AutismKB 2.0

Annotation Detail for SRMS


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Basic Information Top
Gene Symbol:SRMS ( C20orf148,SRM,dJ697K14.1 )
Gene Full Name: src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
Band: 20q13.33
Quick LinksEntrez ID:6725; OMIM: NA; Uniprot ID:SRMS_HUMAN; ENSEMBL ID: ENSG00000125508; HGNC ID: 11298
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of SRMS mRNAdecreases expression 18648102
D010634 Phenobarbital Phenobarbital results in increased methylation of SRMS promoterincreases methylation 19482888
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 4.326195326
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 3.003712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.8617620307
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 6.091440618 11289319
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.187296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.1817173139 20007298 20935162 1701930 6705139
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.867296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.087505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 5.024080065
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.5119486331 9022650
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.5514531868 8156756 2524372 11298694 11906362 18759878 12868966 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 4.102952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.066482804 16192314 11289319 18648102 18692083 6679447 18289764 9653073 9022650 9328219 8291058 1440618 7440962
MESH:D004421 Dystonia Phenobarbital 4.611851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.873659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.943922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.1020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 4.016401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 5.027750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.903659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.193581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 6.096705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.647505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.196705139
MESH:D006529 Hepatomegaly Phenobarbital 4.2516109766
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.7015034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 6.098074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.406582329
MESH:D008103 Liver Cirrhosis Phenobarbital 3.1221047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.479327722 15034207
MESH:D008107 Liver Diseases Phenobarbital 2.2519363144
MESH:D008113 Liver Neoplasms Phenobarbital 2.4521047994 19073162 15975961 19812893 19482888 8742319
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.893712494 598648 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.896150874 17172636 2563599 1399818 18308698
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.3617484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.623581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.216679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.926482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 6.093988306
MESH:D010018 Osteomalacia Phenobarbital 5.2517016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.6216965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.247296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.546228378
MESH:D011230 Precancerous Conditions Phenobarbital 4.092563599
MESH:D019310 Pseudolymphoma Phenobarbital 5.5612752131
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.743692021
MESH:D012640 Seizures Phenobarbital 3.013137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.716407741
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 8.446582329 7505956 3712494 1399818 6587162
MESH:D013964 Thyroid Neoplasms Phenobarbital 8.441399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.428074119
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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