AutismKB 2.0

Annotation Detail for SREBF2


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Basic Information Top
Gene Symbol:SREBF2 ( SREBP2,bHLHd2 )
Gene Full Name: sterol regulatory element binding transcription factor 2
Band: 22q13.2
Quick LinksEntrez ID:6721; OMIM: 600481; Uniprot ID:SRBP2_HUMAN; ENSEMBL ID: ENSG00000198911; HGNC ID: 11290
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
hypercholesterolemia
cholesterol
cholesterol, LDL
hyperlipidemia
METABOLIC
Hypertriglyceridemia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014024 2,4,5,2',4',5'-hexachlorobiphenyl 2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of SREBF2 mRNAdecreases expression 20005886
C007997 25-hydroxycholesterol 25-hydroxycholesterol results in decreased activity of SREBF2 proteindecreases activity 17052361
C007997 25-hydroxycholesterol Clozapine inhibits the reaction [25-hydroxycholesterol results in decreased activity of SREBF2 protein]decreases activity|decreases reaction 17052361
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SREBF2 mRNAaffects expression 21346803
C065250 4-hydroxy-equilenin 4-hydroxy-equilenin results in decreased expression of SREBF2 mRNAdecreases expression 15135645
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of SREBF2 mRNAincreases expression 16541421
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of SREBF2 mRNAincreases expression 16990341
D000639 Amitriptyline Amitriptyline results in increased cleavage of and results in increased activity of SREBF2 proteinincreases activity|increases cleavage 16324787
C065179 atorvastatin atorvastatin results in increased expression of SREBF2 mRNAincreases expression 12065722
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SREBF2 mRNAdecreases expression 20106945
D001629 Bezafibrate Bezafibrate results in increased expression of SREBF2 mRNAincreases expression 14685799
D002104 Cadmium Cadmium results in increased expression of SREBF2 mRNAincreases expression 17066326
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of SREBF2 mRNAincreases expression 17066326
D002746 Chlorpromazine Chlorpromazine results in increased cleavage of and results in increased activity of SREBF2 proteinincreases activity|increases cleavage 17052361
D002791 Cholesterol, Dietary [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SREBF2 mRNAaffects cotreatment|decreases expression 19509184
D015283 Citalopram Citalopram results in increased cleavage of and results in increased activity of SREBF2 proteinincreases activity|increases cleavage 16324787
D002997 Clomipramine Clomipramine results in increased cleavage of and results in increased activity of SREBF2 proteinincreases activity|increases cleavage 16324787
D003024 Clozapine Clozapine inhibits the reaction [25-hydroxycholesterol results in decreased activity of SREBF2 protein]decreases activity|decreases reaction 17052361
D003024 Clozapine Clozapine results in increased cleavage of and results in increased activity of SREBF2 proteinincreases activity|increases cleavage 17052361
D003024 Clozapine Clozapine results in increased expression of SREBF2 mRNAincreases expression 17052361
C012258 compactin compactin results in increased expression of SREBF2 proteinincreases expression 17526932
D004041 Dietary Fats [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SREBF2 mRNAaffects cotreatment|decreases expression 19509184
C108606 ezetimibe ezetimibe results in decreased expression of SREBF2 mRNAdecreases expression 16177187
D011345 Fenofibrate Fenofibrate results in increased expression of SREBF2 mRNAincreases expression 14685799
D005632 Fructose [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SREBF2 mRNAaffects cotreatment|decreases expression 19509184
D015248 Gemfibrozil Gemfibrozil results in increased expression of SREBF2 mRNAincreases expression 14685799
C442817 GW 707 Oncostatin M promotes the reaction [GW 707 affects the localization of SREBF2 protein]affects localization|increases reaction 12524230
D006220 Haloperidol Haloperidol results in increased cleavage of and results in increased activity of SREBF2 proteinincreases activity|increases cleavage 17052361
D006861 Hydrogen Peroxide [isoquercitrin co-treated with Hydrogen Peroxide] results in increased cleavage of and results in increased activity of SREBF2 proteinaffects cotreatment|increases activity|increases cleavage 18032389
D006861 Hydrogen Peroxide [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SREBF2 mRNAaffects cotreatment|increases expression 18032389
D006861 Hydrogen Peroxide SREBF2 protein affects the susceptibility to [isoquercitrin co-treated with Hydrogen Peroxide]affects cotreatment|affects response to substance 18032389
D007099 Imipramine Imipramine results in increased cleavage of and results in increased activity of SREBF2 proteinincreases activity|increases cleavage 16324787
C016527 isoquercitrin [isoquercitrin co-treated with Hydrogen Peroxide] results in increased cleavage of and results in increased activity of SREBF2 proteinaffects cotreatment|increases activity|increases cleavage 18032389
