AutismKB 2.0

Annotation Detail for BRCA1


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Basic Information Top
Gene Symbol:BRCA1 ( BRCAI,BRCC1,BROVCA1,IRIS,PNCA4,PSCP,RNF53 )
Gene Full Name: breast cancer 1, early onset
Band: 17q21.31
Quick LinksEntrez ID:672; OMIM: 113705; Uniprot ID:BRCA1_HUMAN; ENSEMBL ID: ENSG00000012048; HGNC ID: 1100
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04120Ubiquitin mediated proteolysis
Pathway IDPathway Name
DNA Repair
Pathway IDPathway Name
200171Validated targets of C-MYC transcriptional repression
200038Coregulation of Androgen receptor activity
200027E2F transcription factor network
200174BARD1 signaling events
200166Aurora A signaling
200116ATF-2 transcription factor network
200194FOXA1 transcription factor network
No data
Pathway IDPathway Name
500044Recruitment of repair and signaling proteins to double-strand breaks
500043ATM mediated phosphorylation of repair proteins
500068Fanconi Anemia pathway
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
H00031Breast cancer
H00027Ovarian cancer
Cancers of the breast and female genital organs
Desease IDDesease Name
1740Alzheimer's disease
1870Drug abuse
1894Abortion
1901Endometriosis
1934Cancer
2016Tic disorder
2064Spinal dysraphism
2068Skin disease
2102Polycystic ovary syndrome
2120Rabies
Desease Name
ovarian cancer
endometrial carcinoma
breast cancer, male
CANCER
breast cancer
germline BRCA1 mutation
tumor progression
No data
Desease Name
Breast-ovarian cancer, familial, 1
Pancreatic cancer, susceptibility to, 4
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C029790 2,2',3',4,4',5-hexachlorobiphenyl 2,2',3',4,4',5-hexachlorobiphenyl inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]decreases reaction|increases expression 12473173
C014024 2,4,5,2',4',5'-hexachlorobiphenyl 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]decreases reaction|increases expression 12473173
C425784 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole binds to AHR protein] which results in increased activity of BRCA1 proteinaffects binding|increases activity 18259752
C425784 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole BRCA1 protein promotes the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYP1A1 mRNA]increases expression|increases reaction 16567799
C091768 3'-methoxy-4'-nitroflavone 3'-methoxy-4'-nitroflavone inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]decreases reaction|increases expression 16489025
C065250 4-hydroxy-equilenin 4-hydroxy-equilenin results in decreased expression of BRCA1 mRNAdecreases expression 15135645
D000082 Acetaminophen Acetaminophen affects the expression of BRCA1 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of BRCA1 mRNAdecreases expression 17942131
C011512 alpha-naphthoflavone alpha-naphthoflavone inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]decreases reaction|increases expression 16489025
C011512 alpha-naphthoflavone alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased activity of BRCA1 protein]affects binding|decreases reaction|increases activity 18259752
D015081 2-Naphthylamine 2-Naphthylamine results in decreased expression of BRCA1 mRNAdecreases expression 18247414
D000643 Ammonium Chloride Ammonium Chloride affects the expression of BRCA1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of BRCA1 mRNAincreases expression 20458559
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of BRCA1 mRNAaffects expression 17331233
D001564 Benzo(a)pyrene Benzo(a)pyrene inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]decreases reaction|increases expression 16489025
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of BRCA1 mRNAdecreases expression 18247414
20064835
11782367
D001564 Benzo(a)pyrene TP53 protein promotes the reaction [Benzo(a)pyrene results in decreased expression of BRCA1 mRNA]decreases expression|increases reaction 11782367
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of BRCA1 mRNAdecreases expression 17942131
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of BRCA1 mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BRCA1 mRNAdecreases expression 20382639
11782367
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BRCA1 proteindecreases expression 11782367
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide TP53 protein promotes the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BRCA1 mRNA]decreases expression|increases reaction 11782367
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide TP53 protein promotes the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BRCA1 protein]decreases expression|increases reaction 11782367
C006780 bisphenol A bisphenol A results in decreased expression of BRCA1 mRNAdecreases expression 16029874
C006780 bisphenol A BRCA1 protein affects the reaction [bisphenol A results in increased activity of ESR1 protein]affects reaction|increases activity 20868731
C006780 bisphenol A BRCA1 protein affects the susceptibility to bisphenol Aaffects response to substance 20868731
C006780 bisphenol A BRCA1 gene mutant form results in increased susceptibility to bisphenol Aincreases response to substance 20868731
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of BRCA1 mRNAdecreases expression 17942131
D002166 Camptothecin Camptothecin results in decreased expression of BRCA1 mRNAdecreases expression 10344722
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of BRCA1 mRNAincreases expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of BRCA1 mRNAaffects expression 12734012
D003513 Cycloheximide Cycloheximide inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of BRCA1 mRNA]decreases expression|decreases reaction 10344722
D016572 Cyclosporine Cyclosporine results in decreased expression of BRCA1 mRNAdecreases expression 17942131
C004742 daidzein daidzein results in increased expression of BRCA1 mRNAincreases expression 17266178
C014347 decitabine decitabine affects the localization of BRCA1 protein modified formaffects localization 17991895
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of BRCA1 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of BRCA1 mRNA]decreases reaction|increases expression 17854601
D004317 Doxorubicin Doxorubicin results in decreased expression of BRCA1 mRNAdecreases expression 15607317
10344722
D004958 Estradiol 2,2',3',4,4',5-hexachlorobiphenyl inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]decreases reaction|increases expression 12473173
D004958 Estradiol 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]decreases reaction|increases expression 12473173
D004958 Estradiol 3'-methoxy-4'-nitroflavone inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]decreases reaction|increases expression 16489025
D004958 Estradiol AHR protein affects the reaction [Estradiol results in increased expression of BRCA1 mRNA]affects reaction|increases expression 16489025
D004958 Estradiol [AHR protein binds to ESR1 protein] affects the reaction [Estradiol results in increased expression of BRCA1 mRNA]affects binding|affects reaction|increases expression 16489025
D004958 Estradiol alpha-naphthoflavone inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]decreases reaction|increases expression 16489025
D004958 Estradiol Benzo(a)pyrene inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]decreases reaction|increases expression 16489025
D004958 Estradiol BRCA1 protein affects the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA3 protein]]affects binding|affects reaction|increases reaction 18997820
D004958 Estradiol BRCA1 protein affects the reaction [Estradiol results in increased expression of CCND1 mRNA]affects reaction|increases expression 18997820
D004958 Estradiol BRCA1 protein affects the reaction [Estradiol results in increased expression of MYC mRNA]affects reaction|increases expression 18997820
D004958 Estradiol BRCA1 protein affects the reaction [Estradiol results in increased expression of PGR mRNA]affects reaction|increases expression 18997820
D004958 Estradiol BRCA1 protein inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of AKT1 protein]decreases reaction|increases activity|increases phosphorylation 18997820
