AutismKB 2.0

Annotation Detail for SRD5A2


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Basic Information Top
Gene Symbol:SRD5A2 ( MGC138457 )
Gene Full Name: steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Band: 2p23.1
Quick LinksEntrez ID:6716; OMIM: 607306; Uniprot ID:S5A2_HUMAN; ENSEMBL ID: ENSG00000049319; HGNC ID: 11285
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-378androgen biosynthesis
Pathway IDPathway Name
hsa00140Steroid hormone biosynthesis
hsa05215Prostate cancer
Pathway IDPathway Name
Hormone biosynthesis
Metabolism of lipids and lipoproteins
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
AGING
micropenis
prostate cancer prostate specific antigen
androgen
hypospadias
serum androgen concentrations
prostate cancer
CANCER
breast cancer
clinical parameters and endocrine status in elderly men
METABOLIC
DEVELOPMENTAL
No data
Desease Name
Pseudovaginal perineoscrotal hypospadias
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SRD5A2 proteinaffects expression 20106945
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of SRD5A2 mRNAincreases expression 15056816
D013196 Dihydrotestosterone hydroxyflutamide inhibits the reaction [Dihydrotestosterone results in increased expression of SRD5A2 mRNA]decreases reaction|increases expression 15056816
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SRD5A2 mRNAaffects expression 16483693
C028895 androstane-3,17-diol glucuronide SRD5A2 gene SNP results in decreased abundance of androstane-3,17-diol glucuronidedecreases abundance 17136762
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased activity of SRD5A2 proteindecreases activity 17218080
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of SRD5A2 mRNAincreases expression 16938428
D016572 Cyclosporine Cyclosporine results in decreased expression of SRD5A2 mRNAdecreases expression 20106945
C020735 dibutyldichlorotin dibutyldichlorotin results in decreased activity of SRD5A2 proteindecreases activity 17218080
D003633 Dichlorodiphenyl Dichloroethylene Dichlorodiphenyl Dichloroethylene results in decreased activity of SRD5A2 proteindecreases activity 17218080
C108373 dutasteride dutasteride results in decreased expression of SRD5A2 mRNAdecreases expression 16806904
D004958 Estradiol Estradiol results in decreased expression of SRD5A2 mRNAdecreases expression 20106945
C033789 fenarimol fenarimol results in decreased activity of SRD5A2 proteindecreases activity 17218080
D018120 Finasteride Finasteride results in decreased activity of SRD5A2 proteindecreases activity 17218080
D005485 Flutamide Flutamide results in decreased activity of SRD5A2 proteindecreases activity 17218080
C014290 hydroxyflutamide hydroxyflutamide inhibits the reaction [Dihydrotestosterone results in increased expression of SRD5A2 mRNA]decreases reaction|increases expression 15056816
D008044 Linuron Linuron results in decreased activity of SRD5A2 proteindecreases activity 17218080
D008777 Methyltestosterone Methyltestosterone results in decreased activity of SRD5A2 proteindecreases activity 17218080
C032727 piperidine piperidine analog results in decreased activity of SRD5A2 proteindecreases activity 10896124
C032727 piperidine piperidine analog results in decreased activity of SRD5A2 proteindecreases activity 10896124
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SRD5A2 mRNAaffects binding|decreases expression|increases activity 19710929
C025299 polyphenols polyphenols results in decreased expression of SRD5A2 mRNAdecreases expression 16293270
C045362 prochloraz prochloraz results in decreased activity of SRD5A2 proteindecreases activity 17218080
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SRD5A2 mRNAincreases expression 11222880
C011559 tributyltin tributyltin results in decreased activity of SRD5A2 proteindecreases activity 12231121
C030665 triphenyltin triphenyltin results in decreased activity of SRD5A2 proteindecreases activity 17218080
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6815322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3918287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.9618653653
MESH:D000230 Adenocarcinoma Estradiol 2.0611473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3316835633
MESH:D000382 Agricultural Workers' Diseases Dichlorodiphenyl Dichloroethylene 4.6316487989
MESH:D000505 Alopecia marker/mechanism 17136762
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8011748828
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.2519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6515746008
MESH:D001943 Breast Neoplasms Dichlorodiphenyl Dichloroethylene 2.0815061365
MESH:D001943 Breast Neoplasms dutasteride 2.0816806904
MESH:D001943 Breast Neoplasms Estradiol 2.0819861407 16675129 17261762 12948864 18497071 17018787 17289903 14630087
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0820435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2916111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6616835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 2.9512619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 2.9516924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2716120746 18850075 18670907
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.1912371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.1918566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D002779 Cholestasis Cyclosporine 7.3419486331
MESH:D002779 Cholestasis pirinixic acid 7.3419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0312621046 15340226 16354765 8697196 15668235
MESH:D003110 Colonic Neoplasms polyphenols 2.6516293270
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 15322242 10048152
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3518249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6317107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2719279558
