MESH:D008545 Melanoma Vinblastine 3.5017761969 18505091 16248763 18176117 15577323 12374674 15577320 16432458 18332650 16809738
MESH:D008569 Memory Disorders Ethanol 3.7715451040 18411066
MESH:D008654 Mesothelioma Doxorubicin 2.8717638057
MESH:D008881 Migraine Disorders Indomethacin 3.3611903285
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.1015792986
MESH:D009062 Mouth Neoplasms Indomethacin 3.6512636206
MESH:D052016 Mucositis Doxorubicin 4.3517415656
MESH:D009101 Multiple Myeloma arsenic trioxide 2.7919549372 14977855 19417148 11468182 15949261
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.2218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 2.8816882451 16105982
MESH:D009203 Myocardial Infarction Doxorubicin 2.7619429709 15857846
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6712213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0317484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.8718551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.5416624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 12.023581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 12.023581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 12.0218259882
MESH:D009362 Neoplasm Metastasis Indomethacin 12.0211239499 16537180 11053908
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 7.428820588
MESH:D009369 Neoplasms lycopene 7.4217051425
MESH:D009369 Neoplasms Mitoxantrone 7.4216640825
MESH:D009374 Neoplasms, Experimental Indomethacin 3.7110663608 15625704
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.3319196722
MESH:D009401 Nephrosis Doxorubicin 4.3416899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.6315640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.8014600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.276679447
MESH:D009436 Neural Tube Defects arsenic trioxide 6.2710525206
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.7517168769
MESH:D009447 Neuroblastoma Doxorubicin 6.4915555623
MESH:D009447 Neuroblastoma Topotecan 6.4915176712
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.3820387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 7.3812349958
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6620387270
MESH:D009503 Neutropenia Vinblastine 4.1717378895
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.529802331
MESH:D009765 Obesity Plant Extracts 3.0319056576 20132043
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.726374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 12.8516049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 12.8516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 12.856482804 4026338
MESH:D014009 Onychomycosis Fluconazole 5.9014966256
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.573988306
MESH:D010003 Osteoarthritis Indomethacin 3.397009135
MESH:D010018 Osteomalacia Phenobarbital 3.9217016548
MESH:D010024 Osteoporosis Isoflavones 3.8216562857
MESH:D015663 Osteoporosis, Postmenopausal Dehydroepiandrosterone 4.6216397352
MESH:D012516 Osteosarcoma Doxorubicin 3.7615930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.4216624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Progesterone 4.4216525653 17393432
MESH:D010146 Pain Indomethacin 3.1217627676 13679232 17440234 3291741
MESH:D010149 Pain, Postoperative Indomethacin 4.2312538197 18702446
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 10.8915580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 10.8916540662
MESH:D010190 Pancreatic Neoplasms Ethanol 10.8912384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 10.8916965848
MESH:D010195 Pancreatitis Indomethacin 3.5217883296 15028970
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2811578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.037296757
MESH:D010212 Papilloma Plant Extracts 8.0316517061 15173996
MESH:D010235 Paraganglioma arsenic trioxide 3.7519927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.2716537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.7412349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.2711903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8012520081
MESH:D010437 Peptic Ulcer Indomethacin 4.7111148446
MESH:D010518 Periodontitis Indomethacin 4.4617225004
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.026228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.7017983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.7017638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1418163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.862563599
MESH:D011230 Precancerous Conditions Phenobarbital 7.862563599
MESH:D011225 Pre-Eclampsia Zinc 3.8317114810
MESH:D047928 Premature Birth Indomethacin 4.6917000239
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 8.2017132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.2011399792 11896295 11222880 11118676
MESH:D011470 Prostatic Hyperplasia ganoderol B 6.6417499997
MESH:D011471 Prostatic Neoplasms Androgens 2.7616998812 17909013 15389811
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.7619131511
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.7615897917 15749863 18437689 16888761 16729912 16868541