D004958 Estradiol BRCA1 protein inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of MAPK1 protein]decreases reaction|increases activity|increases phosphorylation 18997820
D004958 Estradiol BRCA1 protein inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of MAPK3 protein]decreases reaction|increases activity|increases phosphorylation 18997820
D004958 Estradiol BRCA1 protein promotes the reaction [indole-3-carbinol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]decreases reaction|increases activity|increases reaction 11110848
D004958 Estradiol Estradiol affects the localization of BRCA1 proteinaffects localization 16061635
D004958 Estradiol Estradiol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BRCA1 promoter]]affects binding|decreases reaction|increases reaction 16489025
D004958 Estradiol Estradiol promotes the reaction [EP300 protein binds to BRCA1 promoter]affects binding|increases reaction 16489025
D004958 Estradiol Estradiol promotes the reaction [ESR1 protein binds to BRCA1 promoter]affects binding|increases reaction 16489025
D004958 Estradiol Estradiol promotes the reaction [ESR1 protein binds to CREBBP protein binds to BRCA1 protein]affects binding|increases reaction 16417649
D004958 Estradiol Estradiol promotes the reaction [NCOA1 protein binds to BRCA1 promoter]affects binding|increases reaction 16489025
D004958 Estradiol Estradiol results in increased expression of BRCA1 mRNAincreases expression 12473173
17266178
16489025
D004958 Estradiol fulvestrant inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]decreases reaction|increases expression 12473173
D004958 Estradiol PCB 180 inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]decreases reaction|increases expression 12473173
D004958 Estradiol [Tetrachlorodibenzodioxin co-treated with Estradiol] promotes the reaction [HDAC1 protein binds to BRCA1 promoter]affects binding|affects cotreatment|increases reaction 16489025
D004958 Estradiol Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [EP300 protein binds to BRCA1 promoter]]affects binding|decreases reaction|increases reaction 16489025
D004958 Estradiol Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [NCOA1 protein binds to BRCA1 promoter]]affects binding|decreases reaction|increases reaction 16489025
D004958 Estradiol Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]decreases reaction|increases expression 16489025
12473173
D005047 Etoposide BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of CDK2 protein]decreases reaction|increases expression 16417649
D005047 Etoposide BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of RAD52 protein]decreases reaction|increases expression 16417649
D005047 Etoposide BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of RAD54L protein]decreases reaction|increases expression 16417649
D005047 Etoposide BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC2 protein]decreases reaction|increases expression 16417649
D005047 Etoposide BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC3 protein]decreases reaction|increases expression 16417649
D005047 Etoposide BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC4 protein]decreases reaction|increases expression 16417649
D005047 Etoposide Etoposide results in decreased expression of BRCA1 mRNAdecreases expression 15607317
D005419 Flavonoids Flavonoids results in increased expression of BRCA1 mRNAincreases expression 18035473
D005472 Fluorouracil Fluorouracil results in decreased expression of BRCA1 mRNAdecreases expression 15607317
17982676
D005472 Fluorouracil Fluorouracil results in increased expression of BRCA1 mRNAincreases expression 16101138
16557594
D005472 Fluorouracil TP53 protein inhibits the reaction [Fluorouracil results in decreased expression of BRCA1 mRNA]decreases expression|decreases reaction 17982676
C070081 fulvestrant fulvestrant inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]decreases reaction|increases expression 12473173
D019833 Genistein Genistein results in increased expression of BRCA1 mRNAincreases expression 17266178
16434996
D019833 Genistein Genistein results in increased expression of BRCA1 proteinincreases expression 16434996
D019833 Genistein [indole-3-carbinol co-treated with Genistein] results in increased expression of BRCA1 proteinaffects cotreatment|increases expression 16434996
D006861 Hydrogen Peroxide BRCA1 protein results in decreased susceptibility to Hydrogen Peroxidedecreases response to substance 15520196
C016517 indole-3-carbinol BRCA1 protein promotes the reaction [indole-3-carbinol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]decreases reaction|increases activity|increases reaction 11110848
C016517 indole-3-carbinol [indole-3-carbinol co-treated with Genistein] results in increased expression of BRCA1 proteinaffects cotreatment|increases expression 16434996
C016517 indole-3-carbinol indole-3-carbinol promotes the reaction [AHR protein binds to BRCA1 protein]affects binding|increases reaction 18259752
C016517 indole-3-carbinol indole-3-carbinol results in increased expression of BRCA1 mRNAincreases expression 16434996
C016517 indole-3-carbinol indole-3-carbinol results in increased expression of BRCA1 proteinincreases expression 11110848
16434996
D008748 Methylcholanthrene Methylcholanthrene promotes the reaction [AHR protein binds to BRCA1 protein]affects binding|increases reaction 18259752
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of BRCA1 mRNAincreases expression 20713471
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of BRCA1 mRNAincreases expression 12634122
D015741 Metribolone Metribolone results in increased expression of BRCA1 mRNAincreases expression 17010196
D009538 Nicotine Nicotine results in decreased expression of BRCA1 mRNAdecreases expression 18247414
D009588 Nitrogen Mustard Compounds Cycloheximide inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of BRCA1 mRNA]decreases expression|decreases reaction 10344722
D009588 Nitrogen Mustard Compounds Nitrogen Mustard Compounds results in decreased expression of BRCA1 mRNAdecreases expression 10344722
C122062 NSC 674495 BRCA1 protein promotes the reaction [NSC 674495 results in increased expression of CYP1A1 mRNA]increases expression|increases reaction 16567799
C122062 NSC 674495 NSC 674495 promotes the reaction [AHR protein binds to BRCA1 protein]affects binding|increases reaction 18259752
D010100 Oxygen Oxygen deficiency results in decreased expression of BRCA1 proteindecreases expression 17599377
D017239 Paclitaxel Paclitaxel results in decreased expression of BRCA1 mRNAdecreases expression 15607317
D010269 Paraquat BRCA1 protein results in decreased susceptibility to Paraquatdecreases response to substance 15520196
C410127 PCB 180 PCB 180 inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]decreases reaction|increases expression 12473173
C006253 pirinixic acid pirinixic acid results in increased expression of BRCA1 mRNAincreases expression 17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of BRCA1 mRNA]increases expression|increases reaction 17950772
D011794 Quercetin Quercetin results in increased expression of BRCA1 mRNAincreases expression 14715546
D012402 Rotenone Rotenone results in increased expression of BRCA1 mRNAincreases expression 18191903
C017947 sodium arsenite sodium arsenite results in increased expression of BRCA1 mRNAincreases expression 12760830
C017947 sodium arsenite sodium arsenite affects the expression of BRCA1 mRNAaffects expression 16507464
C017947 sodium arsenite [sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of BRCA1 mRNAaffects cotreatment|decreases expression 16368122
D018038 Sodium Selenite Sodium Selenite results in decreased expression of BRCA1 mRNAdecreases expression 10344722
D013467 Sulindac Sulindac results in decreased expression of BRCA1 mRNAdecreases expression 16273229
D013629 Tamoxifen BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]]affects binding|affects reaction|increases reaction 18997820
D013629 Tamoxifen BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOR2 protein]]affects binding|affects reaction|increases reaction 18997820