C016527 isoquercitrin [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SREBF2 mRNAaffects cotreatment|increases expression 18032389
C016527 isoquercitrin SREBF2 protein affects the susceptibility to [isoquercitrin co-treated with Hydrogen Peroxide]affects cotreatment|affects response to substance 18032389
D008798 Mevalonic Acid Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]]affects binding|decreases reaction|increases reaction 14500290
C076029 olanzapine olanzapine results in increased cleavage of and results in increased activity of SREBF2 proteinincreases activity|increases cleavage 17052361
D053683 Oncostatin M Oncostatin M promotes the reaction [GW 707 affects the localization of SREBF2 protein]affects localization|increases reaction 12524230
D012643 Selenium Selenium results in increased expression of SREBF2 mRNAincreases expression 19244175
D019821 Simvastatin Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]]affects binding|decreases reaction|increases reaction 14500290
D019821 Simvastatin Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]affects binding|increases reaction 14500290
C025462 sulindac sulfide sulindac sulfide results in decreased expression of SREBF2 mRNAdecreases expression 16184548
D013739 Testosterone Testosterone results in increased expression of SREBF2 mRNAincreases expression 16579987
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SREBF2 mRNAdecreases expression 20005886
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5014514962 15322242 11752688
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9020464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.456695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.0216835633
MESH:D000380 Agranulocytosis Clozapine 4.7112649775 14617031 16160616
MESH:D000544 Alzheimer Disease Cholesterol, Dietary 4.7920157255
MESH:D000544 Alzheimer Disease sulindac sulfide 4.7918759972
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6411748828
MESH:D000987 Antisocial Personality Disorder Testosterone 5.497506515
MESH:D001008 Anxiety Disorders Citalopram 5.1418083778
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7319183758
MESH:D001161 Arteriosclerosis Cholesterol, Dietary 9.5415552841
MESH:D001161 Arteriosclerosis Dietary Fats 9.5415238619
MESH:D050197 Atherosclerosis Cadmium 3.4315687053
MESH:D001321 Autistic Disorder Citalopram 2.6518775368 19232924
MESH:D001321 Autistic Disorder Haloperidol 2.6519368416 18080171
MESH:D001321 Autistic Disorder olanzapine 2.6518685284 17069543
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.7312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5415746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9217474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 1.9220435547
MESH:D001943 Breast Neoplasms Testosterone 1.9217261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5216835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 1.7216705839
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.3212391285
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 1.9520419170
MESH:D006332 Cardiomegaly atorvastatin 6.5518360054
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.5516120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.2716936243
MESH:D002375 Catalepsy Haloperidol 4.561977408 15215559
MESH:D002386 Cataract Simvastatin 4.4212518039
MESH:D002389 Catatonia olanzapine 5.8916772815 18071103
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.206135515
MESH:D002471 Cell Transformation, Neoplastic Cadmium 6.2017332340
MESH:D002659 Child Development Disorders, Pervasive Citalopram 6.4915782081
MESH:D002659 Child Development Disorders, Pervasive Testosterone 6.4920678186
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8716835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9515668235 15340226 16354765 12621046 8697196
MESH:D003072 Cognition Disorders Clozapine 4.6217123785
MESH:D003092 Colitis Selenium 3.4417936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7617141729 14669216
MESH:D003324 Coronary Artery Disease atorvastatin 4.0116368305
MESH:D003327 Coronary Disease Fructose 4.2518504504
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2415322242 10048152 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.6718551238
MESH:D003550 Cystic Fibrosis Simvastatin 4.6419747007
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.5220210726
MESH:D003704 Dementia Haloperidol 4.2611575062
MESH:D003866 Depressive Disorder Amitriptyline 16.5915014590 18083778
MESH:D003866 Depressive Disorder Citalopram 16.5915014590
MESH:D003866 Depressive Disorder Clomipramine 16.5918083778
MESH:D003866 Depressive Disorder Imipramine 16.5920305041
MESH:D002658 Developmental Disabilities olanzapine 4.4517069543
MESH:D003921 Diabetes Mellitus, Experimental Fructose 4.2118603373
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.7616402076
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 6.7618603373
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7617107852
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.1915331141
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.1018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Chlorpromazine 8.1011461765