MESH:D011471 Prostatic Neoplasms Finasteride 2.7612597149
MESH:D011471 Prostatic Neoplasms ganoderol B 2.7617499997
MESH:D011471 Prostatic Neoplasms Isoflavones 2.7617219775 17571952 17374662 16365062
MESH:D011471 Prostatic Neoplasms lycopene 2.7617337101 15084515
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.7617804756 14666653
MESH:D011471 Prostatic Neoplasms Zinc 2.7612429649 16517595 16606632 16700911
MESH:D011507 Proteinuria Indomethacin 3.7611849393
MESH:D011537 Pruritus Ethinyl Estradiol 2.8716919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.0412752131
MESH:D051437 Renal Insufficiency Doxorubicin 3.7917922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 7.903692021
MESH:D012162 Retinal Degeneration Zinc 7.9016584753
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6918045962
MESH:D012509 Sarcoma Doxorubicin 3.6115625365 18313854 17710206 15675481 16767912 17203757
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 8.8816646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 8.8814601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.3517846226
MESH:D012640 Seizures 2,4-dinitrotoluene 11.5818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 11.5818551238
MESH:D012640 Seizures Ethanol 11.589754883
MESH:D012640 Seizures Phenobarbital 11.583137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.386407741
MESH:D012878 Skin Neoplasms Doxorubicin 8.2815692506
MESH:D012878 Skin Neoplasms Plant Extracts 8.2815173996 16517061
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.2816192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.1317203757 16767912 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 3.4916709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.8415862959 16503802
MESH:D013272 Stomach Diseases Indomethacin 3.9817160473 10486359 10192188 17207306 18209964 17638125 15472012 18545984 15038085 16184426 16113693 16280098 10215738
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.3317007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.3318456281
MESH:D013274 Stomach Neoplasms Ethanol 4.3318456281
MESH:D013274 Stomach Neoplasms Indomethacin 4.3315609394
MESH:D013276 Stomach Ulcer Ethanol 9.999211565 17189318 11906479 17918041 9562338 16755016
MESH:D013276 Stomach Ulcer Indomethacin 9.9910878458 18237397 10423059 11595431 18726076 12467913 11906479 16755016 17895592 11523592 18181030 15104355 17918041 18543354 1323529 18299717 12787963 16150113 16631530 18193104 17654042 17135157 17977527 11595415 18087811 15255614 10750652 17657623 16397915 16169175 11145282 12077510 12500499 17627676 12498302 16252198 15138204 16934674 18431645 11729361 18209962 14567935
MESH:D013276 Stomach Ulcer Plant Extracts 9.9918237397 17135157 12787963 15255614 18193104
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.879754883
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 5.0317997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 28.611399818 7505956 6587162 6582329 3712494
MESH:D013964 Thyroid Neoplasms arsenic trioxide 28.6119014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 28.617505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 28.6116010429 17909728
MESH:D013964 Thyroid Neoplasms Indomethacin 28.6111352223 14736730 18791128
MESH:D013964 Thyroid Neoplasms Phenobarbital 28.611399818
MESH:D013964 Thyroid Neoplasms triadimefon 28.6117178689
MESH:D014062 Tongue Neoplasms Zinc 4.0116543248
MESH:D016171 Torsades de Pointes arsenic trioxide 3.5215213294
MESH:D014456 Ulcer Indomethacin 4.4517380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 13.7716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 13.7716049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 13.778074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 13.7712845720 11780464 20435036 12973940
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 13.7717653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.5110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8814692618
MESH:D014625 Vaginal Neoplasms Vinblastine 4.6115577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1414671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 9.0717334414 16364871 17678736 17638931
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 9.0718097624
MESH:D020257 Ventricular Remodeling Plant Extracts 4.8718097624
MESH:D014839 Vomiting Indomethacin 4.3011897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8015886252
MESH:D014947 Wounds and Injuries Plant Extracts 3.8919894650 20213670
Pathway ID Pathway Name
REACT:15314 Hormone biosynthesis
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:00140 Steroid hormone biosynthesis
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00367 inhibitor Triquilar 28 Tab Contraceptives;Contraceptives, Oral, Synthetic;Contraceptive Agents, Female
DB01126 antagonist Dutasteride Enzyme Inhibitors;Anti-baldness Agents;Antihyperplasia Agents
DB01216 antagonist Finasteride Enzyme Inhibitors;Skin and Mucous Membrane Agents;Anti-baldness Agents;Antihyperplasia Agents
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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