D013629 Tamoxifen BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to PHB2 protein]]affects binding|affects reaction|increases reaction 18997820
D013629 Tamoxifen BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [NCOR2 protein binds to CCND1 promoter]]affects binding|affects reaction|increases reaction 18997820
D013629 Tamoxifen BRCA1 protein affects the reaction [Tamoxifen results in decreased expression of CCND1 mRNA]affects reaction|decreases expression 18997820
D013629 Tamoxifen BRCA1 protein affects the reaction [Tamoxifen results in decreased expression of MYC mRNA]affects reaction|decreases expression 18997820
D013629 Tamoxifen BRCA1 protein affects the reaction [Tamoxifen results in decreased expression of PGR mRNA]affects reaction|decreases expression 18997820
D013629 Tamoxifen BRCA1 protein results in increased susceptibility to Tamoxifenincreases response to substance 18997820
D013749 Tetrachlorodibenzodioxin alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased activity of BRCA1 protein]affects binding|decreases reaction|increases activity 18259752
D013749 Tetrachlorodibenzodioxin ARNT protein affects the reaction [Tetrachlorodibenzodioxin promotes the reaction [BRCA1 protein binds to CYP1B1 promoter]]affects binding|affects reaction|increases reaction 16567799
D013749 Tetrachlorodibenzodioxin BRCA1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]increases expression|increases reaction 16567799
D013749 Tetrachlorodibenzodioxin BRCA1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]increases expression|increases reaction 16567799
D013749 Tetrachlorodibenzodioxin Estradiol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BRCA1 promoter]]affects binding|decreases reaction|increases reaction 16489025
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Estradiol] promotes the reaction [HDAC1 protein binds to BRCA1 promoter]affects binding|affects cotreatment|increases reaction 16489025
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [EP300 protein binds to BRCA1 promoter]]affects binding|decreases reaction|increases reaction 16489025
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [NCOA1 protein binds to BRCA1 promoter]]affects binding|decreases reaction|increases reaction 16489025
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]decreases reaction|increases expression 16489025
12473173
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BRCA1 promoter]affects binding|increases reaction 16489025
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BRCA1 protein]affects binding|increases reaction 18259752
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [BRCA1 protein binds to CYP1A1 promoter]affects binding|increases reaction 16567799
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [BRCA1 protein binds to CYP1B1 promoter]affects binding|increases reaction 16567799
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [HDAC1 protein binds to BRCA1 promoter]affects binding|increases reaction 16489025
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of BRCA1 mRNAincreases expression 19465110
D013749 Tetrachlorodibenzodioxin BRCA1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]increases expression|increases reaction 16567799
D013755 Tetradecanoylphorbol Acetate [sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of BRCA1 mRNAaffects cotreatment|decreases expression 16368122
D019284 Thapsigargin Thapsigargin results in increased expression of BRCA1 mRNAincreases expression 16434996
D019284 Thapsigargin Thapsigargin results in increased expression of BRCA1 proteinincreases expression 16434996
D014112 Toxaphene Toxaphene results in increased expression of BRCA1 mRNAincreases expression 12473173
D014212 Tretinoin Tretinoin results in increased expression of BRCA1 mRNAincreases expression 16054129
D014212 Tretinoin Tretinoin results in increased expression of BRCA1 mRNAincreases expression 17198874
D014415 Tunicamycin Tunicamycin results in increased expression of BRCA1 proteinincreases expression 16434996
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 11.1014745880
MESH:D000008 Abdominal Neoplasms Tamoxifen 11.1014745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.3015322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.0018287403
MESH:D058186 Acute Kidney Injury Sulindac 3.817897758
MESH:D055371 Acute Lung Injury Oxygen 7.5016759491
MESH:D055371 Acute Lung Injury pirinixic acid 7.5018653653
MESH:D000230 Adenocarcinoma arsenic trioxide 21.5611798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 21.5620127859 20464547
MESH:D000230 Adenocarcinoma daidzein 21.5611473722
MESH:D000230 Adenocarcinoma Doxorubicin 21.5617418594
MESH:D000230 Adenocarcinoma Estradiol 21.5611473722
MESH:D000230 Adenocarcinoma Fluorouracil 21.5617638652
MESH:D000230 Adenocarcinoma Genistein 21.5611473722
MESH:D000230 Adenocarcinoma Sulindac 21.5611910360
MESH:D000236 Adenoma Benzo(a)pyrene 13.146695378
MESH:D000236 Adenoma Diethylnitrosamine 13.1410737359 6695378
MESH:D000236 Adenoma Methylcholanthrene 13.1410545420 6695378
MESH:D000236 Adenoma Sulindac 13.1410223192
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.0117620307 19052882 19061943 17162532 16434500 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.0116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.0116835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.1117611924 12394442 16460482 11874996 15623613 11535846 19003578
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.3217306315 16712894
MESH:D000382 Agricultural Workers' Diseases Paraquat 7.4411874814
MESH:D000382 Agricultural Workers' Diseases Toxaphene 7.4416132792
MESH:D000419 Albuminuria Doxorubicin 4.0121441931
MESH:D000505 Alopecia Tretinoin 3.1615955085
MESH:D000544 Alzheimer Disease Nicotine 3.1416627626
MESH:D000740 Anemia Fluorouracil 7.0515504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.0511748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.7317084956
MESH:D000799 Angioedema Acetaminophen 3.2710982225
MESH:D000860 Anoxia Oxygen 4.4920872349
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.5219183758
MESH:D001169 Arthritis, Experimental Tretinoin 2.7116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1116292516
MESH:D001249 Asthma Tretinoin 2.1516456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.4115336622
MESH:D050197 Atherosclerosis Methylcholanthrene 5.9711922910
MESH:D050197 Atherosclerosis Oxygen 5.9716391483
MESH:D001284 Atrophy fulvestrant 4.3111514358
MESH:D001321 Autistic Disorder Acetaminophen 1.5018445737
MESH:D001327 Autoimmune Diseases Quercetin 3.8619761891
MESH:D001471 Barrett Esophagus Tretinoin 3.8616935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 17.7916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 17.7919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 17.7912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 17.7916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3815746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 10.2414601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 10.2414601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.0415867366
MESH:D001862 Bone Resorption bisphenol A 3.3611985600
MESH:D001913 Bowen's Disease Sulindac 4.7811207687
MESH:D001932 Brain Neoplasms Doxorubicin 3.3217150277
MESH:D001943 Breast Neoplasms marker/mechanism 20135344 18066063 15894690
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 19.6120146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 19.6117123778
MESH:D001943 Breast Neoplasms decitabine 19.6118320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 19.6117474063
MESH:D001943 Breast Neoplasms Doxorubicin 19.6116264153 17983394 16096432 15692762 15939500 17426702 18628466 16115903 18695136 15136595 17369602 15567936 19526202 11325840 18234424 15993339 16595493 16826403 16935488 15668708 18382427 15634643 15994142 16322301
MESH:D001943 Breast Neoplasms Estradiol 19.6119861407 14630087 17261762 12948864 17289903 18497071 16675129 17018787
MESH:D001943 Breast Neoplasms Etoposide 19.6116322251