MESH:D056486 Drug-Induced Liver Injury Selenium 8.1015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.1020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5011462148
MESH:D050171 Dyslipidemias Clozapine 18.7016402076
MESH:D050171 Dyslipidemias Dietary Fats 18.7018367378
MESH:D050171 Dyslipidemias Fenofibrate 18.7016707586
MESH:D050171 Dyslipidemias Gemfibrozil 18.7016707586
MESH:D004487 Edema Amitriptyline 14.1212798668
MESH:D004487 Edema Clomipramine 14.1212798668
MESH:D004487 Edema Imipramine 14.1212798668
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.1211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5418230668 15322242 16714409
MESH:D016889 Endometrial Neoplasms Fenofibrate 3.8616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.729294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7511564622
MESH:D005234 Fatty Liver Dietary Fats 7.2519551842 17967931 19004024 18296743
MESH:D005234 Fatty Liver Fructose 7.2518641190 18395287 19196556
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1111858732
MESH:D005355 Fibrosis Dietary Fats 12.9218296743
MESH:D005355 Fibrosis Fructose 12.9218504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.9220067830
MESH:D005391 Firesetting Behavior Testosterone 5.497506515
MESH:D005909 Glioblastoma Testosterone 3.8217162496
MESH:D018149 Glucose Intolerance Fructose 5.0019165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2310696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.8120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.8111294989 10048152
MESH:D006333 Heart Failure atorvastatin 6.9416360360
MESH:D006333 Heart Failure Selenium 6.9417162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5512621046 15340226 16120746
MESH:D006561 Herpes Simplex Chlorpromazine 4.941682908
MESH:D006628 Hirsutism Testosterone 5.2917019078
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.688697196 18606429 16959395 15340226 16354765
MESH:D017588 Hyperandrogenism Testosterone 4.9517019078
MESH:D006937 Hypercholesterolemia atorvastatin 19.4411583720
MESH:D006937 Hypercholesterolemia Cholesterol, Dietary 19.4410876104
MESH:D006937 Hypercholesterolemia Dietary Fats 19.4421332399
MESH:D006937 Hypercholesterolemia ezetimibe 19.4417076980 15374793
MESH:D006946 Hyperinsulinism Fructose 4.6118563319 18360027 19008412 14757778 15752949
MESH:D006948 Hyperkinesis Clozapine 4.5616046005
MESH:D006949 Hyperlipidemias Dietary Fats 8.4721332399
MESH:D006949 Hyperlipidemias Fructose 8.4715752949
MESH:D006938 Hyperlipoproteinemia Type II atorvastatin 9.5316238680
MESH:D006938 Hyperlipoproteinemia Type II Simvastatin 9.5316238680
MESH:D006963 Hyperphagia olanzapine 5.8717933447
MESH:D006973 Hypertension atorvastatin 8.1017042910
MESH:D006973 Hypertension Fructose 8.1014568997 16843071 19008412 14573337 14633139
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.1018850075 18670907
MESH:D015228 Hypertriglyceridemia Fructose 4.7719342510 19799862
MESH:D007006 Hypogonadism Testosterone 4.3412002444
MESH:D007018 Hypopituitarism Testosterone 5.8417426086
MESH:D007174 Impulse Control Disorders Testosterone 5.497506515
MESH:D007249 Inflammation Amitriptyline 17.5412798668
MESH:D007249 Inflammation atorvastatin 17.5416908763
MESH:D007249 Inflammation Clomipramine 17.5412798668
MESH:D007249 Inflammation Dietary Fats 17.5420412841
MESH:D007249 Inflammation Imipramine 17.5412798668
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 17.5412878042 12200463
MESH:D007251 Influenza, Human Selenium 3.8416624496
MESH:D007333 Insulin Resistance Dietary Fats 7.0711836018 18457598
MESH:D007333 Insulin Resistance Fructose 7.0719586609 18981581 14573337 14757778 18057795 19342510 18563319 19799862 14633139 19008412 17133782
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0216580747
MESH:D007674 Kidney Diseases Cadmium 6.0016322080 16226777 16962696
MESH:D007674 Kidney Diseases Cadmium Chloride 6.0016962696
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 8.9816518626
MESH:D007676 Kidney Failure, Chronic Selenium 8.9816518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.7016705839
MESH:D008064 Lipidoses Amitriptyline 27.3515342952 17567588
MESH:D008064 Lipidoses Chlorpromazine 27.3515342952 17567588
MESH:D008064 Lipidoses Citalopram 27.3517567588
MESH:D008064 Lipidoses Clomipramine 27.3515342952 17567588
MESH:D008064 Lipidoses Clozapine 27.3517567588
MESH:D008064 Lipidoses Imipramine 27.3517567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.6818296743
MESH:D008106 Liver Cirrhosis, Experimental atorvastatin 3.5317347453
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 3.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008107 Liver Diseases Chlorpromazine 3.5914986274
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 12.7518644402 16835634
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 12.757678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 12.7520195826 21137059
MESH:D008113 Liver Neoplasms Fenofibrate 12.7518978307
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.7516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 8.632876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 8.6318775883 18253720