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 6.1017851650
MESH:D056486 Drug-Induced Liver Injury polyphenols 6.1019370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.1020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6311462148
MESH:D004417 Dyspnea Dichlorodiphenyl Dichloroethylene 5.0916487989
MESH:D004487 Edema pirinixic acid 6.0312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7315322242 16714409 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 2.8711473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.879294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8911564622
MESH:D005234 Fatty Liver Cyclosporine 7.0419224547
MESH:D005234 Fatty Liver pirinixic acid 7.0420131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2911858732
MESH:D005355 Fibrosis Cyclosporine 7.9212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.9220067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.058708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2410048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2515720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1811000095
MESH:D006505 Hepatitis Dichlorodiphenyl Dichloroethylene 4.8716487989
MESH:D006529 Hepatomegaly fenarimol 13.652387028
MESH:D006529 Hepatomegaly pirinixic acid 13.6519772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.6515340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8615709030
MESH:D019584 Hot Flashes Estradiol 3.5817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8716959395 18606429 8697196 15340226 16354765
MESH:D017588 Hyperandrogenism Flutamide 5.2915356085
MESH:D006943 Hyperglycemia pirinixic acid 9.3420558911
MESH:D006943 Hyperglycemia triphenyltin 9.3410522495
MESH:D006973 Hypertension Cyclosporine 4.7310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7318850075 18670907
MESH:D015228 Hypertriglyceridemia triphenyltin 5.8010522495
MESH:D007246 Infertility triphenyltin 5.8615205045
MESH:D007248 Infertility, Male Dichlorodiphenyl Dichloroethylene 4.1717192596 12948891
MESH:D007249 Inflammation polyphenols 4.8616366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8612200463 12878042
MESH:D007333 Insulin Resistance Estradiol 6.8316627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.8316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2715604871
MESH:D007674 Kidney Diseases Cyclosporine 5.618314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 5.6115618244
MESH:D007680 Kidney Neoplasms Cyclosporine 6.8112371664
MESH:D007680 Kidney Neoplasms Estradiol 6.8115610895
MESH:D007896 Leishmaniasis fenarimol 5.2818372651
MESH:D017880 Limb Deformities, Congenital Dichlorodiphenyl Dichloroethylene 4.5712745335
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.2614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.2615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.2612878042
MESH:D008107 Liver Diseases polyphenols 2.7416698588
MESH:D008113 Liver Neoplasms Aflatoxin B1 6.9715890375 9163691 2125692 18177683
MESH:D008113 Liver Neoplasms pirinixic acid 6.9716377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 6.9716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.458603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.4512151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.2414755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.4516891317 11408345 17203775 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.3119453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6216801185
MESH:D009135 Muscular Diseases pirinixic acid 3.3416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.8116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.8116411023
MESH:D009369 Neoplasms pirinixic acid 1.8717405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5617289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1419348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 8.9111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.9114600291
MESH:D009765 Obesity pirinixic acid 1.7720558911
MESH:D010051 Ovarian Neoplasms Estradiol 2.1719401270
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0812520081
MESH:D011085 Polycystic Ovary Syndrome Flutamide 4.8515356085
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0812371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0211118676 11399792 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7320887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17823934 18306354 16998812 17136762
MESH:D011471 Prostatic Neoplasms Estradiol 3.1016740699
MESH:D011471 Prostatic Neoplasms Finasteride 3.1012597149
MESH:D011471 Prostatic Neoplasms Flutamide 3.103169114
MESH:C535830 Pseudovaginal perineoscrotal hypospadias marker/mechanism
MESH:D011565 Psoriasis Cyclosporine 2.1716882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6718990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9716192470
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.0817997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7312697716
MESH:D013978 Tibial Fractures Estradiol 4.5119048282
MESH:D014564 Urogenital Abnormalities marker/mechanism
MESH:D014570 Urologic Diseases Dichlorodiphenyl Dichloroethylene 5.5716487989
MESH:D014605 Uveitis Cyclosporine 3.811336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2717120751
Pathway ID Pathway Name
REACT:15314 Hormone biosynthesis
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:05215 Prostate cancer
KEGG:00140 Steroid hormone biosynthesis
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00548 inhibitor Azelaic Acid Antineoplastic Agents;Dermatologic Agents
DB01126 antagonist Dutasteride Enzyme Inhibitors;Anti-baldness Agents;Antihyperplasia Agents
DB01216 antagonist Finasteride Enzyme Inhibitors;Skin and Mucous Membrane Agents;Anti-baldness Agents;Antihyperplasia Agents
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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