MESH:D001943 Breast Neoplasms Fluorouracil 19.6116110121 16595493 18357371 18608205 19217205 15136595 16557594
MESH:D001943 Breast Neoplasms fulvestrant 19.6118984771
MESH:D001943 Breast Neoplasms Genistein 19.6116873071 16541309 17200150
MESH:D001943 Breast Neoplasms indole-3-carbinol 19.6116082211
MESH:D001943 Breast Neoplasms Methylcholanthrene 19.6117474063
MESH:D001943 Breast Neoplasms Oxygen 19.6117263869
MESH:D001943 Breast Neoplasms Paclitaxel 19.6116115903 16273361 11325840 15136595 18323546 16244791 18234424 18223236
MESH:D001943 Breast Neoplasms Quercetin 19.6118628248
MESH:D001943 Breast Neoplasms Sulindac 19.6116642371
MESH:D001943 Breast Neoplasms Tamoxifen 19.6120859285 18351453 18425577 16818667 21152245 19189210 19289846 17242785 19200415 19244106 19288272 18821012 16873071 19011961 19103187 11161223 18984771 16202921 20005174 19155303 17440819 20135344 20390343 20065188 17049068 18855134 19410462 18629630 19115204 19066611 15565566 18815881 15668708 19142967 20544844 17893378 19084267 19221464 19487384 19059307 17261762 16273361 21138602 18997820 19189212
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 19.6120435547
MESH:D001943 Breast Neoplasms Tretinoin 19.6116166294 16443354 16873071
OMIM:604370 BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 marker/mechanism
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.0216813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.8111589617
MESH:D002105 Cadmium Poisoning Quercetin 4.9716962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.2310355542 16227642 15721981 15700767 16097048 18705752 16050911 15673190 16011737 16192424 3786805 16124888
MESH:D002276 Carcinoid Tumor Doxorubicin 10.4316051944
MESH:D002276 Carcinoid Tumor Fluorouracil 10.4316051944
MESH:D002277 Carcinoma Fluorouracil 11.3717121937
MESH:D002277 Carcinoma Methylcholanthrene 11.3710545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 11.3716835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.9519066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.5816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 29.273084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 29.2715553829 14691202 15073043 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 29.2718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 29.2716830150 16935385 19822196 19919837 16540662 3084413 3581430 19052882 16807293 10672840 18506893 20727157 20007298 18210153 21159647 16569478 19519916 18393292 11831363 19208518 16288022 17055752 19394651 17761372 20935162 20214788 16779866 16878318 17173139 20432363 20524982 18056438 19171122 20512989 20084675 19383236 19539802 20514400 16698587 18978308 17428255 18971187 19335982 18691550 19701751 18494052 18785209 16681979 17138121 19107877 17978847 16328049 17162532 18788625 10737359 19418558 18665156 16502159 20101231
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 29.2716234567 17876044 18059187 16023760
MESH:D006528 Carcinoma, Hepatocellular Estradiol 29.2716924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 29.2717045692 17971768 16799960 17088986 16332177 18930000
MESH:D006528 Carcinoma, Hepatocellular Genistein 29.2716924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 29.2716313753
MESH:D006528 Carcinoma, Hepatocellular Quercetin 29.2719519916 12508355
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 29.2715276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 29.2716924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 29.271917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.4217123778
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.4017234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.3019014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 5.6916201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 5.6918695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.6212490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 18.8820419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 18.8819215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 18.886189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 18.8818986760 17066447 16280240 16757204
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 18.8818572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 18.8818922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 18.8816051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.1217572228
MESH:D006332 Cardiomegaly Quercetin 5.6719794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.6718670907 18850075 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.1417924179 16612575 15792986 15476868 17007740 16731534 17974986 17519947 16952015 16651473 16278810 17329180 15811867 17131338 16242529 17308081 17928571 16364871 16455267 16109756 17351982 17382496 18627295 16269455 15505089
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.7216243910 17334414
MESH:D002318 Cardiovascular Diseases daidzein 10.0216332659
MESH:D002318 Cardiovascular Diseases Genistein 10.0216332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 10.0216936243
MESH:D002386 Cataract Acetaminophen 6.0410977129
MESH:D002386 Cataract Tretinoin 6.0417460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 25.6220889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 25.6212371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 25.6217174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 25.6218566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 25.6216192471
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 25.622727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 25.6219524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0216129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.7319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.7316835633
MESH:D002779 Cholestasis Cyclosporine 6.3319486331
MESH:D002779 Cholestasis pirinixic acid 6.3319176532
MESH:D002822 Choriocarcinoma Tretinoin 4.5816461808
MESH:D019457 Chromosome Breakage marker/mechanism 15894690
MESH:D019457 Chromosome Breakage Sodium Selenite 4.2015894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.8712621046 15668235 16354765 15340226 8697196
MESH:D002972 Cleft Palate Tretinoin 4.879407595
MESH:D003092 Colitis Tretinoin 3.1617035595
MESH:D003110 Colonic Neoplasms decitabine 9.5917616700
MESH:D003110 Colonic Neoplasms Fluorouracil 9.5915001691 17169374 16510598 17016597 17725105 17018589 16340194 18772588 17172411 17287894
MESH:D003110 Colonic Neoplasms Genistein 9.5917182828
MESH:D003110 Colonic Neoplasms Quercetin 9.5911134977 19056647 19440933 17191121 15741050 16640504 17148506
MESH:D003110 Colonic Neoplasms Sulindac 9.5912458338 12902858
MESH:D015179 Colorectal Neoplasms arsenic trioxide 9.3020501625
MESH:D015179 Colorectal Neoplasms decitabine 9.3018981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 9.3018259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 9.3015289873 16282729 17594712 18383874 18949393 16524972 17255274 18802399 14970324 17454858 15148649 18509181 17016601 16303861 18288408 17695437 17094418 18448328 17401013 20501625 16331619 16391804
MESH:D015179 Colorectal Neoplasms Paclitaxel 9.3018802399
MESH:D015179 Colorectal Neoplasms Quercetin 9.3018095365 18852136
MESH:D015179 Colorectal Neoplasms Sulindac 9.3018059344 10666051 11197048 11076880
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5814669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 3.6512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.3010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.3015322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.309125849 9211117 9664655 16925845 14991402 9224671 8800419 9142499 17551590 10589399
MESH:D007644 Darier Disease Fluorouracil 4.2316733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.5715213294
MESH:D003711 Demyelinating Diseases Tamoxifen 3.8119031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1418249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.3016285004
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.2719496084
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 8.8216647724