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.6312151625
MESH:D008133 Long QT Syndrome olanzapine 4.4620210726
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.0717053015 20135361 20464547 18520028 20869020 6695378 20064080 18816296 18569708
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.0711884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.5415318939
MESH:D001523 Mental Disorders Amitriptyline 36.7616856516
MESH:D001523 Mental Disorders Chlorpromazine 36.7616856516
MESH:D001523 Mental Disorders Citalopram 36.7616856516
MESH:D001523 Mental Disorders Clomipramine 36.7616856516
MESH:D001523 Mental Disorders Clozapine 36.7616856516
MESH:D001523 Mental Disorders Haloperidol 36.7616856516
MESH:D001523 Mental Disorders Imipramine 36.7616856516
MESH:D001523 Mental Disorders olanzapine 36.7616856516
MESH:D008654 Mesothelioma Selenium 2.6515107826
MESH:D008659 Metabolic Diseases olanzapine 5.0719142110
MESH:D024821 Metabolic Syndrome X Clozapine 9.0919142101
MESH:D024821 Metabolic Syndrome X Fructose 9.0917261469 17098227 18497449 16815490 19165636
MESH:D008881 Migraine Disorders Amitriptyline 4.5418803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9216381670
MESH:D009135 Muscular Diseases atorvastatin 16.2416239165
MESH:D009135 Muscular Diseases Bezafibrate 16.2416239165
MESH:D009135 Muscular Diseases Gemfibrozil 16.2416239165
MESH:D009175 Mycoplasma Infections Chlorpromazine 5.6410773494
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7412213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.517678174 18551238
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 4.868820588
MESH:D009369 Neoplasms Benzo(a)pyrene 4.8611141357
MESH:D009404 Nephrotic Syndrome atorvastatin 4.8619348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.8814600291
MESH:D009765 Obesity Clozapine 10.0018515891 19142110
MESH:D009765 Obesity Dietary Fats 10.0020132043 20518802 18674790 17217161 19632207 21332399 11836018 18457598 16723640
MESH:D009765 Obesity Fructose 10.0018585860 17707055
MESH:D009765 Obesity olanzapine 10.0018515891
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.1316049721
MESH:D010146 Pain Amitriptyline 10.3312798668
MESH:D010146 Pain Clomipramine 10.3312798668
MESH:D010146 Pain Imipramine 10.3312798668
MESH:D010212 Papilloma Hydrogen Peroxide 3.7412065085
MESH:D010300 Parkinson Disease Cholesterol, Dietary 4.0419014385
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8912520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.0315687053
MESH:D010954 Plasmacytoma Selenium 4.5315087411
MESH:D011085 Polycystic Ovary Syndrome Simvastatin 5.0317105841
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8411896295 11399792 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 4.7420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.5817292933
MESH:D011471 Prostatic Neoplasms Cadmium 3.5817075824
MESH:D011595 Psychomotor Agitation Haloperidol 10.6611575062
MESH:D011595 Psychomotor Agitation olanzapine 10.6618685284
MESH:D011618 Psychotic Disorders Clozapine 8.3115331141
MESH:D011618 Psychotic Disorders Haloperidol 8.3111575062
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5018990726
MESH:D012559 Schizophrenia Clozapine 5.5320521320 20107430 11151749 18855531 19369910 20168265 20452607 20580759 17123785 16141801 20521326 17667964 11763009 17726453 18806925
MESH:D012559 Schizophrenia Haloperidol 5.5318513383 1830565 20107430 19369910
MESH:D012559 Schizophrenia olanzapine 5.5320107430 20521326 17726453
MESH:D012640 Seizures 2,6-dinitrotoluene 2.3118551238
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.8416631401
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.4419755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 8.4412065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.4416192470
MESH:D012892 Sleep Deprivation Imipramine 5.8419798453
MESH:D007319 Sleep Initiation and Maintenance Disorders Amitriptyline 5.0915341891
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5520155912 2093021
MESH:D017180 Tachycardia, Ventricular Haloperidol 9.8420210726
MESH:D017180 Tachycardia, Ventricular olanzapine 9.8420210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5412697716
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.4916049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.4917053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.9610091137
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.3218645019
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8915886252
MESH:D015430 Weight Gain Clozapine 14.7117502770 20521320 20564506 16402076 16141801 20107430
MESH:D015430 Weight Gain Dietary Fats 14.7116723640
MESH:D015430 Weight Gain olanzapine 14.7117933447 20107430 19434072
MESH:D015431 Weight Loss Clozapine 4.7217933447
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA336
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    Releated drug ID Related drug Name
    PA449061clozapine
    PA449841haloperidol
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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