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 8.8220387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 8.8216647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 8.8217107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.2519279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.2519279558
MESH:D003930 Diabetic Retinopathy Sulindac 4.6417621415 12861449
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.5619416960 19923254 11287661 17906064 18071297 12594235 19739265 16109766 14725611 11834606 16781746 14986274 10915739 2444490 11529661 11421492 12705907 15968718 11743745 16177239 11739529 19164858 11461765 16227642 12153990 16081117 12540782 15619225 18713872 19085960 14550746 17522070 10774834 12958197 10663392 19420014 19370779 17562736 16485898 12392966 16393943
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.562869522 7120509 15027814 6623471 10092053 11566570 9327722 3786805 6884620 15998439 4309450 16227642 10915739 15968718 17522070 3732212 7179309 19336974 21278145 16177239 19085960 7440962
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.5619107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 12.5617416283
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.5615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.5620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5219426721
MESH:D004362 Drug Toxicity Doxorubicin 6.6818602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.6811462148
MESH:D004417 Dyspnea Oxygen 4.2620016425
MESH:D020821 Dystonic Disorders Nicotine 5.3617881519
MESH:D004487 Edema pirinixic acid 8.5812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.5811000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 8.589599246 8273558 8113982 16716910 11698051 15177302 7812673
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.0315322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.0318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.0119031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.5419294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.0216402032
MESH:D016889 Endometrial Neoplasms daidzein 24.1011473722
MESH:D016889 Endometrial Neoplasms Doxorubicin 24.1017359293
MESH:D016889 Endometrial Neoplasms Estradiol 24.1011473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 24.1011473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 24.1017893378 20544844 16202921 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 24.1016569247
MESH:D004715 Endometriosis Sulindac 7.5515652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.5510568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.5818037988
MESH:D007172 Erectile Dysfunction daidzein 4.4814972507
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5416302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.0620426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 15.0612903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 15.0616530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 15.0616337965 16785472 15173087 16481741 17638652
MESH:D004938 Esophageal Neoplasms Paclitaxel 15.0616481741
MESH:D004938 Esophageal Neoplasms Sulindac 15.0612235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.4011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.409664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 24.1715073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 24.1761145 16045604 19224547 17595544 12631006 15959796 12795759 16239168
MESH:D005234 Fatty Liver Cyclosporine 24.1719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 24.1721071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 24.1720131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 24.1719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.8716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9111858732
MESH:D018221 Fibromatosis, Abdominal Sulindac 11.0714745880
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 11.0714745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 16.2819069698
MESH:D018222 Fibromatosis, Aggressive Sulindac 16.2819069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 16.2819069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.3714633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 21.9118705752
MESH:D005355 Fibrosis Cyclosporine 21.9112639820 12168785
MESH:D005355 Fibrosis Quercetin 21.9119474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 21.9120067830
MESH:D005355 Fibrosis Tretinoin 21.9117994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.7216904648
MESH:D005739 Gas Poisoning Oxygen 4.6420016425
MESH:D005756 Gastritis Acetaminophen 3.1016983495
MESH:D005764 Gastroesophageal Reflux Sulindac 4.4711910360
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.1116452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.658708960
MESH:D005909 Glioblastoma Doxorubicin 13.8017150277
MESH:D005909 Glioblastoma Genistein 13.8016598420
MESH:D005909 Glioblastoma Quercetin 13.8019804834
MESH:D005909 Glioblastoma Tretinoin 13.8017312396
MESH:D005910 Glioma Fluorouracil 5.3316145905
MESH:D005910 Glioma Quercetin 5.3317643826
MESH:D005911 Gliosis Paraquat 4.5911124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0210696789
MESH:D006258 Head and Neck Neoplasms decitabine 15.2019215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 15.2015692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 15.2015162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 15.2016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.5816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.2020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.2011294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 9.209664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 3.0818006777 12587719 16495754 16144979 17875725 16244371 16330681 17888722 16244372 16707910 18674790 16879835 14766674
MESH:D006333 Heart Failure Doxorubicin 5.8217481944
MESH:D006333 Heart Failure pirinixic acid 5.8220558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.4015692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8515720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8311000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.0619900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 6.4419772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.4416120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.4515709030
MESH:D006561 Herpes Simplex Etoposide 4.0010809021
MESH:D006689 Hodgkin Disease Doxorubicin 13.7117606976 18501091 15147373
MESH:D006689 Hodgkin Disease Etoposide 13.7118180244 17606976 15147373 16200630 16135485
MESH:D006689 Hodgkin Disease Nitrogen Mustard Compounds 13.7116794504
MESH:D006689 Hodgkin Disease sodium arsenite 13.7112676792
MESH:D019584 Hot Flashes Estradiol 3.1817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.4715340226 16959395 16354765 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 6.1316870215
MESH:D006930 Hyperalgesia Tretinoin 6.1316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.9716899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0116778211
MESH:D006943 Hyperglycemia pirinixic acid 7.6020558911
MESH:D006943 Hyperglycemia Quercetin 7.6011834736 18262572
MESH:D006973 Hypertension Cyclosporine 10.3510903974
MESH:D006973 Hypertension daidzein 10.3517169123
MESH:D006973 Hypertension Quercetin 10.3518356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 10.3518850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.5415338365
MESH:D007248 Infertility, Male 2,2',3',4,4',5-hexachlorobiphenyl 17.0012948891
MESH:D007248 Infertility, Male decitabine 17.0017581917
MESH:D007248 Infertility, Male fulvestrant 17.0011514358
MESH:D007248 Infertility, Male Paraquat 17.004850670
MESH:D007248 Infertility, Male sodium arsenite 17.0012646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 15.7818785209
MESH:D007249 Inflammation Flavonoids 15.7817296493
MESH:D007249 Inflammation Sulindac 15.783291741
MESH:D007249 Inflammation Tamoxifen 15.7819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.7812200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 15.788273558 7812673 15177302 7562506 11698051
MESH:D007251 Influenza, Human Quercetin 3.9316624496
MESH:D007333 Insulin Resistance bisphenol A 14.4716393666
MESH:D007333 Insulin Resistance Estradiol 14.4716393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 14.4716306350
MESH:D007333 Insulin Resistance Sodium Selenite 14.4714714311
MESH:D007410 Intestinal Diseases Tretinoin 3.2217994277
MESH:D007414 Intestinal Neoplasms Sulindac 4.1410213222 12584176 12663524 12351151 10223192 12628509
MESH:D007417 Intestinal Polyps Sulindac 4.4612394442 11245490
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.2416580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.2417551590 15992940
MESH:D007627 Keloid Quercetin 4.4017086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8615604871
MESH:D007674 Kidney Diseases Acetaminophen 19.3212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 19.328314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 19.3215369732 15699352 16775033
MESH:D007674 Kidney Diseases Estradiol 19.3215618244
MESH:D007674 Kidney Diseases Quercetin 19.3216962696
MESH:D007674 Kidney Diseases sodium arsenite 19.3220008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.4416707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 8.4416518626
MESH:D007680 Kidney Neoplasms Cyclosporine 13.9612371664
MESH:D007680 Kidney Neoplasms Estradiol 13.9615610895
MESH:D007680 Kidney Neoplasms Fluorouracil 13.9616985049
MESH:D007680 Kidney Neoplasms Tamoxifen 13.9618625569
MESH:D007938 Leukemia arsenic trioxide 16.3915070760
MESH:D007938 Leukemia decitabine 16.3919235587 18980019
MESH:D007938 Leukemia Genistein 16.3918980019 17468513
MESH:D007938 Leukemia Quercetin 16.3917468513
MESH:D007938 Leukemia Tretinoin 16.3917143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.5816085563
MESH:D007945 Leukemia, Lymphoid Toxaphene 5.7216132792
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.2917077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.7416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.0014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 13.0719077051
MESH:D007951 Leukemia, Myeloid decitabine 13.0718454857 17236224 19117987
MESH:D007951 Leukemia, Myeloid Tretinoin 13.0716482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.3416467208 17050201 19850784 20471514 16968895
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.3419010910 18460780 18206229 17679729 19387464 18704418
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.3419850784 16294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.8818055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 6.3417649720 16891316 9834237 19075265 16112521 12679006 19035177 11161223 17217047 17869043 16823087 15213294 17712046 19225113 17107899 16966277 12712474 15748426 11468182 16331271 12018890 15336539 19642359 16330433 15622746
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.3416766008 16140955 17712046 17506722 16788101 16935935 19642359 12679006 17368321 17217047 17107899 17301526 17339181 19075265 9834237 17294898 19035177 17649720 16331271 16823087 15748426 19225113 17361223 19029980 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.8116882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.899224671
MESH:D008064 Lipidoses Tamoxifen 2.7417567588 15342952
MESH:D008080 Liposarcoma Paclitaxel 4.3017353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.4911903743 16221502 16943688 17157831 17174718 17334410 11408273 21278145 16239168
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.4920032147 19638242 18522880 18665156 18407596
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 3.8512468960
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 13.7517922224 18395914 18317297 18205269 14724832 18279442 14716833 17525996 16116963 17557913 15996030 15818738 18166357 18412020 14748882 18429990 17565644 12546737 15123356 12445421 17900296 12667390 16097048 18418968 15959796 12898905 18705752 13678700 11481614 15876570 17766677 18156304 18481824 12632512 16638106 16027843 17481882 17631135 17976157 17721639 12649538 10355542 17869086 16192424 15362042 17640975 18472094 15338365 20821823 15673190 12741479 18376398 16136751 16015684 12609069 12445418 18263696 18251166 15057751 15730626 18472332 18054572 16033810 17805973 12586293 16248980 18277467 15931870 17944888 12632514 15052691 17761835 18395095 15925388 16011737 18006644 18420326 18210741 18339082 14620537 15650968 12389079 12958196 17708605 15893842 17698563 18187930 14512876 17714472 15370692 12666154 17823541 14716496
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 13.7516595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 13.7514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 13.7517823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 13.7515474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 13.7512741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 13.7518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 13.7512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 13.7516248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 7.8812969438 12587719 19784758 11587558 16611625 16610002 19460945 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 7.8815720792 16246199 15830285 16964402 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 7.8817034775
MESH:D008107 Liver Diseases Sulindac 7.8814986274 16867024
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 7.7716871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 7.7714706259 16899240
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 32.7516835634 18644402
MESH:D008113 Liver Neoplasms arsenic trioxide 32.7514682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 32.7521137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 32.7519294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 32.7512112319 18978307 19499222 19090486 20137499 2422723 19642983 21071580 19833225 2862719 16942905 15885732 21047994 20434301 19256749 20118626 19427195 19850985 21167192 20501860 12771043 19551842 19073162 19294768 19690152 18644402 19255062 18754104 19996281 20101389 20492335 19638242 21278145 18648771 9163691 18977376 20583210 15175105 19426721 20452335 10737359 19254457 20405173 19812893
MESH:D008113 Liver Neoplasms Fluorouracil 32.7515113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 32.7516377806 20007298 15890375
MESH:D008113 Liver Neoplasms Quercetin 32.7518980244
MESH:D008113 Liver Neoplasms sodium arsenite 32.7515276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 32.7516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 32.7516984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 22.5520377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 22.5515583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 22.5518775883 3124819 18079962 19126423 18544905 19519916 16267830 17942915 17854601 18308698 21159647 18093689 9362446 18164116 19004024 18253720 16842330 18282651 2563599 19539802 19009564 17174075
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 22.5517085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 22.551399818 598648
MESH:D008114 Liver Neoplasms, Experimental Quercetin 22.5519519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 22.5512151625
MESH:D008133 Long QT Syndrome arsenic trioxide 2.9115213294
MESH:D008171 Lung Diseases sodium arsenite 2.7819095001
MESH:D055370 Lung Injury Asbestos, Crocidolite 7.6717365036
MESH:D055370 Lung Injury Oxygen 7.6718339021
MESH:D008175 Lung Neoplasms arsenic trioxide 20.7111798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 20.7120869020 17053015 20064080 18520028 20135361 20464547 6695378 18816296 18569708
MESH:D008175 Lung Neoplasms Diethylnitrosamine 20.7120512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Doxorubicin 20.7117418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 20.7115246190
MESH:D008175 Lung Neoplasms Methylcholanthrene 20.7120970405 1399818 16271038 7750092 16337739 15390079 17909032 10545420 21163286 11893704 20512841 9230183 6695378
MESH:D008175 Lung Neoplasms Quercetin 20.7116280456
MESH:D008175 Lung Neoplasms sodium arsenite 20.7115276417 16712894 19931552 17306315 17077188
MESH:D008175 Lung Neoplasms Sulindac 20.7119359593 15713900
MESH:D008175 Lung Neoplasms Tamoxifen 20.7118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 20.7111884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 20.7111807781
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.2315086387
MESH:D008223 Lymphoma decitabine 10.2819470736
MESH:D008223 Lymphoma Doxorubicin 10.2816098063
MESH:D008223 Lymphoma Etoposide 10.2812556972 12854902
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.5414737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 7.4117654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 7.4114749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.0115621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.2019428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 14.7915458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 14.7917203775 11408345 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 14.7914578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 14.7919196723 19196722 16827153 11731420 14580682
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 14.798985016
MESH:D020149 Manganese Poisoning Estradiol 10.7319453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.7319453300
MESH:D008527 Medulloblastoma Tretinoin 2.5317453147
MESH:D008545 Melanoma decitabine 13.3316505122 17785578
MESH:D008545 Melanoma Doxorubicin 13.3316827129
MESH:D008545 Melanoma Paclitaxel 13.3312025231 12040289 16342250
MESH:D008545 Melanoma sodium arsenite 13.3319082730 16487513
MESH:D008545 Melanoma Sulindac 13.3316642371
MESH:D008545 Melanoma Tamoxifen 13.3312393984 19393235
MESH:D008545 Melanoma Tretinoin 13.3316752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.6215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0219513568
MESH:D008591 Meningomyelocele Tretinoin 3.8716940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 5.5716166281 16966607 18303189
MESH:D008654 Mesothelioma Doxorubicin 5.5717638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2116801185
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.3217671175
MESH:D028361 Mitochondrial Diseases Doxorubicin 3.9915792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.0616381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.0616757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.2217415656
MESH:D009101 Multiple Myeloma arsenic trioxide 9.8015949261 11468182 19549372 19417148 14977855
MESH:D009101 Multiple Myeloma decitabine 9.8018172295
MESH:D009101 Multiple Myeloma Paclitaxel 9.8014749477
MESH:D009135 Muscular Diseases pirinixic acid 2.9616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.0918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 10.3216105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 10.3219010910 19157545 18608210 16882708
MESH:D009190 Myelodysplastic Syndromes Tretinoin 10.3217596541
MESH:D009203 Myocardial Infarction Doxorubicin 11.3419429709 15857846
MESH:D009203 Myocardial Infarction Genistein 11.3417141266
MESH:D009203 Myocardial Infarction pirinixic acid 11.3419151258
MESH:D009203 Myocardial Infarction Quercetin 11.3419595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.5712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 16.6716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 16.6717141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 16.6716411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 16.6719207477
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.4216624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 11.479029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 11.4718259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 11.4715867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 11.4719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3019410462
MESH:D009369 Neoplasms therapeutic 15520196
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 30.718820588
MESH:D009369 Neoplasms Benzo(a)pyrene 30.7111141357
MESH:D009369 Neoplasms decitabine 30.7119116145 17925555 19470736
MESH:D009369 Neoplasms Fluorouracil 30.7118600527 18239605 16928823
MESH:D009369 Neoplasms Nicotine 30.7116365874
MESH:D009369 Neoplasms pirinixic acid 30.7117405874
MESH:D009369 Neoplasms Quercetin 30.7115185748
MESH:D009369 Neoplasms sodium arsenite 30.7111559025
MESH:D009369 Neoplasms Toxaphene 30.718820588
MESH:D009369 Neoplasms Tretinoin 30.7116594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.1220056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.4319196722 19200415 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 8.4917289903
MESH:D009389 Neovascularization, Pathologic Nicotine 8.4916365874
MESH:D009401 Nephrosis Doxorubicin 4.2216636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 7.7019348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 7.7015640375 16889571
MESH:D009410 Nerve Degeneration Paraquat 7.1816893418
MESH:D009410 Nerve Degeneration Rotenone 7.1817356569 18619942 15790535
MESH:D009421 Nervous System Malformations bisphenol A 25.0616427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 25.0616427766 11399458
MESH:D009421 Nervous System Malformations Genistein 25.0616427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 25.0614600291
MESH:D009421 Nervous System Malformations Tretinoin 25.069125849
MESH:D009436 Neural Tube Defects arsenic trioxide 9.9110525206
MESH:D009436 Neural Tube Defects sodium arsenite 9.9112854658
MESH:D009436 Neural Tube Defects Tretinoin 9.919142499
MESH:D009447 Neuroblastoma Doxorubicin 2.9515555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 11.4318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 11.4320387270
MESH:D019636 Neurodegenerative Diseases Sulindac 11.4316850258 17266991
MESH:D020078 Neurogenic Inflammation Quercetin 3.8417929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5420387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.0416436463
MESH:D009765 Obesity pirinixic acid 1.6520558911
MESH:D010014 Osteolysis Paclitaxel 4.4115867366
MESH:D010024 Osteoporosis Genistein 2.8919401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 8.4016169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 8.4019495926
MESH:D012516 Osteosarcoma Doxorubicin 3.6615930896
MESH:D010049 Ovarian Diseases bisphenol A 4.4211985600
MESH:D010051 Ovarian Neoplasms marker/mechanism 17688236 15894690
MESH:D010051 Ovarian Neoplasms arsenic trioxide 23.3412452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms decitabine 23.3419331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 23.3419401270
MESH:D010051 Ovarian Neoplasms Genistein 23.3419005980
MESH:D010051 Ovarian Neoplasms Paclitaxel 23.3411161223
MESH:D010051 Ovarian Neoplasms Quercetin 23.3419005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 23.3415276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 23.3416936753
MESH:D010146 Pain Acetaminophen 8.6616870215
MESH:D010146 Pain Sulindac 8.663291741
MESH:D010146 Pain Tretinoin 8.6616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 29.2615580305
MESH:D010190 Pancreatic Neoplasms decitabine 29.2619294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 29.2616540662
MESH:D010190 Pancreatic Neoplasms Etoposide 29.2619003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 29.2615113037 16929163 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Quercetin 29.2616965848
MESH:D010190 Pancreatic Neoplasms Sulindac 29.2616820089 11504793
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 29.2615976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 29.2615976015
MESH:D010212 Papilloma Hydrogen Peroxide 7.7912065085
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 7.7912065085 8330346 18922899 18404319
MESH:D010235 Paraganglioma arsenic trioxide 3.6419927285
MESH:D010300 Parkinson Disease Paraquat 4.7711445065 11181820 15451049 15824117 16140633 12911755 16510128 11124998
MESH:D010300 Parkinson Disease Rotenone 4.7716140633 16412576 11445065 18191903 19114014 19232380 11535288 18619942 15451049
MESH:D010302 Parkinson Disease, Secondary Paraquat 3.8816190885
MESH:D020734 Parkinsonian Disorders Rotenone 3.5915574749 15795934 18197244 15927086
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6712520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.5817983394
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.3410923243
MESH:D010997 Pleural Neoplasms Doxorubicin 4.5817638057
MESH:D011014 Pneumonia Paraquat 3.8912504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0218163543
MESH:D011230 Precancerous Conditions Cyclosporine 12.5512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 12.552563599
MESH:D011230 Precancerous Conditions Quercetin 12.5519056647
MESH:D011248 Pregnancy Complications Toxaphene 5.312087686
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 7.6410548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.6411118676 11896295 11399792 11222880
MESH:D055728 Primary Myelofibrosis decitabine 4.1717616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.8620887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.8620887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17585057
MESH:D011471 Prostatic Neoplasms arsenic trioxide 5.3319131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 5.3317292933
MESH:D011471 Prostatic Neoplasms bisphenol A 5.3316740699
MESH:D011471 Prostatic Neoplasms Doxorubicin 5.3315897917 18437689 15749863 16888761 16868541 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 5.3316740699
MESH:D011471 Prostatic Neoplasms Etoposide 5.3317172428
MESH:D011471 Prostatic Neoplasms Fluorouracil 5.3318626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 5.3315256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Paclitaxel 5.3317136230 17172428 16356831 16729912
MESH:D011471 Prostatic Neoplasms Quercetin 5.3317292933 14715546
MESH:D011471 Prostatic Neoplasms sodium arsenite 5.3316039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 5.3318760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 5.3315067354
MESH:D011507 Proteinuria Tretinoin 3.0916636307
MESH:D011565 Psoriasis Cyclosporine 2.0016882103
MESH:D011625 Pterygium Tretinoin 4.2316723453
MESH:D011629 Puberty, Precocious bisphenol A 4.2210548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 5.0717975199 15814490 17322281 17365031
MESH:D011658 Pulmonary Fibrosis Paraquat 5.0717997886 16324872
MESH:D012004 Rectal Neoplasms Fluorouracil 3.5318722050 15538739 18286688 16160472
MESH:D051437 Renal Insufficiency Doxorubicin 3.6717922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.0919058328
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 7.7217627322 18339021
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 7.7211700416
MESH:D012135 Respiratory Sounds Paraquat 3.5111874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3018990726
MESH:D012162 Retinal Degeneration Paraquat 3.4416458197
MESH:D012208 Rhabdomyosarcoma decitabine 9.2119155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.2116283617 16116481
MESH:D012509 Sarcoma Doxorubicin 3.5017203757 17710206 15675481 18313854 16767912 15625365
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 14.2216646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 14.2214601052 16326096
MESH:D012512 Sarcoma, Ewing's Etoposide 14.2214601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.2217846226
MESH:D012554 Schistosomiasis japonica Quercetin 4.9716862918
MESH:D012640 Seizures Nicotine 3.4217873105
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 22.6419755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 22.6415692506
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 22.6412065085
MESH:D012878 Skin Neoplasms sodium arsenite 22.6419524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 22.6416192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 22.6411807781 18404319 12065085 8330346 8985016
MESH:D012878 Skin Neoplasms Tretinoin 22.6416467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.0115625365 17203757 16767912
MESH:D013088 Spermatocele Tamoxifen 3.7216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.4719457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.3512854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 9.1417007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 9.142093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 9.1419037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 9.1418456281
MESH:D013274 Stomach Neoplasms Fluorouracil 9.1419084572 18396642 17172411 17522103 15786421 19015929 16424979 18567086 17498489 16951190
MESH:D013274 Stomach Neoplasms Paclitaxel 9.1418506536 18396642
MESH:D013274 Stomach Neoplasms Tretinoin 9.1417261132
MESH:D019966 Substance-Related Disorders bisphenol A 3.4216684133 16045194
MESH:D013398 Sudden Infant Death Oxygen 4.9812563064
MESH:D024801 Tauopathies Camptothecin 9.9616930453
MESH:D024801 Tauopathies Paclitaxel 9.9616930453
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3312697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 17.8519014326
MESH:D013964 Thyroid Neoplasms decitabine 17.8517967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 17.857505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 17.8517909728 16010429
MESH:D013964 Thyroid Neoplasms Tretinoin 17.8516026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.1119048282
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.3116720336 11259349 16785264
MESH:D014029 Tobacco Use Disorder Nicotine 4.9018041664 17979512 15735609 18305452
MESH:D014062 Tongue Neoplasms Fluorouracil 8.1916280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.1916051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.4015213294
MESH:D014376 Tuberculosis Tretinoin 2.8616040207
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 24.0011144890
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 24.0012845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 24.0017053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 24.0017616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 24.0017653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 24.0016720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 24.0011723127 16712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 24.0017572228 8653321 16712894
MESH:D014581 Urticaria Acetaminophen 2.4610982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 18.6416803524
MESH:D002583 Uterine Cervical Neoplasms indole-3-carbinol 18.6416082211
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 18.6411813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 18.6416129372
MESH:D014591 Uterine Diseases bisphenol A 4.4314652134
MESH:D014594 Uterine Neoplasms Sulindac 4.0718645019
MESH:D014604 Uveal Neoplasms decitabine 10.9117785578
MESH:D014604 Uveal Neoplasms Tretinoin 10.9116752155
MESH:D014605 Uveitis Cyclosporine 3.411336536
MESH:D014652 Vascular Diseases sodium arsenite 3.8617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0212125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.6717334414 16364871 17678736 17638931
MESH:D014820 Vitiligo Tretinoin 3.5216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6715886252
MESH:D009396 Wilms Tumor Tretinoin 3.4916287080
MESH:D014985 Xerophthalmia Cyclosporine 3.8617120751
Pathway ID Pathway Name
REACT:216 DNA Repair
REACT:27271 Meiotic Recombination
REACT:27235 Meiotic Recombination (mouse)
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25411
    • No data
    Releated disease ID Related disease Name
    PA152132901Hereditary Breast/Ovarian Cancer Syndrome
    PA443560Breast Neoplasms
    PA445204Ovarian Neoplasms
    PA443685Uterine Cervical Neoplasms
    PA445218Pancreatic Neoplasms
    PA445425Prostatic Neoplasms
    PA446004Uterine Neoplasms
    PA446745Breast Neoplasms, Male
    PA443756Colonic Neoplasms
    PA444144Fallopian Tube Neoplasms
    PA445742Stomach Neoplasms
    PA445062Neoplasms
    Releated drug ID Related drug Name
    PA448710caffeine
    PA450500mifepristone
    PA451581tamoxifen
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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